Collaboration Agreements - Merck Immunosynthen Agreement (Details) $ in Thousands	1 Months Ended	12 Months Ended
	Feb. 28, 2023 USD ($)	Dec. 31, 2022 USD ($) target performanceObligation	Dec. 31, 2021 USD ($)	Dec. 31, 2020 USD ($)
Collaboration agreements
Deferred revenue		$ 147,653	$ 3,944	$ 3,987
Contract with customer, receivable, after allowance for credit loss		30,000
Collaboration revenue		$ 26,581	$ 43	$ 828
2022 Merck KGaA Agreement
Collaboration agreements
Number of targets designated | target		2
Performance obligations identified | performanceObligation		4
Revised transaction price		$ 32,000
Deferred revenue		30,000
Contract with customer, receivable, after allowance for credit loss		30,000
Collaboration revenue		0
2022 Merck KGaA Agreement | Subsequent Event
Collaboration agreements
Upfront payment received	$ 30,000
2022 Merck KGaA Agreement | Developmental And Regulatory
Collaboration agreements
Aggregate milestones		200,000
2022 Merck KGaA Agreement | Commercial
Collaboration agreements
Aggregate milestones		$ 600,000