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Note 4 - Stockholders' Equity, Stock Options and Warrants (Tables)
 6 Months Ended
Jun. 30, 2019
Notes Tables  
Share-based Payment Arrangement, Activity [Table Text Block]
    Stock Options   Warrants
    Number of
Shares		   Average
Exercise
Price		   Number of
Shares		   Average
Exercise
Price
Outstanding at December 31, 2017    
2,764,983
     $
2.00
      
1,951,257
     $
23.74
  
                                 
Issued    
1,098,858
      
1.01
      
2,336,154
      
1.07
  
Expired    
(194,564
 )    
2.00
      
(10,706
 )    
199.55
  
Exercised    
-
      
-
      
(650,062
 )    
1.00
  
                                 
Outstanding at December 31, 2018    
3,669,277
     $
1.70
      
3,626,643
     $
4.17
  
                                 
Issued    
3,731,868
      
0.72
      
17,212,545
      
0.95
  
Expired    
(101,397
 )    
2.00
      
(919
 )    
603.89
  
Exercised    
-
      
-
      
(578,560
 )    
0.01
  
                                 
Outstanding at June 30, 2019    
7,299,748
     $
1.20
      
20,259,709
     $
1.67