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Note 4 - Stockholders' Equity, Stock Options and Warrants (Tables)
 9 Months Ended
Sep. 30, 2019
Notes Tables  
Share-based Payment Arrangement, Activity [Table Text Block]
    Stock Options   Warrants
    Number of
Shares		   Average
Exercise
Price		   Number of
Shares		   Average
Exercise
Price
Outstanding at December 31, 2017    
276,498
     $
19.95
      
195,126
     $
237.40
  
                                 
Issued    
109,886
      
10.13
      
233,615
      
10.67
  
Expired    
(19,456
 )    
20.00
      
(1,071
 )    
1,995.53
  
Exercised    
-
      
-
      
(65,006
 )    
10.00
  
                                 
Outstanding at December 31, 2018    
366,928
     $
17.03
      
362,664
     $
41.67
  
                                 
Issued    
366,120
      
7.12
      
1,805,943
      
9.36
  
Expired    
(19,484
 )    
14.73
      
(630
 )    
3,258.32
  
Exercised    
-
      
-
      
(59,700
 )    
0.10
  
                                 
Outstanding at September 30, 2019    
713,564
     $
11.84
      
2,108,277
     $
15.33