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Note 16 - Income Taxes - Reconciliation of Federal Statutory Income Tax Rate to Effective Tax Rate (Details)
12 Months Ended
Dec. 31, 2021
Dec. 31, 2020
Dec. 31, 2019
Federal tax statutory rate 21.00% 21.00% 21.00%
State tax (net of federal benefit) 2.10% 2.10% 2.10%
Share based compensation (2.30%) (1.30%) (0.50%)
Valuation allowance against deferred tax assets 8.90% 2.00% 1.40%
Contingent consideration reduction (7.00%) 0.00% 0.00%
Research and development credit (4.00%) (3.70%) (2.80%)
Foreign rate differential (2.20%) (0.80%) (0.30%)
Tax reserves (1.00%) 1.40% 1.10%
Provision to return difference (0.70%) (1.40%) 0.00%
Miscellaneous 2.20% (0.10%) (0.40%)
Total 17.00% 19.20% 21.60%