Exhibit 10.1

[ * ] = Certain confidential information contained in this document, marked by brackets, has been omitted and filed separately with the Securities and Exchange Commission pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as amended.

COLLABORATION AND LICENSE AGREEMENT

This Collaboration and License Agreement (this “Agreement”) is entered into as of August 27, 2009 (the “Signing Date”), by and between Facet Biotech Corporation, a Delaware corporation having a principal place of business at 1500 Seaport Blvd., Redwood City, California 94063 (“Facet”) and Trubion Pharmaceuticals, Inc., a Delaware corporation having a principal place of business at 2401 4th Avenue, Suite 1050, Seattle, Washington 98121 (“Trubion”). Facet and Trubion may each be referred to herein individually as a “Party” and collectively as the “Parties”.

WHEREAS, Facet and Trubion are engaged in the research and development of pharmaceutical products;

WHEREAS, Trubion has developed a proprietary compound known as TRU-016 directed at the CD37 Antigen (as defined below) and shall initially manufacture such compound for the collaboration; and

WHEREAS, Facet and Trubion desire to collaborate on the research, development and commercialization of products directed at the CD37 Antigen (as defined below) as provided herein.

NOW THEREFORE, in consideration of the mutual promises and covenants set forth below and other good and valuable consideration, the receipt and sufficiency of which is hereby acknowledged, the Parties hereby agree as follows:

1. DEFINITIONS.

1.1 “AAA” has the meaning set forth in Section 15.3.

1.2 “Acquired Party” has the meaning set forth in Section 7.3.

1.3 “Affiliate(s)” means, with respect to any Person, any other Person which controls, is controlled by or is under common control with such Person for so long as such control exists. For the purposes of this definition, the word “control” (including, with correlative meaning, the terms “controlled by” or “under the common control with”) means the actual power, either directly or indirectly through one or more intermediaries, to direct or cause the direction of the management and policies of such entity, whether by the ownership of more than fifty percent (50%) of the voting stock of such entity, or by contract or other means.

1.4 “Audited Party” has the meaning set forth in Section 9.9(b).

1.5 “Auditing Party” has the meaning set forth in Section 9.9(b).

1.6 “Bankrupt Party” has the meaning set forth in Section 14.7.

1.7 “BLA” means a Biologic License Application, as defined in the United States Public Health Service Act, as amended, and applicable regulations promulgated thereunder by the FDA.

1.8 “Bulk API” means the active pharmaceutical ingredient form of a Product in bulk form.

1.9 “Business Day” means a day other than a Saturday, Sunday, or bank or other public holiday in the State of Washington or California.

1.10 “Calendar Quarter” means, for each Calendar Year, the respective periods of three (3) consecutive calendar months ending on March 31, June 30, September 30 or December 31.

1.11 “Calendar Year” means, for the first calendar year, the period commencing on the Signing Date and ending on December 31 of the calendar year during which the Signing Date occurs, and each successive period beginning on January 1 and ending twelve (12) consecutive calendar months later on December 31.

1.12 “CD37 Antigen” means the human protein antigen that is known as CD37, and identified as a full length CD37 protein antigen in GenBank, and identified as of the Signing Date by GenBank Accession Nos. [ * ].

1.13 “CD37 Competitor” means a Third Party who is at the applicable time Developing or Commercializing a protein therapeutic that [ * ] the [ * ] (or [ * ]) [ * ] the [ * ] of [ * ] and wherein such protein therapeutic is [ * ] or [ * ] or being [ * ] to [ * ] through [ * ] to the [ * ] (or [ * ]).

1.14 “Change of Control” means, with respect to a Party: (i) the sale of all or substantially all of such Party’s assets or business relating to this Agreement; (ii) a merger, reorganization, or consolidation involving such Party in which the voting securities of such Party outstanding immediately prior thereto cease to represent at least fifty percent (50%) of the combined voting power of the surviving entity immediately after such merger, reorganization, or consolidation; or (iii) a Person or group of Persons, acting in concert acquire more than fifty percent (50%) of the voting equity or management control of such Party.

1.15 “CHMP” means the Committee for Medicinal Products for Human Use that is responsible for preparing the opinions on all questions concerning medicinal products for human use for the European Medicines Agency, or any successor thereto.

1.16 “Clinical Costs” means all costs incurred by or on behalf of a Party that are directly attributable and reasonably allocated to the conduct of Clinical Trials of a Collaboration Product, or Clinical Trials of a [ * ] that were [ * ] to the [ * ] to the extent that such costs [ * ] the [ * ] for in the [ * ] that was [ * ] on the [ * ], in the Field in the Territory, whether alone or in combination with another product or agent. [ * ], Clinical Costs shall consist of the following: (a) the preparation for and conduct of Clinical Trials (except for related Manufacturing Costs otherwise included in Development Costs); (b) data collection and analysis, and report writing; and (c) clinical laboratory work. Notwithstanding the above, Clinical Costs shall exclude costs

incurred in connection with Phase IV Clinical Studies for purposes other than label expansion and Regulatory Approval, and post-marketing surveillance activities, which shall be considered Sales and Marketing Costs. Clinical Costs shall be calculated in accordance with GAAP, consistently applied with allocations by a Party calculated in accordance with a methodology [ * ] (which methodology shall be consistent with GAAP) and based upon [ * ] by [ * ] (i.e., not to [ * ] costs to [ * ] of [ * ] when [ * ] to costs for [ * ] by [ * ]).

1.17 “Clinical Trial” means any human clinical trial of a Product.

1.18 “Collaboration” has the meaning set forth in Section 2.1.

1.19 “Collaboration Inventions” has the meaning set forth in Section 10.1(a).

1.20 “Collaboration Product” means a Product with respect to which neither Party has exercised the Opt-Out Option, nor has been deemed to have exercised its Opt-Out Option under Section 14.2(b).

1.21 “Combination Product” means any product containing as active ingredients both (a) a Royalty Product and (b) one or more other pharmaceutically active compounds or substances.

1.22 “Commercialization Budget” means the budget of Commercialization Costs set forth in the Commercialization Plan to be incurred by the Parties in connection with the performance of the Commercialization Plan.

1.23 “Commercialization Costs” means all costs incurred by or on behalf of a Party in performing its obligations under the then-current Commercialization Plan that are directly attributable and reasonably allocated to the Commercialization of a Collaboration Product in the Field in the Territory. [ * ], Commercialization Costs shall consist of: (a) Manufacturing Costs for a Collaboration Product for commercial sale; (b) Sales and Marketing Costs; (c) costs associated with Medical Education Activities incurred after the First Commercial Sale of the applicable Collaboration Product, and other ancillary services to the foregoing; (d) Distribution Costs; (e) subject to Section 8.7, payment to a Third Party under a Future Third Party License incurred after the First Commercial Sale of the applicable Collaboration Product; (f) Trademark Costs incurred after the First Commercial Sale of the applicable Collaboration Product; (g) patent costs described in Section 10.3(b)(i); and (h) patient assistance and indigent/expanded access programs with respect to a Collaboration Product. Commercialization Costs shall specifically exclude general corporate and administrative overhead of each Party. In the calculation of Commercialization Costs, a Party’s FTE effort shall be calculated at the FTE Rate. Commercialization Costs shall be calculated in accordance with GAAP, consistently applied with allocations by a Party calculated in accordance with a methodology [ * ] (which methodology shall be consistent with GAAP) and based upon [ * ] by [ * ] (i.e., not to [ * ] costs to [ * ] of [ * ] when [ * ] to [ * ] costs for [ * ] of [ * ]).

1.24 “Commercialization Plan” means the written plan for the Commercialization of a Collaboration Product described in Section 5.2.

1.25 “Commercialize” means to promote, market, distribute, sell (and offer for sale or contract to sell) or provide product support for a Product, including by way of example: (a) detailing and other promotional activities in support of a Product; (b) advertising and public relations in support of a Product, including market research, development and distribution of selling, advertising and promotional materials, field literature, direct-to-consumer advertising campaigns, media/journal advertising, and exhibiting at seminars and conventions; (c) developing reimbursement programs and information and data specifically intended for national accounts, managed care organizations, governmental agencies (e.g., federal, state and local), and other group purchasing organizations, including pull-through activities; (d) conducting Medical Education Activities and journal advertising; and (e) conducting Phase IV Clinical Studies for purposes other than label expansion and Regulatory Approval, and post-marketing surveillance activities. For clarity, “Commercializing” and “Commercialization” have a correlative meaning.

1.26 “Commercial Supply Agreement” has the meaning set forth in Section 6.5.

1.27 “Committee” means the JSC, the JDC, the JCC, the JFC, the JPC, or any other committee established by the JSC in accordance with the terms of this Agreement.

1.28 “Competing Program” has the meaning set forth in Section 8.5.

1.29 “Confidential Information” of a Party means all Know-How or other information, including, without limitation, proprietary information and materials (whether or not patentable) regarding such Party’s technology, products, business information or objectives, that is communicated in any way or form by such Party to the other Party pursuant to this Agreement, and that is identified as confidential at the time of disclosure; provided that, information not identified as confidential by the disclosing Party shall be deemed to be Confidential Information of the disclosing Party if the receiving Party knows, or should have had a reasonable expectation, that such information communicated by the disclosing Party is confidential or proprietary information of the disclosing Party. Notwithstanding the foregoing, all Know-How and information [ * ] by [ * ] in the [ * ] of [ * ] and [ * ] under [ * ] shall be deemed Confidential Information of [ * ]. All confidential information disclosed by either Party pursuant to that certain Mutual Non-Disclosure Agreement between the Parties dated December 22, 2008 (the “Non-Disclosure Agreement”) that is related to the subject matter of this Agreement shall be deemed to be such Party’s Confidential Information hereunder. The terms and conditions of this Agreement shall be considered Confidential Information of both Parties.

1.30 “Consolidated Party” and “Consolidation Party” shall have the respective meanings set forth in Section 9.9(e).

1.31 “Control” or “Controlled” means, with respect to any item of Know-How, Patent Rights, or other intellectual property right, the possession (whether by ownership or license, other than a license granted by one Party to the other pursuant to this Agreement) by a Party of the ability to grant to the other Party access, a license or a sublicense (as applicable), or to extend other rights as provided in this Agreement, to such intellectual property right, without violating the terms of any agreement or other arrangements with any Third Party existing at the

time such Party would be first required to grant any such access, license or sublicense under this Agreement.

1.32 “Co-Commercialization” means the joint Commercialization of a Collaboration Product in the Field, in the Territory by both Parties under the terms of this Agreement. “Co-Commercialize,” when used as a verb, means to engage in such Co-Commercialization.

1.33 “Co-Development” means the joint Development of a Collaboration Product in the Field, in the Territory by both Parties under the terms of this Agreement. “Co-Develop,” when used as a verb, means to engage in such Co-Development.

1.34 “Detail” or “Detailing” means an interactive presentation (whether face-to-face or via live videoconferencing, including over the Internet) by a Party’s sales representative, to one or several medical professional(s) having prescribing authority in the applicable territory in the Field, as well as to other mutually agreed individuals or entities that have the ability to impact or influence prescribing decisions in the applicable territory in the Field, where the principal objective of such presentation is to emphasize the features and function of such Collaboration Product in the Field in compliance with applicable Laws. A Detail does not include a reminder or sample drop or a non-interactive webcast or similar presentation.

1.35 “Development” or “Develop” means research, pre-clinical and clinical drug development activities pertaining to a Product, including, without limitation, toxicology, pharmacology, test method development, stability testing, process development, formulation development, delivery system development, quality assurance and quality control development, statistical analysis, clinical studies (including pre- and post-approval studies), regulatory affairs, pharmacovigilance and Regulatory Approval and clinical study regulatory activities (including regulatory activities directed to obtaining pricing and reimbursement approvals). Development shall include development and regulatory activities for additional indications for a Product after Regulatory Approval of such Product, but shall exclude Phase IV Clinical Studies for purposes other than label expansion and Regulatory Approval and post-marketing surveillance activities.

1.36 “Development Budget” means the budget for Development Costs set forth in the Development Plan which shall include a detailed budget for the first year thereof, which budget shall be allocated between the Parties on a [ * ] basis, and a forecast for the subsequent [ * ] years.

1.37 “Development Costs” means the costs incurred by or on behalf of a Party in performing its obligations under the then-current Development Plan, that are directly attributable and reasonably allocated to the Development of a Collaboration Product, or Clinical Trials of a [ * ] that were [ * ] to the [ * ] to the extent that such costs [ * ] the [ * ] for in the [ * ] that was [ * ] on the [ * ], in the Field in the Territory, and that are directed to achieving or maintaining Regulatory Approval of such Collaboration Product or Royalty Product. The Development Costs shall include amounts, without mark-up, that a Party pays to Third Parties involved in such Development of a Collaboration Product, and all internal costs incurred by a Party in connection with such Development of such Collaboration Product. [ * ], Development Costs include the following: (a) preclinical costs, such as toxicology and the creation of product assays such as those for pharmacokinetic and immunogenicity testing; (b) formulation development, process

development, test method development, delivery system development, stability testing and statistical analysis; (c) Clinical Costs; (d) costs associated with Medical Education Activities incurred prior to the First Commercial Sale of the applicable Collaboration Product, and other ancillary services to the foregoing, (e) Manufacturing Costs for a Collaboration Product for use in preclinical and clinical activities including the manufacture, purchase or packaging of comparators or placebo for use in Clinical Trials of a Collaboration Product (with the manufacturing costs for comparators or placebo to be determined in the same manner as Manufacturing Costs are determined for any Collaboration Product), as well as the direct costs and expenses of disposal of drugs and other supplies used in such clinical studies; (f) subject to Section 8.7, payment to a Third Party under a Future Third Party License incurred prior to the First Commercial Sale of the applicable Collaboration Product; (g) losses incurred in connection with claims set forth in Section 13.5, to the extent provided therein; (h) development of the Manufacturing process for a Collaboration Product (including with respect to any excipients or adjuvants included in such Collaboration Product) and related scale-up, manufacturing process validation, manufacturing process improvements, and qualification and validation of Third Party contract manufacturers; (i) regulatory expenses relating to Development activities for the purpose of obtaining Regulatory Approval for an indication for a Collaboration Product; (j) patent costs described in Section 10.3(b)(i); (k) Trademark Costs incurred prior to the First Commercial Sale of the applicable Collaboration Product; and (l) other out-of pocket Collaboration Product Development expenses that meet the criteria set forth above in this Section 1.37 including, without limitation institutional and advisory review boards, investigator meetings, quality of life studies, epidemiology and outcomes research. For clarity, scale-up and validation costs as described in clause (h) above will be considered Development Costs until commercial Collaboration Product that is eligible for sale has been manufactured. Development Costs shall specifically exclude general corporate and administrative overhead of each Party. In the calculation of Development Costs, a Party’s FTE effort shall be calculated at the FTE Rate. Development Costs shall be calculated in accordance with GAAP, consistently applied with allocations by a Party calculated in accordance with a methodology [ * ] (which methodology shall be consistent with GAAP) and based upon [ * ] by [ * ] (i.e., not to [ * ] costs to [ * ] of [ * ] when [ * ] to [ * ] costs for [ * ] of [ * ]).

1.38 “Development Plan” means the written plan for the Development of a Collaboration Product described in Section 3.3.

1.39 “Diligent Efforts” means, with respect to the efforts to be expended by any Party with respect to any objective, those [ * ], [ * ], [ * ] efforts to accomplish such objective as such Party would [ * ] use to accomplish a [ * ] under [ * ]. With respect to any objective relating to the Development and/or Commercialization of a Product by any Party, “Diligent Efforts” means those efforts and resources [ * ] by [ * ] with respect to a [ * ] or [ * ] by [ * ] which [ * ] is [ * ] in its [ * ] or [ * ] and is of [ * ] in the [ * ] taking into account [ * ], [ * ], [ * ], the [ * ] of all [ * ] in the [ * ], the [ * ] and other [ * ] of the [ * ], the [ * ] of [ * ] given the [ * ] involved, the [ * ] of the [ * ] including the [ * ] to [ * ] of [ * ] or other [ * ], [ * ] and other relevant factors. Diligent Efforts shall be determined on a [ * ] and [ * ] basis for a particular [ * ], and it is anticipated that the [ * ] of [ * ] shall be [ * ] for [ * ], and shall [ * ], reflecting [ * ] in the [ * ] of the [ * ] and the [ * ] involved. Diligent Efforts requires a Party to: (a) [ * ] for such [ * ] to specific [ * ] who are [ * ] for the [ * ] and [ * ] such [ * ] on an [ * ] basis, (b) [ * ] and [ * ] to [ * ] and [ * ] for [ * ] such [ * ], and (c) [ * ] and [ * ] and [ * ] to [ * ] with respect to such [ * ].

1.40 “Distribution Costs” means the costs, excluding general corporate and administrative overhead, incurred by or on behalf of a Party that are directly attributable and reasonably allocated to the distribution of a Collaboration Product in the Field in the Territory for Commercialization purposes, including, unless otherwise determined by the JSC: (a) handling and transportation to fulfill orders with respect to a Collaboration Product in the Territory to the extent such costs are not included in one or more items listed in Section 1.92 (a)-(d); (b) customer services, including order entry, billing and adjustments, inquiry and credit and collection with respect to a Collaboration Product in the Territory; and (c) costs of storage and distribution of Collaboration Products for sale in the Territory. Distribution Costs shall be calculated in accordance with GAAP, consistently applied with allocations by a Party calculated in accordance with a methodology [ * ] (which methodology shall be consistent with GAAP) and based upon [ * ] by [ * ] (i.e., not to [ * ] costs to [ * ] of a [ * ] when [ * ] to [ * ] costs for [ * ] of [ * ]).

1.41 “Dollars” or “$” means the legal tender of the United States.

1.42 “Drug Approval Application” means a NDA, BLA, or any MAA.

1.43 “End-of-Phase 2 Meeting” means a meeting with FDA, the purpose of which is to determine the safety of initiating a first Phase III Clinical Study, to evaluate the Phase III Clinical Study plan and protocols and the adequacy of current studies and plans to assess pediatric safety and effectiveness, and to identify any additional information necessary to support a Drug Approval Application for the uses under investigation, as further defined in 21 C.F.R. 312.47(b)(1), as amended from time to time, or the corresponding foreign equivalent.

1.44 “European Union” or “EU” means all of the European Union member states as of the applicable time during the Term.

1.45 “Executive Officers” means the Chief Executive Officer of Facet (or an executive officer of Facet designated by such Chief Executive Officer) and the Chief Executive Officer of Trubion (or an executive officer of Trubion designated by such Chief Executive Officer).

1.46 “Existing Inventory” has the meaning set forth in Section 7.5(b)(vi).

1.47 “Facet Applied Know-How” means the Facet Know-How applied, [ * ] the [ * ] or the [ * ] of [ * ] of [ * ] by [ * ] under Section [ * ] or by [ * ] under Section [ * ], as applicable, or [ * ] the [ * ] or the [ * ] of [ * ], as applicable, to the extent [ * ] of Facet Know-How was [ * ] in the [ * ] of the [ * ] or the [ * ], as applicable, to the Development, Manufacture, use, importation or Commercialization of (a) in the case of an Opt-Out, a Royalty Product in the Field that, [ * ] the [ * ], is in [ * ] or is being [ * ] in the [ * ], or (b) in the case of a termination of this Agreement by [ * ] under Section [ * ] or by [ * ] under Section [ * ], a Product in the Field that, [ * ] the [ * ] of [ * ], is in [ * ] or is being [ * ] in the [ * ].

1.48 “Facet Applied Patent Rights” means the Facet Patent Rights that claim [ * ], [ * ] or [ * ], or that would otherwise be infringed, absent a license, by [ * ], [ * ] or [ * ] (a) in the case of an Opt-Out, a Royalty Product in the Field that, [ * ] the [ * ], is in [ * ] or is being [ * ] in the [ * ], as such Royalty Product [ * ] of such [ * ] or, for a Royalty Product in [ * ], is [ * ] as [ *

] in the [ * ] of the [ * ], or (b) in the case of a termination of this Agreement by [ * ] under Section [ * ], a Product that, [ * ] the [ * ] of [ * ], is in [ * ] or is being [ * ] in the [ * ], as such Product [ * ] of such [ * ], or, for a Product in [ * ], is [ * ] as [ * ] in the [ * ] of the [ * ] of [ * ].

1.49 “Facet Applied Technology” means the Facet Applied Know-How and Facet Applied Patent Rights.

1.50 “Facet Collaboration Patent Rights” means Facet Patent Rights that (a) claim a Collaboration Invention generated solely by Facet, or its Affiliate(s), including through their employees, agents or independent contractors, and (b) are not Facet Product Patent Rights.

1.51 “Facet Know-How” means any Know-How that (a) is a [ * ] by Facet, or its Affiliate(s), including through their employees, agents or independent contractors, or is otherwise [ * ] by Facet and/or its Affiliate(s); and (b) is [ * ] for the Development, Manufacture, use, importation or Commercialization of Products in the Field. For clarity, the use of “Affiliate” in this definition shall exclude any Third Party that becomes an Affiliate due to a Third Party’s acquisition of Facet, except as provided in Section 16.1.

1.52 “Facet Patent Right” means a Patent Right that (a) claims a [ * ] by Facet, or its Affiliate(s), including through their employees, agents or independent contractors, or is Facet’s [ * ] in a [ * ] or is otherwise [ * ] by Facet and/or its Affiliates; and (b) claims the [ * ] or [ * ] one or more Products in the Field or that would otherwise be infringed, absent a license, by the [ * ] or [ * ] any Products in the Field. For clarity, the use of “Affiliate” in this definition shall exclude any Third Party that becomes an Affiliate due to a Third Party’s acquisition of Facet, except as provided in Section 16.1.

1.53 “Facet Product Patent Rights” means those Facet Patent Rights that claim the [ * ], [ * ] or [ * ] one or more Products in the Field, and do not claim the [ * ], [ * ] or [ * ] of any [ * ] that is [ * ].

1.54 “FDA” means the United States Food and Drug Administration or any successor agency thereto.

1.55 “FD&C Act” means the United States Federal Food, Drug, and Cosmetic Act (21 U.S.C. § 301 et seq.), as amended, and the rules and regulations promulgated thereunder.

1.56 “Field” means all human and animal applications.

1.57 “First Commercial Sale” means, with respect to a given Product in the Field and any country in the Territory, the first sale or transfer for value of such Product under this Agreement by either Party or its Affiliates or permitted sublicensees to a Third Party for end use or consumption in such country following receipt of Regulatory Approval from the appropriate Regulatory Authority permitting commercial sale of such Product in such country. First Commercial Sale excludes any sale or other distribution for use in a Clinical Trial or other Development activities.

1.58 “FTE” means the equivalent of a full-time individual’s work, currently [ * ] hours per year for a twelve (12) month period, on Development or Commercialization of Collaboration

Products. In the case that any full time personnel of a Party works partially on the Development or Commercialization of Collaboration Products and partially on other work outside this Agreement in a given fiscal year, then the full-time equivalent to be attributed to such individual’s work hereunder shall be equal to the percentage of such individual’s total work time in such fiscal year that such individual spent working on activities related to the Development or Commercialization of Collaboration Products. In the event that any part-time personnel of a Party works on the Development or Commercialization of Collaboration Products, the full time equivalent to be attributed to such work shall reflect appropriate adjustment for such personnel’s reduced total work time relative to full time personnel. FTE efforts shall not include general corporate and administrative overhead. Each Party shall track FTEs using its standard practice and normal systems and methodologies as approved by the JFC.

1.59 “FTE Rate” means the partially burdened FTE personnel cost incurred by a Party, which for purposes of this Agreement shall initially be set at an annual rate of [ * ] per FTE. Commencing with the Calendar Year [ * ], the FTE Rate shall be [ * ] by [ * ].

1.60 “Future Third Party License” has the meaning set forth in Section 8.7.

1.61 “GAAP” means United States generally accepted accounting principles, consistently applied, in accordance with the rules and guidance of the United States Securities and Exchange Commission.

1.62 “Good Clinical Practices” or “GCP” means the then-current good clinical practice standards, practices and procedures promulgated or endorsed by FDA as set forth in the guidelines entitled “Guidance for Industry E6 Good Clinical Practice: Consolidated Guidance,” including related regulatory requirements imposed by FDA, and comparable regulatory standards, practices and procedures in jurisdictions outside the United States, in each case as they may be updated from time to time.

1.63 “Good Laboratory Practices” or “GLP” means the then-current good laboratory practice standards promulgated or endorsed by FDA as defined in 21 C.F.R. Part 58, and comparable regulatory standards in jurisdictions outside the United States, in each case as they may be updated from time to time.

