Note 6 - Notes Payable (Details Textual) - USD ($)								1 Months Ended				3 Months Ended			12 Months Ended
	Mar. 01, 2021	Feb. 24, 2021	Apr. 21, 2020	Apr. 20, 2020	Mar. 19, 2020	Feb. 05, 2020	Sep. 28, 2018	Jan. 31, 2020	Sep. 30, 2019	Feb. 27, 2019	Nov. 30, 2018	Dec. 31, 2020	Sep. 30, 2020	Mar. 31, 2020	Dec. 31, 2021	Dec. 31, 2020	Apr. 05, 2020	Mar. 05, 2020	Jul. 15, 2019	Dec. 31, 2018
Debt Instrument, Face Amount												$ 4,676,755			$ 0	$ 4,676,755
Gain (Loss) on Extinguishment of Debt, Total															(0)	541,867
Payments for Penalties															1,073,470	247,327
Debt Instrument, Unamortized Discount, Total												244,830			0	244,830
Repayments of Debt															4,162,744	1,472,389
Debt Conversion, Converted Instrument, Amount															0	$ 267,328
Chief Executive Officer [Member]
Debt Conversion, Converted Instrument, Shares Issued (in shares)								50,000
Investor of Promissory Note [Member]
Stock Issued During Period, Shares, New Issues (in shares)						46,875
Dr. Schwartz [Member]
Debt Conversion, Converted Instrument, Shares Issued (in shares)		100,401
Shares Issued, Price Per Share (in dollars per share)			$ 1.43
Stock Issued, Agreement, Not to be Transferred or Sold For Three Months (in shares)			766,740
Stock Issued, Agreement, Not to be Transferred or Sold for Six Months (in shares)			766,741
Dr. Schwartz [Member] | DrSchwartz Notes [Member]
Debt Conversion, Converted Instrument, Shares Issued (in shares)		143,573
Conversion of Bridge Loan to Common Stock [Member]
Debt Conversion, Converted Instrument, Shares Issued (in shares)																170,000
Promissory Note Exchange Agreement [Member] | Chief Executive Officer [Member]
Debt Conversion, Converted Instrument, Amount								$ 2,115,000
Conversion of Promissory Note Into Common Stock [Member]
Shares Issued, Price Per Share (in dollars per share)			$ 1.43
Bridge Loan Warrants [Member]
Class of Warrant or Right, Number of Securities Called by Warrants or Rights (in shares)							107,178
Class of Warrant or Right, Exercise Price of Warrants or Rights (in dollars per share)							$ 11.55
Warrant for Promissory Notes [Member]
Class of Warrant or Right, Number of Securities Called by Warrants or Rights (in shares)									68,237
Class of Warrant or Right, Exercise Price of Warrants or Rights (in dollars per share)									$ 6.21
Warrants Issued With Promissory Note, One [Member]
Class of Warrant or Right, Number of Securities Called by Warrants or Rights (in shares)						94,631
Warrants Issued With Promissory Note, Two [Member]
Class of Warrant or Right, Number of Securities Called by Warrants or Rights (in shares)																		92,700
Warrants Issued With Promissory Note, Three [Member]
Class of Warrant or Right, Number of Securities Called by Warrants or Rights (in shares)																	92,700
Warrants Issued With Promissory Note [Member]
Class of Warrant or Right, Exercise Price of Warrants or Rights (in dollars per share)						$ 2.992
Dr. Schwartz Notes Warrants [Member]
Class of Warrant or Right, Number of Securities Called by Warrants or Rights (in shares)																			22,129
Class of Warrant or Right, Exercise Price of Warrants or Rights (in dollars per share)																			$ 8.36
Convertible Promissory Note [Member]
Debt Instrument, Face Amount												1,721,776			$ 0	$ 1,721,776
Promissory Note [Member] | Chief Executive Officer [Member]
Debt Instrument, Interest Rate, Stated Percentage								12.00%
Second Promissory Note [Member]
Debt Instrument, Face Amount						$ 1,450,000
