Accrued expenses (Details) - USD ($) $ in Thousands	Mar. 31, 2022	Dec. 31, 2021
Accrued Liabilities, Current [Abstract]
Accrued clinical expenses	$ 7,569	$ 7,879
Accrued manufacturing expenses	9,381	8,476
Accrued preclinical expenses	4,824	3,848
Accrued payroll and related expenses	3,456	7,319
Accrued professional fees	1,751	909
Accrued other	494	285
Total	$ 27,475	$ 28,716