Note 3 - Stockholders' Equity (Deficit), Stock Options and Warrants (Tables)

12 Months Ended

Dec. 31, 2016

Notes Tables

Share-based Compensation, Activity [Table Text Block]

	Stock Options					Warrants
	Number of Shares			Average Exercise Price		Number of Shares			Average Exercise Price
Outstanding at December 31, 2014		17,945		$	187.75		20,029		$	198.75
Issued		14,171			69.00		303,269			123.75
Expired		(766	)		293.25		(79	)		283.50
Exercised		-			-		(120	)		123.75
Outstanding at December 31, 2015		31,350		$	133.23		323,099		$	128.40
Issued		157,982			3.14		1,487,881			0.71
Cancelled		(22,377	)		122.13		-			-
Exercised		(1,312	)		65.75		(939,879	)		-
Outstanding at December 31, 2016		165,643		$	11.22		871,101		$	52.22

Schedule of Share-based Compensation Shares Authorized Under Stock Option and Warrant Plans by Exercise Price Range [Table Text Block]

Range of Exercise Prices		Shares		Weighted Average Remaining Life
Options:
$	2.25		293		9.65
$	2.42		37,152		9.64
$	2.80		57,145		10.00
$	3.75		44,000		9.50
$	4.125		3,636		9.75
$	4.1975		7,147		9.72
$	4.25		3,529		9.25
$	5.125		3,902		9.69
$	65.75		342		8.81
$	73.50		1,157		9.01
$	77.50		2,323		8.50
$	80.25		187		8.75
$	86.25		232		8.25
$	121.875		5		6.20
$	131.25		81		5.69
$	148.125		928		6.21
$	150.00		1,760		5.63
$	162.50		123		8.01
$	206.25		121		7.75
$	248.4375		121		6.54
$	262.50		130		6.54
$	281.25		529		6.04
$	318.75		3		6.35
$	346.875		72		7.25
$	431.25		306		7.19
$	468.75		133		7.15
$	506.25		188		7.00
$	543.75		53		6.77
$	596.25		45		6.75
Total			165,643
Warrants:
$	4.46		756,999		4.92
$	93.75		2,255		1.19
$	123.75		94,085		3.67
$	150.00		4,114		1.20
$	225.00		107		1.07
$	243.75		2,529		2.59
$	281.25		5,897		0.95
$	309.375		2,850		2.61
$	309.50		222		2.85
$	337.50		178		1.46
$	371.25		944		1.41
$	506.25		59		2.12
$	609.375		862		2.09
Total			871,101

Disclosure of Share-based Compensation Arrangements by Share-based Payment Award [Table Text Block]

Stock Options:
Year	Shares		Price
2011		175			281.25
2012		1,841		131.25	–	150.00
2013		1,612		121.88	–	596.25
2014		969		162.50	–	468.75
2015		4,240		65.75	–	86.25
2016		156,806		2.25	–	5.13
Total		165,643		$ 2.25	–	596.25

Warrants:
Year	Shares		Price
2012		2,792			281.25
2013		10,703		93.75	–	371.25
2014		6,455		243.75	–	609.38
2015		94,152		0.00	–	243.75
2016		756,999			4.46
Total		871,101		$ 0.00	–	609.38