Accrued expenses (Details) - USD ($) $ in Thousands	Dec. 31, 2024	Dec. 31, 2023
Accrued Liabilities, Current [Abstract]
Accrued payroll and related expenses	$ 7,341	$ 8,807
Accrued manufacturing expenses	5,862	2,566
Accrued clinical expenses	3,883	5,063
Accrued professional fees	800	936
Accrued research and non-clinical expenses	782	3,090
Accrued restructuring expenses	0	1,047
Accrued other	296	389
Total	$ 18,964	$ 21,898