1.64 “Good Manufacturing Practices” or “GMP” means the then-current good manufacturing practices required by FDA, as set forth in the FD&C Act and the regulations promulgated thereunder, for the manufacture and testing of pharmaceutical materials, and comparable Laws applicable to the manufacture and testing of pharmaceutical materials in jurisdictions outside the United States, including without limitation the guideline promulgated by the International Conference on Harmonization designated ICH Q7A, entitled “Q7A Good Manufacturing Practice Guidance for Active Pharmaceutical Ingredients” and the regulations promulgated thereunder, in each case as they may be updated from time to time.

1.65 “Governmental Authority” means any multi-national, federal, state, local, municipal or other government authority of any nature (including any governmental division, subdivision, department, agency, bureau, branch, office, commission, council, court or other tribunal).

1.66 “ICH” has the meaning set forth in Section 4.7.

1.67 “IND” means an Investigational New Drug Application, as defined in the FD&C Act, that is required to be filed with FDA before beginning clinical testing of a Product in human subjects, or an equivalent foreign filing.

1.68 “Initial Development Plan” has the meaning set forth in Section 3.3(b).

1.69 “Joint Commercialization Committee” or “JCC” has the meaning set forth in Section 2.1(a).

1.70 “Joint Development Committee” or “JDC” has the meaning set forth in Section 2.1(a).

1.71 “Joint Finance Committee” or “JFC” has the meaning set forth in Section 2.1(a).

1.72 “Joint Invention” has the meaning set forth in Section 10.1(c).

1.73 “Joint Patent Committee” or “JPC” has the meaning set forth in Section 2.1(a).

1.74 “Joint Patent Right” means a Patent Right that claims a Joint Invention.

1.75 “Joint Steering Committee” or “JSC” has the meaning set forth in Section 2.1(a).

1.76 “Know-How” means any data, results, and information of any type whatsoever, in any tangible or intangible form, including, without limitation, know-how, trade secrets, practices, techniques, methods, processes, inventions, developments, specifications, formulations, formulae, materials or compositions of matter of any type or kind (patentable or otherwise), software, algorithms, marketing reports, clinical and non-clinical study reports, regulatory submission summaries and regulatory submission documents, expertise, technology, test data including pharmacological, biological, chemical, biochemical, toxicological, and clinical test data, analytical and quality control data, stability data, studies and procedures.

1.77 “Laws” means all relevant laws, statutes, rules, regulations, guidelines, ordinances and other pronouncements having the effect of law of any federal, national, multinational, state, provincial, county, city or other political subdivision, domestic or foreign.

1.78 “Lead Commercialization Party” has the meaning set forth in Section 5.1.

1.79 “Lead Development Party” has the meaning set forth in Section 3.2.

1.80 “Lead Manufacturing Party” has the meaning set forth in Section 6.1.

1.81 “Lead Regulatory Party” has the meaning set forth in Section 4.1.

1.82 “Major European Countries” means [ * ], and the [ * ].

1.83 “Major Market Countries” means the United States, [ * ] Major European Countries, and [ * ].

1.84 “Manufacturing” or “Manufacture” means activities directed to producing, manufacturing, processing, filling, finishing, packaging, labeling, quality assurance testing and release, shipping and storage of a Product.

1.85 “Manufacturing Costs” means the costs incurred by or on behalf of a Party that are directly attributable and reasonably allocated to the Manufacturing of Collaboration Products. [ * ], Manufacturing Costs shall consist of (a) if the Collaboration Product is manufactured by a Third Party manufacturer, (i) a Party’s [ * ] cost (expressed in the case of [ * ] on a [ * ] basis) of manufacturing, processing, testing, filling, finishing, packaging and labeling such Collaboration Product, and (ii) any costs incurred by such Party for [ * ] and [ * ] in accordance with the Development Plan or the Commercialization Plan, as applicable; or (b) if the Collaboration Product is manufactured by a Party, the [ * ] cost of manufacturing, processing, testing, filling, finishing, packaging and labeling such Collaboration Product, including without limitation raw materials, direct labor and benefits, and the [ * ] of [ * ]. For clarity, the [ * ] cost referenced under subsection (b) above shall be calculated on a [ * ] basis (with reasonable [ * ] and [ * ]) with the [ * ] to [ * ] representing the [ * ] of [ * ] or [ * ] of [ * ] or [ * ] as a [ * ] of the [ * ] of [ * ] or [ * ], including those of [ * ], that [ * ] in [ * ] during a [ * ]. Manufacturing Costs shall be calculated in accordance with GAAP, consistently applied with allocations by a Party calculated in accordance with a methodology [ * ] (which methodology shall be consistent with GAAP) and based upon [ * ] by [ * ] (i.e., not to [ * ] costs to [ * ] of [ * ] when compared to [ * ] costs for [ * ] of [ * ].

1.86 “Marketing Authorization Application” or “MAA” means an application for Regulatory Approval (but excluding Pricing Approval) in any particular jurisdiction other than the United States.

1.87 “Marks” means trade marks, service marks, trade names, service names, logos, slogans, tag lines, trade dress, and Internet domain names and addresses.

1.88 “Medical Education Activities” means activities designed to ensure or improve appropriate medical use of, conduct medical education of, or further research regarding, a Collaboration Product sold or to be sold in the Territory, including by way of example: (a) activities of medical sales liaisons; (b) grants to support continuing medical education, symposia, or research related to a Collaboration Product in the Territory (excluding Phase IV Clinical Studies, which, with respect to a Collaboration Product, shall be considered Sales and Marketing Costs if conducted for a purpose other than label expansion or Regulatory Approval and otherwise shall be considered Development Costs); (c) development, publication and dissemination of publications relating to a Collaboration Product in the Territory, as well as medical information services provided in response to inquiries communicated via sales representatives or received by letter, phone call or email; and (d) conducting advisory board meetings or other consultant programs, the purpose of which is to obtain advice and feedback related to the Development or Commercialization of a Collaboration Product in the Territory.

1.89 “Milestone Payment” has the meaning set forth in Section 9.3.

1.90 “Multi-Specific Product” means a SMIP or other protein therapeutic that binds to the CD37 Antigen (or a portion thereof) and binds to one or more additional biological targets that are not part of the CD37 Antigen, in each case [ * ] of [ * ] and wherein such SMIP or protein therapeutic is [ * ] or [ * ] or [ * ] to [ * ] a [ * ] through [ * ] the [ * ] (or a [ * ]) and a [ * ] through [ * ] the [ * ].

1.91 “NDA” means a New Drug Application, as defined in the FD&C Act and the regulations promulgated thereunder by the FDA.

1.92 “Net Sales” means all amounts invoiced on sales of Royalty Products by a Party, its Affiliates or permitted sublicensees to Third Parties, less the following deductions actually allowed or taken by such Third Parties and not otherwise recovered by or reimbursed to the seller whose sales are being measured:

(a) trade, quantity or volume, and cash discounts, including amounts paid or credited to customers under distribution and channel services agreements;

(b) credits, rebates and chargebacks (including those to managed-care entities and government agencies), allowances for bad debt not to exceed [ * ] and allowances to customers on account of rejection or returns or retroactive price reductions;

(c) freight, postage and transportation charges, including handling and insurance to the extent added to the sales price and set forth separately as such in the total amount invoiced; and

(d) sales (such as VAT or its equivalent) and excise taxes, other consumption taxes and customs duties to the extent added to the sales price and set forth separately as such in the total amount invoiced.

Sales between a Party and its Affiliates or permitted sublicensees for resale shall be excluded from the computation of Net Sales. In any other sale of Royalty Products that is made on other than arms’-length terms, the amounts invoiced shall be deemed, for purposes of this definition, to be no less than the amount that would be invoiced in a substantially contemporaneous, arms’-length transaction.

In the event a Royalty Product is sold in a country as part of a Combination Product, for purposes of determining payments due a Party under this Agreement, Net Sales of Combination Products shall be calculated by multiplying the Net Sales of the Combination Product by the fraction A over A+B, in which A is the Gross Selling Price of the Royalty Product when such Royalty Product is sold in the relevant country in substantial quantities where the Royalty Product is the sole therapeutically active ingredient during the applicable accounting period in which the sales of the Royalty Product were made, and B is the Gross Selling Price of the other therapeutically active ingredients contained in the Combination Product sold separately in the relevant country in substantial quantities during the accounting period in question. All Gross Selling Prices of the therapeutically active ingredients of the Royalty Product and Combination Products shall be calculated as the average Gross Selling Price of the therapeutically active ingredients in such products in the relevant country during the applicable accounting period for which the Net Sales are being calculated. In the event that no separate sale of either the Royalty

Product as the sole therapeutically active ingredient or the other therapeutically active ingredients of the Combination Product are made in the relevant country during the accounting period in which the sale was made or if the Gross Selling Price for a particular therapeutically active ingredient cannot be determined for an accounting period, Net Sales allocable to the Royalty Product and Combination Product shall be determined by mutual agreement reached in good faith by the Parties prior to the end of the accounting period in question based on an equitable method of determining same that takes into account the relative contribution of each therapeutically active ingredient in the Combination Product, and relative value to the end user of each therapeutically active ingredient. For purposes of this definition, “Gross Selling Price” means the gross price at which an active ingredient is sold to a Third Party, before discounts, deductions, credits, taxes or allowances.

1.93 “Non-Clinical Studies” means all non-human studies of Products.

1.94 “Non-Opt-Out Party” means the Party which receives an Opt-Out Notice pursuant to Section 7.2, 7.3 or 8.5 or provides a written notice of continuation to the breaching Party pursuant to Section 14.2(b).

1.95 “Opt-Out Effective Date” has the meaning set forth in Section 7.4.

1.96 “Opt-Out Notice” has the meaning set forth in Section 7.1.

1.97 “Opt-Out Option” has the meaning set forth in Section 7.1.

1.98 “Opt-Out Party” means the Party which has exercised its Opt-Out Option pursuant to Sections 7.2, 7.3 or 8.5 or which is deemed to have exercised its Opt-Out Option pursuant to Section 14.2(b).

1.99 “Opt-Out Product” has the meaning set forth in Section 7.2.

1.100 “Patent Rights” means any and all (a) patents; (b) pending patent applications, including, without limitation, all provisional applications, substitutions, continuations, continuations-in-part, divisions, renewals, and all patents granted thereon, (c) all patents-of-addition, reissues, reexaminations and extensions or restorations by existing or future extension or restoration mechanisms, including, without limitation, supplementary protection certificates or the equivalent thereof, (d) inventor’s certificates, and (e) all United States and foreign counterparts of any of the foregoing.

1.101 “Person” means an individual, sole proprietorship, partnership, limited partnership, limited liability partnership, corporation, limited liability company, business trust, joint stock company, trust, incorporated association, joint venture or similar entity or organization, including a government or political subdivision, department or agency of a government.

1.102 “Pharmacovigilance Agreement” has the meaning set forth in Section 4.12.

1.103 “Phase I Clinical Study” means a study of a Product in the Field in human subjects with the endpoint of determining initial tolerance, safety or pharmacokinetic information

in single dose, single ascending dose, multiple dose and/or multiple ascending dose regimens, which is prospectively designed to generate sufficient data (if successful) to commence a Phase II Clinical Study of such Product, as further defined in 21 C.F.R. 312.21(a), as amended from time to time, or the corresponding foreign regulations.

1.104 “Phase II Clinical Study” means a study of a Product in the Field in human patients to determine initial efficacy and dose range and/or regimen finding before embarking on Phase III Clinical Studies, as further defined in 21 C.F.R. 312.21(b), as amended from time to time, or the corresponding foreign regulations.

1.105 “Phase III Clinical Study” means a pivotal study (whether or not denominated a “Phase III” clinical study under applicable regulations) in the Field in human patients with a defined dose or a set of defined doses of a Product designed to ascertain efficacy and safety of such Product for the purpose of enabling the preparation and submission of Drug Approval Applications to the competent Regulatory Authorities in a country of the Territory, as further defined in 21 C.F.R. 312.21(c), as amended from time to time, or the corresponding foreign regulations.

1.106 “Phase IV Clinical Study” means a product support clinical trial of a Product that is commenced after receipt of Regulatory Approval in the country where such trial is conducted. A Phase IV Clinical Study may include epidemiological studies, modeling and pharmacoeconomic studies, “post-marketing surveillance trials” and investigator-sponsored Clinical Trials studying a Product that are approved by the JCC and that otherwise fit the foregoing definition.

1.107 “Pre-BLA Meeting” means a meeting with FDA, the primary purpose of which is to uncover any major unresolved problems, to identify those studies that the sponsor is relying on as adequate and well-controlled to establish the drug’s effectiveness, to identify the status of ongoing or needed studies adequate to assess pediatric safety and effectiveness, to acquaint FDA reviewers with the general information to be submitted in the marketing application (including technical information), to discuss appropriate methods for statistical analysis of the data, and to discuss the best approach to the presentation and formatting of data in the marketing application, as further defined in 21 C.F.R. 312.47(b)(2), as amended from time to time, or the corresponding foreign equivalent.

1.108 “Pricing Approval” means such approval, agreement, determination or governmental decision establishing prices for the Products that can be charged to consumers and shall be reimbursed by Governmental Authorities in regulatory jurisdictions where the Governmental Authorities or Regulatory Authorities approve or determine pricing of pharmaceutical products for reimbursement or otherwise.

1.109 “Product” means any SMIP or other protein therapeutic that binds to the CD37 Antigen (or a [ * ]) [ * ] of [ * ] and wherein such SMIP or protein therapeutic is [ * ] or [ * ] or [ * ] to [ * ] its [ * ] through [ * ] the [ * ] (or a [ * ]), including without limitation TRU-016 [ * ] any [ * ] Products.

1.110 “Product Labeling” means (a) the full prescribing information for a Collaboration Product approved in the Field by the applicable Regulatory Authority, and (b) all labels and other written, printed or graphic information included in or placed upon any container, wrapper or package insert used with or for the Collaboration Product in the Field.

1.111 “Product Profit” means (a) gross sales of Collaboration Products (i.e. all amounts invoiced on sales of Collaboration Products by a Party or its Affiliates), less (b) Commercialization Costs, and (c) deductions for items listed in 1.92(a)-(d) to the extent actually allowed or taken by the Lead Commercialization Party and not otherwise recovered by or reimbursed to the Lead Commercialization Party. For sake of clarity, Product Profit shall be determined prior to application of any income taxes.

1.112 “Promotion” means the marketing and advertising of a Collaboration Product in the relevant Field in the applicable territory in accordance with the relevant Commercialization Plan, including medical education, information and communication, market development and medical liaison activities, but not including Detailing. “Promote,” when used as a verb, means to engage in such Promotion.

1.113 “Promotional Materials” means all sales representative training materials and all written, printed, graphic, electronic, audio or video presentations of information, including, without limitation, journal advertisements, sales visual aids, formulary binders, reprints, direct mail, direct-to-consumer advertising, internet postings, broadcast advertisements and sales reminder aides (for example, note pads, pens and other such items) intended for use or used by or on behalf of the Parties or their Affiliates or permitted sublicensees in connection with any Promotion of a Collaboration Product, in the Field, in the Territory (all to the extent applicable for the Commercialization in the Territory), but excluding Product Labeling.

1.114 “Pursuit Notice” has the meaning set forth in Section 7.5(b).

1.115 “Recall” has the meaning set forth in Section 5.10.

1.116 “Regulatory Approval” means the technical, medical and scientific licenses, registrations, authorizations and approvals (including, without limitation, approvals of Drug Approval Applications, supplements and amendments, pre- and post- approvals, Pricing Approvals, and labeling approvals) of any national, supra-national, regional, state or local regulatory agency, department, bureau, commission, council or other governmental entity, necessary for the commercial Manufacture, distribution, marketing, promotion, offer for sale, use, import, export and sale of Product(s) in a regulatory jurisdiction in the Field, in the Territory. For the sake of clarity, Regulatory Approval shall [ * ] have been [ * ] in a country [ * ] the [ * ] until any applicable [ * ] have [ * ] in such country. Regulatory Approval of a Product shall [ * ] have been [ * ] in the [ * ] upon [ * ] of [ * ] for such Product in the [ * ].

1.117 “Regulatory Authorit(y/ies)” means any national (e.g., FDA), supra-national (e.g., the European Commission, the Council of the European Union, or the European Agency for the Evaluation of Medicinal Products); regional, state or local regulatory agency, department, bureau, commission, council or other governmental entity in each country of the Territory that

governs the Regulatory Approval for a Product in the Field in such applicable regulatory jurisdiction.

1.118 “Regulatory Exclusivity” means any exclusive marketing rights or data exclusivity rights conferred by any Regulatory Authority with respect to a Product other than patents, including, without limitation, rights conferred in the United States under the Hatch-Waxman Act or the FDA Modernization Act of 1997 (including pediatric exclusivity), or rights similar thereto outside the United States.

1.119 “Regulatory Materials” means regulatory applications, submissions, notifications, registrations, Regulatory Approvals or other submissions made to or with a Regulatory Authority that are necessary or reasonably desirable in order to Develop, Manufacture, and Commercialize the Products in a particular country, territory or possession. Regulatory Materials include, without limitation, INDs, Drug Approval Applications, and amendments and supplements for any of the foregoing, and applications for Pricing Approvals.

1.120 “Royalty Period” means the period of time beginning on the date of the First Commercial Sale of a Royalty Product, in the Field, in a particular country in the Territory and, on a Royalty Product-by-Royalty Product and country-by-country basis, extending until the later of (i) the date on which the last Valid Claim included within the Trubion Patent Rights and the Facet Applied Patent Rights ceases to be a Valid Claim, which Valid Claim would be infringed by [ * ] or [ * ] such Royalty Product in such country, (ii) the expiration of any Regulatory Exclusivity granted with respect to such Royalty Product in such country and (iii) the [ * ] year anniversary of the First Commercial Sale of such Royalty Product in such country.

1.121 “Royalty Product” means a Product with respect to which a Party has exercised or is deemed to have exercised the Opt-Out Option and the other Party has provided or is deemed to have provided a Pursuit Notice in accordance with Section 7.5(b) or 14.2(b).

1.122 “Sales and Marketing Costs” means the direct costs that are directly attributable and reasonably allocated to the sales and marketing of a Collaboration Product in Field in the Territory. [ * ], Sales and Marketing Costs shall consist of: (a) activities directed to the advertising and marketing of a Collaboration Product in the Territory; (b) professional education (to the extent not performed by sales representatives), including launch meetings; (c) costs of advertising, public relations and medical education agencies with respect to a Collaboration Product in the Territory; (d) peer-to-peer activities with respect to a Collaboration Product in the Territory, such as continuing medical education, grand rounds, and lunch and dinner meetings; (e) speaker programs with respect to a Collaboration Product in the Territory, including the training of such speakers; (f) grants to support continuing medical education or research (excluding costs associated with Clinical Trials other than Phase IV Clinical Studies for a Collaboration Product for purposes other than label expansion and Regulatory Approval); (g) development, publication and dissemination of publications with respect to a Collaboration Product in the Territory; (h) developing, obtaining and providing training with respect to a Collaboration Product in the Territory, as well as training packages, promotional literature, promotional materials and other selling materials with respect to a Collaboration Product in the Territory; (i) developing and performing market research with respect to a Collaboration Product in the Territory; (j) conducting symposia and opinion leader development activities with respect

to a Collaboration Product in the Territory; (k) developing reimbursement programs with respect to a Collaboration Product in the Territory; (l) developing information and data specifically intended for national accounts, managed care organizations and group purchasing organizations with respect to a Collaboration Product in the Territory; (m) losses incurred in connection with claims set forth in Section 13.5, to the extent provided therein; (n) costs of transporting, housing and maintaining sales representatives for training with respect to a Collaboration Product in the Territory; (o) conducting Phase IV Clinical Studies for Collaboration Products for purposes other than label expansion and Regulatory Approval; and (p) administration, operation and maintenance of the sales force that promotes a Collaboration Product in the Territory, sales bulletins and other communications, sales meetings, specialty sales forces, consultants, call reporting and other monitoring/tracking costs, district and regional sales management, home office personnel who support the sales force. Sales and Marketing Costs shall include costs of such activities that are undertaken at any time during the Term (including prior to the initial Regulatory Approval of a Collaboration Product in the Territory). Sales and Marketing Costs shall be calculated in accordance with GAAP, consistently applied with allocations by a Party calculated in accordance with a methodology [ * ] (which methodology shall be consistent with GAAP) and based upon [ * ] by [ * ] (i.e., not to [ * ] costs to [ * ] of a [ * ] when compared to [ * ] costs for [ * ] of [ * ]).

1.123 “SMIP(s)” or “small modular immuno-pharmaceutical(s)” means a single chain polypeptide that (i) is [ * ] having [ * ] and [ * ] or a [ * ] of such [ * ], (ii) binds with specificity to a target antigen, (iii) has a binding domain, and (iv) may have an effector domain which may or may not have effector function, including, but not limited to, any [ * ] or [ * ] thereof, any [ * ] or [ * ] thereof, any [ * ] or [ * ] thereof, and any other [ * ] or [ * ].

1.124 “Subcommittee” has the meaning set forth in Section 2.7(a).

1.125 “Term” has the meaning set forth in Section 14.1.

1.126 “Territory” means worldwide.

1.127 “Third Part(y/ies)” means any Person(s) other than Facet and its Affiliates or Trubion and its Affiliates.

1.128 “Trademark Costs” mean the fees and expenses paid to outside counsel and other Third Parties, direct costs of in-house counsel and filing and maintenance expenses, in each case incurred in connection with the establishment and maintenance of rights under Marks applicable to Collaboration Product in the Territory, including costs of trademark filing and registration fees, actions to enforce or maintain a trademark and other trademark proceedings. Trademark Costs shall be calculated in accordance with GAAP, consistently applied with allocations by a Party calculated in accordance with a methodology [ * ] (which methodology shall be consistent with GAAP) and based upon [ * ] by [ * ] (i.e., not to [ * ] costs of [ * ] to a [ * ] when compared to [ * ] costs for [ * ] of [ * ]).

1.129 “Transition Assistance” shall have the meaning set forth in Section 7.5(b)(iii).

1.130 “TRU-016” means the humanized SMIP directed against the CD37 Antigen that is currently designated by Trubion as “TRU-016,” as further described on Exhibit A.

1.131 “Trubion Know-How” means any Know-How Controlled as of the Signing Date or thereafter during the Term by Trubion and/or its Affiliate(s) and [ * ] for the Development, Manufacture, use, importation or Commercialization of Products in the Field. For clarity, the use of “Affiliate” in this definition shall exclude any Third Party that becomes an Affiliate due to a Third Party’s acquisition of Trubion, except as provided in Section 16.1.

1.132 “Trubion Core Patent Rights” means those Trubion Patent Rights that are not Trubion Product Patent Rights. As of the Signing Date, the Patent Rights listed in Schedule 1.132 are Trubion Core Patent Rights.

1.133 “Trubion Patent Rights” means Patent Rights that are Controlled as of the Signing Date or thereafter during the Term by Trubion and/or its Affiliate(s) (including without limitation Trubion’s interest in Joint Patent Rights) and that claim [ * ] or [ * ] one or more Products in the Field or that would otherwise be infringed, absent a license, by the [ * ] or [ * ] any Products in the Field. For clarity, the use of “Affiliate” in this definition shall exclude any Third Party that becomes an Affiliate due to a Third Party’s acquisition of Trubion except as provided in Section 16.1.

1.134 “Trubion Product Patent Rights” means those Trubion Patent Rights that claim the composition of matter, manufacture or use of one or more Products in the Field, and do not claim the composition of matter, manufacture or use of any other product that is not a Product. As of the Signing Date, the Patent Rights listed in Schedule 1.134 are Trubion Product Patent Rights.

1.135 “United States” or “U.S.” means the United States of America and its possessions and territories.

1.136 “Valid Claim” means a claim that (a) in the case of any unexpired patent, such claim shall not have been dedicated to the public, disclaimed, nor held invalid or unenforceable by a court or government agency of competent jurisdiction in an unappealed or unappealable decision, or (b) in the case of any patent application, such claim (i) shall not have been cancelled, withdrawn or abandoned, without being refiled in another application, in the applicable jurisdiction, (ii) shall not have been finally rejected by an administrative agency or other governmental action from which no appeal can be taken, and (iii) shall not have been pending (including in any [ * ]) for more than [ * ] from its filing date. If a claim of a patent application that ceased to be a Valid Claim under (b) due to the passage of time later issues as part of a patent described within (a) then it shall again be considered to be a Valid Claim effective as of the issuance of such patent.

