X0306 4 2020-12-22 0 0001445283 YUMANITY THERAPEUTICS, INC. YMTX 0001348587 Allen Patricia L C/O YUMANITY THERAPEUTICS, INC 40 GUEST STREET, SUITE 4410 BOSTON MA 02135 1 0 0 0 Stock Option (Right to Buy) 8.16 2020-12-22 4 A 0 12495 A 2029-09-08 Common Stock 12495 12495 D Stock Option (Right to Buy) 8.16 2020-12-22 4 A 0 5271 A 2030-04-06 Common Stock 5271 5271 D On August 22, 2020, the Issuer (formerly known as Proteostasis Therapeutics, Inc.) entered into an Agreement and Plan of Merger and Reorganization, as amended on November 6, 2020, with Pangolin Merger Sub, Inc. ("Merger Sub"), Yumanity, Inc. (formerly known as Yumanity Therapeutics, Inc.) and Yumanity Holdings, LLC ("Holdings"). On December 22, 2020, Merger Sub was merged with and into Yumanity, Inc., with Yumanity, Inc. surviving as a wholly-owned subsidiary of the Issuer (the "Merger"). Immediately prior to the consummation of the Merger, Holdings was merged with and into Yumanity, Inc., with Yumanity, Inc. as the surviving entity. The shares subject to the option vest in equal quarterly installments over four years, commencing on August 15, 2019. Received in the Merger in exchange for a stock option to acquire 59,266 shares of Yumanity, Inc. common stock for $1.72 per share. The shares subject to the option vest in equal quarterly installments over four years, commencing on February 18, 2020. Received in the Merger in exchange for a stock option to acquire 25,000 shares of Yumanity, Inc. common stock for $1.72 per share. /s/ Marie Epstein, Attorney-in-Fact 2020-12-28