Nature of business and basis of presentation (Details) $ in Thousands	12 Months Ended
	Dec. 31, 2023 USD ($) candidate	Dec. 31, 2022 USD ($)	Dec. 31, 2021 USD ($)
Organization, Consolidation and Presentation of Financial Statements [Abstract]
Number of additional preclinical candidates | candidate	2
Net loss	$ 171,670	$ 204,212	$ 170,060
Accumulated deficit	$ 826,361	$ 654,691