Note 3 - Stockholders' Equity, Stock Options and Warrants (Details Textual)											1 Months Ended	3 Months Ended				9 Months Ended	12 Months Ended		193 Months Ended
	Apr. 01, 2018 USD ($) shares	Mar. 12, 2018 $ / shares shares	Feb. 21, 2018 USD ($) $ / shares shares	Jan. 15, 2018 $ / shares shares	Jan. 11, 2018 USD ($) shares	Nov. 30, 2017 USD ($) $ / shares shares	Nov. 29, 2016 USD ($) $ / shares shares	Mar. 31, 2016 shares	Aug. 31, 2015 USD ($) $ / shares shares	Feb. 04, 2014 USD ($) $ / shares shares	Jan. 31, 2018 USD ($) $ / shares shares	Mar. 31, 2018 USD ($) $ / shares shares	Dec. 31, 2017 USD ($) $ / shares shares	Mar. 31, 2017 USD ($)	Jul. 06, 2016 shares	Sep. 30, 2016 $ / shares shares	Dec. 31, 2018 $ / shares shares	Dec. 31, 2017 USD ($) $ / shares shares	Mar. 31, 2018 USD ($) $ / shares shares	Jan. 02, 2018 shares	Dec. 28, 2017 $ / shares shares	Jan. 29, 2017 shares	Oct. 27, 2016 shares	Apr. 21, 2016 shares	Mar. 25, 2016 $ / shares shares
Shares Issued, Price Per Share | $ / shares									$ 9
Underwriter Price | $ / shares									8.28
Underwriting Discount | $ / shares									$ 0.72
Underwriting Commission									8.00%
Proceeds from Issuance or Sale of Equity, Total | $									$ 13,800,000
Option Granted to Underwriter to Purchase Additional Units Period									45 days
Option Granted to Underwriter to Purchase Additional Units Number of Units Granted									250,000
Underwriting Agreement Non-accountable Expense Allowance Percentage									1.00%
Common Stock, Par or Stated Value Per Share | $ / shares			$ 0.01									$ 0.01	$ 0.01					$ 0.01	$ 0.01		$ 0.01
Share Price | $ / shares																$ 4.125
Class of Warrant or Right, Outstanding												2,860,052							2,860,052
Stock Issued During Period, Value, New Issues | $												$ 2,755,087						$ 3,421,188
Common Stock, Shares Authorized												50,000,000	50,000,000					50,000,000	50,000,000		50,000,000	24,000,000	8,000,000
Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Expected Dividend Rate												0.00%
Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested and Expected to Vest, Exercisable, Number												1,957,291							1,957,291
Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested and Expected to Vest, Outstanding, Weighted Average Exercise Price | $ / shares												$ 2.18							$ 2.18
Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested and Expected to Vest, Outstanding, Weighted Average Remaining Contractual Term												9 years 83 days
Class of Warrant or Right Number of Warrants Vested and Exercisable												2,860,052							2,860,052
Allocated Share-based Compensation Expense, Total | $												$ 226,387		$ 99,307
Employee Service Share-based Compensation, Nonvested Awards, Compensation Not yet Recognized, Stock Options | $												$ 1,180,348							$ 1,180,348
Share-based Compensation Arrangement by Share-based Payment Award, Plan Modification, Incremental Compensation Cost | $													$ 1,900,000
Vice President of Sales [Member]
Common Stock, Par or Stated Value Per Share | $ / shares				$ 0.01
Share-based Compensation Arrangement by Share-based Payment Award, Options, Grants in Period, Gross				50,000
Share-based Compensation Arrangements by Share-based Payment Award, Options, Grants in Period, Weighted Average Exercise Price | $ / shares				$ 0.97
Number of Equal Installments Options are Expected to Vest				4
Vice President of Sales and Marketing [Member]
Common Stock, Par or Stated Value Per Share | $ / shares		$ 0.01
Share-based Compensation Arrangement by Share-based Payment Award, Options, Grants in Period, Gross		111,112
Share-based Compensation Arrangements by Share-based Payment Award, Options, Grants in Period, Weighted Average Exercise Price | $ / shares		$ 1.35
Number of Equal Installments Options are Expected to Vest		4
Stock Incentive Plan 2012 [Member]
Share-based Compensation Arrangement by Share-based Payment Award, Options, Grants in Period, Gross																		2,500,000
Share-based Compensation Arrangement by Share-based Payment Award, Number of Shares Authorized																				5,000,000
The 2016 Registered Direct Offering [Member]
