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Nature of business and basis of presentation (Details) - USD ($)
$ in Thousands
3 Months Ended
Mar. 31, 2023
Mar. 31, 2022
Dec. 31, 2022
Organization, Consolidation and Presentation of Financial Statements [Abstract]      
Net loss $ (56,163) $ (47,258)  
Accumulated deficit $ (710,854)   $ (654,691)