Note 9 - Income Taxes - Reconciliation of Income Tax Benefit (Expense) (Details) - USD ($)	12 Months Ended
	Dec. 31, 2019	Dec. 31, 2018
Statutory federal income tax benefit	$ 3,977,561	$ 2,118,160
State tax benefit, net of federal taxes	368,635	66,117
Foreign tax benefit	104,050	132,931
Foreign operations tax rate differential	(73,869)	(94,373)
State rate adjustment	(17,585)	15,355
R&D tax credit	51,143	22,532
Nondeductible/nontaxable items	(517,465)	(118,905)
State NOL adjustment	(1,054,778)	746,479
OID and derivatives	141,908	(159,037)
Helomics purchase adjustment	66,394,188
Other	115,896	47,868
Valuation allowance increase	(69,489,684)	(2,777,127)
Total income tax benefit	$ 0