2. COLLABORATION MANAGEMENT.

2.1 General. The Parties desire and intend to establish a collaboration with respect to the Development, Manufacture and Commercialization of Collaboration Products in the Field in the Territory on an exclusive basis under the terms of this Agreement (“Collaboration”). Unless and until a Party exercises or is deemed to have exercised its Opt-Out Option in respect of one or more Collaboration Products, each Party shall participate in the clinical development of TRU-016 in the Field, in the Territory and in the preclinical and clinical development of Collaboration

Products other than TRU-016 in the Field, in the Territory pursuant to an agreed-upon Development Plan with respect to each such Collaboration Product, as further described below. The Parties shall share equally the costs incurred in connection with the performance of each Development Plan, as set forth in, and in accordance with, Article 3. The Parties shall Co-Commercialize such Collaboration Products in the Field and share profits equally, subject to the payment obligations in Article 9 and the other terms of this Agreement. If either Party elects to exercise its Opt-Out Option for a Collaboration Product as provided for under Article 7 or Section 8.5, or is deemed to have exercised its Opt-Out Option under Section 14.2(b), and if the other Party so elects, such other Party shall continue and be solely responsible for the Development, Manufacturing and Commercialization of such Product at its cost and expense pursuant to Section 7.5(b), and shall have the exclusive right to Develop, Manufacture and Commercialize such Product as a Royalty Product in the Field in the Territory, subject to payments with respect to such Royalty Product pursuant to Article 9 and the other terms of this Agreement.

(a) Role of Committees. Subject to Section 2.1(b) and the other terms and conditions of this Agreement, the Parties shall establish: five (5) specialized joint committees consisting of: (A) one to set the goals and strategy and approve the budgets for the Development, Manufacture and Commercialization of Collaboration Products and to oversee the other committees (such committee, the “Joint Steering Committee” or “JSC”); (B) one to focus on Development, Manufacturing (for Development purposes) and Regulatory Approval of Collaboration Products and other regulatory matters (such committee, the “Joint Development Committee” or “JDC”); (C) one to focus on Commercialization of Collaboration Products (such committee, the “Joint Commercialization Committee” or “JCC”); (D) one to focus on financial matters (such committee, the “Joint Finance Committee” or “JFC”); and (E) one to focus on intellectual property matters (such committee, the “Joint Patent Committee” or “JPC”). Each Committee shall have the responsibilities and authority allocated to it in this Article 2 and elsewhere in this Agreement.

(b) Limitations on the Authority of Committees. Notwithstanding the Committee structure established pursuant to Section 2.1(a) to oversee the Collaboration, each Party shall retain the rights, powers and discretion granted to it under this Agreement, and no such rights, powers, or discretion shall be delegated to or vested in a Committee unless such delegation or vesting of rights is expressly provided for in this Agreement or the Parties expressly so agree in writing. Without limiting the generality of the foregoing, no Committee shall have any authority or jurisdiction to: (i) amend, modify, or waive compliance with this Agreement, any of which shall require mutual written agreement of the Parties; (ii) interpret this Agreement, or determine whether or not a Party has met its diligence or other obligations under the Agreement or whether or not a breach of this Agreement has occurred; (iii) make any decision on any matter that this Agreement expressly states is an option or election to be made by a Party; (iv) make any retroactive updates, amendments and modifications to, or waivers of provisions of, a Development Plan or Commercialization Plan, any of which shall require the mutual agreement of the Parties; or (v) such other matters as are reserved to the consent, approval, agreement or other decision-making authority of one or both Parties in this Agreement and that are not required by this Agreement to be considered by a Committee prior to the exercise of such consent, approval or other decision-making authority. Notwithstanding the foregoing, neither Party shall be restricted from bringing before any appropriate Committee for

discussion any matter relating to the Collaboration that it believes warrants discussion between the Parties through the Committees, provided that the consideration of any such matter by any Committee shall not infringe or limit the exercise of a Party’s right of consent or approval or other decision-making authority granted to it by this Agreement, nor shall any such consideration, as contemplated by this sentence, subject any such right of consent or approval or other decision-making authority to any dispute resolution mechanism provided for in Section 2.7 or Article 15 or elsewhere in this Agreement.

(c) Representatives. Each Party shall designate representatives to each Committee as provided for in Sections 2.2-2.6 below. Each representative may serve on more than one Committee as appropriate in view of the individual’s expertise.

2.2 Joint Steering Committee.

(a) Purpose; Formation. Within [ * ] after the Signing Date, the Parties shall establish a Joint Steering Committee that shall monitor and coordinate communication regarding the Parties’ performance under this Agreement to Develop, obtain Regulatory Approval for, Manufacture, and Commercialize Collaboration Products in the Field in the Territory. The JSC shall have only the powers assigned expressly to it in this Section 2.2 and elsewhere in this Agreement, and the JSC shall not have any power to amend, modify or waive compliance with this Agreement.

(b) Composition. Each Party shall initially appoint three (3) representatives to the JSC, each of whom will be an officer or employee of such Party and will have sufficient seniority within the applicable Party to make decisions arising within the scope of the JSC’s responsibilities. The JSC may change its size from time to time by mutual consent of its members. Each Party may replace its JSC representatives at any time upon written notice to the other Party. The JSC may invite non-members (including consultants and advisors of a Party who are under an obligation of confidentiality consistent with this Agreement) to participate in the discussions and meetings of the JSC, provided that such participants shall have no voting authority at the JSC. The JSC shall have a chairperson. Each Party shall have the right, on an alternating Calendar Year basis, to select from among its JSC representatives a representative to serve as the chairperson of the JSC during such Calendar Year. Such Party shall have the right during such Calendar Year to replace the chairperson of the JSC with one of its other JSC representatives. The initial chairperson shall be designated by [ * ]. The role of the chairperson shall be to convene and preside at meetings of the JSC, to prepare agendas (with due input from the other Party’s representatives), circulate agendas and to ensure the preparation of meeting minutes, but the chairperson shall have no additional powers or rights beyond those held by the other JSC representatives.

(c) Specific Responsibilities. In addition to its overall responsibility for monitoring and providing a forum to discuss and coordinate the Parties’ activities under this Agreement, the JSC shall in particular:

(i) oversee the collaborative activities of the Parties under this Agreement, create and review the overall strategy for Developing and seeking Regulatory

Approval for, Manufacturing, and Commercializing Collaboration Products, in the Field in the Territory;

(ii) receive and discuss reports from the JDC, the JCC, the JFC, and the JPC, and provide guidance thereto, approve the Development Plan(s) (including the Development Budget(s)) and the Commercialization Plan(s) (including the Commercialization Budget(s)), and any amendments thereto;

(iii) establish such additional joint subcommittees as it deems necessary to achieve the objectives and intent of this Agreement;

(iv) attempt to resolve issues presented to it by, and disputes within, the JDC, the JCC, the JFC, and the JPC, or any other committee;

(v) review and approve decisions to terminate Development on any Collaboration Product, including with respect to specific indications;

(vi) discuss and decide whether to Develop Collaboration Products (other than TRU-016) and for which indications;

(vii) select the Lead Development Party, Lead Regulatory Party, Lead Manufacture Party, and Lead Commercialization Party, and review and approve any changes thereto;

(viii) review and approve the manufacturing plan for [ * ] and [ * ] or [ * ] with associated budget, resource allocation and regulatory plans;

(ix) review and approve (A) inclusion of any costs not specifically enumerated in the definitions of Development Costs or Commercialization Costs or any component thereof, and (B) any costs incurred by a Party that exceed that the portion of the applicable Development Budgets or Commercialization Budgets allocated to such Party with respect to the relevant Calendar Quarter by more than [ * ];

(x) review and approve any changes to the specific responsibilities of the JDC, the JCC, the JFC, and the JPC;

(xi) discuss and make determinations regarding material safety issues with respect to the Collaboration Product; and

(xii) perform such other functions as appropriate to further the purposes of this Agreement as allocated to it in writing by the Parties.

(d) Meetings. Unless the Parties mutually agree in writing to a different frequency, the JSC shall hold at least [ * ] meetings per year (at least [ * ] of which shall be held in person) on such dates and at such times each year as it elects. The meetings of the JSC shall alternate between the Parties’ business locations or as otherwise decided by the JSC. Meetings of the JSC shall be effective only if at least two (2) representatives of each Party are present or participating. Each Party shall bear the expense of its respective members’ participation in JSC

meetings. The chairperson of the JSC shall be responsible for preparing and issuing minutes of each such meeting within [ * ] thereafter. Such minutes shall not be finalized until each Party reviews and confirms the accuracy of such minutes in writing; provided that any minutes shall be deemed approved unless a member of the JSC objects to the accuracy of such minutes within [ * ] after the circulation of the minutes by the chairperson of the JSC.

(e) Decision-Making. The JSC shall act by consensus. The representatives from each Party will have, collectively, one (1) vote on behalf of that Party. If the JSC cannot reach consensus on an issue that comes before the JSC and over which the JSC has oversight, then such matter shall be resolved in accordance with Section 2.7.

2.3 Joint Development Committee.

(a) Formation and Composition. Within [ * ] after the Signing Date, the Parties shall establish a Joint Development Committee that shall oversee the Development and Manufacture (for Development) of Collaboration Products in Field in the Territory in accordance with the Development Plans for such Collaboration Products and to coordinate the Development and related Manufacturing activities of the Parties with respect to such Collaboration Products. Each Party shall initially appoint three (3) representatives to the JDC, each of whom will be an officer or employee of such Party and will have knowledge and expertise in the Development or Manufacture of products similar to the Collaboration Products and sufficient seniority within the applicable Party to make decisions arising within the scope of the JDC’s responsibilities. The JDC may change its size from time to time by mutual consent of its members. Each Party may replace its JDC representatives at any time upon written notice to the other Party. The JDC may invite non-members (including consultants and advisors of a Party who are under an obligation of confidentiality consistent with this Agreement) to participate in the discussions and meetings of the JDC, provided that such participants shall have no voting authority at the JDC. The JDC shall have a chairperson. Each Party shall have the right, on an alternating Calendar Year basis, to select from among its JDC representatives a representative to serve as the chairperson of the JDC during such Calendar Year. Such Party shall have the right during such Calendar Year to replace the chairperson of the JDC with one of its other JDC representatives. The initial chairperson shall be designated by [ * ]. The role of the chairperson shall be to convene and preside at meetings of the JDC, to prepare agendas (with due input from the other Party’s representatives), circulate agendas and to ensure the preparation of meeting minutes, but the chairperson shall have no additional powers or rights beyond those held by the other JDC representatives.

(b) Specific Responsibilities. In addition to its general responsibilities set forth in Section 2.3(a), the JDC shall in particular:

(i) discuss, prepare and approve for submission to the JSC annual and interim amendments to the Development Plan and the Development Budget for each Collaboration Product;

(ii) oversee the implementation of the Development Plan for each Collaboration Product;

(iii) implement the overall strategy for Development and Manufacturing (for Development) of Collaboration Products, create, implement and review the design and objectives of all Clinical Trials and Non-Clinical Studies conducted under each Development Plan;

(iv) decide whether and when to initiate or discontinue, and oversee the conduct of, any Clinical Trial and any Non-Clinical Study under each Development Plan;

(v) allocate budgeted resources and determine priorities for each Clinical Trial and Non-Clinical Study under each Development Plan;

(vi) establish procedures for each Party to access records, data and Know-How and related financial information of the other Party with respect to work performed under the Development Plan; and

(vii) perform such other functions as may be appropriate to further the purposes of this Agreement, as directed by the JSC.

(c) Meetings. Unless the Parties mutually agree in writing to a different frequency, the JDC shall hold at least [ * ] meetings per year (at least [ * ] of which shall be held in person) on such dates at such times each year as it elects. The meetings of the JDC shall alternate between the Parties’ business locations or as otherwise decided by the JDC. Meetings of the JDC shall be effective only if at least two (2) representatives of each Party are present or participating. Each Party shall bear the expense of its respective members’ participation in JDC meetings. The chairperson of the JDC shall be responsible for preparing and issuing minutes of each such meeting within [ * ] days thereafter. Such minutes shall not be finalized until each Party reviews and confirms the accuracy of such minutes in writing; provided that any minutes shall be deemed approved unless a member of the JDC objects to the accuracy of such minutes within [ * ] days after the circulation of the minutes by the chairperson of the JDC.

(d) Decision-Making. The JDC shall act by consensus. The representatives from each Party will have, collectively, one (1) vote on behalf of that Party. If the JDC cannot reach consensus on an issue that comes before the JDC and over which the JDC has oversight, then such matter shall be resolved in accordance with Section 2.7.

2.4 Joint Commercialization Committee.

(a) Formation and Composition. At such time as determined by the JSC, but in any event not later than [ * ] following the [ * ] of the [ * ], the Parties shall establish a Joint Commercialization Committee that shall oversee the Commercialization and Manufacturing (for Commercialization) of Collaboration Products. Each Party shall initially appoint three (3) representatives to the JCC, each of whom will be an officer or employee of such Party and will have knowledge and expertise in the Commercialization and Manufacturing of products similar to the Collaboration Products and sufficient seniority within the applicable Party to make decisions arising with the scope of the JCC’s responsibilities. The JCC may change its size from time to time by mutual consent of its members. Each Party may replace its JCC representatives at any time upon written notice to the other Party. The JCC may invite non-members (including consultants and advisors of a Party who are under an obligation of

confidentiality consistent with this Agreement) to participate in the discussions and meetings of the JCC, provided that such participants shall have no voting authority at the JCC. The JCC shall have a chairperson. Each Party shall have the right, on an alternating Calendar Year basis, to select from among its JCC representatives a representative to serve as the chairperson of the JCC during such Calendar Year. Such Party shall have the right during such Calendar Year to replace the chairperson of the JCC with one of its other JCC representatives. The role of the chairperson shall be to convene and preside at meetings of the JCC, to prepare agendas (with due input from the other Party’s representatives), circulate agendas and to ensure the preparation of meeting minutes, but the chairperson shall have no additional powers or rights beyond those held by the other JCC representatives.

(b) Specific Responsibilities. In addition to its general responsibilities set forth in Section 2.4(a), the JCC shall in particular:

(i) discuss, prepare and approve for submission to the JSC the Commercialization Plan and the Commercialization Budget for each Collaboration Product, and any amendment thereto;

(ii) allocate, in a manner consistent with the Commercialization Plan, primary responsibility as between the Parties for tasks relating to Commercialization of Collaboration Products on a Product-by-Product basis;

(iii) oversee the implementation of the Commercialization Plan for each Collaboration Product;

(iv) review and discuss the Commercialization activities of each Party with respect to each Collaboration Product in the Territory;

(v) review and update sales forecasts for Collaboration Products at least quarterly;

(vi) review strategies for obtaining, maintaining, defending and enforcing trademark protection for Collaboration Products;

(vii) review, discuss, coordinate and approve the Parties’ medical affairs activities (the responsibility for which may be delegated by the JCC to a subcommittee of the JCC that is comprised of medical representatives of the Parties); and

(viii) perform such other functions as may be appropriate to further the purposes of this Agreement, as directed by the JSC.

(c) Meetings. Unless the Parties mutually agree in writing to a different frequency, the JCC shall hold at least [ * ] meetings per year (at least [ * ] of which shall be held in person) on such dates at such times each year as it elects. The meetings of the JCC shall alternate between the Parties’ business locations or as otherwise decided by the JCC. Meetings of the JCC shall be effective only if at least two (2) representatives of each Party are present or participating. Each Party shall bear the expense of its respective members’ participation in JCC meetings. The chairperson of the JCC shall be responsible for preparing and issuing minutes of

each such meeting within [ * ] thereafter. Such minutes shall not be finalized until each Party reviews and confirms the accuracy of such minutes in writing; provided that any minutes shall be deemed approved unless a member of the JCC objects to the accuracy of such minutes within [ * ] after the circulation of the minutes by the chairperson of the JCC.

(d) Decision-Making. The JCC shall act by consensus. The representatives from each Party will have, collectively, one (1) vote on behalf of that Party. If the JCC cannot reach consensus on an issue that comes before the JCC and over which the JCC has oversight, then such matter shall be resolved in accordance with Section 2.7.

2.5 Joint Finance Committee.

(a) Formation and Purpose. Within [ * ] after the Signing Date, the Parties shall create a Joint Finance Committee that shall operate under the direction of the JSC to provide services to and consult with the JDC and the JCC in order to address the financial, budgetary and accounting issues that arise in connection with the Development Plans and Commercialization Plans. Additionally, the JFC will lead the economic analyses to help drive decisions regarding the collaborative activities of the Parties under this Agreement, and lead the reporting and reconciliation processes outlined in Section 3.7 and Section 9.4. The JFC shall operate by the procedures set forth in this Section 2.5 and in Section 2.7.

(b) Membership of the JFC. Each Party shall appoint two (2) representatives to the JFC each of whom will be an officer or employee of such Party and will have appropriate knowledge and expertise and sufficient seniority within the applicable Party to make decisions arising within the scope of the JFC’s responsibilities. Each Party may replace any or all of its JFC representatives at any time upon prior written notice to the other Party. Such representatives will include individuals with expertise and responsibilities in the areas of accounting, cost allocation, budgeting and financial reporting.

(c) Specific Responsibility of the JFC. In addition to its general responsibilities set forth in Section 2.5(a), the JFC shall, in particular:

(i) coordinate with the JSC and other Committees as applicable regarding the preparation and submission of the Development Budget and the Commercialization Budget to the JSC for review and approval;

(ii) develop specific schedules, procedures and methods to implement the financial reporting and reconciliation provisions of this Agreement, such schedules, procedures and methods to implement the provisions of Section 3.7 and Section 9.4 shall, unless otherwise determined by the JSC, be developed within [ * ] after the Signing Date;

(iii) review and update financial forecasts, which shall be updated at least quarterly for the remainder of each Calendar Year unless otherwise determined by the JSC, to ensure that Development Costs and Commercialization Costs incurred or projected to be incurred by each Party are within the approved Development Budget and Commercialization Budget, respectively;

(iv) coordinate and agree upon the calculations, allocations and reports

by each Party of Development Costs, Commercialization Costs, and Product Profit; and

(v) perform such other functions as appropriate to further the purposes of this Agreement as determined by the JSC.

(d) Meetings of the JFC. The JFC shall meet as frequently as members of the JSC determine is required (but in no event, less frequently than [ * ] times every Calendar Year), on such dates and at such times as agreed to by the Parties, with all scheduled in-person meetings to alternate between a Trubion site and a Facet site as designated by the respective Party prior to such meeting, or at other locations as determined by the JFC. All meetings shall be held in person or by audio or videoconference. Additional representatives or consultants, who are under an obligation of confidentiality consistent with this Agreement, may be invited to attend JFC meetings from time to time by agreement of the JFC. Each Party shall be responsible for its own expenses for participating in the JFC. Meetings of the JFC shall be effective only if at least one representative of each Party is present or participating.

(e) Decision-Making. The JFC shall act by consensus. The representatives from each Party will have, collectively, one (1) vote on behalf of that Party. If the JFC cannot reach consensus on an issue that comes before the JFC and over which the JFC has oversight, then such matter shall be resolved in accordance with Section 2.7.

2.6 Joint Patent Committee.

(a) Formation and Purpose. Within [ * ] after the Signing Date, the Parties shall create a Joint Patent Committee. The purposes of the JPC shall be to prepare, file and prosecute the Trubion Product Patent Rights, Facet Product Patent Rights and Joint Patent Rights, as described in and subject to the terms of Article 10. The JPC shall operate by the procedures set forth in this Section 2.6 and Section 2.7.

(b) Membership of the JPC. Each Party shall appoint one (1) representative to the JPC who will be an officer or employee of such Party and will have appropriate knowledge and expertise and sufficient seniority within such Party to make decisions arising within the scope of the JPC’s responsibilities. Each Party may replace its representative at any time upon prior written notice to the other Party.

(c) Specific Responsibilities of the JPC. In addition to its general responsibilities set forth in Section 2.6(a), the JPC shall, in particular be responsible for:

(i) managing the filing and prosecution of Trubion Product Patent Rights, Facet Product Patent Rights and Joint Patent Rights as described in and subject to the terms of Article 10;

(ii) making decisions with respect to certain claims in the Trubion Core Patent Rights as described in and subject to the terms of Article 10;

(iii) keeping updated lists of the Trubion Core Patent Rights, Trubion Product Patent Rights, Facet Product Patent Rights and Facet Patent Rights that would be [ * ] in

the event of [ * ] or [ * ] of [ * ] that reflect newly filed patent applications and claim amendments];

(iv) reviewing invention disclosures in accordance with the terms of Article 10;

(v) reviewing licensing and enforcement activities and conflicts involving intellectual property rights, and making appropriate recommendations to the JSC regarding such matters;

(vi) providing advice, periodic updates and reports to the JSC regarding intellectual property matters;

(vii) using reasonable and customary efforts to monitor and timely analyze freedom to operate and other intellectual property related issues relating to Collaboration Products;

(viii) using good faith efforts to keep the Parties informed as to material developments with respect to the prosecution of, and any adversarial proceedings involving intellectual property rights, to the extent a Party’s representative on the JPC concludes that such prosecution or proceeding directly affects a Collaboration Product; and

(ix) performing such other functions as appropriate to further the purposes of this Agreement as determined by the JSC.

(d) Meetings of the JPC. The JPC shall communicate on such dates and at such times as agreed upon by its members but in no event, less frequently than once every other Calendar Quarter. Meetings may be held in person or by audio or video conference. The JPC may permit visitors who are under an obligation of confidentiality consistent with this Agreement to attend meetings of the JPC. Each Party shall be responsible for its own expenses for participating in the JPC. Meetings of the JPC shall be effective only if the representative of each Party is present or participating.

(e) Decisions. Subject to Article 10 below, any approval, determination or other action of the JPC shall require agreement of both members of the JPC. In the event that a decision cannot be reached by the JPC, then the matter shall be referred to the respective senior management of the in-house legal department of each Party. In the event such senior management is unable to resolve the matter, then the matter will be resolved pursuant to Section 2.7 and Article 15.

2.7 Resolution of Committee Disputes.

(a) Within Subcommittees. All decisions within the JDC, the JCC, the JFC, the JPC, and any other Committee created by the JSC (each, a “Subcommittee”) shall be made by consensus, and if a dispute arises which cannot be resolved within such Subcommittee, then the representatives of either Party may cause such matter to be referred to the JSC for resolution as provided in Section 2.7(b).

(b) Within The JSC. All decisions within the JSC (whether originating there, or referred to it by a Subcommittee) shall be made by consensus. If a matter is referred by a Subcommittee to the JSC, the JSC shall use good faith efforts to resolve promptly such matter. If the JSC is unable to reach consensus on any issue, either Party may elect to submit such issue to the Parties’ Executive Officers in accordance with Section 2.7(c).

(c) Referral To Executive Officers. If a Party makes an election under Section 2.7(b) to refer a matter to the Executive Officers, the JSC shall submit in writing the respective positions of the Parties to the Executive Officers. Such Executive Officers shall use good faith efforts to resolve promptly such matter, which good faith efforts shall include at least one [ * ] meeting between such Executive Officers within [ * ] after the JSC’s submission of such matter to them. If the Executive Officers are unable to reach consensus on any such matter within [ * ] after the referral of such matter to the Executive Officers, then the dispute shall be resolved through arbitration as provided for (a) under Section 15.3(c), with respect to disputes regarding: (i) the [ * ], (ii) [ * ] and related [ * ] and [ * ] thereto, (iii) [ * ] and related [ * ] and [ * ] thereto, (iv) whether and when to [ * ] a [ * ] (which may be a [ * ], [ * ] or a [ * ]) for the [ * ] of a [ * ], (v) whether and when to [ * ] a [ * ], (vi) determination of the identity of a [ * ], [ * ], [ * ], and [ * ], and (v) the appointment of a Party to [ * ] the [ * ] or [ * ] thereto; or (b) under Section 15.3(b), with respect to all other disputes.

2.8 Discontinuation of Participation on a Committee. Either Party may, in its sole discretion, terminate its participation on a Committee by providing to the other Party written notice of its intention to no longer participate in such Committee, which may be made upon [ * ] written notice at any time during the Co-Development or Co-Commercialization period. In the event a Party has provided written notice as referred to in this Section 2.8, the Party electing to terminate its participation shall have no further rights with respect to the decisions otherwise subject to determination by the Committee and the notified Party shall control any decisions that were previously the responsibility of the Committee.

3. DEVELOPMENT.

3.1 Overview. As stated in greater detail in this Article 3, the Parties will Co-Develop each Collaboration Product in the Field throughout the Territory pursuant to a Development Plan and will share equally the associated Development Costs.

