Note 3 - Stockholders' Deficit, Stock Options and Warrants (Tables)

3 Months Ended

Mar. 31, 2016

Notes Tables

Schedule of Share-based Compensation, Activity [Table Text Block]

	Stock Options					Warrants
	Number of Shares			Average Exercise Price		Number of Shares			Average Exercise Price
Outstanding at December 31, 2014		448,601		$	7.51		500,722		$	7.95
Issued		354,253			2.76		7,581,722			4.95
Expired		(19,136	)		11.73		(1,967	)		11.34
Exercised		-			-		(3,000	)		4.95
Outstanding at December 31, 2015		783,718		$	5.33		8,077,477		$	5.14
Issued		117,648			0.17		-			-
Expired		-			-		-			-
Exercised		(32,796	)		2.63		(4,746,405	)		4.95
Outstanding at March 31, 2016		868,570		$	4.73		3,331,072		$	5.27

Schedule of Share-based Compensation Shares Authorized Under Stock Option and Warrant Plans by Exercise Price Range [Table Text Block]

Range of Prices		Shares		Weighted Remaining Life
Options
$	0.17		117,648		10.00
$	0.75		7,333		5.27
$	2.63		217,685		9.56
$	2.94		30,614		9.76
$	3.10		59,681		9.25
$	3.21		6,232		9.51
$	3.45		7,245		9.01
$	4.875		134		6.95
$	5.25		2,031		6.44
$	5.625		192,000		6.96
$	5.925		23,206		6.97
$	6.00		123,998		6.38
$	6.50		3,845		8.76
$	8.25		3,636		8.51
$	9.9375		3,019		7.29
$	10.50		3,238		7.29
$	11.25		13,666		6.85
$	12.75		67		7.11
$	13.875		2,160		8.01
$	17.25		40,261		7.94
$	18.75		3,334		7.90
$	20.25		4,940		7.76
$	21.75		1,336		7.52
$	23.850		1,260		7.50
			868,570
	Warrants
$	3.75		56,381		1.95
$	4.95		2,830,627		4.42
$	6.00		102,857		1.95
$	9.00		2,666		1.82
$	9.75		63,232		3.35
$	11.25		147,420		1.70
$	12.375		71,257		3.36
$	12.38		5,557		3.61
$	13.50		4,444		2.22
$	14.850		23,612		2.16
$	20.25		1,481		2.88
$	24.375		21,538		2.85
			3,331,072

Disclosure of Share-based Compensation Arrangements by Share-based Payment Award [Table Text Block]

Stock Options:
Year	Shares		Price
2011		11,666		$0.75	-	11.20
2012		126,029		5.25	-	6.00
2013		232,756		4.875	-	23.85
2014		59,013		6.50	-	18.75
2015		321,458		2.63	-	3.45
2016		117,648			0.17
Total		868,570		$ 0.17	-	23.85

Warrants:
Year	Shares		Price
2012		69,801			11.25
2013		267,579		3.75	-	14.85
2014		161,375		9.75	-	24.375
2015		2,832,317		$ 4.95	-	9.75
Total		3,331,072		$ 3.75	-	24.375