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Formation and Business of the Company - Additional Information (Detail) - USD ($)
$ in Thousands
1 Months Ended 3 Months Ended 12 Months Ended
Jun. 30, 2016
Dec. 31, 2018
Sep. 30, 2018
Jun. 30, 2018
Mar. 31, 2018
Dec. 31, 2017
Sep. 30, 2017
Jun. 30, 2017
Mar. 31, 2017
Dec. 31, 2018
Dec. 31, 2017
Dec. 31, 2016
Formation and Business of the Company [Line Items]                        
Net loss   $ 9,607 $ 11,265 $ 10,620 $ 17,713 $ 4,311 $ 6,230 $ 11,610 $ 14,507 $ 49,205 $ 36,658 $ 31,778
Cash used in operations                   5,708 14,273 $ 58,503
Accumulated deficit   $ 306,082       $ 257,844       $ 306,082 $ 257,844  
1.75% Convertible Senior Notes due 2021 [Member]                        
Formation and Business of the Company [Line Items]                        
Debt instrument due year 2021                 2021