3.2 Development Responsibilities. The JSC shall select the lead development party (“Lead Development Party”) for each Clinical Trial of a Collaboration Product, provided that Trubion shall be the initial Lead Development Party for all Clinical Trials and Non-Clinical Studies of TRU-016 that are on-going as of the Signing Date. The JSC shall, in allocating Lead Development Party responsibilities between the Parties: (a) endeavor to take advantage of the respective resources, capabilities and expertise of Facet and Trubion; (b) endeavor to (i) maintain, to the extent reasonably practical and appropriate, continuity in functions and commitments of personnel and physical resources of the Parties, (ii) avoid duplication of efforts by the Parties and (iii) foster efficient use by the Parties of resources and personnel, consistent with this Agreement and the Development Plan and Development Budget; and (c) act in the best interests of the Collaboration. The Lead Development Party shall be responsible for implementing the Development Plan with respect to the applicable Clinical Trial, provided that

the other Party shall perform all tasks with respect to such Clinical Trial that are allocated to it pursuant to the Development Plan and may direct and conduct certain additional Development activities not specifically allocated to either Party pursuant to the Development Plan, if the JDC agrees upon such allocation. The Lead Development Party shall not have the right to change the Development Plan or to make changes to the Clinical Trial protocol or the statistical analysis plan or make changes that affect study design or Clinical Trial strategy (any of the foregoing actions falling under the authority of the JDC or JSC, as applicable).

3.3 Development Plan.

(a) Scope. The Development of Collaboration Products shall be governed by development plans (each, a “Development Plan”), which, unless otherwise determined by the JSC, shall be Collaboration Product-specific, indication-specific, multi-year and world-wide (i.e., it shall cover the Development of each such Collaboration Product for use in the U.S., Japan, each of the Major European Countries and the EU as a whole, and the remaining countries in the Territory). Each Development Plan may, as determined by the JSC: (i) provide a planned Development program that is designed to generate the non-clinical, clinical and regulatory information required for submitting Drug Approval Applications and to obtain Regulatory Approvals for the relevant indications in the Territory; (ii) indicate the initial indications that will be pursued with respect to such Collaboration Product; (iii) address the target product profile for each Collaboration Product for each indication, as periodically updated; (iv) specify all material Development activities per indication to be performed for such Collaboration Product for such year, including without limitation, Clinical Trial protocols, additional preclinical tests (including any and all carcinogenicity and toxicology studies), Collaboration Product manufacturing plan including production and supply, and stability studies, enrollment numbers, submission dates and estimated dates of meetings with FDA for such Collaboration Product; (v) set forth the target timelines for each indication with respect to such Development activities; (vi) include a forecast of the amount of Bulk API or finished Collaboration Product needed for such Development activities; and (vii) assign tasks to each Party with respect to the performance of the Development activities contemplated by such Development Plan. Each Development Plan shall include a Development Budget. Each Development Plan and updates thereof shall be prepared by the Party appointed by the JDC, with input from the other Party’s key clinical development personnel, and submitted pursuant to the procedures set forth in clause (c) below to the JDC for review and submission to the JSC for approval.

(b) Initial Development Plan. A draft of the initial Development Plan, together with associated initial Development Budget, for TRU-016 is attached hereto as Exhibit B (the “Initial Development Plan”). The Parties shall make good faith efforts to agree upon the definitive Initial Development Plan and have it appropriately approved by the JSC within [ * ] after the Signing Date.

(c) Updates to the Development Plan. On an annual basis (no later than [ * ] of each Calendar Year), the Party appointed by the JDC shall prepare amendments to each then-current Development Plan and each Development Budget. Each such amended Development Plan shall cover the next Calendar Year and shall contain a corresponding Development Budget. Each such updated and amended Development Plan shall reflect any changes, re-prioritization of studies within, reallocation of resources with respect to, or additions

to Development of the applicable Collaboration Product. The amended Development Plan and Development Budget shall be submitted to the JDC for review and, following such review, to the JSC for its review and approval. Once approved by the JSC, the amended Development Plan and Development Budget shall become effective on January 1 of each Calendar Year and shall be in full force throughout such Calendar Year unless further amended in accordance with this Section 3.3(c). In any event, any amended or updated Development Plan and Development Budget shall supersede the previous Development Plan and Development Budget.

3.4 Standards of Conduct; Diligence.

(a) Each Party shall perform the Development activities for which it is responsible under the Development Plan in good scientific manner and in compliance with applicable Laws, including without limitation applicable GCP, GLP, and GMP. Each Party will keep the other Party fully informed regarding the progress and results of such Party’s Development activities with respect to the Collaboration Products through the JDC meetings on a quarterly basis and other than through the JDC at such other time as necessary under the circumstances.

(b) Each Party shall use Diligent Efforts to execute and carry out the activities assigned to it in the Development Plan and shall use Diligent Efforts to execute and carry out such activities within the Development Budget; provided that if a Party exceeds the portion of such Development Budget allocated to it with respect to the relevant Calendar Quarter by greater than [ * ] without the approval of the JSC, any amount in excess of such number shall not be considered Development Costs and such Party shall be solely responsible for payment of such excess.

(c) The Parties shall cooperate in good faith to establish appropriate and consistent medical information support relating to Collaboration Products.

3.5 Third Parties.

(a) Contractors. Any Third Party retained by a Party to perform Development activities with respect to Collaboration Products must be approved in advance in writing by the JSC, such approval not to be unreasonably withheld or delayed, unless such Third Party and such activities are pre-existing obligations listed in Schedule 3.7 or are specifically approved in the Development Plan or Development Budget. Each Party shall remain liable for the performance of its obligations hereunder which it delegates to such Third Parties.

(b) Obligations with Respect to Third Party Contracts. Any Third Parties performing Development activities hereunder shall be subject to confidentiality and non-use obligations at least as stringent as those set forth in Article 11 with a minimum duration of [ * ] and must comply with the terms of Section 10.1(c) with respect to any invention or Know-How generated in the course of performing the Development activities. Unless otherwise determined by the JSC, each Party shall include provisions in its contracts with Third Parties entered into after the Signing Date and specifically related to Development or Commercialization of a Collaboration Product that would permit, in the event that such Collaboration Product becomes a

Royalty Product (i) the assignment of such contract by the Opt-Out Party to the Non-Opt-Out Party, or (ii) the granting of a sublicense or equivalent right of access to the Non-Opt-Out Party.

(c) Intellectual Property. Neither Party shall knowingly introduce to any Collaboration Product any Patent Right or Know-How that is not Controlled by such Party, except with the prior approval of the JSC.

3.6 Limitations on Development. After the Signing Date and during the Term, neither Party nor any of its Affiliates shall, directly or through any Third Party, sponsor, conduct or cause to be conducted, otherwise assist in, or supply any Collaboration Product for use in connection with, or otherwise fund, any Clinical Trial of any Collaboration Product outside of the Development Plan, without the prior written consent of the other Party.

3.7 Development Costs.

(a) In general. All Development Costs incurred by either Party shall be borne by the Parties as follows: Facet shall bear fifty percent (50%) of all Development Costs and Trubion shall bear fifty percent (50%) of all Development Costs, provided that such costs were incurred pursuant to the Development Plan, and either do not exceed the portion of the Development Budget allocated to the applicable Party with respect to the relevant Calendar Quarter by more than [ * ] or are otherwise approved by the JSC. For clarity, any costs otherwise or previously shared by the Parties shall not be double counted or otherwise included as a Development Cost even if it meets such definition.

(b) FTE Records and Calculations. Each Party shall record its FTE effort for the Development of each Collaboration Product to the extent that such FTE efforts are included in Development Costs that are, or may in the future be, shared under this Agreement, and shall report such FTE effort to the JDC, on a Calendar Quarterly basis, in each case in a manner that allocates such FTE effort to the extent practicable to each applicable Collaboration Product. Except to the extent provided herein, each Party shall calculate and maintain records of FTE effort incurred by it in the same manner as used for other products developed by such Party in accordance with a methodology approved by the JSC. The JFC shall facilitate any reporting hereunder.

(c) Other Expenses. Any expenses incurred by a Party for Development activities that do not fall within the definitions of Development Costs shall be borne solely by such Party unless the JSC determines otherwise.

(d) Pre-existing Obligations. Unless otherwise determined by the JSC, any Third Party obligations of either Party in existence prior to the Signing Date, such as [ * ] or other obligations described in Section [6.3], other than those listed in Schedule 3.7 will not be considered Development Costs and will not be subject to expense sharing. For the avoidance of doubt, any [ * ] to the [ * ] will [ * ] to [ * ] (unless [ * ] by the [ * ]).

(e) Reports. Each Party shall report to the other Party within [ * ] after the end of each Calendar Quarter with regard to the Development Costs incurred by it during such quarter. Such report shall be prepared in accordance with GAAP and shall specify in reasonable detail all expenses included in such Development Costs during such quarter and shall be

accompanied by invoices, and/or such other appropriate supporting documentation in accordance with the procedures established by the JSC. Each Party’s report shall include, in addition to the Development Costs incurred by it during the relevant Calendar Quarter a comparison of the amounts budgeted in the Development Plan for such activities and the amounts incurred by such Party for such activities. The Parties shall seek to resolve any questions related to such accounting statements within [ * ] following receipt by each Party of the other Party’s report hereunder. The JFC shall facilitate the reporting of Development Costs hereunder and the resolution of any questions concerning such reports. Each Party shall have the right at reasonable times and upon reasonable prior notice to audit the other Party’s records as provided in Section 9.9(b) to confirm the accuracy of the other Party’s costs and reports with respect to Development Costs that are shared under this Agreement.

(f) Development Cost Accounts. Each Party shall charge all Development Costs as incurred by it or its Affiliates on its books and records in accordance with GAAP to enable the tracking of expenses incurred in connection with each Development Plan. Each Party shall provide the other Party with an interim quarterly report of monthly estimates for the current Calendar Quarter charges within [ * ] after the end of the second calendar month in each Calendar Quarter.

(g) Reconciliation Payment. Within [ * ] after the end of each of the first three Calendar Quarters and, for the last Calendar Quarter in a Calendar Year, within [ * ] after the end of such quarter, the Party that has incurred less than its share of such Development Costs shall make a reconciling payment to the other Party to achieve the appropriate allocation of Development Costs provided for in Section 3.7(a).

(h) Records. Each Party shall keep detailed records of the Development Costs it incurs, including all supporting documentation for such expenses. Each Party shall keep such records for at least [ * ] after the date that such expense was incurred.

(i) General Procedures Apply. Any reimbursement payments made pursuant to this Section 3.7 shall be subject to the general payment procedures set forth in Sections 9.6-9.9.

3.8 Records, Reports and Information. Each Party shall maintain complete, current and accurate records of all work conducted by it under the Development Plan and all data and other Know-How resulting from such work. Such records shall fully and properly reflect all work done and results achieved in the performance of the Development Plan in sufficient detail and in good scientific manner appropriate for patent and regulatory purposes. Each Party shall provide written reports to the JDC on its Development and regulatory activities with the Collaboration Product pursuant to the Development Plan on a quarterly basis at the end of each Calendar Quarter, at a level of detail reasonably sufficient to enable the other Party to determine the reporting Party’s compliance with its Diligent Efforts obligations under Section 3.4. Each Party shall have the right to review any such records maintained by the other Party at reasonable times and upon written request in accordance with procedures established by the JDC.

4. REGULATORY MATTERS.

4.1 Transfer of Data and Regulatory Materials. The JDC shall determine the content and manner for sharing data and Regulatory Materials between the Parties. The lead Party for regulatory activities with respect to a particular Collaboration Product in a particular country (such Party, the “Lead Regulatory Party”), as provided in Section 4.3, shall provide the other Party with copies of the IND and of such other Regulatory Materials Controlled by the Lead Regulatory Party, in each case with respect to Collaboration Products. Specifically, within [ * ] after the Signing Date, Trubion shall provide Facet with a copy of all TRU-016 related Regulatory Materials in the form then existing, generated as of the Signing Date and Controlled by Trubion. The non-Lead Regulatory Party shall have the right, without any additional consideration, to use any and all such data and reports supplied by the Lead Regulatory Party under this Section 4.1 in connection with the Development and/or Commercialization of any Collaboration Products or Royalty Products in the Field, in the Territory in accordance with the terms of this Agreement, including the incorporation of such data or reports in any regulatory submissions.

4.2 Ownership of Regulatory Dossier. The Lead Regulatory Party will own all regulatory filings for each Collaboration Product in each country where such Party is the Lead Regulatory Party in order to facilitate such Party’s interactions with Regulatory Authorities in such country with respect to each such Collaboration Product. Trubion, as initial Lead Regulatory Party for TRU-016 in the Unites States, will initially own all Regulatory Materials for [ * ] in the [ * ], including all Regulatory Materials related to [ * ] as of the [ * ]. Promptly upon the JSC’s decision to change the Lead Regulatory Party or the delivery of a Pursuit Notice or a deemed Pursuit Notice if the Lead Regulatory Party has exercised or has been deemed to have exercised its Opt-Out Option pursuant to Article 7, Section 8.5 or Section 14.2(b), the former Lead Regulatory Party shall transfer and assign to the other Party (and the other Party hereby agrees to receive from the former Lead Regulatory Party) all of the former Lead Regulatory Party’s right, title and interest to the applicable regulatory filings.

4.3 Lead Regulatory Party. The Parties intend that each Development Plan shall set forth the regulatory strategy approved by the JSC for the applicable Collaboration Product. The JSC shall select the Lead Regulatory Party for each Collaboration Product, provided that Trubion shall be the initial Lead Regulatory Party for TRU-016 in the United States and the JSC may change the Lead Regulatory Party for any Collaboration Product at any time. The Lead Regulatory Party shall be responsible for the implementation of such strategy in the applicable country. The Lead Regulatory Party shall comply with applicable Laws and other regulatory obligations related to the submission and maintenance of any Regulatory Materials for Regulatory Approval of a Collaboration Product, in the Field, in the applicable country(ies) of the Territory. The Party that is not the Lead Regulatory Party shall have a participatory role in all material regulatory activities that would have a potential impact on Collaboration Products in the relevant country, including all interactions with Regulatory Authorities. All material regulatory decisions (including the content of any regulatory filing or dossier, pharmacovigilance reports, patient risk management strategies and plans, Product Labeling and safety) will be made by the JSC and implemented by the Lead Regulatory Party. Notwithstanding any other provision of this Agreement, the decision to [ * ] any [ * ] for a [ * ] must be the result of consensus by the JSC or, in the event that the JSC is unable to reach consensus with respect to such a [ * ] decision

and the matter is submitted to the Parties’ Executive Officers pursuant to Section 2.7(b), the unanimous agreement of the Executive Officers pursuant to Section 2.7(c) to [ * ] such [ * ]. If the Executive Officers are unable to reach consensus on any such matter within the applicable [ * ] period, then the JSC will be deemed to have decided not to [ * ] such [ * ]. In no event will a dispute regarding whether to [ * ] a [ * ] for a [ * ] be resolved through arbitration under Article 15.

4.4 Regulatory Filings.

(a) The Lead Regulatory Party shall prepare, for timely review by the JDC, all IND and BLA submissions (including any supplements or modifications thereto, but excluding routine submissions such as study site documentation and adverse event reports (i.e., not relating to serious adverse events as defined by applicable Law)) to the applicable Regulatory Authority. The other Party shall have a right to review and comment upon (through its members of the JDC) all draft material regulatory filings, including without limitation all correspondence to be submitted to the Regulatory Authority related to Clinical Trial design, the content and subject matter of, and strategy for, each Drug Approval Application, all proposed Product Labeling (including the final Regulatory Authority-approved Labeling) and post-Regulatory Approval labeling changes. The Lead Regulatory Party shall accept and incorporate all reasonable comments provided by the other Party. Each Party shall promptly provide the other with copies of all written or electronic communications received by it from, or sent by it to, a Regulatory Authority including IND submissions and amendments thereof, and all communications (other than routine communications) with respect to obtaining and maintaining, Regulatory Approvals for a Collaboration Product (it being understood that routine adverse event filings (i.e., not relating to serious adverse events as defined by applicable Law) shall not fall within the meaning of maintenance) and copies of all contact reports produced by such Party. The Lead Regulatory Party shall be the sole Party to initiate contact with any Regulatory Authorities regarding a Collaboration Product, and shall initiate such contact at the reasonable request of the other Party.

(b) Notice of Regulatory Filing Requirements. The Lead Regulatory Party shall provide to the other Party, within [ * ] of discovery or receipt thereof by the Lead Regulatory Party, notice of (i) any event with respect to any Collaboration Product that triggers any Regulatory Authority filing requirement, (ii) any additional requirements which the applicable Regulatory Authority may impose with respect to obtaining or maintaining Regulatory Approval for a Collaboration Product (including additional Clinical Trials), and (iii) all Regulatory Authority inquiries with respect to a Collaboration Product that require a response or for a which a response may be advisable. The JDC shall discuss in good faith and on a timely basis determine the most effective and expeditious means of responding to such Regulatory Authority filing requirements, additional requirements or inquiries.

4.5 Regulatory Meetings. The Lead Regulatory Party shall provide the other Party with notice of all meetings, conferences, and discussions (including Regulatory Authority advisory committee meetings and any other meeting of experts convened by the Regulatory Authority concerning any topic relevant to a Collaboration Product, as well as Collaboration Product labeling and post-Regulatory Approval Collaboration Product labeling discussions with any Regulatory Authority) scheduled by the Regulatory Authority concerning any pending Drug Approval Application or any material regulatory matters relating to a Collaboration Product

within [ * ] after the Lead Regulatory Party receives notice of the scheduling of such meeting, conference, or discussion (or within such shorter period as may be necessary in order to give the other Party a reasonable opportunity to participate in such meetings, conferences and discussions). The other Party shall be entitled to be present at, and to participate in, all such meetings, conferences or discussions. Facet’s and Trubion’s respective members of the JDC shall use reasonable efforts to agree in advance on the scheduling of such meetings and on the objectives to be accomplished at such meetings, conferences, and discussions and the agenda for the meetings, conferences, and discussions with the Regulatory Authority. The Lead Regulatory Party shall reasonably attempt to include the other Party in any unscheduled, ad-hoc meetings, conferences and discussions with the Regulatory Authority concerning any pending IND, Drug Approval Application or any material regulatory matters relating to a Collaboration Product, and will promptly copy such other Party on a contact report.

4.6 Regulatory Data. In accordance with procedures established by the JDC, each Party shall provide to the other Party on a timely basis access to or copies of all material pre-clinical and clinical data generated or compiled pursuant to the Development Plan with respect to Regulatory Materials maintained by such Party (via electronic copies of such data in a form that may be analyzed and manipulated by the other Party).

4.7 Common Database. If deemed appropriate by the JDC, the Parties will establish a common database to be controlled, maintained and administered by the Party designated by the JDC for the receipt, investigation, recordation, communication, and exchange (as between the Parties) of data arising from Clinical Trials for Collaboration Products. The Parties shall agree upon guidelines and procedures for such common database that shall be in accordance with, and enable the Parties to fulfill their reporting obligations under applicable Law. Furthermore, such guidelines and procedures shall be consistent with relevant International Council for Harmonisation (“ICH”) guidelines. The Parties’ costs incurred in connection with receiving, investigating, recording, reviewing, communicating, and exchanging such data shall be included as an element of Development Costs or as Commercialization Costs, as applicable, calculated on a FTE cost (calculated at the FTE Rate) and direct out-of-pocket cost basis.

4.8 Rights of Reference. Each Party shall have the right to cross reference, file or incorporate by reference any regulatory filing or drug master file (as defined in 21 C.F.R. 314.420, or as amended from time to time, or the corresponding foreign equivalent) (and any data contained therein) for any Collaboration Product, or any component thereof, made in any country in the Territory (including all Regulatory Approvals) in order to support regulatory filings that such Party is permitted to make under this Agreement for any Collaboration Product or Royalty Product and to enable either Party to fulfill its obligations under this Agreement to Develop, Manufacture or Commercialize in the Territory any such Collaboration Product or Royalty Product. Each Party shall support the other, as may be reasonably necessary, in obtaining Regulatory Approvals for each Collaboration Product and Royalty Product, including providing necessary documents, or other materials required by applicable Law to obtain Regulatory Approvals, in each case in accordance with the terms and conditions of this Agreement.

4.9 Costs and Expenses. Unless otherwise agreed by the JSC and subject to Section 3.4(b), any costs required for the Parties to prepare, submit and maintain all Regulatory Materials

in the Territory shall be treated as Development Costs to the extent such costs are incurred in accordance with the Development Plan and do not exceed the portion of the Development Budget allocated to such regulatory activities to the applicable Party with respect to the relevant Calendar Quarter by more than [ * ] or are otherwise approved by the JSC.

4.10 Consultation, Reporting and Review.

(a) Each Lead Regulatory Party shall keep the other Party reasonably and regularly informed of the status of the preparation of all Regulatory Materials, Regulatory Authority review of Regulatory Materials, and Regulatory Approvals made by it for Collaboration Products in the Field.

(b) Each Lead Regulatory Party shall provide the other Party, in a timely manner, with copies of all Regulatory Approvals it receives for Collaboration Products in the Field.

(c) Each Party shall provide the other Party, in a timely manner, with copies of, and all information received by it pertaining to, notices, questions, actions and requests from or by Regulatory Authorities with respect to Collaboration Products, in the Field, or the testing, manufacture, distribution or facilities in relation thereto, including without limitation any notices of non-compliance with Laws in connection with Collaboration Products in the Field (e.g., warning letters or other notices of alleged non-compliance), audit notices, notices of initiation by Regulatory Authorities of investigations, inspections, detentions, seizures or injunctions concerning Collaboration Products (or their manufacture, distribution, or facilities connected thereto), notice of violation letters (i.e., an untitled letter), warning letters, service of process or other inquiries.

4.11 Regulatory Inspection or Audit. If a Regulatory Authority in the Territory desires to conduct an inspection or audit with regard to a Collaboration Product of a Party’s facility or a facility under contract with a Party, or with regard to a Royalty Product of the Opt-Out Party’s facility or a facility under contact with the Opt-Out Party when the Opt-Out Party continues to supply the Royalty Product to the Non-Opt-Out Party pursuant to Section 7.5(b)( vi), such Party shall promptly notify the other Party. In such case, the audited Party shall permit and cooperate with such inspection or audit, and shall cause the contract facility to permit and cooperate with such Regulatory Authority during such inspection or audit. The other Party shall have the right to have a representative observe such inspection or audit and shall, if requested by the audited Party, assist the audited Party in preparing for, facilitating or enabling such inspection or audit. Following receipt of the inspection or audit observations of such Regulatory Authority (a copy of which the audited Party shall immediately provide to the other Party), the audited Party shall prepare a draft response to any such observations, in consultation with the other Party, and the Party that holds the Regulatory Materials in the applicable country or territory shall prepare and file the final response with such Regulatory Authority. If the Regulatory Authority is conducting an inspection or audit with regard to a Party’s contract facility, such Party shall (subject to the terms of the applicable contract with a Third Party manufacturer) cause its contract facility to prepare, submit to both Parties for input, and file the final response incorporating such input with such Regulatory Authority, and copy both Parties on such submission.

4.12 Pharmacovigilance Agreement. Subject to the terms of this Agreement, and at a date to be determined by the JDC, Facet and Trubion shall define and finalize the actions the Parties shall employ to protect patients and promote their well-being in a written agreement (hereinafter referred to as the “Pharmacovigilance Agreement”). These responsibilities shall include mutually acceptable guidelines and procedures for the receipt, investigation, recordation, communication, and exchange (as between the Parties) of adverse event reports, pregnancy reports, and any other information concerning the safety of any Collaboration Product. Such guidelines and procedures shall be in accordance with, and enable the Parties to fulfill, local and national regulatory reporting obligations to Governmental Authorities. Furthermore, such agreed procedures shall be consistent with relevant ICH guidelines, except where said guidelines may conflict with existing local regulatory safety reporting requirements, in which case local reporting requirements shall prevail. The Pharmacovigilance Agreement will provide for a worldwide safety database to be maintained by the Party appointed by the JDC. Each Party hereby agrees to comply with its respective obligations under such Pharmacovigilance Agreement (as the Parties may agree to modify it from time to time) and to cause its Affiliates and permitted sublicensees to comply with such obligations.

5. COMMERCIALIZATION.

5.1 Overview. The Parties agree to collaborate with respect to the Commercialization of Collaboration Products, in the Field, in the Territory as provided in this Article 5. The JSC shall choose the Party, on a country-by-country and Collaboration Product-by-Collaboration Product basis, with the greatest applicable Commercial capability with respect to a particular Collaboration Product in a particular country as the lead commercialization party (“Lead Commercialization Party”) for such Collaboration Product in such country to coordinate the implementation of the Commercialization Plan in accordance with the allocation of responsibilities set forth therein.

