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Note 5 - Loss Per Share (Tables)
6 Months Ended 12 Months Ended
Jun. 30, 2018
Dec. 31, 2017
Notes Tables    
Schedule of Earnings Per Share, Basic and Diluted [Table Text Block]
    Three Months Ended June 30,   Six Months Ended June 30,
    2018   2017   2018   2017
Numerator                                
Net loss available in basic and diluted calculation   $
(2,373,410
)   $
(2,543,670
)   $
(4,133,432
)   $
(3,885,517
)
Comprehensive loss    
(2,373,410
)    
(2,543,670
)    
(4,133,432
)    
(3,885,517
)
Denominator:                                
Weighted average common shares outstanding-basic    
11,878,490
     
6,167,689
     
11,632,221
     
6,308,554
 
                                 
Effect of diluted stock options, warrants and preferred stock (1)    
-
     
-
     
-
     
-
 
                                 
Weighted average common shares outstanding-basic    
11,878,490
     
6,167,689
     
11,632,221
     
6,308,554
 
                                 
Loss per common share-basic and diluted   $
(0.20
)   $
(0.41
)   $
(0.36
)   $
(0.62
)
    Year Ended December 31,
    2017   2016
Numerator:                
Net loss available in basic and diluted calculation   $
(7,746,593
)   $
(6,526,014
)
Other comprehensive income:                
Unrealized gain (loss) from marketable securities    
-
     
1,501
 
Comprehensive (loss)    
(7,746,593
)    
(6,524,513
)
Denominator:                
Weighted average common shares outstanding-basic    
6,362,989
     
2,823,345
 
                 
Effect of dilutive stock options, warrants and preferred stock (1)    
-
     
-
 
                 
Weighted average common shares outstanding-basic    
6,362,989
     
2,823,345
 
                 
Loss per common share-basic and diluted   $
(1.22
)   $
(2.31
)