X0306 4 2021-12-01 0 0001445283 YUMANITY THERAPEUTICS, INC. YMTX 0001834469 Epstein Marie C/O YUMANITY THERAPEUTICS, INC 40 GUEST STREET, SUITE 4410 BOSTON MA 02135 0 1 0 0 Principal Accounting Officer Common Stock 2021-12-01 4 A 0 12665 0.00 A 12665 D Restricted stock award granted under the Yumanity Therapeutics, Inc. Amended and Restated 2018 Stock Option and Grant Plan. Fifty percent of the shares subject to the award will vest six months after the grant date and fifty percent will vest twelve months after the grant date, provided that the award recipient continues to have a service relationship with the Company at such time. /s/ Marie Epstein 2021-12-03