Note 3 - Stockholders' Deficit, Stock Options and Warrants (Tables)

9 Months Ended

Sep. 30, 2016

Notes Tables

Schedule of Share-based Compensation, Activity [Table Text Block]

	Stock Options					Warrants
	Number of Shares			Average Exercise Price		Number of Shares			Average Exercise Price
Outstanding at December 31, 2014		17,945		$	187.75		20,029		$	198.75
Issued		14,171			69.00		303269			123.75
Expired		(766	)		293.25		(79	)		283.50
Exercised		-			-		(120	)		123.75
Outstanding at December 31, 2015		31,350		$	133.23		323,099		$	128.40
Issued		100,837			3.329		730,882			1.44
Expired		(22,377	)		122.132		-			-
Exercised		(1,312	)		65.750		(939,879	)		-
Outstanding at September 30, 2016		108,498		$	15.652		114,102		$	369.06

Schedule of Share-based Compensation Shares Authorized Under Stock Option and Warrant Plans by Exercise Price Range [Table Text Block]

	Range of Prices	Shares	Weighted Remaining Life
Options
$	2.25	293	9.90
$	2.42	37,152	9.89
$	3.75	44,000	9.76
$	4.125	3,636	10.00
$	4.1975	7,147	9.97
$	4.25	3,529	9.50
$	5.125	3,902	9.94
$	65.75	342	9.06
$	73.50	1,157	9.26
$	77.50	2,323	8.75
$	80.25	187	9.01
$	86.25	232	8.50
$	121.875	5	6.45
$	131.25	81	5.94
$	148.125	928	6.47
$	150.00	1,760	5.88
$	162.50	123	8.26
$	206.25	121	8.01
$	248.4375	121	6.79
$	262.50	130	6.79
$	281.25	529	6.30
$	318.75	3	6.60
$	346.875	72	7.50
$	431.25	306	7.44
$	468.75	133	7.40
$	506.25	188	7.25
$	543.75	53	7.02
$	596.25	42	7.00
		108,498
Warrants
$	93.75	2,255	1.45
$	123.75	94,084	3.92
$	150.00	4,114	1.45
$	225.00	107	1.32
$	243.75	2,529	2.84
$	281.25	5,897	1.20
$	309.375	2,850	2.86
$	309.50	222	3.10
$	337.50	178	1.72
$	371.25	944	1.66
$	506.25	59	2.38
$	609.375	862	2.34
		114,102

Disclosure of Share-based Compensation Arrangements by Share-based Payment Award [Table Text Block]

Stock Options:
Year	Shares		Price
2011		173		0.00	-	281.25
2012		1,841		131.25	-	150.00
2013		1,612		121.88	-	596.25
2014		969		162.50	-	468.75
2015		4,240		65.75	-	86.25
2016		99,661		2.25	-	5.13
Total		108,498		$0.00	-	596.25

Warrants:
Year	Shares		Price
2012		2,792			281.25
2013		10,703		93.75	-	371.25
2014		6,455		243.75	-	609.38
2015		94,152		0.00	-	243.75
Total		114,102		$0.00	-	609.38