Accrued expenses (Details) - USD ($) $ in Thousands	Jun. 30, 2023	Dec. 31, 2022
Accrued Liabilities, Current [Abstract]
Accrued clinical expenses	$ 10,741	$ 14,822
Accrued manufacturing expenses	8,378	11,536
Accrued payroll and related expenses	7,591	11,558
Accrued research and non-clinical expenses	4,589	2,767
Accrued professional fees	1,649	1,865
Accrued other	520	636
Total	$ 33,468	$ 43,184