Proceeds from Issuance or Sale of Equity, Total | $							$ 1,983,337
Class of Warrant or Right, Exercise Price of Warrants or Rights | $ / shares							$ 4.46
Share Price | $ / shares							$ 2.62
Stock Issued During Period, Shares, New Issues							756,999
Class of Warrant or Right, Number of Securities Called by Warrants or Rights							756,999
Class of Warrant or Right Term							5 years
Class of Warrant or Right, Vesting Period							180 days
Proceeds from Issuance or Sale of Equity, Net of Stock Issuance Costs | $							$ 1,739,770												1,739,770
Private Placement [Member]
Class of Warrant or Right, Exercise Price of Warrants or Rights | $ / shares						$ 1.26
Stock Issued During Period, Value, New Issues | $																		$ 1,213,819
Class of Warrant or Right, Number of Securities Called by Warrants or Rights						606,910
Class of Warrant or Right Term						5 years 182 days
Class of Warrant or Right, Vesting Period						180 days
Proceeds from Issuance of Convertible Preferred Stock | $						$ 1,300,000
The 2018 Public Offering [Member]
Proceeds from Issuance or Sale of Equity, Total | $											$ 2,755,000								$ 2,755,000
Share Price | $ / shares											$ 0.95
Stock Issued During Period, Shares, New Issues											2,900,000
Over-Allotment Option [Member]
Shares Issued, Price Per Share | $ / shares			$ 0.9497									$ 0.9497							$ 0.9497
Proceeds from Issuance or Sale of Equity, Total | $																			$ 358,312
Stock Issued During Period, Value, New Issues | $												$ 204,422						$ 393,750
Stock Issued During Period, Shares, New Issues			215,247
Sale of Stock, Underwriter Option Term											45 days
Sale of Stock, Underwriter Option, Maximum Additional Shares of Common Stock Available for Purchase											290,000
Sale of Stock, Underwriter Option, Number of Securities Called by Maximum Additional Warrants Available for Purchase											87,000
Sale of Stock, Underwriter Option, Exercise Price of Additional Warrants Available for Purchase | $ / shares											$ 0.001
Proceeds from Underwriter Shares Exercised, Net | $			$ 188,066
Stock Issued During Period, Underwriter Discount | $			$ 16,354
Underwriter Discount Percentage			8.00%
Conversion from Series C Convertible Preferred Stock to Common Stock [Member]
Convertible Preferred Stock, Shares Issued upon Conversion												1.167							1.167
Conversion of Stock, Shares Issued												1,250,269
The Convertible Notes [Member]
Debt Instrument Redemption Principal Amount | $									$ 933,074
Debt Instrument Redemption Premium Percentage									40.00%
Debt Instrument Redemption Price | $									$ 1,548,792
Debt Instrument Redemption Amount Paid to Affiliates | $									$ 167,031
Series B Convertible Preferred Stock [Member]
Beneficial Ownership Limitation Percentage												4.99%
Stock Issued During Period, Value, New Issues | $										$ 2,055,000
Stock Issued During Period, Shares, New Issues										20,550
Preferred Stock Par Value | $ / shares										$ 0.01
Preferred Stock Stated Value | $ / shares										$ 100
Preferred Stock, Shares Outstanding, Ending Balance												79,246	79,246					79,246	79,246
Series A Convertible Preferred Stock [Member]
Preferred Stock, Shares Outstanding, Ending Balance									0
Series C Convertible Preferred Stock [Member]
Preferred Stock, Shares Outstanding, Ending Balance												0	647,819					647,819	0
Series A Warrants [Member] | Exchange Offer [Member]
Stock to be Issued for Exchange Offer, Shares, Maximum																									3,157,186
Cashless Exercise of Common Stock Warrants, Total								10.05
Class of Warrant or Right, Number of Securities Called by Warrants or Rights																								1,770,556
Exchange from Series B Warrants to Warrant Shares [Member] | Exchange Offer [Member]
Common Stock, Par or Stated Value Per Share | $ / shares																									$ 0.01
Series B Warrants [Member] | Exchange Offer [Member]
Class of Warrant or Right, Number of Securities Called by Each Warrant or Right								1
Class of Warrant or Right Exercised During Period															1,251,510
Stock Issued During Period, Shares, Warrants Exercised															20,122
