Note 2 - Stockholders' Equity (Deficit), Stock Options and Warrants (Tables)

3 Months Ended

Mar. 31, 2017

Notes Tables

Share-based Compensation, Activity [Table Text Block]

	Stock Options					Warrants
	Number of Shares			Average Exercise Price		Number of Shares			Average Exercise Price
Outstanding at December 31, 2015		31,350		$	133.23		323,099		$	128.40
Issued		157,982			3.14		1,487,881			0.71
Expired		(22,377	)		122.13		-			-
Exercised		(1,312	)		65.75		(939,879	)		-
Outstanding at December 31, 2016		165,643		$	11.22		871,101		$	52.22
Issued		14,286			2.10		385,000			2.25
Expired		(8,472	)		10.41		-			-
Exercised		-			-		-			-
Outstanding at March 31, 2017		171,457		$	10.50		1,256,101		$	36.90

Schedule of Share-based Compensation Shares Authorized Under Stock Option and Warrant Plans by Exercise Price Range [Table Text Block]

Range of Prices		Shares		Weighted Remaining Life
Options
$	2.10		14,286		10.00
$	2.25		293		9.41
$	2.42		28,896		9.39
$	2.80		57,145		9.76
$	3.75		44,000		9.26
$	4.125		3,636		9.51
$	4.1975		7,147		9.47
$	4.25		3,529		9.01
$	5.125		3,902		9.44
$	65.75		266		8.56
$	73.50		1,157		8.76
$	77.50		2,323		8.25
$	80.25		187		8.51
$	86.25		232		8.01
$	131.25		81		5.44
$	148.125		928		5.97
$	150.00		1,760		5.38
$	162.50		123		7.76
$	206.25		121		7.51
$	248.4375		121		6.29
$	262.50		130		6.29
$	281.25		529		5.80
$	318.75		3		6.11
$	346.875		72		7.01
$	431.25		306		6.94
$	506.25		188		6.76
$	543.75		53		6.52
$	596.25		42		6.50
			171,457
Warrants
$	2.25		385,000		4.82
$	4.46		756,999		4.67
$	93.75		2,255		0.95
$	123.75		94,084		3.42
$	150.00		4,114		0.95
$	225.00		107		0.82
$	243.75		2,529		2.35
$	281.25		5,897		0.70
$	309.375		2,850		2.36
$	309.50		222		2.61
$	337.50		178		1.22
$	371.25		944		1.16
$	506.25		59		1.88
$	609.375		862		1.85
			1,256,101

Disclosure of Share-based Compensation Arrangements by Share-based Payment Award [Table Text Block]

Stock Options:
Year	Shares		Price
2011		173		$281.25
2012		1,841	131.25	–	150.00
2013		1,606	148.125	–	596.25
2014		835	162.50	–	431.25
2015		4,164	65.75	–	86.25
2016		148,551	2.25	–	5.13
2017		14,286		2.10
Total		171,457	$2.10	–	596.25

Warrants:
Year	Shares		Price
2012		2,792		$281.25
2013		10,703	93.75	-	371.25
2014		6,455	243.75	–	609.38
2015		94,152	0.00	–	243.75
2016		756,999		4.46
2017		385,000		2.25
Total		1,256,101	$0.00	–	609.38