Debt Instrument, Interest Rate, Stated Percentage						8.00%
Debt Conversion, Original Debt, Amount												$ 503,354
Debt Conversion, Converted Instrument, Shares Issued (in shares)												1,075,911
Proceeds from Short-term Debt, Total						$ 400,000
Payments for Penalties																0
Penalties Accrued												$ 314,011				314,011
Short-term Debt, Total												1,464,146				1,464,146
Debt Instrument, Unamortized Discount, Total												0				0
Debt Instrument, Convertible, Conversion Price (in dollars per share)						$ 2.589
Dr. Schwartz Note, One [Member]
Debt Instrument, Face Amount																				$ 370,000
Debt Instrument, Unamortized Discount, Total																				$ 63,028
Proceeds from Related Party Debt											$ 370,000
DrSchwartz Notes [Member]
Debt Instrument, Face Amount			$ 2,115,000					$ 2,115,000											$ 1,920,000
Debt Instrument, Interest Rate, Stated Percentage								12.00%
Short-term Debt, Total			2,192,878
Interest Payable			$ 77,878
DrSchwartz Notes [Member] | Conversion of Promissory Note Into Common Stock [Member]
Debt Conversion, Converted Instrument, Shares Issued (in shares)			1,583,481
Borrowings Against Equity Line [Member]
Debt Instrument, Face Amount												$ 1,098,684				$ 1,098,684
Debt Instrument, Interest Rate, Stated Percentage												8.00%				8.00%
Proceeds from Short-term Debt, Total																$ 1,020,000
Payments for Penalties																247,327
Short-term Debt, Total												$ 0				0
Repayments of Short-term Debt, Total																1,459,973
Bridge Notes [Member] | Convertible Promissory Note [Member]
Debt Instrument, Face Amount							$ 2,297,727
Proceeds from Notes Payable, Total							$ 2,000,000
Stock Issued During Period, Shares, New Issues (in shares)							65,000			16,667
Debt Instrument, Interest Rate, Stated Percentage							8.00%
Debt Instrument, Increase (Decrease), Net, Total										$ 344,659
Debt Conversion, Original Debt, Amount																267,328
Securities Purchase Agreements [Member] | Promissory Note [Member]
Debt Instrument, Face Amount					$ 300,000				$ 847,500
Stock Issued During Period, Shares, New Issues (in shares)									8,857
Debt Instrument, Interest Rate, Stated Percentage									8.00%
Debt Conversion, Original Debt, Amount												$ 525,000
Debt Conversion, Converted Instrument, Shares Issued (in shares)												1,136,448
Proceeds from Short-term Debt, Total									$ 700,000
Stock Issued During Period, Shares, Extension of Notes Payable (in shares)					30,000
Gain (Loss) on Extinguishment of Debt, Total													$ (345,000)	$ (300,000)
Payments for Penalties																0
Penalties Accrued												$ 320,542				320,542
Short-term Debt, Total												1,490,833				1,490,833
Debt Instrument, Unamortized Discount, Total												$ 244,830				$ 244,830
Securities Purchase Agreements [Member] | Promissory Note [Member] | Maturity Extension to March 31, 2021 [Member]
Gain (Loss) on Extinguishment of Debt, Total													(690,000)
Securities Purchase Agreements [Member] | Second Promissory Note [Member]
Gain (Loss) on Extinguishment of Debt, Total													(172,500)
Securities Purchase Agreements [Member] | Second Promissory Note [Member] | Maturity Extension to March 31, 2021 [Member]
Gain (Loss) on Extinguishment of Debt, Total													$ (345,000)
Debt Issued in September 2018, September, 2019, and February 2020 [Member]
Repayments of Debt	$ 5,906,802
Paycheck Protection Program CARES Act [Member]
Proceeds from Issuance of Long-term Debt, Total				$ 541,867