Federal and state net operating loss carry forwards expiration year.

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- Definition

Income taxes.

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No definition available.

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- Definition

Percentage of domestic federal statutory tax rate applicable to pretax income (loss).

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- Definition

Amount of operating loss carryforward, before tax effects, available to reduce future taxable income under enacted tax laws.

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- Definition

The amount of the tax credit carryforward, before tax effects, available to reduce future taxable income under enacted tax laws.

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- Definition

Amount of unrecognized tax benefits.

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Amount accrued for interest on an underpayment of income taxes and penalties related to a tax position claimed or expected to be claimed in the tax return.

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Amount of increase (decrease) in the valuation allowance for a specified deferred tax asset.

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Income Taxes - Additional Information (Detail) - USD ($)	12 Months Ended
	Dec. 31, 2018	Dec. 31, 2017	Dec. 31, 2016	Dec. 31, 2015
Income Taxes [Line Items]
Tax at statutory federal rate	21.00%	34.00%	34.00%
Increase in valuation allowance	$ 12,600,000	$ 2,400,000	$ 18,700,000
Unrecognized tax benefits	5,200,000	4,233,000	3,384,000	$ 3,844,000
Accrued interest and penalties	0	$ 0	$ 0
Research and Development Credit Carryforwards [Member] \| California state [Member]
Income Taxes [Line Items]
Tax credit carry forwards	6,800,000
Federal [Member]
Income Taxes [Line Items]
Net operating loss carryforward	$ 291,600,000
Net operating loss expiration date	2026
Federal [Member] \| Research and Development Credit Carryforwards [Member]
Income Taxes [Line Items]
Tax credit carry forwards	$ 9,600,000
State and Local Jurisdiction [Member]
Income Taxes [Line Items]
Net operating loss carryforward	$ 124,200,000
Net operating loss expiration date	2020