X0206 3/A 2016-02-10 2016-02-10 0 0001445283 PROTEOSTASIS THERAPEUTICS, INC. PTI 0001565579 PERRIGO SCIENCE ONE LTD. TREASURY BUILDING LOWER GRAND CANAL STREET DUBLIN L2 2 IRELAND 0 0 1 0 0000737186 PERRIGO CORP LTD. TREASURY BUILDING, LOWER GRAND CANAL STREET DUBLIN L2 2 IRELAND 0 0 1 0 0001307004 ELAN PHARMA INTERNATIONAL LTD. TREASURY BUILDING, LOWER GRAND CANAL STREET DUBLIN L2 2 IRELAND 0 0 1 0 0001323996 PERRIGO HOLDINGS LTD. TREASURY BUILDING, LOWER GRAND CANAL STREET DUBLIN L2 2 IRELAND 0 0 1 0 0001585364 PERRIGO Co plc TREASURY BUILDING, LOWER GRAND CANAL STREET DUBLIN L2 2 IRELAND 0 0 1 0 Series A Convertible Redeemable Preferred Stock Common Stock 2416612 D Series B Convertible Redeemable Preferred Stock Common Stock 366455 D The Series A Convertible Redeemable Preferred Stock (the "Series A Shares") are convertible on a 10.8102-to-1 basis into the Issuer's Common Stock at any time at the election of the Reporting Person and will automatically convert, together with the accrued but unpaid dividends, upon closing of the Issuer's initial public offering into the number of shares of the Issuer's Common Stock shown in column 3. The Series A Shares do not have an expiration date. Perrigo Science One Ltd. ("Science") (formerly Elan Science One Ltd.) is the direct owner of these securities. Science is a direct or indirect, wholly-owned subsidiary of each of the other reporting persons. The Series B Convertible Redeemable Preferred Stock (the "Series B Shares") are convertible on a 10.8102-to-1 basis into the number of shares of the Issuer's Common Stock as shown in column 3 at any time at the election of the Reporting Person and will automatically convert upon the closing of the Issuer's initial public offering. The Series B Shares do not have an expiration date. This form amends and restates the Form 3 previously filed to reflect the change in name of Elan Science One Ltd. to Perrigo Science One Ltd. and to add each of Perrigo Company plc, Perrigo Holdings Ltd., Elan Pharma International Limited and Perrigo Corporation Limited as additional reporting persons. The additional reporting persons are the direct and indirect parents of Science. /s/Todd Kingma, Secretary of Perrigo Science One Ltd. 2016-02-18 /s/Todd Kingma, Secretary of Perrigo Corporation Limited 2016-02-18 /s/Todd Kingma, Director of Elan Pharma International Limited 2016-02-18 /s/Todd Kingma, Secretary of Perrigo Holdings Ltd. 2016-02-18 /s/Todd Kingma, Secretary of Perrigo Company plc 2016-02-18