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Collaboration agreements - 2016 Takeda and XMT-1522 Agreements - Accounting (Details) - USD ($)
$ in Thousands
1 Months Ended 3 Months Ended 9 Months Ended
Jan. 31, 2016
Sep. 30, 2017
Sep. 30, 2016
Sep. 30, 2017
Sep. 30, 2016
Accounting analysis          
Research and development   $ 11,412 $ 7,555 $ 32,145 $ 23,163
2016 Restated Tokeda Agreement and XMT-1522 Agreement          
Accounting analysis          
Total arrangement consideration $ 50,089 46,148   46,148  
Upfront payment received 13,500        
Expected fees for research services 9,515 4,160   4,160  
Remaining deferred revenue 7,498        
Non-creditable portion of XMT-1522 upfront fee 13,250        
Expected reimbursement for related services 6,326 7,740   7,740  
License consideration and research plan extension fee received       800  
2016 Restated Tokeda Agreement and XMT-1522 Agreement | Exclusive development and commercialization license and related research services, First designated target          
Accounting analysis          
Selling price allocation 4,502        
2016 Restated Tokeda Agreement and XMT-1522 Agreement | Research license and related services, Second designated target          
Accounting analysis          
Selling price allocation 1,362        
2016 Restated Tokeda Agreement and XMT-1522 Agreement | Discount on exclusive license, Second designated target          
Accounting analysis          
Selling price allocation 553        
2016 Restated Tokeda Agreement and XMT-1522 Agreement | Exclusive development and commercialization license and related research services, Third designated target          
Accounting analysis          
Selling price allocation 4,546        
2016 Restated Tokeda Agreement and XMT-1522 Agreement | Exclusive development and commercialization license and related research services, Fourth designated target          
Accounting analysis          
Selling price allocation 4,975        
2016 Restated Tokeda Agreement and XMT-1522 Agreement | Exclusive development and commercialization license and related research services, Fifth designated target          
Accounting analysis          
Selling price allocation 4,975        
2016 Restated Tokeda Agreement and XMT-1522 Agreement | Exclusive development and commercialization license and related research services, Sixth designated target          
Accounting analysis          
Selling price allocation 4,975        
2016 Restated Tokeda Agreement and XMT-1522 Agreement | Exclusive development and commercialization license and related research services, Seventh designated target          
Accounting analysis          
Selling price allocation 4,975        
2016 Restated Tokeda Agreement and XMT-1522 Agreement | First replacement right, Designated target          
Accounting analysis          
Selling price allocation 3,685        
2016 Restated Tokeda Agreement and XMT-1522 Agreement | Discount on second replacement right, Designated target          
Accounting analysis          
Selling price allocation 3,276        
2016 Restated Tokeda Agreement and XMT-1522 Agreement | Future technological improvements          
Accounting analysis          
Selling price allocation 1,843        
2016 Restated Tokeda Agreement and XMT-1522 Agreement | Joint research committee services, Takeda          
Accounting analysis          
Selling price allocation 157        
2016 Restated Tokeda Agreement and XMT-1522 Agreement | License and related services, XMT-1522          
Accounting analysis          
Selling price allocation 39,901        
2016 Restated Tokeda Agreement and XMT-1522 Agreement | Joint research committee services, XMT-1522          
Accounting analysis          
Selling price allocation 472        
XMT-1522 Agreement          
Accounting analysis          
Research and development   $ 924 $ 196 $ 1,719 $ 353
Upfront payment received $ 26,500