X0306 4 2020-01-15 0000874015 IONIS PHARMACEUTICALS INC IONS 0001442730 Geary Richard S C/O IONIS PHARMACEUTICALS, INC. 2855 GAZELLE COURT CARLSBAD CA 92010 0 1 0 0 SVP, Development Common Stock 2020-01-15 2020-01-15 4 M 0 13139 0 A 34722 D Common Stock 2020-01-15 2020-01-15 4 F 0 4654 62.06 D 30068 D Retricted Stock Units 2020-01-15 2020-01-15 4 A 0 24205 0 A Common Stock 24205 24205 D Restricted Stock Units 2020-01-15 2020-01-15 4 M 0 13139 0 D Common Stock 13139 27639 D Acquired pursuant to vesting and release of shares in accordance with Restricted Stock Unit awards. Shares withheld to cover the required tax withholding obligations pursuant to the Ionis Pharmaceuticals, Inc. Amended and Restated 2011 Equity Incentive Plan. Grant to reporting person of Restricted Stock Units under the Ionis Pharmaceuticals, Inc. Amended and Restated 2011 Equity Incentive Plan. Each Restricted Stock Unit represents a contingent right to receive one share of Ionis common stock, or its equivalent cash value. Restricted Stock Units vest in four equal annual installments. Upon vesting, the Restricted Stock Units will be paid out in whole shares of Ionis common stock or cash as may be determined by Ionis. /s/Patrick R. O'Neil, attorney-in-fact 2020-01-17