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Note 7 - Stockholders' Equity, Stock Options and Warrants (Tables)
 3 Months Ended
Mar. 31, 2020
Notes Tables  
Share-based Payment Arrangement, Activity [Table Text Block]
    Stock Options   Warrants
    Number of
Shares		   Average
Exercise
Price		   Number of
Shares		   Average
Exercise
Price
Outstanding at December 31, 2018    
366,928
     $
17.03
      
362,664
     $
41.67
  
                                 
Issued    
423,295
      
6.53
      
1,869,299
      
9.25
  
Forfeited    
(23,799
 )    
13.30
      
(653
 )    
3,249.28
  
Exercised    
-
      
-
      
(59,700
 )    
0.10
  
                                 
Outstanding at December 31, 2019    
766,424
     $
11.34
      
2,171,610
     $
15.26
  
                                 
Issued    
38,350
      
2.37
      
5,001,591
      
1.42
  
Forfeited    
(10,736
 )    
9.20
      
(119,441
 )    
6.47
  
Exercised    
-
      
-
      
-
      
-
  
                                 
Outstanding at March 31, 2020    
794,038
     $
10.90
      
7,053,760
     $
4.57