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Note 7 - Derivatives (Tables)
12 Months Ended
Dec. 31, 2021
Notes Tables  
Schedule of Derivative Liabilities at Fair Value [Table Text Block]

Derivative liability balance at December 31, 2019

  $ 50,989  

Derivative instrument recognized for A, B and Agent Warrants

    2,669,995  

Derivative instrument related to Promissory Note 2020

    120,921  

Derivative instrument recognized for May 2020 Warrants

    1,324,184  

Derivative instrument recognized for June 2020 Warrants

    1,749,721  

Derivative instrument related to Promissory Note 2020

    20,542  

Reclassification of Warrant liabilities to Equity on exercise

    (1,701,756 )

Reclassification of Warrant liabilities to Equity

    (2,669,408 )

Derivative instrument related to September 30 debt amendments

    495,100  

Gain recognized to revalue derivative instrument at fair value

    (1,765,906 )

Derivative liability balance at December 31, 2020

  $ 294,382  

Gain recognized to revalue derivative instrument at fair value

    (164,902 )

Derivative liability balance at December 31, 2021

  $ 129,480