X0306 4 2020-12-22 0 0001445283 YUMANITY THERAPEUTICS, INC. YMTX 0001197018 COLES N ANTHONY C/O YUMANITY THERAPEUTICS, INC 40 GUEST STREET, SUITE 4410 BOSTON MA 02135 1 1 0 0 Executive Chair Common Stock 2020-12-22 4 A 0 689890 A 689890 D Common Stock 2020-12-22 4 A 0 52669 A 52669 I By the Coles 2016 Irrevocable Trust Stock Option (Right to Buy) 8.16 2020-12-22 4 A 0 72496 A 2028-12-08 Common Stock 72496 72496 D Stock Option (Right to Buy) 8.16 2020-12-22 4 A 0 12082 A 2029-09-09 Common Stock 12082 12082 D Warrant (Right to Buy) 24.05 2020-12-22 4 A 0 6038 A 2016-02-08 2025-08-14 Common Stock 6038 6038 D On August 22, 2020, the Issuer (formerly known as Proteostasis Therapeutics, Inc.) entered into an Agreement and Plan of Merger and Reorganization, as amended on November 6, 2020, with Pangolin Merger Sub, Inc. ("Merger Sub"), Yumanity, Inc. (formerly known as Yumanity Therapeutics, Inc.) and Yumanity Holdings, LLC ("Holdings"). On December 22, 2020, Merger Sub was merged with and into Yumanity, Inc., with Yumanity, Inc. surviving as a wholly-owned subsidiary of the Issuer (the "Merger"). Immediately prior to the consummation of the Merger, Holdings was merged with and into Yumanity, Inc., with Yumanity, Inc. as the surviving entity. The shares were received in exchange for 3,272,078.16 shares of Yumanity, Inc. common stock in connection with the Merger. The shares were received in exchange for 249,950 shares of Yumanity, Inc. common stock in connection with the Merger. 25% of the shares subject to the option vested on December 4, 2019. The remaining 75% vest in equal monthly installments over the subsequent three years. Received in the Merger in exchange for a stock option to acquire 343,841 shares of Yumanity, Inc. common stock for $1.72 per share. 25% of the shares subject to the option vested on December 4, 2019. The remaining 75% vest in equal monthly installments over the subsequent three years. Received in the Merger in exchange for a stock option to acquire 57,307 shares of Yumanity, Inc. common stock for $1.72 per share. Received in the Merger in exchange for a warrant to purchase 28,642 shares of Yumanity, Inc. common stock for $5.069 per share. /s/ Marie Epstein, Attorney-in-Fact 2020-12-28