Accrued expenses (Details) - USD ($) $ in Thousands	Mar. 31, 2023	Dec. 31, 2022
Accrued Liabilities, Current [Abstract]
Accrued manufacturing expenses	$ 7,801	$ 11,536
Accrued clinical expenses	13,414	14,822
Accrued research and non-clinical expenses	3,488	2,767
Accrued payroll and related expenses	4,754	11,558
Accrued professional fees	2,726	1,865
Accrued other	405	636
Total	$ 32,588	$ 43,184