X0306 4 2018-04-10 0 0000906709 NEKTAR THERAPEUTICS NKTR 0001443159 Hora Maninder C/O NEKTAR THERAPEUTICS 455 MISSION BAY BOULEVARD SOUTH SAN FRANCISCO CA 94158 0 1 0 0 SVP Pharma Dev & Mfg Ops Common Stock 2018-04-10 4 M 0 502 7.21 A 80763 D Common Stock 2018-04-10 4 S 0 502 105.67 D 80261 D Stock Option 7.21 2018-04-10 4 M 0 502 0.00 D 2016-02-08 2020-02-07 Common Stock 502 32500 D This transaction was made pursuant to a Rule 10b5-1 trading plan adopted by the reporting person. This number includes 6,500 shares held by the reporting person from the Issuer's ESPP plan. The acquisition of these shares under this plan is exempt under Rule 16b-3(c). This transaction was executed in multiple trades at prices ranging from $105.03 to $105.81. The price reported above reflects the weighted average sale price. The reporting person hereby undertakes to provide full information regarding the number of shares and the prices at which the transactions were effected upon request to the SEC staff, the issuer, or a security holder of the issuer. Mark A. Wilson, Attorney-in-Fact 2018-04-12