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Note 10 - Related Party Transactions (Details Textual) - USD ($)					1 Months Ended		3 Months Ended	12 Months Ended
	Mar. 12, 2019	Feb. 06, 2019	Feb. 01, 2019	Jan. 08, 2019	Dec. 31, 2018	Nov. 30, 2018	Mar. 31, 2019	Dec. 31, 2018	Dec. 31, 2017	Jul. 11, 2018	Jul. 10, 2018
Proceeds from Issuance of Common Stock								$ 2,959,509	$ 3,814,938
Shares Issued, Price Per Share										$ 1.17	$ 1.18
Schwartz Warrant First Tranche [Member]
Class of Warrant or Right, Number of Securities Called by Warrants or Rights						221,292
Class of Warrant or Right, Exercise Price of Warrants or Rights						$ 0.836
Schwartz Warrant Second Tranche [Member] \| Subsequent Event [Member]
Class of Warrant or Right, Share Limit				78,128
Schwartz Warrant Third Tranche [Member] \| Subsequent Event [Member]
Class of Warrant or Right, Number of Securities Called by Warrants or Rights		138,889
Class of Warrant or Right, Exercise Price of Warrants or Rights		$ 1.188
Class of Warrant or Right, Share Limit		1,108,596
Schwartz Warrant [Member] \| Subsequent Event [Member]
Class of Warrant or Right, Additional Shares Increase, Percentage			0.50%
Class of Warrant or Right, Share Limit		2,818,350
Class of Warrant or Right, Share Limit Percentage		19.90%
Director [Member]
Related Party Transaction, Monthly Cash Payment								$ 12,000
Related Party Transaction, Contract Term								180 days
Chief Executive Officer [Member]
Proceeds from Related Party Debt					$ 370,000	$ 370,000
Chief Executive Officer [Member] \| Subsequent Event [Member]
Proceeds from Related Party Debt	$ 1,300,000	$ 300,000		$ 950,000			$ 1,300,000
Due to Related Parties, Total				$ 1,320,000
Stock Issued During Period, Shares, New Issues				78,125
Proceeds from Issuance of Common Stock				$ 50,000
Shares Issued, Price Per Share				$ 0.64
Cash Payment In Lieu of Share Increase As Percentage of Principal Balance of Note		0.50%
Chief Executive Officer [Member] \| Subsequent Event [Member] \| Schwartz Note [Member]
Debt Instrument, Face Amount		$ 1,620,000
Chief Executive Officer [Member] \| Schwartz Warrant Second Tranche [Member] \| Subsequent Event [Member]
Class of Warrant or Right, Number of Securities Called by Warrants or Rights				742,188
Class of Warrant or Right, Exercise Price of Warrants or Rights				$ 0.704
TumorGenesis [Member]
Ownership Percentage					100.00%			100.00%