Note 3 - Stockholders' Equity (Deficit), Stock Options and Warrants - Schedule of Listing of Stock Options and Warrants (Details) - $ / shares	12 Months Ended
Dec. 31, 2016	Dec. 31, 2015
Shares, options (in shares)	165,643
Shares, warrants (in shares)	871,101
Minimum [Member]
Price, options (in dollars per share)	$ 2.25	$ 6.875
Price, warrants (in dollars per share)	0
Maximum [Member]
Price, options (in dollars per share)	596.25	$ 139.2375
Price, warrants (in dollars per share)	$ 609.38
Warrants 2012 [Member]
Shares, warrants (in shares)	2,792
Price, warrants (in dollars per share)	$ 281.25
Warrants 2013 [Member]
Shares, warrants (in shares)	10,703
Warrants 2013 [Member] \| Minimum [Member]
Price, warrants (in dollars per share)	$ 93.75
Warrants 2013 [Member] \| Maximum [Member]
Price, warrants (in dollars per share)	$ 371.25
Warrants 2014 [Member]
Shares, warrants (in shares)	6,455
Warrants 2014 [Member] \| Minimum [Member]
Price, warrants (in dollars per share)	$ 243.75
Warrants 2014 [Member] \| Maximum [Member]
Price, warrants (in dollars per share)	$ 609.38
Warrants 2015 [Member]
Shares, warrants (in shares)	94,152
Warrants 2015 [Member] \| Minimum [Member]
Price, warrants (in dollars per share)	$ 0
Warrants 2015 [Member] \| Maximum [Member]
Price, warrants (in dollars per share)	$ 243.75
Warrants 2016 [Member]
Shares, warrants (in shares)	756,999
Price, warrants (in dollars per share)	$ 4.46
Stock Options 2011 [Member]
Shares, options (in shares)	175
Price, options (in dollars per share)	$ 281.25
Stock Options 2012 [Member]
Shares, options (in shares)	1,841
Stock Options 2012 [Member] \| Minimum [Member]
Price, options (in dollars per share)	$ 131.25
Stock Options 2012 [Member] \| Maximum [Member]
Price, options (in dollars per share)	$ 150
Stock Options 2013 [Member]
Shares, options (in shares)	1,612
Stock Options 2013 [Member] \| Minimum [Member]
Price, options (in dollars per share)	$ 121.88
Stock Options 2013 [Member] \| Maximum [Member]
Price, options (in dollars per share)	$ 596.25
Stock Options 2014 [Member]
Shares, options (in shares)	969
Stock Options 2014 [Member] \| Minimum [Member]
Price, options (in dollars per share)	$ 162.50
Stock Options 2014 [Member] \| Maximum [Member]
Price, options (in dollars per share)	$ 468.75
Stock Options 2015 [Member]
Shares, options (in shares)	4,240
Stock Options 2015 [Member] \| Minimum [Member]
Price, options (in dollars per share)	$ 65.75
Stock Options 2015 [Member] \| Maximum [Member]
Price, options (in dollars per share)	$ 86.25
Stock Options 2016 [Member]
Shares, options (in shares)	156,806
Stock Options 2016 [Member] \| Minimum [Member]
Price, options (in dollars per share)	$ 2.25
Stock Options 2016 [Member] \| Maximum [Member]
Price, options (in dollars per share)	$ 5.13

Exercise price per share or per unit of warrants or rights outstanding.

Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 235
-SubTopic 10
-Section S99
-Paragraph 1
-Subparagraph (SX 210.4-08.(i)(4))
-URI http://asc.fasb.org/extlink&oid=26873400&loc=d3e23780-122690

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+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 235
-SubTopic 10
-Section S99
-Paragraph 1
-Subparagraph (SX 210.4-08.(i))
-URI http://asc.fasb.org/extlink&oid=26873400&loc=d3e23780-122690

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Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 718
-SubTopic 10
-Section 50
-Paragraph 2
-URI http://asc.fasb.org/extlink&oid=96867065&loc=d3e5070-113901

Reference 2: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 718
-SubTopic 10
-Section 50
-Paragraph 2
-Subparagraph (c)(1)(i)-(ii)
-URI http://asc.fasb.org/extlink&oid=96867065&loc=d3e5070-113901

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