Nature of business and basis of presentation (Details) $ in Thousands	3 Months Ended
	Mar. 31, 2024 USD ($) candidate	Mar. 31, 2023 USD ($)	Dec. 31, 2023 USD ($)
Organization, Consolidation and Presentation of Financial Statements [Abstract]
Number of additional preclinical candidates | candidate	2
Net loss	$ (19,306)	$ (56,163)
Accumulated deficit	$ (845,667)		$ (826,361)