Cashless Exercise of Common Stock Warrants, Total								10.2
Class of Warrant or Right, Number of Securities Called by Warrants or Rights																								18,059,671
Series E Warrants [Member]
Class of Warrant or Right, Exercise Price of Warrants or Rights | $ / shares												$ 1							$ 1
Series E Warrants [Member] | The 2018 Public Offering [Member]
Class of Warrant or Right, Number of Securities Called by Each Warrant or Right											1
Class of Warrant or Right, Exercise Price of Warrants or Rights | $ / shares											$ 1
Class of Warrant or Right, Issued per Unit											0.3
Common Stock [Member]
Stock Issued During Period, Shares, Conversion of Convertible Securities												589,747						660,522
Stock Issued During Period, Value, New Issues | $												$ 29,000						$ 17,500
Stock Issued During Period, Shares, New Issues												2,900,000						1,750,000
Common Stock [Member] | Private Placement [Member]
Stock Issued During Period, Value, New Issues | $
Stock Issued During Period, Shares, New Issues
Common Stock [Member] | Over-Allotment Option [Member]
Stock Issued During Period, Value, New Issues | $												$ 2,153						$ 1,750
Stock Issued During Period, Shares, New Issues												215,247						175,000
Common Stock [Member] | Series E Warrants [Member]
Stock Issued During Period, Shares, Warrants Exercised												55,796
Preferred Stock [Member]
Stock Issued During Period, Value, New Issues | $
Preferred Stock [Member] | Private Placement [Member]
Stock Issued During Period, Value, New Issues | $																		12,138
Preferred Stock [Member] | Over-Allotment Option [Member]
Stock Issued During Period, Value, New Issues | $
Preferred Stock [Member] | Series C Convertible Preferred Stock [Member] | Subsequent Event [Member]
Stock Redeemed or Called During Period, Shares	142,466
Payments for Repurchase of Convertible Preferred Stock | $	$ 189,285
Preferred Stock [Member] | Series C Convertible Preferred Stock [Member] | Private Placement [Member]
Shares Issued, Price Per Share | $ / shares						$ 1.071
Stock Issued During Period, Shares, New Issues						1,213,819
Corporate Stock Transfer Inc. [Member]
Unit Agreement Number of Shares of Common Stock Included in Each Unit									1
Common Stock, Par or Stated Value Per Share | $ / shares									$ 0.01
Corporate Stock Transfer Inc. [Member] | Series A Warrants [Member]
Class of Warrant or Right, Number of Securities Called by Each Warrant or Right																40
Class of Warrant or Right, Exercise Price of Warrants or Rights | $ / shares												$ 123.75							123.75
Cash Less Exercise Formula Definition of Letter C in the Formula Closing Bid Price Number of Trading Days Prior to the Time of Exercise												2 days
Cash Less Exercise Formula Closing Bid Price Per Share Minimum to Be Used in the Formula | $ / shares												$ 0.43							$ 0.43
Warrants Option to Settle in Cash Fair Value Disclosure | $ / shares																$ 4.319
Class of Warrant or Right Exercised During Period																6,141,115
Stock Issued During Period, Shares, Warrants Exercised																2,318,663
Class of Warrant or Right, Outstanding												35,084							35,084
Class of Warrant or Right Cash less Exercise Common Stock Price That Would Result in a Dilutive Exercise | $ / shares												$ 0.43							$ 0.43
Beneficial Ownership Limitation Percentage												4.99%
Corporate Stock Transfer Inc. [Member] | Series A Warrants [Member] | Scenario, All Outstanding Warrants Exercised at Minimum Bid Price [Member]
Stock Issued During Period, Shares, Warrants Exercised																564
Corporate Stock Transfer Inc. [Member] | Series B Convertible Preferred Stock [Member]
Unit Agreement Number of Shares of Common Stock Included in Each Unit									1
Corporate Stock Transfer Inc. [Member] | Series A Convertible Preferred Stock [Member]
Unit Agreement Number of Shares of Common Stock Included in Each Unit									4
Class of Warrant or Right, Number of Securities Called by Each Warrant or Right									1
Helomics Holding Corp. [Member]
Stock Issued During Period, Shares, New Issues					1,100,000