5.2 Commercialization Plan.

(a) Scope. The Commercialization of Collaboration Products shall be conducted pursuant to commercialization plans (each, a “Commercialization Plan”), which, unless otherwise determined by the JSC, shall be Collaboration Product-specific, multi-year, world-wide, and shall set forth the anticipated Commercialization activities (including market studies, launch plans, Detailing and Promotion) and timelines, shall allocate responsibility for carrying out such activities between Facet and Trubion, and shall include the Commercialization Budget for such activities. Each Commercialization Plan may, as determined by the JSC, include a lifecycle plan and the plan, with respect to each country, for: (i) Detailing and Promotion activities for the applicable Collaboration Product for the next [ * ] (as to the initial Commercialization Plan, the [ * ] following launch) and timelines for performing such activities, (ii) target audience, (iii) anticipated expenses, (iv) assumptions regarding product profile, (v) sales force size, and (vi) Promotional efforts. Each Commercialization Plan shall include a Commercialization Budget. Each Commercialization Plan and updates thereof shall be prepared by the Lead Commercialization Party in the United States for such Collaboration Product, with review by and input from the other Party’s key personnel for Commercialization and Manufacturing activities, and submitted pursuant to the procedures set forth in clauses (b) and (c) below to the JCC for review and submission to the JSC for approval.

(b) Initial Commercialization Plan. Promptly following the JSC’s request for a Commercialization Plan for a particular Collaboration Product and at least [ * ] prior to the then-current date of expected Regulatory Approval for such Collaboration Product in the Field, the Lead Commercialization Party in the United States for such Collaboration Product, with strategic guidance from the JSC, shall prepare the initial Commercialization Plan for such Collaboration Product and submit such plan to the JCC for review and, following such review, to the JSC for its review and approval. The Parties agree and acknowledge that any such Commercialization Plan will reasonably allocate all Commercialization activities between the Parties, giving equal consideration to each Party’s abilities when making such allocation.

(c) Updates to the Commercialization Plan. On an annual basis (no later than [ * ] of each Calendar Year), the Lead Commercialization Party in the United States for such Collaboration Product shall prepare amendments to the then-current Commercialization Plan and the Commercialization Budget. Such amended Commercialization Plan shall cover the next Calendar Year and shall contain a corresponding Commercialization Budget. Such updated and amended Commercialization Plan shall reflect any changes, re-prioritization of activities within, reallocation of resources with respect to, or additions to Commercialization of the applicable Collaboration Product. The amended Commercialization Plan and Commercialization Budget shall be submitted to the JCC for review and, following such recommendation, to the JSC for its review and approval. Once approved by the JSC, the amended Commercialization Plan and Commercialization Budget shall become effective on January 1 of each Calendar Year and shall be in full force throughout such Calendar Year unless further amended in accordance with this Section 5.2(c). In any event, any amended or updated Commercialization Plan and Commercialization Budget shall supersede the previous Commercialization Plan and Commercialization Budget.

5.3 Commercialization Reports. Each Party will keep the JCC fully informed regarding the progress and results of its Commercialization activities with respect to Collaboration Products under this Agreement.

5.4 Standards of Conduct.

(a) Each Party shall perform, or shall ensure that its Affiliates and permitted sublicensees and Third Party contractors perform, all Commercialization activities assigned to it in a good scientific and ethical business manner and in compliance with applicable Laws.

(b) Each Party shall use Diligent Efforts to execute and carry out the activities assigned to it in the Commercialization Plan and each Party shall use Diligent Efforts to execute and carry out such activities within the Commercialization Budget; provided that if a Party exceeds the portion of the Commercialization Budget allocated to it with respect to the relevant Calendar Quarter by greater than [ * ] without the approval of the JSC, any amount in excess of such number shall not be considered Commercialization Costs hereunder and such Party shall be solely responsible for payment of such excess.

5.5 Sales Force Training. The Lead Commercialization Party shall develop and conduct training programs for the sales representatives of one or both Parties’ sales representatives (depending on whether one or both Parties will be Detailing the Collaboration

Product), specifically relating to the Collaboration Products to be Commercialized. Each Party agrees to utilize such training programs on an ongoing basis to assure a consistent, focused promotional strategy.

5.6 Product Labeling and Promotional Materials. The JCC shall determine which Party shall be responsible for designing and supplying the Product Labeling and Promotional Materials for each Collaboration Product in the Territory. Such responsible Party shall provide samples of such labeling and materials to the JCC for review and consultation prior to finalizing such materials for use by the Parties’ sales representatives. The Parties shall describe in the applicable Commercialization Plan how and the manner in which the Parties shall be presented and described to the medical community in any Promotional Materials and the placement of the names and logos of the Parties therein, in each case as permitted by applicable Law and in accordance with the labeling for the Collaboration Product approved by the applicable Regulatory Authority.

5.7 Branding. Each Collaboration Product Commercialized under this Agreement shall be Commercialized under and in connection with the Marks selected in accordance with Section 10.7. To the extent that a Party is granted rights under this Agreement to Commercialize a Collaboration Product, it shall Commercialize such Collaboration Product solely under and in connection with the Marks selected and approved pursuant to the terms of Section 10.7 (except for Marks that include, in whole or part, any corporate name or logo of such Party, which Marks do not require such approval).

5.8 Pricing. The JSC will determine the selling price (including volume discounts (including those available, without limitation, to managed care providers, indemnity plans, unions, self insured entities, and government payer, insurance or contracting programs such as Medicare, Medicaid, or the United States Dept. of Veterans Affairs), rebates, and similar matters, credit terms, and return policies) for all Collaboration Products Commercialized hereunder. The Lead Commercialization Party for a particular Collaboration Product in a particular country shall have the right and responsibility for proposing to the JCC for review and submission to the JSC for approval the terms and conditions (and any updates and revisions thereof) with respect to the sale of such Collaboration Product in such country, including any terms and conditions relating to or affecting the price at which the Collaboration Product shall be sold, discounts, any discount attributable to payments on receivables, distribution of the Collaboration Product, and credits, price adjustments, or other discounts and allowances to be granted or refused.

5.9 Booking of Sales. The Lead Commercialization Party for a particular Collaboration Product in a particular country will book sales in accordance with GAAP including handling inventory, receivables, managing relationships with the trade, returns, reimbursements, and charge-backs, trade-customer complaints and inquiries with respect to such Collaboration Product in such country. For clarity, each Party’s expenses in connection with the activities described in this Section 5.9 will be included as Sales and Marketing Costs or Distribution Costs, as appropriate.

5.10 Product Recalls. Decisions with respect to recalls, withdrawals or other corrective actions (“Recall”) with respect to any Collaboration Product related to manufacturing or product quality issues shall be handled in accordance with the Commercial Supply

Agreement. Decisions with respect to any other Recall related to any Collaboration Product shall be made only upon mutual agreement of the Parties; provided, however, that nothing herein shall [ * ] Party [ * ] or [ * ] any [ * ] (i) [ * ] by a [ * ] or [ * ] or (ii) which in [ * ] is, or such Party [ * ] will [ * ], a [ * ] or [ * ] (under [ * ], or [ * ] of the [ * ]). The Parties shall cooperate with respect to any actions taken or public statements made in connection with any such Recall. Except as otherwise provided in this Section 5.10, the Parties will share all costs of a Recall with respect to any Collaboration Product as Sales and Marketing Costs. Notwithstanding the foregoing, a Party shall bear any and all costs of a Recall, market withdrawal or other corrective action with respect to a Collaboration Product in the Territory, including the Manufacturing Costs for the Collaboration Product in question, to the extent the Recall is attributable to the fault of such Party and results from (a) a grossly negligent or reckless act or omission or intentional misconduct of such Party (or its Affiliate, agent or permitted sublicensee), (b) in the case such Party is the Lead Manufacturing Party, the failure of the Lead Manufacturing Party or its Affiliate, agent or sublicensee to perform its responsibilities and Manufacture the Collaboration Product in compliance with the specifications (as set forth in the Commercial Supply Agreement), or with applicable Laws, including applicable Good Manufacturing Practices, (c) any defect or condition introduced by a Party, its Affiliates or permitted sublicensees following delivery of the Collaboration Product from the Lead Manufacturing Party or its contract manufacturer, into a Collaboration Product or its packaging or labeling, or (d) a breach of any Laws or the terms of this Agreement by such Party.

5.11 Co-Promotion Agreement. In the event that both Parties have their own sales forces with appropriate expertise or that the Parties otherwise agree to share promotional responsibilities with respect to one or more Collaboration Products in one or more countries, the Parties shall negotiate in good faith and enter into a co-promotion agreement for such Collaboration Product in such countries to implement the promotional activities contemplated in the Commercialization Plan for such Collaboration Product in such country.

5.12 Limitations on Commercialization. After the Signing Date and during the Term, neither Party nor any of its Affiliates shall, directly or through any Third Party, Commercialize any Collaboration Product outside of the Commercialization Plan, without the prior written consent of the other Party.

6. MANUFACTURING.

6.1 Roles of the Parties. The JSC shall select the lead manufacturing Party (“Lead Manufacturing Party”) for each Collaboration Product and the Lead Manufacturing Party shall be responsible for the supply of the Parties’ entire requirements of such Collaboration Product in accordance with the terms set forth below. Trubion shall be the initial Lead Manufacturing Party for TRU-016.

(a) Facet acknowledges that Trubion uses Third Party manufacturers to Manufacture TRU-016, and Trubion confirms that it shall be solely responsible for the performance of such Third Party manufacturers until such time as the Parties determine to engage an alternate or additional source of supply, or the Parties agree to amend such agreements in accordance with Section 6.4.

(b) Trubion shall promptly notify existing Third Party manufacturers of execution of this Agreement, and, if Trubion proposes to materially amend, or to extend the term of, any existing Product manufacturing agreement with a Third Party, use Diligent Efforts to include Facet as a party to such agreement or to provide Facet with third party beneficiary rights with respect to such agreement and to allow for assignment of such agreement, or, if such agreement also applies to products that are not Products, assignment of all rights and obligations to the extent related to such Product, in each case from Trubion to Facet without consent from such Third Party manufacturer.

6.2 Pre-Clinical and Clinical Supply. The Lead Manufacturing Party with respect to a particular Collaboration Product shall, by itself or through its Third Party contract manufacturers, timely supply all quantities of such Collaboration Product agreed upon by the JDC as required by the Parties to carry out all Development activities (pre-clinical and clinical) for such Collaboration Product pursuant to the Development Plan. Such quantities of Collaboration Product, and the schedule for such supply, shall be confirmed and if necessary updated by the JDC in a manner consistent with the Development Plan. Such supply shall be considered a Development Cost and charged on an accrual basis; provided that any [ * ] of [ * ] of the [ * ] shall [ * ] as [ * ]. [ * ] in [ * ] of the [ * ] shall [ * ] as [ * ] except when it is [ * ] to [ * ] or [ * ] after [ * ] by the [ * ]. The JSC shall, in allocating Lead Manufacturing Party responsibilities between the Parties: (a) endeavor to take advantage of the respective resources, capabilities and expertise of Facet and Trubion; (b) endeavor to (i) maintain, to the extent reasonably practical and appropriate, continuity in functions and commitments of personnel and physical resources of the Parties, (ii) avoid duplication of efforts by the Parties and (iii) foster efficient use by the Parties of resources and personnel, consistent with this Agreement and the applicable then-current Development Plan and Development Budget; and (c) act in the best interests of the Collaboration. The Lead Manufacturing Party shall ensure that all finished Collaboration Product supplied pursuant to the Development Plan shall, when delivered, have been manufactured, handled and stored in compliance with all agreed-upon specifications, then-current GMP requirements and applicable Laws, including without limitation prohibitions on misbranding and adulteration. The Lead Manufacturing Party shall reasonably determine the process for quantity orders, timing for delivery and shipping terms to permit the Parties to fulfill their obligations under the Development Plan.

6.3 Pre-existing Obligations with Third-Party Manufacturers. Unless otherwise determined by the JSC, any Third Party obligations in existence prior to the Signing Date for manufacturing of TRU-016, such as manufacturing capacity reservation, other than those listed in Schedule 3.7 will not be considered Manufacturing Costs and will not be subject to expense sharing. For the avoidance of doubt, any [ * ] to the [ * ] will [ * ] to [ * ] (unless [ * ] by the [ * ]).

6.4 Alternative Supply Arrangements. Unless otherwise determined by the JSC, in the event that: (a) the Lead Manufacturing Party proposes to enter into one or more new manufacturing agreements, (b) the Lead Manufacturing Party proposes to materially amend, to renegotiate or to renew its then existing Third Party manufacturing agreements, or (c) the Lead Manufacturing Party notifies the JSC that capacity or quality under the existing Third Party manufacturing agreements will not be sufficient to meet the needs of the Parties under the Development Plan, the JSC shall determinate the appropriate course of action, including a

determination of whether a second source of supply is appropriate. In any event, the Lead Manufacturing Party shall notify the other Party and the JSC prior to entry into any such new, amended or renewed Third Party manufacturing agreement, and the JSC shall review and approve the proposed terms of such new, amended or renewed agreement; provided that such agreement may include, as agreed upon by the JSC (i) attempting to order in full lot or production run batches and otherwise reducing the Manufacturing Cost of Collaboration Product, (ii) providing for sufficient capacity and timely supply to satisfy the requirements of the then-current Development Plan, (iii) having Facet and Trubion as parties (and in any event third party beneficiaries) with respect to the rights and obligations related to Collaboration Products pursuant to such Third Party agreement, (iv) ensuring that in the event of the exercise or deemed exercise of an Opt-Out Option by a Party, the remaining Party shall be the sole obligor pursuant to such Third Party Agreement, (v) providing that the Parties shall have joint rights and obligations under the agreement with respect to Collaboration Product, but that one Party shall be designated as the “principal party” under such agreement, (v) providing both Parties with the right to audit and inspect such Third Party’s facilities on at least [ * ], which efforts shall be coordinated between the Parties in the event both Parties desire to conduct such audit and inspection, and (vi) providing for complete sharing of any and all information under and the terms and conditions of such agreement between the Parties. The Lead Manufacturing Party shall be responsible for negotiating the terms of such agreement, with the other Party having consultation and review rights on the terms of such Third Party agreement.

6.5 Commercial Supply Agreement. Unless a Party has already exercised its Opt-Out Option or is deemed to have exercised its Opt-Out Option under Section 14.2(b), at least [ * ] prior to the anticipated commercial launch of a Collaboration Product, the Parties shall negotiate in good faith and enter into a manufacturing and supply agreement (the “Commercial Supply Agreement”) governing the commercial supply of such Collaboration Product. Such Commercial Supply Agreement shall contain customary terms governing such manufacturing and supply relationships, but shall in any event provide as follows:

(a) Collaboration Product (i) shall meet the agreed specification, then-current GMP and be manufactured in accordance with applicable Laws including prohibitions on adulteration and misbranding, (ii) shall be supplied by or on behalf of the Lead Manufacturing Party in a timely manner consistent with established and agreed manufacturing and delivery schedules; and (iii) shall be supplied at a cost equal to the Manufacturing Cost of such Collaboration Product.

(b) Upon a material and uncured breach by the Lead Manufacturing Party of its supply obligations, the other Party shall have the right to obtain the transfer and the Lead Manufacturing Party shall have the obligation to (i) effect such transfer [ * ] to the other Party, without undue delay, of any and all manufacturing technology reasonably necessary for the Manufacture of the applicable Collaboration Product included in the Trubion Know-How or included in the Facet Know-How that (x) has been applied to the Manufacture of the applicable Collaboration Product prior to Facet ceasing to be the Lead Manufacturing Party, or (y) is [ * ] in the [ * ] applied to the Manufacture of the applicable Collaboration Product [ * ], as applicable, not already in the other Party’s possession in the form and format in which such Know-How is maintained by the Lead Manufacturing Party or its Third Party manufacturers in the ordinary course of business, and to (ii) at the other Party’s request, use Diligent Efforts to obtain an

assignment of any Third Party manufacturing agreement in each case as reasonably necessary to enable the other Party to Manufacture or have Manufactured Collaboration Product in accordance with the terms of this Agreement, provided, however, that the Lead Manufacturing Party shall be required to assign any such agreement solely to the extent assignment is permitted by such agreement, provided that the Lead Manufacturing Party uses Diligent Efforts to obtain any consent necessary for such assignment, and the Lead Manufacturing Party is not required to pay any consideration or commence litigation in order to effect an assignment of any such agreement to the other Party. In the event the Lead Manufacturing Party exercises or is deemed to have exercised its Opt-Out Option pursuant to Article 7, Section 8.5 or Section 14.2(b), then Sections 7.5(b)(iii) and 7.5(b)(x) shall apply.

(c) The Manufacturing Costs of commercial supplies of Collaboration Product as well as the duty, freight, postage, shipping, transportation, insurance, warehousing and handling charges actually allowed or paid with regard to such Collaboration Product shall be included in the calculation of cost of goods sold as part of Commercialization Costs.

6.6 Facility Audits. The JDC shall propose and submit to the JSC for approval a schedule for periodic audit and inspection of the facilities of any Third Party contract manufacturer on at least an annual basis subject to the terms of any applicable existing contract with a Third Party contract manufacturer. Pursuant to the schedule approved by the JSC, or upon request of the JDC, the Lead Manufacturing Party shall conduct an inspection or audit of the facilities of such Third Party contract manufacturers. The Lead Manufacturing Party shall provide not less than [ * ] notice to the other Party of any planned inspection and such other Party shall be permitted to participate in any audit, provided that, if the consent of the Third Party contract manufacturer is required under the applicable contract to allow such other Party to participate in such audit, the Lead Manufacturing Party shall use Diligent Efforts to obtain such consent. Any inspection or audit requested by the JDC (other than pursuant to the schedule approved by the JSC) shall be conducted no more frequently than [ * ] at a given facility, and shall occur as promptly as possible following written notice by the JDC of its desire for such inspection or audit, but in no event shall such inspection commence later than [ * ] thereafter (unless such audit is triggered by a material safety or GMP non-conformance issue, in which case the audit may be conducted as frequently as necessary and the maximum notice period shall be [ * ] if permitted under the applicable contract). Costs associated with auditing shall be Development Costs or Commercialization Costs as applicable.

6.7 Quality Agreement. The Parties shall negotiate in good faith and enter into a quality agreement governing the quality control, quality assurance and validation of the commercial and clinical supply of Bulk API and Product.

7. OPT-OUT.

7.1 General. Each Party shall have the right to opt-out of all of its rights and obligations to Co-Develop and Co-Commercialize any Collaboration Product pursuant to Sections 7.2 and 7.3 below (an “Opt-Out Option”). In addition, each Party may also exercise its Opt-Out Option pursuant to Section 8.5, and may be deemed to have exercised its Opt-Out Option pursuant to Section 14.2(b). The Opt-Out Party may exercise its Opt-Out Option pursuant

to Sections 7.2, 7.3 or 8.5 by providing a written notice (an “Opt-Out Notice”) to the Non-Opt-Out Party.

7.2 Opt-Out Option. Each Party may, on a Product-by-Product basis, exercise its Opt-Out Option with respect to any Collaboration Product by providing an Opt-Out Notice to the other Party during one of the following periods: (a) the period beginning with the [ * ] for such Collaboration Product and ending [ * ] later; (b) the period beginning with the [ * ] for such Collaboration Product and ending [ * ] later. In addition, Trubion may, on a Product-by-Product basis, exercise its Opt-Out Option with respect to any Collaboration Product by providing an Opt-Out Notice to Facet at any time after [ * ] after the [ * ] and prior to the [ * ] for such Collaboration Product. Each such Opt-Out Notice shall identify the Collaboration Product for which the Opt-Out Party is exercising the Opt-Out Option (the “Opt-Out Product”). If a Party is deemed to have exercised its Opt-Out Option pursuant to Section 14.2(b), all Collaboration Products shall be deemed Opt-Out Products and Royalty Products.

7.3 Opt-Out Option Following Change of Control. If either Party (the “Acquired Party”) experiences a Change of Control, it shall inform the other Party within [ * ] following the effectiveness of such Change of Control and it shall use Diligent Efforts to arrange for the acquiring entity to discuss with the other Party the acquiring entity’s (a) intentions with respect to the Development and Commercialization of the Collaboration Products and (b) contemplated proposals for amending the Development Plan and, if applicable, Commercialization Plan for each Collaboration Product, and the other Party may exercise its Opt-Out Option with respect to all Collaboration Products by providing an Opt-Out Notice to the Acquired Party or its successor in interest within [ * ] of such Change of Control and all Collaboration Products shall become Opt-Out Products on the Opt-Out Effective Date.

7.4 Opt-Out Effective Date. An Opt-Out Option shall become effective [ * ] after the Non-Opt-Out Party’s receipt of such Opt-Out Notice (the “Opt-Out Effective Date”). Notwithstanding the foregoing, if a Party, after uncured material breach, is deemed to have exercised its Opt-Out Option pursuant to Section 14.2(b), then both the date of the Opt-Out Notice and the Opt-Out Effective Date for such Opt-Out Option shall be deemed to be the date on which the other Party provides the notice under Section 14.2(b) to continue this Agreement and all Collaboration Products shall become Royalty Products on such date.

7.5 Consequences of Opt-Out.

(a) The Opt-Out Party’s obligations and rights to Co-Develop and Co-Commercialize a particular Opt-Out Product shall terminate upon the applicable Opt-Out Effective Date, and the Opt-Out Party shall have no liability for Development Costs or Commercialization Costs incurred by the Non-Opt-Out Party in respect of the Opt-Out Product(s) following the Opt-Out Effective Date, provided, however, that the Opt-Out Party shall remain liable for its share of (i) [ * ] for all [ * ] for the [ * ] that were [ * ] to the [ * ] to the extent that such [ * ] for such [ * ] by [ * ] the [ * ] therefor in the [ * ] that was [ * ] on the [ * ], (ii) all other [ * ] and all [ * ] with respect to the [ * ] the [ * ] in accordance and consistent with the [ * ] or [ * ], as applicable and [ * ], and (iii) all [ * ], including [ * ] and [ * ], [ * ] in connection with [ * ] and [ * ] under Section [ * ], to the extent related to [ * ], [ * ], [ * ] or [ * ] of the applicable [ * ] within the Field anywhere in the Territory [ * ] the [ * ] and [ * ] the [ * ]

for such activities for which [ * ] is [ * ] under Section [ * ] or Section [ * ] and to the extent provided in Section [ * ].

