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Collaboration agreements - Merck KGaA Agreement (Details)
$ in Thousands
1 Months Ended 3 Months Ended 9 Months Ended 31 Months Ended
Jun. 30, 2014
USD ($)
item
Sep. 30, 2017
USD ($)
item
Sep. 30, 2016
USD ($)
Sep. 30, 2017
USD ($)
item
Sep. 30, 2016
USD ($)
Dec. 31, 2016
USD ($)
Collaboration agreements            
Collaboration revenue   $ 6,267 $ 3,262 $ 14,284 $ 13,175  
Accounts receivable   731   731   $ 1,051
Deferred revenue, current   16,476   16,476   22,731
Merck KGaA            
Collaboration agreements            
Upfront payment received $ 12,000          
Number of targets | item 6          
Amount of additional fees receivable when target is designated and commercial license to target is granted $ 0          
Aggregate milestones 780,000          
Development milestones 84,000          
Regulatory milestones 264,000          
Sales milestones $ 432,000          
Number of individual development milestones per target | item 6          
Number of individual regulatory milestones per target | item 5          
Number of individual commercial milestones per target | item 3          
Milestone revenue received and recognized   500       2,000
Next potential development milestone payment eligible to receive   $ 500   $ 500    
Number of targets designated | item 6 6   6    
Prior written notice for termination period 60 days          
Total arrangement consideration $ 23,025 $ 19,875   $ 19,875    
Expected fees for research services 11,025 7,875   7,875    
Collaboration revenue   499 $ 777 2,107 $ 2,656  
Accounts receivable   51   51   509
Deferred revenue   7,335   7,335   8,236
Deferred revenue, current   5,213   $ 5,213   $ 6,195
First and second targets combined | Merck KGaA            
Collaboration agreements            
Selling price allocation   6,428        
License and corresponding research and development services | Merck KGaA            
Collaboration agreements            
Selling price allocation $ 3,723 3,214        
Estimated period in which revenue will be recognize 36 months          
Future technological improvements | Merck KGaA            
Collaboration agreements            
Selling price allocation $ 437 376        
Estimated performance period in which revenue will be recognized 10 years          
Joint research committee services | Merck KGaA            
Collaboration agreements            
Selling price allocation $ 248 $ 214        
Estimated performance period in which revenue will be recognized 6 years