Collaboration Agreements - GlaxoSmithKline (Details) - USD ($) $ in Thousands	1 Months Ended	12 Months Ended
	Aug. 31, 2022	Dec. 31, 2022	Dec. 31, 2021	Dec. 31, 2020	Aug. 06, 2022
Collaboration agreements
Collaboration revenue		$ 26,581	$ 43	$ 828
Deferred revenue		147,653	$ 3,944	$ 3,987
GSK Agreement
Collaboration agreements
Revised transaction price					$ 100,000
Upfront payment received	$ 100,000
Collaboration arrangement, potential option exercise receivable	90,000
Collaboration revenue		2,000
Deferred revenue		$ 98,000
GSK Agreement | Developmental, Commercial, And Regulatory
Collaboration agreements
Aggregate milestones	1,300,000
GSK Agreement | Early Clinical Development
Collaboration agreements
Aggregate milestones	$ 30,000