Stock-based compensation - Schedule of Stock-Based Compensation Expense as Reflected in the Company's Condensed Consolidated Statements of Operations and Comprehensive Loss (Details) - USD ($) $ in Thousands	3 Months Ended
	Mar. 31, 2023	Mar. 31, 2022
Stock options
Share-based compensation expense	$ 6,407	$ 5,485
Research and development
Stock options
Share-based compensation expense	3,332	2,933
General and administrative
Stock options
Share-based compensation expense	$ 3,075	$ 2,552