(b) The Non-Opt-Out Party may, in its sole discretion, elect to continue the Development and Commercialization of the Opt-Out Product by notice (the “Pursuit Notice”) to the Opt-Out Party. If the [ * ] does not [ * ] a [ * ] with respect to [ * ] within [ * ] following the [ * ] of the [ * ], the [ * ] shall not [ * ] to [ * ] the [ * ] and [ * ] of the [ * ] and the [ * ] to the [ * ] shall [ * ] with respect to that [ * ]. Notwithstanding the foregoing, if a Party is deemed to have exercised its Opt-Out Option pursuant to Section 14.2(b), then the Non-Opt-Out Party shall be deemed to have provided a Pursuit Notice to the Opt-Out-Party by providing a written notice of continuation of the Agreement pursuant to Section 14.2(b). If the Non-Opt-Out Party delivers a Pursuit Notice with respect to an Opt-Out Product [ * ] such [ * ] or is deemed to have delivered such Pursuit Notice, such Opt-Out Product shall become a Royalty Product, and:

(i) the Non-Opt-Out Party shall be solely responsible, at its sole cost and expense (except for those costs for which the Opt-Out Party remains responsible pursuant to Section 7.5(a)) for the Development of such Royalty Product, the preparation and filing of Regulatory Materials for such Royalty Product, the receipt of Regulatory Approval for such Royalty Product, and the Commercialization of such Royalty Product, in each case in the Field in the Territory. The Non-Opt-Out Party shall use Diligent Efforts to Develop and obtain Regulatory Approval for Royalty Products and to Commercialize such Royalty Products in the Field in the Major Market Countries;

(ii) the Non-Opt-Out Party will inform the Opt-Out Party of the status of the Non-Opt-Out Party’s Development and Commercialization of Royalty Products through [ * ] progress reports submitted in writing to the Opt-Out Party, provided that if the Opt-Out Party remains responsible for the costs of any [ * ] pursuant to Section 7.5(a), the Non-Opt-Out Party shall additionally provide [ * ] reports and invoices with respect to such [ * ];

(iii) the Opt-Out Party shall provide reasonable consultation and assistance during a period of [ * ] following the Opt-Out Party’s receipt of the Pursuit Notice or written notice of continuation of the Agreement pursuant to Section 14.2(b), (“Transition Assistance”) for the purpose of transferring or transitioning to the Non-Opt-Out Party, (i) all Facet Applied Know-How or Trubion Know-How, as applicable, which is reasonably necessary for the continued Development, Manufacture or Commercialization of the Royalty Product not already in the Non-Opt-Out Party’s possession in the form and format in which such Know-How is maintained by the Opt-Out Party or its Affiliate or subcontractor in the ordinary course of business, and (ii) at the Non-Opt-Out Party’s request, the Opt-Out Party shall use Diligent Efforts to assign to the Non-Opt-Out Party all then-existing Third Party agreements that relate solely to the Royalty Product, in the Territory, in the Field and are reasonably necessary for the Non-Opt-Out Party to continue researching, Developing, Manufacturing, or Commercializing such Royalty Product in the Territory, in the Field; provided, however, that the Opt-Out Party shall be required to assign any such agreement solely to the extent assignment is permitted by such agreement provided that the Opt-Out Party uses Diligent Efforts to obtain any consent necessary for such assignment, and the Opt-Out Party is not required to pay any consideration or commence litigation in order to effect an assignment of any such agreement to the Non-Opt-Out Party;

(iv) the Opt-Out Party shall transfer and assign to the Non-Opt-Out Party, in the form and format in which such materials are maintained by the Opt-Out-Party in the ordinary course of business, all Regulatory Materials for such Royalty Product, in the Territory, in the Field, that are Controlled by the Opt-Out-Party or its Affiliates or permitted sublicensees; the Non-Opt-Out Party shall have the right, without any additional consideration, to use any and all such data and reports supplied by the Lead Regulatory Party under this Section 7.5(b)(iv) or pursuant to Section 4.1 in connection with the Development, Manufacture and/or Commercialization of such Royalty Product in the Field, in the Territory in accordance with the terms of this Agreement, including the incorporation of such data or reports in any regulatory submissions; and the Opt-Out Party’s rights to participate in regulatory activities and meetings shall terminate;

(v) all Committees except the JPC shall cease to have any rights, obligations or decision-making capabilities with respect to such Royalty Product and, if there are no Collaboration Products still being pursued at such time, shall disband until such time, if ever, that a Collaboration Product is being pursued. All decisions that were made by such Committees under this Agreement with respect to the Royalty Product prior to the Opt-Out Effective Date shall thereafter be made solely by the Non-Opt-Out Party consistent with such Party’s obligations under Section 7.5(b)(i). The JPC shall continue subject to Section 10.3 unless a Party has exercised or is deemed to have exercised its Opt-Out Option in respect of all Collaboration Products, in which case all decisions that were made by the JPC prior to the Opt-Out Effective Date shall be made solely by the Non-Opt-Out Party consistent with such Party’s obligations under Section 7.5(b)(i);

(vi) if the Opt-Out Party is the Lead Manufacturing Party of the Royalty Product(s), as part of and during the period of the Transition Assistance (1) the Non-Opt-Out Party shall have the right to require the Opt-Out Party to continue supplying Bulk API and finished Product for such Royalty Product(s) under the terms of Article 6 for a period of up to eighteen (18) months (provided that the Non-Opt-Out Party shall use Diligent Efforts to find one or more alternative suppliers for Bulk API and finished Product as soon as reasonably possible following the exercise of the Opt-Out Option), and (2) the Non-Opt-Out Party shall have the right to obtain transfer, and the Opt-Out-Party shall have the obligation to effect transfer, without undue delay, of any and all manufacturing technology included in the Facet Applied Know-How or Trubion Know-How, as applicable, that is reasonably necessary to enable the Non-Opt-Out Party to Manufacture, or have Manufactured such Royalty Product(s). The Non-Opt-Out Party automatically owns one-half (1/2) of any or all of the inventory in existence as of the Opt-Out Effective Date of Bulk API and/or finished Product for such Royalty Product (such inventory, the “Existing Inventory”). In addition, the Non-Opt-Out Party shall have the right to purchase the other half of the Existing Inventory from the Opt-Out Party by reimbursing the Opt-Out Party for the Manufacturing Costs with respect to such Existing Inventory. The Non-Opt-Out Party shall notify the Opt-Out Party within [ * ] after the Effective Opt-Out Date whether the Non-Opt-Out Party elects to exercise such right to purchase the other half of the Existing Inventory;

(vii) the Opt-Out Party shall, as promptly as commercially practicable, assign to the Non-Opt-Out Party all right, title and interest in and to the Marks owned by the Opt-Out Party that were used or intended to be used with the Royalty Products (excluding any

such Marks that include, in whole or part, any corporate name or logo of the Opt-Out Party or its Affiliates or permitted sublicensees), including any goodwill associated therewith. For the avoidance of doubt, only those Marks that have been (A) identified as the single designated lead candidate Mark for a non-commercialized Royalty Product, or (B) actually used in connection with a Commercialized Royalty Product, shall be assigned. The Non-Opt-Out Party shall be responsible for recording such assignment in the Territory with the appropriate Governmental Authority and will bear all costs associated with such assignment and recordation. The Opt-Out Party shall cooperate in facilitating such assignment and recordation by timely executing all necessary documents provided to it by the Non-Opt-Out Party;

(viii) in lieu of the Product Profit payments it would have received if the Opt-Out Party had not exercised its Opt-Out Option or the Opt-Out Party had not been deemed to have exercised its Opt-Out Option under Section 14.2(b) with respect to such Royalty Product, the Opt-Out Party shall receive from the Non-Opt-Out Party royalties on the Net Sales of the Royalty Product(s) as provided for under Section 9.5;

(ix) the Opt-Out Party shall use Diligent Efforts to effect the assignment or the granting of a sublicense or equivalent right of access to the Non-Opt-Out Party, whether through novation or sublicensing of such contracts or otherwise, of any and all rights under any contract between the Opt-Out Party and any Third Party that are reasonably necessary for the Non-Opt-Out Party to continue with Development or Commercialization of such Royalty Product, and the Non-Opt-Out Party shall reasonably cooperate in connection therewith, provided that if such assignment, novation or sublicense is not permissible, the Parties shall discuss in good faith potential alternatives that would enable the Non-Opt-Out Party to exercise at the Non-Opt-Out Party’s expense (on a pass-through basis) the rights and perform the obligations of the Opt-Out Party under such contracts with respect to such Royalty Product while minimizing the continuing obligations of the Opt-Out Party under such contract with respect to such Royalty Product, and, unless the Non-Opt-Out Party informs the Opt-Out Party in writing that it is [ * ] in [ * ] such [ * ] and [ * ] such [ * ] or it is [ * ] for the [ * ] to [ * ], the Opt-Out Party shall [ * ] such [ * ] in [ * ] for the [ * ] of such [ * ] to [ * ] the [ * ] to [ * ] with [ * ] or [ * ] of such [ * ]; and

(x)

a. in the event of an Opt-Out pursuant to Section 7.2 or Section 8.5, the Non-Opt-Out Party shall reimburse the Opt-Out Party for [ * ] of the reasonable expenses incurred by the Opt-Out Party in the course of performing its transfer obligations pursuant to Sections 7.5(b)(iii), 7.5(b)(iv), 7.5(vi)(2) and 7.5(vii), provided that any request for reimbursement of such expenses is accompanied by invoices, and/or such other appropriate supporting documentation evidencing in reasonable detail the expenses for which reimbursement is allowed under this Section 7.5(b)(x); and

b. in the event of an Opt-Out pursuant to Section 7.3, the Non-Opt-Out Party shall reimburse the Opt-Out Party for [ * ] of the reasonable expenses incurred by the Opt-Out Party in the course of performing its transfer obligations pursuant to Sections 7.5(b)(iii), 7.5(b)(iv), 7.5(vi)(2) and 7.5(vii), provided that any request for reimbursement of such expenses is accompanied by invoices, and/or such other appropriate

supporting documentation evidencing in reasonable detail the expenses for which reimbursement is allowed under this Section 7.5(b)(x).

8. LICENSES.

8.1 License to Facet. Subject to the terms and conditions of this Agreement, Trubion, effective as of the Signing Date, hereby grants to Facet an exclusive license (exclusive even as to Trubion, except to the extent necessary for Trubion to perform its obligations and exercise its rights under this Agreement), with the right to grant sublicenses in accordance with the provisions of Section 8.3, under the Trubion Patent Rights and Trubion Know-How, to research Develop, use, make, Manufacture, import, export distribute, market, offer for sale, sell and Commercialize Products, in the Field, in the Territory in accordance with the terms of this Agreement. Notwithstanding the foregoing, the rights granted to Facet under this Section 8.1 shall terminate with respect to an Opt-Out Product effective (a) as of the Opt-Out Effective Date for such Product if Facet exercises or is deemed to have exercised its Opt-Out Option, and (b) [ * ] after the [ * ] for such [ * ] if [ * ] its [ * ] pursuant to Section [ * ] or [ * ] and [ * ] has [ * ] a [ * ] for such [ * ]. For clarity, the rights granted to Facet under this Section 8.1 shall remain in full force and effect if Trubion is deemed to have exercised its Opt-Out Option pursuant to Section 14.2(b).

8.2 Licenses to Trubion.

(a) Subject to the terms and conditions of this Agreement, Facet, effective as of the Signing Date, hereby grants to Trubion a license, with the right to grant sublicenses in accordance with the provisions of Section 8.3, under the Facet Patent Rights and the Facet Know-How, which license shall be non-exclusive, except with respect to Facet’s interest in Joint Patent Rights for which such license shall be co-exclusive, solely for the purpose of, and limited to, Trubion’s exercise of its rights and performance of its obligations under this Agreement, to Develop, use, make, Manufacture, import, export, distribute, market, offer for sale, sell and Commercialize Collaboration Products, in the Field, in the Territory in accordance with the terms of this Agreement.

(b) Subject to the terms and conditions of this Agreement, Facet, effective as of the date of the delivery or deemed delivery of Trubion’s Pursuit Notice with respect to an Opt-Out Product, hereby grants to Trubion an exclusive, royalty-bearing license, with the right to grant sublicenses in accordance with the provisions of Section 8.3, under the Facet Applied Technology, to Develop, use, make, Manufacture, import, export, distribute, market, offer for sale, sell and Commercialize such Royalty Product, in the Field, in the Territory in accordance with the terms of this Agreement.

8.3 Sublicensing.

(a) No Sublicensing. Except as set forth in Sections 8.3(b) and 8.3(c), neither Party shall sublicense any of the rights granted to it under this Agreement to any Third Party without the prior written consent of the other Party, provided that either Party may sublicense such rights: (i) to its Affiliates, further provided that any such sublicense to an Affiliate shall immediately terminate if and when such entity ceases to be an Affiliate of such Party, and (ii)

subject to Sections 3.5(a) and 3.5(b), to subcontractors or consultants to perform such Party’s assigned Development, Manufacturing or Commercialization responsibilities under this Agreement with respect to Collaboration Products, further provided that (A) such Party remains responsible for the work allocated to, and payment to, such subcontractors and consultants to the same extent it would if it were doing such work itself, (B) such sublicense shall be subject and subordinate to, and consistent with, the terms and conditions of this Agreement, (C) such sublicense shall not in any way diminish, reduce or eliminate any of such Party’s obligations under this Agreement, and (D) such Party uses Diligent Efforts to include in such sublicense agreement a provision which permits such Party to provide a copy of such sublicense agreement to the other Party, which copy may be redacted to exclude confidential information not related to the applicable Collaboration Product. Unless prohibited by the terms of the sublicense, such Party shall provide the other Party with a copy of each such sublicense agreement entered into after the Signing Date within [ * ] after the execution thereof, which agreement may be redacted to exclude confidential information not related to the applicable Collaboration Product.

(b) Joint Sublicense. The Parties acknowledge that they may, upon mutual agreement, both grant sublicenses to a Third Party with respect to a particular Collaboration Product, including with respect to a particular country or indication.

(c) Upon Opt-Out. At any time after its delivery or deemed delivery of a Pursuit Notice with respect to a particular Royalty Product, the Non-Opt-Out Party may grant to one or more Third Parties sublicenses of some or all of the rights granted to it under Section 8.1 or 8.2(b), as applicable, but only with respect to such Royalty Product; provided that the Non-Opt-Out Party shall execute a written agreement with each such permitted sublicensee, which sublicense (i) shall be subject and subordinate to, and consistent with, the terms and conditions of this Agreement, (ii) shall not in any way diminish, reduce or eliminate any of the Non-Opt-Out Party’s obligations under this Agreement, (iii) shall require each such permitted sublicensee to comply with all applicable terms of this Agreement, including to keep books and records, and (iv) shall permit the Non-Opt-Out Party to audit (either directly or through an independent auditor) such books and records. The Non-Opt-Out Party shall provide the Opt-Out Party with a copy of each such sublicense agreement within [ * ] after the execution thereof. Such copy may be redacted to exclude confidential, non-Royalty Product-related information and financial information (other than such financial information that is necessary for assessing the obligations to the Opt-Out Party under this Agreement). Upon the Opt-Out Party’s request and at the Opt-Out Party’s expense, the Non-Opt-Out Party shall exercise its right to conduct an audit of a sublicensee’s books and records pertaining to the sale of the applicable Royalty Product under any such sublicense agreement at the next time that conducting such an audit is permissible under such sublicense agreement. The Non-Opt-Out Party shall provide the Opt-Out Party with a copy of the report of the findings made in any such audit. If such audit reveals that such sublicensee has understated its Net Sales by [ * ] or more, the Non-Opt-Out Party shall be responsible for the reasonable out-of-pocket costs of the Opt-Out Party in conducting the audit. The Non-Opt-Out Party shall remain responsible for its obligations hereunder and for the performance of its sublicensees (including, without limitation, making all payments due to the Opt-Out Party by reason of any Net Sales of Royalty Product), and shall ensure that any such sublicensees comply with all relevant provisions of this Agreement. In the event of any uncured material breach by any sublicensee under a sublicense agreement that would constitute a material breach of the Non-Opt-Out Party’s obligations under this Agreement, the Non-Opt-Out Party

will promptly inform the Opt-Out Party in writing and shall take such action which in the Non-Opt-Out Party’s reasonable business judgment will address such default; provided, however, any such uncured material breach by such sublicensee of an obligation that would constitute a material breach of the Non-Opt-Out Party’s obligations under this Agreement shall be deemed an uncured material breach of the Non-Opt-Out Party hereunder unless the Non-Opt-Out Party cures such material breach within the time provided under Section 14.2.

8.4 No Implied Rights. Except as expressly provided in this Agreement, neither Party shall be deemed by estoppel or implication to have granted the other Party any license or other right with respect to any intellectual property of such Party.

8.5 Exclusivity. Except for the Development and Commercialization of Products pursuant to the terms of this Agreement, during the Term neither Party shall Develop or Commercialize any protein therapeutic, including any [ * ], that binds to the CD37 Antigen (or a [ * ]) [ * ] of [ * ] and wherein such protein therapeutic is [ * ] or [ * ] to [ * ] its [ * ] through [ * ] the [ * ] (or a [ * ]) (a “Competing Program”). In the event that, due to a Change of Control of a Party, such Party, or its successor in interest, is conducting a Competing Program during the Term of this Agreement, then such Party, or its successor in interest, shall either (a) exercise its Opt-Out Option with respect to all Collaboration Products by providing an Opt-Out Notice to the other Party; or (b) divest such Competing Program to a Third Party, in each case within [ * ] of such Change of Control.

8.6 [ * ]. Each Party shall promptly bring to the attention of the JSC (or the other Party if there is no JSC in place at the time) any [ * ] that such Party wishes to Develop and Commercialize during the Term. Upon the recommendation of the JSC (or the mutual agreement of the Parties if there is no JSC in place at the time), the Parties shall negotiate in good faith an agreement to Develop and Commercialize such [ * ] on commercially reasonable terms.

8.7 Third Party Licenses. If the JPC determines that it is advisable or necessary to obtain a license (“Future Third Party License”) to any intellectual property right that is owned or controlled by a Third Party and is reasonably necessary or useful to the Development, Manufacture, or Commercialization of a Collaboration Product, the JPC shall so advise the JSC. If the JSC determines to seek a license, the JSC shall designate a Party to negotiate the terms on which such a Third Party license would be granted and to serve as the primary point of contact with the applicable Third Party licensor following the execution of the license agreement. Upon approval of the terms of such Future Third Party License by the JSC, the designated Party may execute such Future Third Party License and any payments that become due pursuant to a Future Third Party License agreement executed pursuant to this Section 8.7 will be treated as Development Costs or Commercialization Costs, as applicable, if incurred prior to the Opt-Out Effective Date or after the Opt-Out Effective Date but with respect to a Collaboration Product. If a Party delivers or is deemed to have delivered a Pursuit Notice for a Collaboration Product, any payments arising under a Future Third Party License from the Development, Manufacturing or Commercialization of the applicable Royalty Product shall be paid by such Non-Opt-Out Party, subject to Section 9.5(e)(iii).

9. CONSIDERATION.

9.1 Upfront Payment. Facet shall pay to Trubion Twenty Million Dollars ($20,000,000.00) within ten (10) days after the Signing Date, which payment shall be non-refundable and non-creditable.

9.2 Equity Investment. Facet and Trubion have entered into the Stock Purchase Agreement attached hereto as Exhibit C, pursuant to which Facet will purchase from Trubion and Trubion will sell to Facet Ten Million Dollars ($10,000,000.00) of newly issued shares of common stock of Trubion at a purchase price per share equal to One Hundred Thirty-Five Percent (135%) of the average closing price of a share of common stock of Trubion over the sixty (60) trading days prior to the Signing Date provided that such purchase price (including the 35% premium) shall not be greater than $[ * ]/share or lower than $[ * ]/share of common stock of Trubion.

9.3 Development Milestone Payments. Facet shall make milestone payments (each a “Milestone Payment”) to Trubion based on the first achievement of each milestone event in the Field, in the Territory for each Product as set forth in this Section 9.3. No Milestone Payment shall be made twice with respect to the same Product. For the purposes of this Section 9.3, two Products are deemed the “same Product” if one Product contains, as its active pharmaceutical ingredient, (i) the same [ * ] or [ * ] that is [ * ] in the [ * ], (ii) a [ * ] that is a [ * ] or [ * ] form of the [ * ] or [ * ] that is [ * ] in the [ * ] or (iii) a [ * ] that is a [ * ] or [ * ] form of a [ * ] or [ * ] from which the [ * ] in the [ * ] was [ * ] or [ * ]. Facet shall pay to Trubion the amounts set forth below, within [ * ] after the first achievement of the corresponding milestone event with respect to the Product. Each Milestone Payment is non-refundable and non-creditable against any other payments due hereunder, provided that if the Development of a Product is abandoned, any Milestone Payments made with respect to such abandoned Product may be credited against the corresponding Milestone Payments payable on a Product which achieves such milestones after the abandonment of the other Product. For the purposes of this Section 9.3, the “[ * ]” of a Clinical Trial shall occur upon the [ * ] of the [ * ] in such [ * ], “[ * ]” and “[ * ]” shall be [ * ] by the [ * ] in advance with respect to such [ * ] in the [ * ] or, following [ * ] for the applicable [ * ], [ * ] by the [ * ] in advance with respect to such [ * ] in [ * ] for the [ * ]. Notwithstanding anything to the contrary in this Agreement, if Trubion is deemed pursuant to Section 14.2(b) to have exercised its Opt-Out Option with respect to all Products on account of an uncured material breach by Trubion, the amount of the milestone payments due pursuant to this Section 9.3 with respect to milestone events achieved by all Products after Facet has provided Trubion with written notice of continuation in accordance with Section 14.2(b) shall be reduced by [ * ].

Milestone Event	Milestone Payment
[ * ] of the [ * ] (includes [ * ])	$	[ * ]

[ * ] of the [ * ] in [ * ] (includes [ * ])	$	[ * ]

[ * ] of the [ * ] in [ * ] (includes [ * ])	$	[ * ]

[ * ] of [ * ] by [ * ] in [ * ]	$	[ * ]

[ * ] of [ * ] by [ * ] in [ * ]	$	[ * ]

[ * ] of [ * ] by [ * ] in [ * ]	$	[ * ]
[ * ] of [ * ] by [ * ] in [ * ]	$	[ * ]

[ * ] of [ * ] by [ * ] in [ * ]	$	[ * ]
[ * ] of [ * ] by [ * ] in [ * ]	$	[ * ]

[ * ] of the [ * ] for the [ * ]	$	[ * ]

[ * ] of the [ * ] for the [ * ]	$	[ * ]

[ * ] or [ * ] of the [ * ] in the [ * ] for the [ * ]	$	[ * ]

[ * ] or [ * ] of the [ * ] in the [ * ] for the [ * ]	$	[ * ]
[ * ] of the [ * ] in [ * ] for the [ * ]	$	[ * ]
[ * ]	$	[ * ]

9.4 Sharing of Product Profit.

(a) Allocation. Facet and Trubion shall share equally in Product Profit (which, for the avoidance of doubt, includes sharing of losses in a given period if the calculation of Product Profit for such period is negative) arising from the sale of each Collaboration Product in the Field in the Territory.

(b) FTE Records and Calculations. Each Party shall record its FTE effort for the Commercialization of each Collaboration Product to the extent that such FTE efforts are included in Commercialization Costs that are, or may in the future be, shared under this Agreement, and shall report such FTE effort to the JCC, on a Calendar Quarterly basis, in each case in a manner that allocates such FTE effort to the extent practicable to each applicable Collaboration Product. Except to the extent provided herein, each Party shall calculate and maintain records of FTE effort incurred by it in the same manner as used for other products commercialized by such Party in accordance with a methodology approved by the JSC. The JFC shall facilitate any reporting hereunder.

(c) Commercialization Costs Accounts. Each Party shall charge all Commercialization Costs as incurred by it or its Affiliates on its books and records in connection with each Commercialization Plan. Each Party shall provide the other Party with an interim quarterly report of monthly estimates for the current Calendar Quarter charges within [ * ] after the end of the second calendar month in each Calendar Quarter.

(d) Other Expenses. Any expenses incurred by a Party for Commercialization activities that do not fall within the definitions of Commercialization Costs shall be borne solely by such Party unless the JSC determines otherwise. In addition, each Party shall bear all costs incurred pursuant to the Commercialization Plan, that exceed the portion of the Commercialization Budget allocated to the Party with respect to the relevant Calendar Quarter by more than [ * ] unless otherwise approved by the JSC.

(e) Pre-existing Obligations. Unless otherwise determined by the JSC, any manufacturing obligations in existence prior to the Signing Date, such as manufacturing capacity reservation or other obligations described in Section 6.3, other than those disclosed in writing by the obligated Party prior to the Signing Date and specifically agreed upon by the Parties, will not be considered Commercialization Costs and will not be subject to expense sharing.

(f) Reporting. Within [ * ] after the end of each Calendar Quarter, commencing with the first Calendar Quarter in which the Parties are implementing a Commercialization Plan for a particular Collaboration Product, each Party shall report to the JCC and the JFC its gross sales and Commercialization Costs for such Collaboration Product in the Territory. In addition, each Party shall provide the JCC and the JFC with a monthly statement on a Product-by-Product and country-by-country basis of the amount of gross sales of Collaboration Products.

(g) Payment. Within [ * ] after receipt of such reports, the JFC shall provide for such Collaboration Product a consolidated financial statement setting forth the Product Profit for such Collaboration Product and calculating each Party’s fifty percent (50%) share of such Product Profit. Thereafter the following remittance obligations shall apply for such Collaboration Product depending on whether such Product Profit is positive or negative:

(i) If there is positive Product Profit for such Calendar Quarter, then one Party shall make a payment to the other Party within [ * ] following delivery of the financial statement referenced above in an amount that will cause each Party to have received an equal share of the Product Profit for such Calendar Quarter.

(ii) If there is negative Product Profit for such Calendar Quarter, then one Party shall make a payment to the other Party so that each Party will bear an equal share of the Product Profit for such Calendar Quarter. Such payment shall be made within [ * ] following delivery of the financial statement referenced above.

(h) Records. Each Party shall keep detailed records of the Commercialization Costs it incurs, including all supporting documentation for such expenses, and remits for payment. Each Party shall keep such records for at least [ * ] after the date that such expense was incurred.

9.5 Royalties.

(a) Base Royalties.

