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Stock-based compensation (Tables)
 12 Months Ended
Dec. 31, 2022
Share-Based Payment Arrangement [Abstract]  
Schedule of Stock Option Activity A summary of stock option activity is as follows:
Number
of Shares
Weighted-
Average
Exercise Price
Weighted Average
Remaining
Contractual Term
Aggregate
Intrinsic Value
Outstanding at January 1, 20228,342,429 $11.25 7.2$8,458 
Granted2,793,659 $5.43 
Exercised(414,914)$3.21 
Cancelled(669,891)$13.09 
Outstanding at December 31, 202210,051,283 $9.84 7.2$8,197 
Exercisable at December 31, 20225,410,541 $9.45 6.1$6,076 
Schedule of Restricted Stock Unit Activity A summary of the RSU activity is as follows:
Number
of Shares		Weighted-Average
Remaining
Contractual Term		Aggregate
Intrinsic Value		Weighted-Average
Grant Date
Fair Value
Unvested at January 1, 2022817,609 1.5$5,086 $15.68 
Granted1,460,924 — $5.70 
Vested(235,591)— $15.62 
Forfeited(172,151)— $8.54 
Unvested at December 31, 20221,870,791 1.5$10,963 $8.55 
Schedule of Stock-Based Compensation Expense by Award Type
The following table presents stock-based compensation expense by award type included within the Company’s consolidated statements of operations and comprehensive loss:
Year ended December 31,
(in thousands)202220212020
Stock options
$15,814 $14,528 $5,725 
Restricted stock units
5,175 3,522 1,187 
Employee stock purchase plan
533 359 260 
Stock-based compensation expense included in total operating expenses$21,522 $18,409 $7,172 
Schedule of Stock-Based Compensation Expense as Reflected in the Company’s Condensed Consolidated Statements of Operations and Comprehensive Loss
The following table presents stock-based compensation expense as reflected in the Company’s consolidated statements of operations and comprehensive loss:
Year ended December 31,
(in thousands)202220212020
Research and development$11,386 $9,984 $3,841 
General and administrative10,136 8,425 3,331 
Stock-based compensation expense included in total operating expenses$21,522 $18,409 $7,172 
Schedule of Weighted Average Assumptions for Estimating Fair Value of Option Awards The fair value of each option award is estimated on the date of grant using the Black–Scholes option pricing model with the following weighted average assumptions:
December 31,
202220212020
Risk-free interest rate
2.1 %0.9 %1.2 %
Expected dividend yield
— %— %— %
Expected term (years)
5.996.066.05
Expected stock price volatility
88 %82 %74 %