Share Exchange Agreement, Shares Received					2,500,000
Share Exchange Agreement, Convertible Notes Receivable | $												$ 500,000							$ 500,000
Share Exchange Agreement, Convertible Notes, Percent of Stock												5.00%							5.00%
Share Exchange Agreement, Potential Interest												25.00%							25.00%
Share Exchange Agreement, Number of Shares Held in Escrow												1,100,000							1,100,000
Share Exchange Agreement, Contingent Revenue, Minimum | $					$ 8,000,000
Convertible Preferred Stock Held, Conversion Feature, Percent					20.00%
Maximum [Member]
Underwriting Agreement Expenses Agreed to Reimburse the Underwriter | $									$ 70,000
Class of Warrant or Right, Exercise Price of Warrants or Rights | $ / shares												$ 609.38							$ 609.38
Share-based Compensation Arrangements by Share-based Payment Award, Options, Grants in Period, Weighted Average Exercise Price | $ / shares												$ 596.25
Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Risk Free Interest Rate												2.87%
Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Expected Volatility Rate												66.00%
Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Expected Term												10 years
Share-based Compensation Arrangement by Share-based Payment Award, Options, Grants in Period, Weighted Average Grant Date Fair Value | $ / shares												$ 1.0044
Maximum [Member] | Equity Incentive Plan [Member]
Share-based Compensation Arrangement by Share-based Payment Award, Award Vesting Period												3 years
Share-based Compensation Arrangement by Share-based Payment Award, Expiration Period												10 years
Minimum [Member]
Class of Warrant or Right, Exercise Price of Warrants or Rights | $ / shares												$ 0							$ 0
Share-based Compensation Arrangements by Share-based Payment Award, Options, Grants in Period, Weighted Average Exercise Price | $ / shares												$ 0.97
Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Risk Free Interest Rate												2.33%
Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Expected Volatility Rate												59.00%
Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Expected Term												5 years
Share-based Compensation Arrangement by Share-based Payment Award, Options, Grants in Period, Weighted Average Grant Date Fair Value | $ / shares												$ 0.4816
Minimum [Member] | Equity Incentive Plan [Member]
Share-based Compensation Arrangement by Share-based Payment Award, Expiration Period												3 years
Exchange Units [Member]
Unit Purchase Option Units Sold									1,666,667
Stock Issued During Period, Shares, Conversion of Convertible Securities									1,895,010
Exchange Units [Member] | Series A Convertible Preferred Stock [Member]
Stock Issued During Period, Shares, Conversion of Convertible Securities									3,991
Exchange Units [Member] | Series A Warrants [Member]
Stock Issued During Period, Shares, Conversion of Convertible Securities									7,580,040
Exchange Units [Member] | Common Stock [Member]
Stock Issued During Period, Shares, Conversion of Convertible Securities									75,801
Exchange Units [Member] | Series B Convertible Preferred Stock [Member]
Stock Issued During Period, Shares, Conversion of Convertible Securities									1,895,010
Exchange Units [Member] | Corporate Stock Transfer Inc. [Member]
Unit Purchase Option Units Issued									228,343
Unit Purchase Option Number of Units Available for Underwriter to Purchase, Percentage									5.00%
Unit Purchase Option Number of Units Available For Underwriter to Purchase									83,333
Unit Purchase Option Exercise Price, Percentage									125.00%
Unit Purchase Option Exercise Price | $ / shares									$ 11.25
Employee Stock Option [Member]
Share-based Compensation Arrangement by Share-based Payment Award, Options, Grants in Period, Gross																	325,595	2,612,070
Share-based Compensation Arrangement by Share-based Payment Award, Options, Grants in Period, Weighted Average Grant Date Fair Value | $ / shares																	$ 1.11	$ 1.45
Employee Service Share-based Compensation, Nonvested Awards, Compensation Cost Not yet Recognized, Period for Recognition												1 year 180 days