(i) Trubion Royalties. Subject to Section 9.5(e), if Trubion has exercised its Opt-Out Option pursuant to Section 7.2, Facet shall pay Trubion royalties on the Net Sales of Royalty Products during the applicable Royalty Period as follows:

Date of Trubion Opt-Out Notice:	Royalty Rate:

At any time after [ * ] from the [ * ] and before the [ * ] for the [ * ]	[ * ]	%

Within [ * ] after the [ * ] for [ * ]	[ * ]	%

Within [ * ] after the [ * ] for [ * ]	[ * ]	%

(ii) Facet Royalties. Subject to Section 9.5(e) if Facet has exercised its Opt-Out Option pursuant to Section 7.2 Trubion shall pay Facet royalties on the Net Sales of Royalty Products during the applicable Royalty Period as follows:

Date of Facet Opt-Out Notice:	Royalty Rate:

Within [ * ] after the [ * ] for the [ * ]	[ * ]	%

Within [ * ] after the [ * ] for [ * ]	[ * ]	%

(b) Royalties after Opt-Out due to Competing Program. Subject to Section 9.5(e), if the Opt-Out Party exercised its Opt-Out Option pursuant to Section 8.5 (i.e., due to a Competing Program following a Change of Control of the Opt-Out Party), the Non-Opt-Out Party shall pay the Opt-Out Party royalties on the Net Sales of Royalty Products during the applicable Royalty Period, as follows:

Date of Opt-Out Notice:	Royalty Rate:

Before the [ * ] of the [ * ]	[ * ]	%

After the [ * ] of [ * ]	[ * ]	%

(c) Royalties after Opt-Out Following Change of Control. Subject to Section 9.5(e), if the Opt-Out Party exercised its Opt-Out Option pursuant to Section 7.3 following a Change of Control of the Non-Opt-Out Party, the Non-Opt-Out Party (or its successor in interest) shall pay the Opt-Out Party royalties on the Net Sales of Royalty Products during the applicable Royalty Period, as follows:

Date of Opt-Out Notice:	Royalty Rate:

Before the [ * ] of the [ * ] for the [ * ]	[ * ]	%

After [ * ] of the [ * ] for the [ * ] and before the [ * ] for [ * ]	[ * ]	%

After the [ * ] for [ * ] and before the [ * ] for [ * ]	[ * ]	%

After the [ * ] for [ * ] and before the [ * ] of [ * ]	[ * ]	%

After the [ * ] of [ * ]	[ * ]	%

(d) Royalties after Opt-Out Following Uncured Breach.

(i) Trubion Royalties. Subject to Section 9.5(e), if Trubion is deemed pursuant to Section 14.2(b) to have exercised its Opt-Out Option with respect to all Products on account of an uncured material breach by Trubion, Facet shall pay Trubion royalties on the Net Sales of Royalty Products during the applicable Royalty Period, as follows:

Date of Trubion Deemed Opt-Out:	Royalty Rate:

Before the [ * ] of the [ * ] for the [ * ]	[ * ]	%

After [ * ] of the [ * ] for the [ * ] and before the [ * ] for [ * ]	[ * ]	%

After the [ * ] for [ * ] and before the [ * ] for [ * ]	[ * ]	%

After the [ * ] for [ * ] and before the [ * ] of [ * ]	[ * ]	%

After the [ * ] of [ * ]	[ * ]	%

(ii) Facet Royalties. Subject to Section 9.5(e), if Facet is deemed pursuant to Section 14.2(b) to have exercised its Opt-Out Option with respect to all Products on account of an uncured material breach by Facet, Trubion shall pay Facet royalties on the Net Sales of Royalty Products during the applicable Royalty Period, as follows:

Date of Facet Deemed Opt-Out:	Royalty Rate:

Before the [ * ] of the [ * ] for the [ * ]	[ * ]	%

After [ ] of the [ ] for the [ ] and before the [ ] for [ *]	[*]	%

After the [ ] for [ ] and before the [ ] for [ ]	[*]	%

After the [ ] for [ ] and before the [ ] of [ ]	[*]	%

After the [ ] of [ ]	[*]	%

(e) Reduced Royalty Rate.

(i) If a Royalty Product is generating Net Sales in a country during the applicable Royalty Period at a time when there is no Valid Claim covering such Royalty Product in such country of sale within the Trubion Patent Rights or the Facet Applied Patent Rights, then the royalty rate applicable to Net Sales of such Royalty Product in such country shall be reduced by [ * ] percent ([ * ]%) of the applicable royalty rate set forth in Section 9.5(a)-(d).

(ii) If a Royalty Product is generating Net Sales in a country during the applicable Royalty Period at a time when a competing product is being actively marketed and sold in such country, then the royalty rate applicable to Net Sales of such Royalty Product in such country shall be reduced by [ * ] percent ([ * ]%) of the applicable royalty rate set forth in Section 9.5(a)-(d). For purposes of this Section 9.5(e)(ii), “competing product” shall mean a third party protein therapeutic that (a) [ * ] the [ * ] (or a [ * ]) [ * ] of [ * ] and wherein such protein therapeutic is [ * ] or [ * ] or [ * ] to [ * ] through [ * ] the [ * ] (or a [ * ]), and (b) is [ * ] for the [ * ] the [ * ].

(iii) The Non-Opt-Out Party may, subject to Section 9.5(e)(iv), deduct from the royalties it would otherwise owe to the Opt-Out Party pursuant to this Section 9.5 for Third Party licenses entered into after the Signing Date, including Future Third Party Licenses, an amount equal to [ * ] percent ([ * ]%) of the amounts paid to Third Parties in consideration for intellectual property rights that the Non-Opt-Out Party reasonably believes are necessary in connection with the Development, Manufacture or Commercialization of a Royalty Product in the Field in the Territory.

(iv) During the Royalty Period, the operation of Sections [ * ] and [ * ] individually or in combination shall not reduce by more than [ * ] percent ([ * ]%) the royalties that would otherwise have been due under in Section 9.5(a)-(d).

(f) Expiration of Royalty Period. After the expiration of the Royalty Period for any Royalty Product in any country in the Territory, no further royalties shall be payable in respect of sales of such Royalty Product in such country and thereafter the licenses granted to the Non-Opt-Out Party under Section 8.1 or 8.2, as applicable, with respect to such Royalty Product in such country shall be fully paid-up, perpetual, irrevocable, royalty-free, non-exclusive licenses.

(g) Cumulative Royalties. The obligation to pay royalties under Section 9.5 shall be imposed only once with respect to a single unit of a Royalty Product, regardless of how many Valid Claims included within the Trubion Patent Rights, or Facet Applied Patent Rights would, but for this Agreement, be infringed by the Manufacture, use, import, offer for sale or sale of such Royalty Product in the countr(y)ies in the Territory of such Manufacture, use or sale.

(h) Royalty Product Reports and Payments. During the Royalty Period, within [ * ] after the end of each Calendar Quarter, the Non-Opt-Out Party shall deliver to the Opt-Out Party a report setting forth for such Calendar Quarter the following information, on a Royalty Product-by-Royalty Product and country-by-country basis: (a) the gross sales amount (by the Non-Opt-Out Party, its Affiliates and permitted sublicensees) for each Royalty Product sold in the Field in the Territory, on a country-by-country basis; (b) the Net Sales for each Royalty Product; and (c) the royalty amount due hereunder for the sale of each Royalty Product. No such reports shall be due for any Royalty Product before the First Commercial Sale of such Royalty Product in the Territory. The total royalty due for the sale of Royalty Products during such Calendar Quarter shall be remitted at the time such report is made.

9.6 Taxes and Withholding. All payments due from one Party to another under this Agreement will be made without any deduction or withholding for or on account of any tax unless such deduction or withholding is required by applicable Laws to be assessed against the receiving Party. If the paying Party is so required to deduct or withhold, the paying Party will (a) promptly notify the receiving Party of such requirement, (b) pay to the relevant authorities the full amount required to be deducted or withheld promptly upon the earlier of determining that such deduction or withholding is required or receiving notice that such amount has been assessed against the receiving Party, (c) promptly forward to the receiving Party an official receipt (or certified copy) or other documentation reasonably acceptable to the receiving Party evidencing such payment to such authorities, and (d) otherwise reasonably cooperate with the receiving Party in connection with the receiving Party’s attempts to obtain favorable tax treatment and credit therefor (where appropriate) in accordance with applicable Laws.

9.7 Currency. All amounts payable and calculations hereunder shall be in Dollars. Conversion of sales recorded in local currencies to Dollars will be performed in a manner consistent with a Party’s normal practices used to prepare its financial statements and consistent with GAAP, provided that such practices use a widely accepted source of published exchange rates (and are approved by the JCC as applicable).

9.8 Interest on Past Due Payments. If either Party fails to pay any payment due under this Agreement on or before the date such payment is due, as provided in this Agreement, such late payment shall bear interest, to the extent permitted by applicable Law, at the [ * ] as [ * ] from time to time [ * ], effective for the first date on which payment was delinquent and calculated on the number of days such payment is overdue or, if such rate is [ * ], as [ * ] as the Parties agree.

9.9 Maintenance of Records; Audits; Consolidation.

(a) Record Keeping. Each Party shall keep accurate books and accounts of record in accordance with GAAP in connection with the Development, Manufacture and

Commercialization of Products, and the calculation of payments to be made under this Agreement in sufficient detail to permit accurate determination of all amounts necessary for verification of royalties and other payments to be paid from one Party to another under this Agreement. Each Party shall maintain such records for a period of at least [ * ] after the end of the Calendar Year in which they were generated.

(b) Audits. Upon thirty (30) days prior written notice, a Party (the “Auditing Party”) may conduct and the other Party (the “Audited Party”) shall permit an independent certified public accounting firm of nationally recognized standing selected by the Auditing Party and reasonably acceptable to the Audited Party, to examine, at the Auditing Party’s sole expense, the relevant books and records of the Audited Party as may be reasonably necessary to verify the accuracy of (a) reports for Development Costs, (b) Manufacturing Costs, (c) Commercialization Costs and (d) the reports submitted by the Audited Party in accordance with this Agreement in connection with the payment of royalties and other amounts hereunder. An examination by the Auditing Party under this Section 9.9(b) shall occur not more than once in any Calendar Year and shall be limited to the pertinent books and records for any Calendar Year ending not more than [ * ] before the date of the request. The accounting firm shall be provided access to such books and records at the Audited Party’s facility(ies) where such books and records are normally kept and such examination shall be conducted during the Audited Party’s normal business hours. The Audited Party may require the accounting firm to sign a standard non-disclosure agreement before providing the accounting firm access to the Audited Party’s facilities or records. Upon completion of the audit, the accounting firm shall provide both the Audited Party and the Auditing Party a written report disclosing whether the reports submitted by the Audited Party are correct or incorrect, whether the amounts paid are correct or incorrect, and in each case, the specific details concerning any discrepancies. No other information shall be provided to the Auditing Party.

(c) Underpayments/Overpayments. If such accounting firm concludes that additional royalties or other payments were due to the Auditing Party, the Audited Party shall pay to the Auditing Party the additional amounts within [ * ] of the date the Audited Party receives such accountant’s written report so concluding. If an underpayment exceeds [ * ] percent ([ * ]%) of the amounts that were to be paid to the Auditing Party, the Audited Party also shall reimburse the Auditing Party for all costs and reasonable out-of-pocket expenses incurred in conducting the audit. If such accounting firm concludes that the Audited Party overpaid the Auditing Party, the Auditing Party, within [ * ] of the date the Auditing Party receives such account’s report so concluding, will refund such overpayments to the Audited Party less the reasonable out-of-pocket costs incurred by the Auditing Party in conducting the audit.

(d) Confidentiality. All financial information of the Audited Party with respect to a Royalty Product which is subject to review under this Section 9.9 shall be deemed to be the Audited Party’s Confidential Information subject to the provisions of Article 11, and the Auditing Party shall not disclose such Confidential Information to any Third Party or use such Confidential Information for any purpose other than verifying payments to be made by the Audited Party with respect to such Royalty Product; provided, however, that such Confidential Information may be disclosed by the Auditing Party to Third Parties only to the extent necessary to enforce the Auditing Party’s rights under this Agreement. All financial information of the Audited Party with respect to a Collaboration Product which is subject to review under this

Section 9.9 shall be deemed to be the Confidential Information of both Parties subject to the provisions of Article

(e) Consolidation. In the event that a Party is, in the opinion of its independent registered accounting firm, reasonably required to consolidate or otherwise report in the financial statements of such Party (the “Consolidating Party”), all or a portion of the financial performance of the other Party (the “Consolidated Party”) for any financial reporting periods, then the Consolidating Party shall promptly notify the Consolidated Party of such determination in writing, and the Consolidated Party agrees to cooperate and promptly provide reasonable access to its books and records in order for the Consolidating Party to fulfill its financial reporting obligations.

10. INTELLECTUAL PROPERTY.

10.1 Ownership of Collaboration Inventions.

(a) The JPC shall, within a reasonable time after the Signing Date, establish and oversee a mutually agreeable procedure for (i) identifying and disclosing all inventions and Know-How generated by one or both Parties, their Affiliates or their respective employees, agents, or independent contractors in the course of conducting activities under this Agreement (“Collaboration Inventions”); and (ii) determining inventorship of each such Collaboration Invention, provided that such determination shall be made in accordance with United States patent laws.

(b) Each Party shall solely own all Collaboration Inventions invented solely by its and/or its Affiliates’ respective employees, agents and/or independent contractors.

(c) All Collaboration Inventions invented jointly by one or more employees, agents, or independent contractors of Trubion and/or its Affiliates and one or more employees, agents, or independent contractors of Facet and/or its Affiliates (collectively, “Joint Inventions”) shall be owned jointly by the Parties in accordance with joint ownership interests of co-inventors under United States patent laws (that is, each Party shall have full rights to license, assign and exploit such Joint Inventions (and any patents arising therefrom) anywhere in the world, without any requirement of gaining the consent of, or accounting to, the other Party), subject to the licenses granted herein and subject to any other intellectual property held by such other Party.

(d) This Agreement is intended by the Parties to be entered into pursuant to 35 U.S.C. 103(c), as such section may be amended from time to time. For clarity, Collaboration Inventions are intended by the Parties to be subject to 35 U.S.C. 103(c)(1) and this Agreement is intended by the Parties to be deemed a “joint research agreement” as defined in 35 U.S.C. 103(c)(3), as such sections may be amended from time to time.

10.2 Disclosure of Inventions. Each Party shall promptly disclose to the JPC all Collaboration Inventions, including all invention disclosures or other similar documents submitted to such Party by its, or its Affiliates’ employees, agents or independent contractors describing Collaboration Inventions.

10.3 Prosecution of Patents.

(a) Trubion Core Patent Rights. Except as otherwise provided in this Section 10.3, as between the Parties, Trubion shall have the sole right and authority to prepare, file, prosecute (including any oppositions, interferences, reissue proceedings, reexaminations and post-grant proceedings) and maintain the Trubion Core Patent Rights in any jurisdiction in the Territory, provided that decisions regarding any claims within the Trubion Core Patent Rights that claim the [ * ] or [ * ] of [ * ] or [ * ] in the [ * ] and do not claim the [ * ] or [ * ] of [ * ] that is [ * ] shall be made by the JPC. Trubion shall provide Facet (i) a reasonable opportunity to review and comment on such filing and prosecution efforts regarding the Trubion Core Patent Rights in the Territory; (ii) a copy of each material communication received from any patent authority in the Territory regarding the Trubion Core Patent Rights, and (iii) drafts of any material filings or material responses to be made to such patent authorities a reasonable amount of time in advance of submitting such filings or responses. If Trubion determines in its sole discretion to abandon, cease prosecution or not maintain any Trubion Core Patent Right anywhere in the Territory, then Trubion shall provide Facet written notice of such determination at least [ * ] before any deadline for taking action to avoid abandonment (or other loss of rights) and shall provide Facet with the opportunity to prepare, file, prosecute and maintain such Trubion Core Patent Right in the affected countries of the Territory on behalf of Trubion. If Facet desires Trubion to file, in a particular jurisdiction in the Territory, a Trubion Core Patent Right that claims priority to (or is based on the subject matter of) another Trubion Core Patent Right, Facet shall provide written notice to Trubion requesting that Trubion file such patent application in such jurisdiction. If Facet provides such written notice to Trubion, Trubion shall either (i) file and prosecute such patent application and maintain any patent issuing thereon in such jurisdiction, or (ii) notify Facet that Trubion does not desire to file such patent application and provide Facet with the opportunity to file and prosecute such patent application and maintain any patent issuing thereon on behalf of Trubion. Facet’s rights under this Section 10.3 with respect to any Trubion Core Patent Right licensed to Trubion by a Third Party shall be subject to the rights of such Third Party to file, prosecute, and/or maintain such Trubion Core Patent Right. Facet shall be responsible for [ * ] percent ([ * ]%) of the out-of-pocket costs incurred by Trubion in the course of preparing, filing, prosecuting and maintaining the Trubion Core Patent Rights and such costs shall not be included in Development Costs or Commercialization Costs. If Facet provides written notice to Trubion that Facet is no longer interested in maintaining a license to a particular Trubion Core Patent Right in a particular country, Facet will not be responsible for any portion of the costs incurred by Trubion after the date of such notice in connection with the preparation, filing, prosecution or maintenance of such Trubion Core Patent Right in such country, and the license granted to Facet under such Trubion Core Patent Right in such country shall terminate upon the delivery of such notice. If Facet assumes responsibility for any Trubion Core Patent Rights, then all costs incurred by Facet in the course of preparing, filing, prosecuting and maintaining such Trubion Core Patent Rights shall be borne by Facet, without reimbursement by Trubion, and such costs shall not be included in Development Costs or Commercialization Costs. If Trubion has exercised or is deemed to have exercised its Opt-Out Option in respect of all Products under this Agreement pursuant to Section 7.2, 7.3, 8.5 or 14.2(b), following the Opt-Out Effective Date, all costs incurred by Trubion in the course of preparing, filing, prosecuting and maintaining the Trubion Core Patent Rights shall be borne solely by Trubion. If Facet has exercised or is deemed to have exercised its Opt-Out Option in respect of all Products under this Agreement pursuant to Section 7.2, 7.3, 8.5 or 14.2(b),

following the Opt-Out Effective Date, all costs incurred by Trubion in the course of preparing, filing, prosecuting and maintaining the Trubion Core Patent Rights shall be borne solely by Trubion and Facet shall not have any rights pursuant to this Section 10.3(a) with respect to the Trubion Core Patent Rights; provided, however, if Facet notifies Trubion in writing within [ * ] following the Opt-Out Effective Date, with respect to one or more Trubion Core Patent Rights, that Facet will continue to be responsible for [ * ] percent ([ * ]%) of the out-of-pocket costs incurred by Trubion in the course of preparing, filing, prosecuting and maintaining such Trubion Core Patent Right(s), then Facet will continue to have all rights set forth in this Section 10.3(a) with respect to such Trubion Core Patent Right(s).

(b) Trubion Product Patent Rights, Facet Product Patent Rights and Joint Patent Rights.

(i) This Section 10.3(b)(i) shall apply if neither Party has exercised its Opt-Out Option, or is deemed to have exercised its Opt-Out Option under Section 14.2(b). Decisions regarding the preparation, filing, prosecution, and maintenance of Trubion Product Patent Rights, Facet Product Patent Rights and Joint Patent Rights, as well as any claims within the Trubion Core Patent Rights that claim the [ * ] or [ * ] of [ * ] or [ * ] in the [ * ] and do not claim the [ * ] or [ * ] of [ * ] that is [ * ], in any jurisdiction in the Territory shall be made by the JPC. The JPC shall designate a Party (the “Implementing Party”) to be responsible, using its in-house counsel or outside patent counsel reasonably acceptable to the other Party, to implement the decisions of the JPC regarding the preparation, filing, prosecution, and maintenance of such Patent Rights, provided that Trubion shall be the Implementing Party for Trubion Product Patent Rights and Facet shall be the Implementing Party for Facet Product Patent Rights. The Implementing Party shall provide the JPC (i) a reasonable opportunity to review and comment on such prosecution efforts regarding such Patent Rights in the Territory, (ii) a copy of each material communication received from any patent authority in the Territory regarding such Patent Rights, and (iii) drafts of any material filings or material responses to be made to such patent authorities a reasonable amount of time in advance of submitting such filings or responses. Each Party shall be responsible for fifty percent (50%) of the out-of-pocket costs incurred by the Parties in the course of preparing, filing, prosecuting and maintaining such Patent Rights and such costs shall be included in Development Costs if incurred prior to First Commercial Sale of a Collaboration Product or Commercialization Costs if incurred after First Commercial Sale of a Collaboration Product.

(ii) This Section 10.3(b)(ii) shall apply if a Party has exercised its Opt-Out Option, or is deemed to have exercised its Opt-Out Option under Section 14.2(b), the Non-Opt-Out Party has delivered or is deemed to have delivered a Pursuit Notice, and the Parties are not actively Developing or Commercializing any Collaboration Products. Subject to this Section 10.3(b)(ii), the Non-Opt-Out Party shall make and implement decisions regarding the preparation, filing, prosecution, and maintenance of Trubion Product Patent Rights, Facet Product Patent Rights and Joint Patent Rights, as well as any claims within the Trubion Core Patent Rights that claim the [ * ] or [ * ] of [ * ] or [ * ] in the [ * ] and do not claim the [ * ] or [ * ] of [ * ] that is [ * ], in any jurisdiction in the Territory. The Non-Opt-Out Party shall provide the Opt-Out Party: (i) a reasonable opportunity to review and comment on such prosecution efforts regarding such Patent Rights in the Territory; (ii) a copy of material communications from any patent authority in the Territory regarding such Patent Rights; and (iii) drafts of any

material filings or material responses to be made to such patent authorities a reasonable amount of time in advance of submitting such filings or responses. If the Non-Opt-Out Party determines to abandon, cease prosecution or not maintain any such Patent Right anywhere in the Territory, then it shall provide the Opt-Out Party written notice of such determination at least [ * ] before any deadline for taking action to avoid abandonment (or other loss of rights) and shall provide the Opt-Out Party with the opportunity to assume the preparation, filing, prosecution and maintenance of such Patent Right in the affected countries of the Territory. Each Party shall be responsible for one hundred percent (100%) of the costs it incurs in the course of preparing, filing, prosecuting and maintaining such Patent Rights and such costs shall not be included in Development Costs or Commercialization Costs.

(iii) If a Party has exercised its Opt-Out Option and the Non-Opt-Out Party has delivered a Pursuit Notice, but the Parties still are actively Developing or Commercializing one or more Collaboration Products (i.e. Products for which neither Party has exercised its Opt-Out Option), then (i) the provisions of Section 10.3(b)(ii) shall apply to (1) all Joint Patent Rights, Trubion Product Patent Rights and Facet Product Patent Rights that claim the [ * ] or [ * ] of a [ * ] and [ * ] in each case in all jurisdictions in the Territory and (2) all claims within the Trubion Core Patent Rights that claim the [ * ] or [ * ] of [ * ] or [ * ] in the [ * ] and do not claim the [ * ] or [ * ] of [ * ], and (ii) the provisions of Section 10.3(b)(i) shall apply to (1) any other Joint Patent Right, Trubion Product Patent Rights and Facet Product Patent Rights and (2) all claims within the Trubion Core Patent Rights that claim the [ * ] or [ * ] of [ * ] or [ * ] in the [ * ] and do not claim the [ * ] or [ * ] of [ * ].

(c) Divisional Patent Application. At the request of Facet or at Trubion’s election, Trubion shall file a continuation or divisional patent application of any Trubion Core Patent Right that contains a claim that claims the [ * ] or [ * ] of [ * ] or [ * ] in the [ * ] and does not claim the [ * ] or [ * ] of [ * ] that is [ * ], including U.S. Patent Application Serial Number [ * ], if permitted by applicable Laws, shall pursue in such continuation or divisional patent applications claims specifically directed to one or more Products and shall not pursue in such continuation or divisional patent applications any claims specifically directed to the product known as [ * ] or any other product that is not a Product. Such continuation or divisional patent applications shall be deemed Trubion Product Patent Rights.

(d) Patents Licensed from Third Parties. If either Party licenses after the Signing Date any Patent Rights from a Third Party and such Patent Rights qualify as Trubion Patent Rights or Facet Product Patent Rights, then each Party’s rights under this Section 10.3 with respect to such Patent Rights shall be subject to the rights of such Third Party to prosecute, maintain and extend such Patent Rights.

10.4 Infringement Actions.

(a) Notification of Litigation. In the event of the institution of any suit by a Third Party against either Trubion or Facet or otherwise, in respect of patent infringement involving the manufacture, use, sale, license, offer for sale, marketing, import or export of a Product within the Field anywhere in the Territory, any Party sued or to whom notice or knowledge of such proceeding shall arise, shall promptly notify the other Party in writing.

