Subsequent Events (Details) - USD ($) $ in Thousands		1 Months Ended	2 Months Ended	20 Months Ended
	Feb. 02, 2022	Feb. 28, 2022	Feb. 25, 2022	Dec. 31, 2021	Feb. 17, 2022
At Market Equity Offering Program (2020 ATM)
Subsequent Event [Line Items]
Net proceeds from issuance of common stock				$ 43,087
Common Stock | At Market Equity Offering Program (2020 ATM)
Subsequent Event [Line Items]
Number of shares sold (in shares)				3,961,074
Subsequent Event | At Market Equity Offering Program (2020 ATM)
Subsequent Event [Line Items]
Net proceeds from issuance of common stock			$ 45,579
Value of shares available for sale			$ 9,414
Subsequent Event | Common Stock | At Market Equity Offering Program (2020 ATM)
Subsequent Event [Line Items]
Number of shares sold (in shares)			9,493,776
Subsequent Event | Janssen
Subsequent Event [Line Items]
Upfront payment received		$ 40,000
Subsequent Event | Synaffix
Subsequent Event [Line Items]
Collaboration Agreement Nonrefundable Execution Fee	$ 1,500
Subsequent Event | Development and Regulatory | Janssen
Subsequent Event [Line Items]
Aggregate milestones		501,000
Subsequent Event | Commercial | Janssen
Subsequent Event [Line Items]
Aggregate milestones		$ 530,000
Subsequent Event | Line of Credit | Amended New Credit Facility, Combined Tranche Four and Five
Subsequent Event [Line Items]
Maximum borrowing capacity					$ 20,000
Tranche availability duration (in days)					90 days