Consolidated Statements of Cash Flows - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2024	Dec. 31, 2023	Dec. 31, 2022
Cash flows from operating activities
Segment and consolidated net loss	$ (69,192)	$ (171,670)	$ (204,212)
Adjustments to reconcile net loss to net cash used in operating activities:
Depreciation	1,628	1,517	927
Net amortization of premiums and discounts on marketable securities	(3,917)	(4,569)	(1,462)
Stock-based compensation	16,458	21,136	21,522
Non-cash operating lease expense	3,116	2,780	2,777
Other non-cash items	305	687	763
Changes in operating assets and liabilities:
Accounts receivable	0	30,000	(30,000)
Prepaid expenses and other current assets	2,689	3,534	3,863
Other assets	(500)	0	0
Accounts payable	(2,857)	(6,080)	947
Accrued expenses	(2,934)	(20,935)	13,594
Operating lease liabilities	(3,254)	(3,143)	(2,539)
Deferred revenue	(23,882)	(22,139)	143,709
Other liabilities	0	0	748
Net cash used in operating activities	(82,340)	(168,882)	(49,363)
Cash flows from investing activities
Maturities of marketable securities	145,000	277,970	97,000
Purchase of marketable securities	(133,431)	(155,919)	(247,519)
Purchase of property and equipment	(132)	(2,168)	(2,197)
Net cash provided by (used in) investing activities	11,437	119,883	(152,716)
Cash flows from financing activities
Proceeds from exercise of stock options	56	427	1,331
Proceeds from purchases of common stock under ESPP	486	1,121	1,065
Proceeds from issuance of debt, net of issuance costs	0	(150)	0
Repayment of debt	(2,083)	0	0
Payments under finance lease obligations	(147)	(262)	(272)
Net cash provided by financing activities	4,092	94,675	153,017
(Decrease) increase in cash, cash equivalents and restricted cash	(66,811)	45,676	(49,062)
Cash, cash equivalents and restricted cash, beginning of period	175,039	129,363	178,425
Cash, cash equivalents and restricted cash, end of period	108,228	175,039	129,363
Supplemental cash flow information:
Cash paid for income taxes	418	0	0
Fair value of common stock retired in exchange for issuance of pre-funded warrants	13,984	0	0
Purchases of property and equipment in accounts payable and accrued expenses	0	132	753
Debt financing costs in accrued expenses	0	0	150
Common stock issuance costs in accounts payable and accrued expenses	0	0	131
Cash paid for interest	3,467	3,380	2,463
Right-of-use assets obtained in exchange for operating lease liabilities	0	0	298
At Market Equity Offering Program
Cash flows from financing activities
Net proceeds from at-the-market facilities	$ 5,780	$ 93,539	$ 150,893