ABBVIE INC COM 00287Y109 BBG0025Y4RZ3 7569955 40782 SH DFND 0 40782 0 AKERO THERAPEUTICS INC COM 00973Y108 BBG00L9211Z7 14202671 266167 SH DFND 0 266167 0 ALNYLAM PHARMACEUTICALS INC COM 02043Q107 BBG001S7FTC8 23550220 72220 SH DFND 0 72220 0 AMYLYX PHARMACEUTICALS INC COM 03237H101 BBG00DP10YW1 4693761 732256 SH DFND 0 732256 0 ARCUTIS BIOTHERAPEUTICS INC COM 03969K108 BBG00QN8K4P1 12945718 923375 SH DFND 0 923375 0 ARGENX SE SPONSORED ADR 04016X101 BBG00GHB88Y8 3989179 7237 SH DFND 0 7237 0 ASCENDIS PHARMA A/S NOTE 2.250% 4/0 04351PAD3 28841447 23000000 PRN DFND 0 23000000 0 ASCENDIS PHARMA A/S SPONSORED ADR 04351P101 BBG007R7VP72 38274740 221754 SH DFND 0 221754 0 AXSOME THERAPEUTICS INC COM 05464T104 BBG00B6G7GM6 50431331 483105 SH DFND 0 483105 0 BIOMARIN PHARMACEUTICAL INC COM 09061G101 BBG001S76R05 9802195 178319 SH DFND 0 178319 0 BLUEPRINT MEDICINES CORP COM 09627Y109 BBG001V11BV0 6209552 48444 SH DFND 0 48444 0 BRIDGEBIO PHARMA INC COM 10806X102 BBG00P9KDZL5 22531022 521793 SH DFND 0 521793 0 CARIBOU BIOSCIENCES INC COM 142038108 BBG008G28LH7 1712127 1358831 SH DFND 0 1358831 0 CENCORA INC COM 03073E105 BBG001S8X7P0 15978107 53287 SH DFND 0 53287 0 CENTESSA PHARMACEUTICALS PLC SPONSORED ADS 152309100 BBG01081FC68 4532932 344972 SH DFND 0 344972 0 COMPASS PATHWAYS PLC SPONSORED ADS 20451W101 BBG00X0VY3F8 4981925 1779259 SH DFND 0 1779259 0 CVS HEALTH CORP COM 126650100 BBG001S5QBD8 33041765 479005 SH DFND 0 479005 0 DANAHER CORPORATION COM 235851102 BBG001S5QGT0 31885524 161413 SH DFND 0 161413 0 DISC MEDICINE INC COM 254604101 BBG00W9MJL04 1631115 30799 SH DFND 0 30799 0 EDWARDS LIFESCIENCES CORP COM 28176E108 BBG001SF2288 30697660 392503 SH DFND 0 392503 0 ELI LILLY & CO COM 532457108 BBG001S5STL8 208931969 268023 SH DFND 0 268023 0 ERASCA INC COM 29479A108 BBG00MTSR892 1361724 1072224 SH DFND 0 1072224 0 HCA HEALTHCARE INC COM 40412C101 BBG001T8NTY2 27694299 72290 SH DFND 0 72290 0 HOLOGIC INC COM 436440101 BBG001S6HWB2 13813008 211986 SH DFND 0 211986 0 HUMANA INC COM 444859102 BBG001S5S1X6 26773249 109511 SH DFND 0 109511 0 ICON PLC SHS G4705A100 BBG001SDCL35 12825926 88181 SH DFND 0 88181 0 INDIVIOR PLC ORD G4766E116 BBG003T4KGV1 19986423 1355931 SH DFND 0 1355931 0 INHIBRX BIOSCIENCES INC COM 45720N103 BBG01MS5QB96 3485604 244261 SH DFND 0 244261 0 INTUITIVE SURGICAL INC COM NEW 46120E602 BBG001S7XR78 48345557 88967 SH DFND 0 88967 0 IO BIOTECH INC COM 449778109 BBG0131XRYY7 2741181 1972073 SH DFND 0 1972073 0 IRHYTHM TECHNOLOGIES INC COM 450056106 BBG001TSQV70 13572652 88157 SH DFND 0 88157 0 MASIMO CORP COM 574795100 BBG001S71GQ6 15888547 94451 SH DFND 0 94451 0 MCKESSON CORP COM 58155Q103 BBG001S8F8P8 52989520 72313 SH DFND 0 72313 0 MERUS N V COM N5749R100 BBG00B8LXMT4 9672193 183882 SH DFND 0 183882 0 MOLINA HEALTHCARE INC COM 60855R100 BBG001SKBQ20 25541648 85739 SH DFND 0 85739 0 NATERA INC COM 632307104 BBG001V0FSF8 17105175 101250 SH DFND 0 101250 0 NEOGENOMICS INC COM NEW 64049M209 BBG001S9DSY4 5628978 770038 SH DFND 0 770038 0 NEUROCRINE BIOSCIENCES INC COM 64125C109 BBG001S8W4X9 1611471 12821 SH DFND 0 12821 0 OSCAR HEALTH INC CL A 687793109 BBG00YMWFVT4 15759108 735033 SH DFND 0 735033 0 OUTSET MED INC COM NEW 690145206 BBG0026ZJTR8 31979406 1664727 SH DFND 0 1664727 0 PENUMBRA INC COM 70975L107 BBG001TRHPB0 42667560 166261 SH DFND 0 166261 0 PRAXIS PRECISION MEDICINES I COM NEW 74006W207 BBG00W9LF2H4 3562182 84713 SH DFND 0 84713 0 REZOLUTE INC COM NEW 76200L309 BBG001XWWJC0 1936238 434134 SH DFND 0 434134 0 SAGIMET BIOSCIENCES INC COM SER A 786700104 BBG0020584Z8 685800 90000 SH DFND 0 90000 0 SOLENO THERAPEUTICS INC COM 834203309 BBG0024L5B95 34115384 407202 SH DFND 0 407202 0 SPDR S&P 500 ETF TR TR UNIT 78462F103 BBG001S72SM3 10583153 17129 SH DFND 0 17129 0 STRUCTURE THERAPEUTICS INC SPONSORED ADS 86366E106 BBG01CBVHMQ6 1173760 56594 SH DFND 0 56594 0 TENET HEALTHCARE CORP COM NEW 88033G407 BBG001S70FY0 87866768 499243 SH DFND 0 499243 0 TEVA PHARMACEUTICAL INDS LTD SPONSORED ADS 881624209 BBG001S62NT9 20763059 1238846 SH DFND 0 1238846 0 UNIQURE NV SHS N90064101 BBG005SSJYG4 2430174 174331 SH DFND 0 174331 0 UNITED THERAPEUTICS CORP DEL COM 91307C102 BBG001S8RV10 10456954 36391 SH DFND 0 36391 0 UNITEDHEALTH GROUP INC COM 91324P102 BBG001S6WCJ1 10801337 34623 SH DFND 0 34623 0 UNITEDHEALTH GROUP INC COM 91324P102 BBG001S6WCJ1 20278050 65000 SH Put DFND 0 65000 0 VERONA PHARMA PLC SPONSORED ADS 925050106 BBG00GD4KBM0 7605745 80416 SH DFND 0 80416 0 VIKING THERAPEUTICS INC COM 92686J106 BBG006LGV887 999819 37729 SH DFND 0 37729 0 WATERS CORP COM 941848103 BBG001S8MDG9 15039785 43089 SH DFND 0 43089 0 WEREWOLF THERAPEUTICS INC COM 95075A107 BBG00QXQ9XL3 437210 401110 SH DFND 0 401110 0