Stock-Based Compensation (Tables)

12 Months Ended

Dec. 31, 2024

Share-Based Payment Arrangement [Abstract]

Summary of Stock Option Activity

The following table summarizes stock option activity under the Company’s equity incentive plans:

	Outstanding Stock Options			Weighted-Average Exercise Price Per Share		Weighted-Average Remaining Contractual Term (years)		Aggregate Intrinsic Value
	(in thousands, except per share amounts and years)
December 31, 2023		1,975		$	9.00		7.6	$	604
Granted		1,028		$	0.38
Exercised		—		$	—
Forfeited		(506	)	$	7.07
Expired		(166	)	$	11.39
Outstanding as of December 31, 2024		2,331		$	5.45		8.2	$	—
Exercisable as of December 31, 2024		1,295		$	8.67		7.6	$	—

Summary of Fair Value of Stock Options Granted for Employee and Non-Employee Awards

The fair value of stock options granted for employee and non-employee awards was estimated at the grant date using the Black-Scholes option pricing model based on the following assumptions:

	Years Ended December 31,
	2024	2023
Expected volatility	121.8% - 124.9%	111.1% - 113.1%
Expected term (years)	1.00	5.35 - 6.08
Risk-free interest rate	4.19% - 5.07%	3.4% - 4.4%
Expected dividend yield	0%	0%

Summary of Companies Restricted Stock Activity

The following table summarizes the Company’s restricted stock activity consisting of RSUs:

	Number of Restricted Stock (RSUs)			Weighted-Average Grant Date Fair Value Per Share
Outstanding and unvested as of December 31, 2023		7,516		$	27.14
Exercised/Released		(6,484	)	$	27.20
Cancelled/Forfeited		(1,032	)	$	26.16
Outstanding and unvested as of December 31, 2024		—

Summary of Total Stock-Based Compensation

The following table summarizes total stock-based compensation included in the Company’s consolidated statements of operations:

	Years Ended December 31,
	2024		2023
	(in thousands)
Research and development	$	259	$	608
General and administrative		981		3,246
Total stock-based compensation	$	1,240	$	3,854