Collaboration Agreements - Summary of Contract Assets and Liabilities (Details) - USD ($)	12 Months Ended
	Dec. 31, 2022	Dec. 31, 2021
Contract Liabilities [Roll Forward]
Balance at Beginning of Period	$ 3,944,000	$ 3,987,000
Additions	170,000,000	0
Deductions	26,291,000	43,000
Balance at End of Period	147,653,000	3,944,000
GSK Agreement
Contract Liabilities [Roll Forward]
Balance at End of Period	98,000,000
Contract assets	0	0
Janssen Agreement
Contract Liabilities [Roll Forward]
Balance at End of Period	15,800,000
Contract assets	0	0
2022 Merck KGaA Agreement
Contract Liabilities [Roll Forward]
Balance at End of Period	30,000,000
Contract assets	0	0
2014 Merck KGaA Agreement and 2018 Merck KGaA Supply Agreement
Contract Liabilities [Roll Forward]
Balance at Beginning of Period	3,900,000
Balance at End of Period	3,900,000	3,900,000
Contract assets	0	0
Amounts included in the contract liability at the beginning of the period	43,000	43,000
Performance obligations satisfied in previous periods	$ 0	$ 0