X0306 4 2020-12-22 0 0001445283 YUMANITY THERAPEUTICS, INC. YMTX 0001584759 Heyman Richard A. C/O YUMANITY THERAPEUTICS, INC 40 GUEST STREET, SUITE 4410 BOSTON MA 02135 1 0 0 0 Common Stock 2020-12-22 4 A 0 6158 A 6158 D Stock Option (Right to Buy) 8.16 2020-12-22 4 A 0 5271 A 2030-04-06 Common Stock 5271 5271 D On August 22, 2020, the Issuer (formerly known as Proteostasis Therapeutics, Inc.) entered into an Agreement and Plan of Merger and Reorganization, as amended on November 6, 2020, with Pangolin Merger Sub, Inc. ("Merger Sub"), Yumanity, Inc. (formerly known as Yumanity Therapeutics, Inc.) and Yumanity Holdings, LLC ("Holdings"). On December 22, 2020, Merger Sub was merged with and into Yumanity, Inc., with Yumanity, Inc. surviving as a wholly-owned subsidiary of the Issuer (the "Merger"). Immediately prior to the consummation of the Merger, Holdings was merged with and into Yumanity, Inc., with Yumanity, Inc. as the surviving entity. The shares were received in exchange for 29,207.20 shares of Yumanity, Inc. common stock in connection with the Merger. The shares subject to the option vest in equal quarterly installments over four years, commencing on February 18, 2020. Received in the Merger in exchange for a stock option to acquire 25,000 shares of Yumanity, Inc. common stock for $1.72 per share. /s/ Marie Epstein, Attorney-in-Fact 2020-12-28