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Stock Options (Tables)
 12 Months Ended
Dec. 31, 2021
Share-based Payment Arrangement [Abstract]  
Schedule of stock option activity A summary of the activity is as follows:
Number
of Shares
Weighted-
Average
Exercise Price
Weighted Average
Remaining
Contractual Term
Aggregate
Intrinsic Value
Outstanding at January 1, 20216,112,948 $7.84 7.3$114,729 
Granted3,308,220 $16.78 
Exercised(421,381)$4.36 
Cancelled(657,358)$11.76 
Outstanding at December 31, 20218,342,429 $11.25 7.2$8,458 
Vested and expected to vest at December 31, 20218,342,429 $11.25 7.2$8,458 
Exercisable at December 31, 20213,997,529 $7.63 5.5$7,539 
Schedule of restricted stock unit activity A summary of the RSU activity under the 2017 Plan is as follow:
Number
of Shares		Weighted-Average
Remaining
Contractual Term		Aggregate
Intrinsic Value		Weighted-Average
Grant Date
Fair Value
Unvested at January 1, 2021716,767 1.0$19,073 $6.00 
Granted715,716 — $18.39 
Vested(419,336)— $5.33 
Forfeited(195,538)— $12.34 
Unvested at December 31, 2021817,609 1.5$5,086 $15.68 
Schedule of stock-based compensation expense by award type
The following table presents stock-based compensation expense by award type included within the Company’s consolidated statement of operations and comprehensive loss:
Year ended December 31,
202120202019
Stock options
$14,528 $5,725 $4,230 
Restricted stock units
3,522 1,187 410 
Employee stock purchase plan
359 260 232 
Stock-based compensation expense included in Total operating expenses
$18,409 $7,172 $4,872 
Schedule of stock-based compensation expense as reflected in the Company’s condensed consolidated statements of operations and comprehensive loss
The following table presents stock-based compensation expense as reflected in the Company’s consolidated statements of operations and comprehensive loss:
Year ended December 31,
202120202019
Research and development$9,984 $3,841 $2,245 
General and administrative8,425 3,331 2,627 
Stock-based compensation expense included in Total operating expenses$18,409 $7,172 $4,872 
Schedule of weighted average assumptions for estimating fair value of option awards The fair value of each option award is estimated on the date of grant using the Black–Scholes option pricing model with the following weighted average assumptions:
December 31,
202120202019
Risk-free interest rate
0.9 %1.2 %2.3 %
Expected dividend yield
— %— %— %
Expected term (years)
6.066.055.99
Expected stock price volatility
82 %74 %74 %