The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ABBVIE INC COM 00287Y109 98,862 916,496 SH   DFND   0 916,496 0
ADAPTIMMUNE THERAPEUTICS PLC SPONDS ADR 00653A907 1,509 291,800 SH Call DFND   0 291,800 0
ADAPTIMMUNE THERAPEUTICS PLC SPONDS ADR 00653A107 22,766 4,403,574 SH   DFND   0 4,403,574 0
AERIE PHARMACEUTICALS INC COM 00771V108 24,883 2,182,684 SH   DFND   0 2,182,684 0
AERIE PHARMACEUTICALS INC NOTE 1.500%10/0 00771VAB4 44,256 48,150,000 PRN   DFND   0 48,150,000 0
ALLENA PHARMACEUTICALS COM 018119107 256 284,285 SH   DFND   0 284,285 0
ALLOGENE THERAPEUTICS INC COM 019770106 19,939 775,819 SH   DFND   0 775,819 0
ARCUS BIOSCIENCES INC COM 03969F109 119,639 3,431,010 SH   DFND   0 3,431,010 0
ASTRAZENECA PLC SPONSORED ADR 046353108 47,192 785,748 SH   DFND   0 785,748 0
ATEA PHARMACEUTICALS INC COM 04683R106 10,607 302,532 SH   DFND   0 302,532 0
AVANTOR INC COM 05352A100 85,058 2,079,657 SH   DFND   0 2,079,657 0
BCLS ACQUISITION CORP COM CL A G0904B105 4,641 464,103 SH   DFND   0 464,103 0
BEYONDSPRING INC SHS G10830100 2,548 161,697 SH   DFND   0 161,697 0
BIOGEN INC COM 09062X103 4,783 16,900 SH   DFND   0 16,900 0
BIOMARIN PHARMACEUTICAL INC NOTE 0.599% 8/0 09061GAH4 47,675 45,910,000 PRN   DFND   0 45,910,000 0
BRISTOL-MYERS SQUIBB CO COM 110122908 36,212 612,000 SH Call DFND   0 612,000 0
BUTTERFLY NETWORK INC COM CL A 124155102 19,088 1,828,311 SH   DFND   0 1,828,311 0
CANO HEALTH INC COM CL A 13781Y103 26,555 2,094,279 SH   DFND   0 2,094,279 0
CARIBOU BIOSCIENCES INC COM 142038108 88,176 4,092,309 SH   DFND   0 4,092,309 0
CATALENT INC COM 148806102 23,660 177,800 SH   DFND   0 177,800 0
CENTENE CORP DEL COM 15135B101 61,367 984,871 SH   DFND   0 984,871 0
CERTARA INC COM 15687V109 4,734 143,028 SH   DFND   0 143,028 0
CYTOKINETICS INC COM NEW 23282W605 112,928 3,159,701 SH   DFND   0 3,159,701 0
DANAHER CORPORATION COM 235851102 53,487 175,690 SH   DFND   0 175,690 0
DECIPHERA PHARMACEUTICALS IN COM 24344T101 4,869 143,297 SH   DFND   0 143,297 0
DEXCOM INC COM 252131107 9,576 17,510 SH   DFND   0 17,510 0
DYNAVAX TECHNOLOGIES CORP COM NEW 268158901 10,024 521,800 SH Call DFND   0 521,800 0
DYNAVAX TECHNOLOGIES CORP COM NEW 268158201 63,077 3,283,570 SH   DFND   0 3,283,570 0
EDWARDS LIFESCIENCES CORP COM 28176E108 58,077 513,005 SH   DFND   0 513,005 0
ERASCA INC COM 29479A108 98,172 5,191,405 SH   DFND   0 5,191,405 0
FLUIDIGM CORP DEL COM 34385P108 6,462 980,505 SH   DFND   0 980,505 0
FS DEVELOPMENT CORP II COM CL A 30318F100 9,950 1,000,000 SH   DFND   0 1,000,000 0
GILEAD SCIENCES INC COM 375558903 67,314 963,700 SH Call DFND   0 963,700 0
GILEAD SCIENCES INC COM 375558103 46,562 666,601 SH   DFND   0 666,601 0
GUARDANT HEALTH INC COM 40131M109 10,558 84,455 SH   DFND   0 84,455 0
HCA HEALTHCARE INC COM 40412C101 94,784 390,507 SH   DFND   0 390,507 0
HERON THERAPEUTICS INC COM 427746102 32,001 2,993,546 SH   DFND   0 2,993,546 0
HORIZON THERAPEUTICS PUB L SHS G46188901 48,132 439,400 SH Call DFND   0 439,400 0
HORIZON THERAPEUTICS PUB L SHS G46188101 171,024 1,561,290 SH   DFND   0 1,561,290 0
HUMANA INC COM 444859902 8,172 21,000 SH Call DFND   0 21,000 0
HUMANA INC COM 444859102 54,255 139,420 SH   DFND   0 139,420 0
ICON PLC SHS G4705A100 41,447 158,183 SH   DFND   0 158,183 0
