Stockholders’ equity - Narrative (Details)		12 Months Ended
	Dec. 19, 2024 $ / shares shares	Dec. 31, 2024 USD ($) vote shares	Dec. 31, 2023 USD ($) shares	Dec. 31, 2022 USD ($) shares	Jan. 31, 2025 shares	Feb. 29, 2024 USD ($)	Nov. 30, 2022 USD ($)	Feb. 28, 2022 USD ($)	May 31, 2020 USD ($)
Class of Stock [Line Items]
Preferred stock, shares authorized (in shares)		25,000,000	25,000,000
Preferred stock, shares issued (in shares)		0	0
Warrant exercise price per share (in dollars per share) | $ / shares	$ 0.0001
Number of shares reserved for future issuance (in shares)		24,188,968	14,736,953
Common Stock
Class of Stock [Line Items]
Retirement of common stock in exchange for pre-funded warrants (in shares)		8,036,688
Number of votes per common share | vote		1
Warrants and share-based payment awards
Class of Stock [Line Items]
Number of shares reserved for future issuance (in shares)		24,188,968	14,736,953
Prefunded Warrants
Class of Stock [Line Items]
Retirement of common stock in exchange for pre-funded warrants (in shares)	8,036,688
Number of shares of common stock into which warrants may be converted (in shares)	8,036,688
Exercise Of Warrants, Beneficial Ownership, Maximum		9.99%
Prefunded Warrants | Subsequent Event
Class of Stock [Line Items]
Number of shares of common stock into which warrants may be converted (in shares)					8,035,395
At Market Equity Offering Program (2020 ATM)
Class of Stock [Line Items]
Amount of shares authorized to be offered and sold | $									$ 100,000,000
Proceeds from issuance of common stock | $				$ 54,800,000
At Market Equity Offering Program (2020 ATM) | Common Stock
Class of Stock [Line Items]
Number of shares sold (in shares)				11,740,210
At Market Equity Offering Program (February 2022 ATM)
Class of Stock [Line Items]
Amount of shares authorized to be offered and sold | $								$ 100,000,000
Proceeds from issuance of common stock | $			$ 1,600,000	$ 96,400,000
At Market Equity Offering Program (February 2022 ATM) | Common Stock
Class of Stock [Line Items]
Number of shares sold (in shares)			256,386	18,757,665
At Market Equity Offering Program (November 2022 ATM)
Class of Stock [Line Items]
Amount of shares authorized to be offered and sold | $							$ 150,000,000
Proceeds from issuance of common stock | $		$ 5,800,000	$ 92,200,000
At Market Equity Offering Program (November 2022 ATM) | Common Stock
Class of Stock [Line Items]
Number of shares sold (in shares)		1,041,201	14,208,145
At Market Equity Offering Program (February 2024 ATM)
Class of Stock [Line Items]
Amount of shares authorized to be offered and sold | $						$ 100,000,000
At Market Equity Offering Program (February 2024 ATM) | Common Stock
Class of Stock [Line Items]
Stock issuance program, remaining unsold and available amount | $		$ 100,000,000