ICU MED INC COM 44930G107 51,481 220,587 SH   DFND   0 220,587 0
INTELLIA THERAPEUTICS INC COM 45826J105 23,908 178,222 SH   DFND   0 178,222 0
IONIS PHARMACEUTICALS INC NOTE 0.125%12/1 462222AB6 21,133 23,000,000 PRN   DFND   0 23,000,000 0
IQVIA HLDGS INC COM 46266C105 85,735 357,916 SH   DFND   0 357,916 0
IVERIC BIO INC COM 46583P102 18,483 1,138,112 SH   DFND   0 1,138,112 0
JIYA ACQUISITION CORP COM CL A 47760M102 4,539 464,103 SH   DFND   0 464,103 0
JOUNCE THERAPEUTICS INC COM 481116101 28,597 3,848,822 SH   DFND   0 3,848,822 0
KARUNA THERAPEUTICS INC COM 48576A100 21,664 177,091 SH   DFND   0 177,091 0
KINNATE BIOPHARMA INC COM 49705R105 6,084 264,293 SH   DFND   0 264,293 0
LIFESTANCE HEALTH GROUP INC COM 53228F101 6,432 443,595 SH   DFND   0 443,595 0
LILLY ELI & CO COM 532457108 121,406 525,455 SH   DFND   0 525,455 0
MCKESSON CORP COM 58155Q103 69,620 349,181 SH   DFND   0 349,181 0
MIRATI THERAPEUTICS INC COM 60468T905 2,654 15,000 SH Call DFND   0 15,000 0
MIRATI THERAPEUTICS INC COM 60468T105 53,169 300,545 SH   DFND   0 300,545 0
MOLINA HEALTHCARE INC COM 60855R100 19,016 70,088 SH   DFND   0 70,088 0
MYRIAD GENETICS INC COM 62855J104 92,767 2,872,918 SH   DFND   0 2,872,918 0
NEUROCRINE BIOSCIENCES INC COM 64125C909 25,080 261,500 SH Call DFND   0 261,500 0
NEUROCRINE BIOSCIENCES INC COM 64125C109 82,874 864,079 SH   DFND   0 864,079 0
NEVRO CORP COM 64157F103 45,712 392,786 SH   DFND   0 392,786 0
NOVAVAX INC COM NEW 670002401 40,883 197,208 SH   DFND   0 197,208 0
NOVAVAX INC NOTE 3.750% 2/0 670002AB0 7,354 4,250,000 PRN   DFND   0 4,250,000 0
OUTSET MED INC COM 690145107 146,674 2,966,712 SH   DFND   0 2,966,712 0
PENUMBRA INC COM 70975L107 47,194 177,088 SH   DFND   0 177,088 0
PMV PHARMACEUTICALS INC COM 69353Y103 8,592 288,334 SH   DFND   0 288,334 0
PRAXIS PRECISION MEDICINES I COM 74006W108 8,420 455,374 SH   DFND   0 455,374 0
PROCEPT BIOROBOTICS CORP COM 74276L105 2,480 65,000 SH   DFND   0 65,000 0
PULMONX CORP COM 745848101 4,914 136,576 SH   DFND   0 136,576 0
SEAGEN INC COM 81181C104 61,914 364,630 SH   DFND   0 364,630 0
SELECT SECTOR SPDR TR FINANCIAL 81369Y905 60,131 1,602,200 SH Call DFND   0 1,602,200 0
SIGHT SCIENCES INC COM 82657M105 10,976 483,538 SH   DFND   0 483,538 0
SILVERBACK THERAPEUTICS INC COM 82835W108 1,879 188,243 SH   DFND   0 188,243 0
SOPHIA GENETICS SA ORDINARY SHARES H82027105 35,455 2,022,552 SH   DFND   0 2,022,552 0
STEVANATO GROUP S P A ORD SHS T9224W109 13,895 549,002 SH   DFND   0 549,002 0
SYNDAX PHARMACEUTICALS INC COM 87164F105 35,482 1,856,738 SH   DFND   0 1,856,738 0
TENET HEALTHCARE CORP COM NEW 88033G407 44,320 667,073 SH   DFND   0 667,073 0
THERMO FISHER SCIENTIFIC INC COM 883556102 40,817 71,442 SH   DFND   0 71,442 0
UNITEDHEALTH GROUP INC COM 91324P902 61,424 157,200 SH Call DFND   0 157,200 0
UNITEDHEALTH GROUP INC COM 91324P102 56,773 145,295 SH   DFND   0 145,295 0
UNIVERSAL HLTH SVCS INC CL B 913903100 72,061 520,786 SH   DFND   0 520,786 0
VECTIVBIO HLDG AG ORD SHS H9060V101 4,208 544,706 SH   DFND   0 544,706 0
WATERS CORP COM 941848103 42,031 117,634 SH   DFND   0 117,634 0
WEREWOLF THERAPEUTICS INC COM 95075A107 6,864 400,000 SH   DFND   0 400,000 0
ZAI LAB LTD ADR 98887Q104 10,473 99,375 SH   DFND   0 99,375 0