(b) Information and Settlement. Each Party shall keep the other Party informed of the status of any patent infringement litigation or settlement thereof concerning the Products within the Field in the Territory.

10.5 Enforcement of Patent Rights.

(a) Notice and Consultation. If either Facet or Trubion becomes aware of any infringement, anywhere in the Territory, of any issued patent within the Trubion Patent Rights, Facet Product Patent Rights, Facet Collaboration Patent Rights, or Joint Patent Rights, which infringing activity adversely affects or is reasonably expected to adversely affect any Product, it will promptly notify the other Party in writing to that effect and the Parties will consult with each other regarding any actions to be taken with respect to such infringing activity.

(b) Enforcement of Patent Rights Before Opt-Out. If neither Party has exercised or is deemed to have exercised its Opt-Out Option, the Parties shall have the joint right, but neither Party shall be obligated, to take action to obtain a discontinuance of infringement or bring suit against a Third Party infringer of (1) the Trubion Patent Rights, Facet Collaboration Patent Rights, or Facet Product Patent Rights, [ * ] such infringement [ * ] a [ * ] (as [ * ] in Section [ * ]) or (2) the Joint Patent Rights, [ * ] of the [ * ] of such infringement. If both Parties wish to so enforce such Patent Rights, Trubion and Facet shall be jointly responsible for, and shall bear equally, all the costs and expenses of any such suit brought by them. Any recoveries obtained by the Parties as a result of any proceeding against such Third Party infringer shall be allocated as follows:

(i) Such recovery shall first be used to [ * ] of the [ * ] for [ * ] in [ * ] such [ * ] by [ * ]; and

(ii) The remainder of the recovery will be [ * ] the [ * ].

If one Party elects not to participate in the infringement action and the Parties have not obtained a discontinuance of the infringement of such Patent Rights, then the other Party shall have the right, but not the obligation, to bring suit against such Third Party infringer of (3) the Trubion Patent Rights, Facet Collaboration Patent Rights or Facet Product Patent Rights, [ * ] such infringement [ * ] a [ * ] (as [ * ] in Section [ * ]) or (4) the Joint Patent Rights, [ * ] of the [ * ] of such infringement; provided in each case that the pursuing Party shall bear all of the expenses of such suit. The other Party will cooperate with the pursuing Party in any such suit and shall have the right to consult with the pursuing Party and to participate in and be represented by independent counsel in such litigation at its own expense. Any recoveries obtained by the pursuing Party as a result of any such proceeding against a Third Party infringer shall be allocated as follows:

(iii) Such recovery shall first be used to [ * ] the [ * ] for [ * ] by such [ * ], and, then, to [ * ] the [ * ] for [ * ] by such [ * ];

(iv) [ * ] of the remainder of the recovery shall [ * ] the [ * ] and [ * ] shall [ * ] the [ * ];

(c) Enforcement of Patent Rights After Opt-Out. If a Party has exercised or is deemed to have exercised its Opt-Out Option with respect to a Collaboration Product under this Agreement and the Non-Opt-Out Party has delivered or is deemed to have delivered a Pursuit Notice and is pursuing the resulting Royalty Product, the Non-Opt-Out Party shall have the first right, but not the obligation, to take action to obtain a discontinuance of infringement or bring suit against a Third Party infringer of (1) the Trubion Patent Rights, Facet Collaboration Patent Rights or Facet Product Patent Rights that are licensed to the Non-Opt-Out Party, [ * ] such infringement [ * ] a [ * ] (as [ * ] in Section [ * ]) or (2) the Joint Patent Rights, [ * ] of the [ * ] of such infringement. If the Non-Opt-Out Party does not wish to enforce such Patent Rights, it shall timely notify the Opt-Out Party in writing and the Opt-Out Party shall have the right, but not the obligation, to take action to obtain a discontinuance of infringement or bring suit against a Third Party infringer of (3) the Trubion Patent Rights, Facet Collaboration Patent Rights or Facet Product Patent Rights that are licensed to the Non-Opt-Out Party, [ * ] such infringement [ * ] a [ * ] (as [ * ] in Section [ * ]) or (4) the Joint Patent Rights, [ * ] of the [ * ] of such infringement. The pursuing Party shall bear all of the expenses of such suit. The other Party will cooperate with the pursuing Party in any such suit and shall have the right to consult with the pursuing Party and to participate in and be represented by independent counsel in such litigation at its own expense. Any recoveries obtained by the Parties as a result of any proceeding against such Third Party infringer shall be allocated as follows:

(i) Such recovery shall first be used to [ * ] the [ * ] for [ * ] by such [ * ], and, then, to [ * ] the [ * ] for [ * ] by such [ * ]; and

(ii) The remainder of the recovery will be allocated as follows:

a. If the [ * ] is the [ * ], the remainder shall be [ * ] as [ * ] of [ * ] by the [ * ];

b. If the [ * ] is the [ * ], [ * ] of the remainder of the recovery shall [ * ] and [ * ] shall [ * ] the [ * ].

(d) Patents Licensed from Third Parties. If either Party licenses any Patent Rights from a Third Party and such Patent Rights qualify as Trubion Patent Rights or Facet Product Patent Rights, then each Party’s rights under this Section 10.5 with respect to such Patent Rights shall be subject to the rights of such Third Party to enforce such Patent Rights against infringers.

10.6 Patent Term Extensions.

(a) All Products. The Parties hereto shall cooperate with each other and provide reasonable assistance to each other to obtain a patent term extension, or its equivalent anywhere in the Territory, including under 35 U.S.C. Section 156 and its foreign counterparts, of any Trubion Patent Right, Facet Collaboration Patent Rights or Facet Product Patent Right with respect to a Product. Subject to Section 10.6(b), to the extent reasonably and legally required in order to obtain any such extension in a particular country, each Party shall make available to the other a copy of the necessary documentation to enable such other Party to use the same for the purpose of obtaining the extension in such country.

(b) Collaboration Products. The JPC shall make all patent term extension decisions with respect to a Collaboration Product. Each Party shall consult with the other Party before applying for or obtaining any patent term extension or related extension of rights, including supplementary protection certificates and similar rights for any Trubion Patent Rights, Facet Collaboration Patent Rights or Facet Product Patent Rights with respect to a Collaboration Product. Neither Party shall proceed with such an extension until the Parties have agreed to a strategy therefor (with any disagreements on such strategy to be resolved by the JPC).

(c) Royalty Products. The Non-Opt-Out Party shall make all elections with respect to obtaining such patent term extension with respect to a Royalty Product for all Joint Patent Rights, Trubion Product Patent Rights and Facet Product Patent Rights that (i) claim the [ * ] or [ * ] of a [ * ] and [ * ] that is then [ * ] or [ * ] by the [ * ] and (ii) are licensed to the Non-Opt-Out Party.

10.7 Trademarks.

(a) The JCC shall decide on a Product-by-Product basis which Party shall be responsible for the selection, registration, maintenance and defense of all Marks for use in connection with the sale or marketing of a Collaboration Product in the Field in the Territory. Such Party shall own such Marks and shall grant the other Party a license with respect thereto to conduct its obligations pursuant to the Commercialization Plan. The Parties shall share equally all Trademark Costs, which shall be Development Costs if incurred prior to the First Commercial Sale of such Collaboration Product and Commercialization Costs if incurred thereafter. All uses of such Marks shall be reviewed by the JCC and shall comply with all applicable Laws and regulations (including, without limitation, those laws and regulations particularly applying to the proper use and designation of trademarks in the applicable countries).

(b) The Non-Opting-Out Party shall be responsible for the selection, registration, maintenance and defense of all Marks for use in connection with the sale or marketing of the applicable Royalty Product in the Field in the Territory, as well as all Trademark Costs associated therewith. Such Party shall own such Marks. All uses of such Marks shall comply with all applicable Laws and regulations (including, without limitation, those laws and regulations particularly applying to the proper use and designation of trademarks in the applicable countries).

(c) Neither Party shall, without the other Party’s prior written consent, use any Mark or Marks that include, in whole or part, any corporate name or logo of the other Party, or marks confusingly similar thereto, in connection with such Party’s marketing or promotion of Products under this Agreement, except as may be expressly authorized in a co-promotion agreement between the Parties pursuant to Section 5.11 and except to the extent required to comply with applicable Laws and regulations.

11. CONFIDENTIALITY.

11.1 Confidentiality.

(a) During the Term and [ * ] thereafter, each Party shall not use or reveal or disclose to Third Parties any Confidential Information of the other Party without first obtaining

the written consent of the other Party, except as may be otherwise provided in, or required in order for a Party to fulfill its obligations or exercise its rights under this Agreement. This confidentiality obligation shall not apply to such information that (i) is or becomes a matter of public knowledge (other than by breach of this Agreement by the receiving Party), (ii) the receiving Party can establish was already known to it or was in its possession, other than under an obligation of confidentiality, at the time of disclosure, (iii) is disclosed to the receiving Party, without any restrictions on further disclosure, by a Third Party having the right to do so and that did not obtain such information from the disclosing Party, or (iv) is subsequently independently developed or discovered by employees or agents of the receiving Party or its Affiliates who have had no access to such Confidential Information. However, the [ * ] in [ * ] shall [ * ] to [ * ] by [ * ] under [ * ]. The Parties shall take reasonable measures to assure that no unauthorized use or disclosure is made by others to whom access to such information is granted.

(b) Each Party may disclose Confidential Information of the other Party to the extent such disclosure is reasonably necessary in any of the following situations:

(i) filing or prosecuting Trubion Patent Rights, Facet Product Patent Rights or Joint Patent Rights;

(ii) regulatory filings and other filings with Governmental Authorities (including Regulatory Authorities), including filings with the SEC or FDA, with respect to a Product;

(iii) prosecuting or defending litigation;

(iv) complying with applicable Laws and regulations, including regulations promulgated by securities exchanges, court order, and administrative subpoena or order;

(v) disclosure to its Affiliates, employees, agents, sublicensees, and independent contractors, to the extent necessary for the purposes of enabling the receiving Party to fulfill its obligations under this Agreement, provided, the receiving Party shall be responsible for breaches of the confidentiality obligations by such Affiliate, employees, agents, and independent contractors, and provided further that, each disclosee must be bound by obligations of confidentiality and non-use at least as equivalent in scope as those set forth in this Article 11 (except with a minimum duration of [ * ] for independent contractors) prior to any such disclosure; and

(vi) disclosure of the material terms of this Agreement and/or of any collaboration results or status reports (including unblinded data from any Clinical Trials) to any bona fide potential or actual investor, investment banker, acquirer, merger partner, sublicensee, or other potential or actual financial or commercial partner; provided that each disclosee must be bound by obligations of confidentiality and non-use at least as equivalent in scope as those set forth in this Article 11 (except with a minimum duration of [ * ]) prior to any such disclosure.

(c) In the event it is necessary for a Party to disclose Confidential Information of the other Party to comply with a court order or administrative subpoena or order, such Party must first use its reasonable efforts to obtain an order preserving the confidentiality of the

information and must give the other Party timely notice of the contemplated disclosure to allow the other Party to intervene to preserve the confidentiality of the information by, for example, seeking an appropriate protective order.

11.2 Scientific Information. During the Term, each Party will submit to the other Party for review and approval all proposed academic, scientific and medical publications and public presentations relating to Products within the Field for review in connection with preservation of patent rights and/or to determine whether any of such other Party’s Confidential Information should be modified or deleted. Written copies of such proposed publications and presentations shall be submitted to the non-publishing Party no later than [ * ] before submission for publication or presentation and the non-publishing Party shall provide its comments with respect to such publications and presentations within [ * ] of its receipt of such written copy. The publishing Party shall delay the submission for publication or presentation for a period of up to [ * ] in the event the non-publishing Party can demonstrate reasonable need for such delay, including without limitation, the preparation and filing of patent applications. By mutual agreement, this period may be further extended. In addition, upon the non-publishing Party’s request, the publishing Party shall delete from the proposed submission any Confidential Information of the non-publishing Party; provided, however, that with respect to a [ * ] or [ * ] by the [ * ] regarding [ * ] data or information, the [ * ] shall [ * ] or [ * ] to the [ * ] or [ * ] of such [ * ]. Trubion and Facet will each comply with standard academic practice regarding authorship of scientific publications and recognition of contribution of other parties in any publications relating to Products within the Field. Notwithstanding the rest of this Section 11.2, the Opt-Out Party may not publish any academic, scientific or medical publications or make any public presentations regarding the Royalty Product without the prior written consent of the Non-Opt-Out Party.

11.3 SEC Filings. Before disclosing this Agreement or any of the terms hereof pursuant to this Section 11.3, the Parties will consult with each other and agree upon the terms of this Agreement to be redacted in making any such disclosure. The Parties shall separately submit confidential treatment request to the SEC but file the same redacted Agreement in such filings. Notwithstanding the foregoing, either Party may disclose the terms of this Agreement and any Confidential Information related to this Agreement, including, without limitation, clinical data, to the extent required, in the reasonable opinion of such Party’s legal counsel, to comply with applicable Laws, including, without limitation, the rules and regulations promulgated by the United States Securities and Exchange Commission (“SEC”), including comment letters received from the SEC related to SEC periodic reports and other filings. .

11.4 Public Announcements. The Parties will make a joint public announcement of this Agreement substantially in the form of the draft press release reviewed and approved by them prior to the signing of this Agreement. No other public announcement or other disclosure to Third Parties concerning the terms of this Agreement shall be made, either directly or indirectly, by either Party, except as may be legally required or as may be required for financial reporting purposes, without first obtaining the written approval of the other Party and agreement upon the nature and text of such announcement or disclosure.

11.5 Non-Solicitation. Without the prior written consent of the other Party, each of Trubion and Facet agrees that during the Term and for [ * ] thereafter, neither it nor any of its

Affiliates will directly or indirectly solicit for purposes of hiring any person employed by the other Party or any of its Affiliates or who was employed by the other Party or any of its Affiliates within the then prior [ * ], or in any manner seek to induce any such person to leave his or her employment; provided, however, that nothing in this Section 11.5 shall prohibit Facet or Trubion, as the case may be, from hiring any employees of the other who respond to general employment solicitations not targeted at employees of a Party or any of its Affiliates, including general advertisements.

12. REPRESENTATIONS AND WARRANTIES.

12.1 Representations of Trubion. Trubion represents and warrants as of the Signing Date that (i) it is a corporation or entity duly organized and validly existing under the laws of the state or other jurisdiction of its incorporation or formation, (ii) the execution, delivery and performance of this Agreement by Trubion has been duly authorized by all requisite corporate action and does not require any shareholder action or approval, (iii) it has the corporate power and authority to execute and deliver this Agreement and to perform its obligations and to grant the licenses granted by it to the other Party pursuant to this Agreement, and (iv) the execution, delivery and performance by Trubion of this Agreement and its compliance with the terms and provisions of this Agreement does not and will not conflict with or result in a breach of any of the terms and provisions of or constitute a default under (A) any agreement or instrument binding or affecting it or the subject matter of this Agreement; (B) the provisions of its charter or operative documents or bylaws; or (C) any order, writ, injunction or decree of any court or governmental authority entered against it or by which any of its property is bound except where such conflict, breach or default would not materially impact (I) Trubion’s ability to meet its obligations hereunder or (II) the rights granted to Facet hereunder.

12.2 Additional Representations of Trubion. In addition, except as disclosed in Schedule 12.2, Trubion hereby represents and warrants as of the Signing Date that:

(a) it has provided a complete and accurate list of all Third Party vendor contracts and Third Party licenses in effect as of the Signing Date to which Trubion or a Trubion Affiliate is a Party (i) that are reasonably necessary for the Development, Manufacture or Commercialization of TRU-016 or any other Product in the Field in the Territory in accordance with the terms of this Agreement or (ii) pursuant to which Development, Manufacture or Commercialization services are being provided or have been ordered as of the Signing Date with respect to TRU-016 or any other Product in the Field in the Territory, all such contracts and licenses are in full force in accordance with their terms except as would not reasonably be expected to, individually or in the aggregate, materially impair the ability of the Parties to exercise the rights and perform the obligations under this Agreement and Trubion is not in breach of any material term thereof;

(b) except for the intellectual property licensed to Trubion pursuant the license agreements listed in Schedule 12.2(b), it owns all right, title and interest in and to all of the Trubion Patent Rights and Trubion Know-How; such license agreements do not and will not require Trubion to make any royalty payments or other payments (other than services fees or other payments not expressly identified as fees for the use of intellectual property rights) to the

applicable Third Party licensors in consideration for the exercise of the rights licensed to Trubion as of the Signing Date under such licenses;

(c) it does not own and has not licensed any intellectual property that in each case would otherwise qualify as Trubion Patent Rights or material Trubion Know-How that is reasonably necessary for the Development, Manufacture, use, importation or Commercialization of Products in the Field under the terms of this Agreement, but for the fact that such intellectual property is not licensable to Facet hereunder and therefore not Controlled by Trubion (and, due solely to such lack of Control despite owning or holding a license thereto, does not meet the definition of Trubion Patent Rights or Trubion Know-How);

(d) it has not received any written notice asserting or alleging that the research or Development of any Product by or on behalf Trubion prior to the Signing Date infringed or misappropriated the intellectual property rights of any Third Party;

(e) to Trubion’s knowledge, the Development, Manufacture and Commercialization after the Signing Date of TRU-016 can be carried out in the manner reasonably contemplated as of the Signing Date without (i) infringing any Patent Rights owned or controlled by a Third Party or (ii) misappropriating any Know-How owned or controlled by a Third Party; provided, however, that Trubion is not making any representation or warranty pursuant to this Section 12.2(e) with respect to (1) the [ * ] of [ * ] that were [ * ] of [ * ] from [ * ] to [ * ] (such [ * ], the “[ * ]”)] or (2) the [ * ] of [ * ] that were [ * ] of [ * ] from [ * ] to [ * ] (such [ * ], the “[ * ]”) ;

(f) to Trubion’s knowledge, there is no unauthorized use, infringement or misappropriation of any of the Trubion Patent Rights or Trubion Know-How by any person;

(g) to Trubion’s knowledge, it has not used in the Development of TRU-016 any employee, agent or independent contractor who has been debarred by any Regulatory Authority, or is the subject of debarment proceedings by a Regulatory Authority;

(h) there are no actions or proceedings (including any inventorship challenges or interferences) pending or, to the knowledge of Trubion, threatened with respect to (i) any of the Trubion Patent Rights and Trubion Know-How or (ii) the Development or Manufacture of TRU-016;

(i) it has made available to Facet a complete and accurate copy of any IND and other related Regulatory Materials for TRU-016 and has not omitted any material data from such IND or Regulatory Materials; and

(j) no Regulatory Authority has, to Trubion’s knowledge, commenced or threatened to initiate any action or proceeding to refuse to file, reject, not approve, or withdraw any Regulatory Material related to the Product(s), nor has Trubion received any notice to such effect; and to Trubion’s knowledge, Trubion is not in violation of any applicable Laws that could reasonably be expected to form the basis for such an action; and

(k) Trubion believes in good faith, based upon due inquiry, that the Development, Manufacture and Commercialization after the Signing Date of TRU-016 can be

carried out in the manner reasonably contemplated as of the Signing Date without infringing (taking into account the provisions of 35 U.S.C. Section 271(e)) the [ * ] (as defined in Section [ * ] above) or the [ * ] (as defined in Section [ * ] above), provided that, in the case of the [ * ], due inquiry means due inquiry given the length of time since the date Trubion was made aware of the [ * ].

12.3 Representations of Facet. Facet represents and warrants as of the Signing Date that (i) it is a corporation or entity duly organized and validly existing under the laws of the state or other jurisdiction of its incorporation or formation, (ii) the execution, delivery and performance of this Agreement by Facet has been duly authorized by all requisite corporate action and does not require any shareholder action or approval, (iii) it has the corporate power and authority to execute and deliver this Agreement and to perform its obligations and to grant the licenses granted by it to the other Party pursuant to this Agreement, and (iv) the execution, delivery and performance by Facet of this Agreement and its compliance with the terms and provisions of this Agreement does not and will not conflict with or result in a breach of any of the terms and provisions of or constitute a default under (A) any agreement or instrument binding or affecting it or the subject matter of this Agreement; (B) the provisions of its charter or operative documents or bylaws; or (C) any order, writ, injunction or decree of any court or governmental authority entered against it or by which any of its property is bound except where such conflict, breach or default would not materially impact (I) Facet’s ability to meet its obligations hereunder or (II) the rights granted to Trubion hereunder.

12.4 Disclaimer. EXCEPT AS OTHERWISE EXPRESSLY SET FORTH IN SECTIONS 12.1, 12.2 AND 12.3, THE PARTIES MAKE NO REPRESENTATIONS AND EXTEND NO WARRANTIES OF ANY KIND, EITHER EXPRESS OR IMPLIED, AND PARTICULARLY THAT PRODUCTS WILL BE SUCCESSFULLY DEVELOPED HEREUNDER, AND IF PRODUCTS ARE DEVELOPED, WITH RESPECT TO SUCH PRODUCTS, THE PARTIES DISCLAIM ALL IMPLIED WARRANTIES OF TITLE, NON-INFRINGEMENT, MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE.

12.5 Mutual Covenant. Each Party covenants to the other Party that it shall at all times comply in all material respects with all applicable Laws relating to its activities under this Agreement.

13. LIABILITY AND INDEMNIFICATION.

13.1 Limitation on Liability. Except for breaches of Section 8.5 or Article 11, neither Party shall be liable to the other Party under this Agreement for any indirect, incidental, punitive, exemplary, special or consequential damages of any kind whatsoever sustained as a result of a breach of this Agreement; provided, however, that this limitation will not reduce or affect the Parties’ obligations in respect of Third Party claims under Section 13.2 or Section 13.3.

13.2 Mutual Indemnification. Each Party shall defend, indemnify and hold harmless the other Party and its Affiliates and their officers, directors, shareholders, employees, agents, representatives, successors and assigns from and against all Third Party claims, complaints, recall obligations and liabilities, or lawsuits for damages (collectively referred to as “Claims”) arising out of (i) any negligent act or omission, or willful wrongdoing by the indemnifying Party,

its Affiliate or sublicensees in the performance of this Agreement, (ii) the failure by the indemnifying Party, its Affiliate or sublicensees to comply with any applicable Law or governmental requirement, and/or (iii) any breach of any representation or warranty of the indemnifying Party contained in this Agreement. The indemnifying Party shall not be obligated under this Section 13.2 to the extent that the Claim was the result of the non-performance, negligence or willful misconduct of the indemnified Party or anyone acting on behalf of the indemnified Party, including its Affiliates and sublicensees, and its and their officers, directors, shareholders, employees, agents, representatives, successors and assigns.

13.3 Indemnification After Opt-Out. In addition to its obligations under Section 13.2, if a Party has exercised or is deemed to have exercised its Opt-Out Option with respect to a Product and the Non-Opt-Out Party has delivered or is deemed to have delivered a Pursuit Notice with respect thereto, the Non-Opt-Out Party shall defend, indemnify and hold harmless the Opt-Out Party and its Affiliates and their officers, directors, shareholders, employees, agents, representatives, successors and assigns from and against all Claims arising out of the Development, manufacture, use, handling, storage, promotion, use, sale, license, offer for sale, marketing, import or export of such Royalty Product (other than to the extent the Opt-Out Party is responsible for the Claim under Section 13.2) on or after the Opt-Out Effective Date. The Non-Opt-Out Party shall not be obligated under this Section 13.3 to the extent that the Claim was the result of the nonperformance, negligence or willful misconduct of the Opt-Out Party or anyone acting on behalf of the Opt-Out Party, including its Affiliates or sublicensees, and their officers, directors, shareholders, employees, agents, representatives, successors and assigns.

13.4 Limitations on Indemnification. The obligations to indemnify, defend, and hold harmless set forth in Sections 13.2 and 13.3 shall be contingent upon the Party seeking indemnification (the “Indemnitee”): (i) notifying the indemnifying Party of a claim, demand or suit within ten (10) days of receipt of same; provided, however, that Indemnitee’s failure or delay in providing such notice shall not relieve the indemnifying Party of its indemnification obligation except to the extent the indemnifying Party is prejudiced thereby; (ii) allowing the indemnifying Party and/or its insurers the right to assume direction and control of the defense of any such claim, demand or suit; (iii) using its [ * ] to cooperate with the indemnifying Party and/or its insurers, at the indemnifying Party’s expense, in the defense of such claim, demand or suit; and (iv) agreeing not to settle or compromise any claim, demand or suit without prior written authorization of the indemnifying Party. The Indemnitee shall have the right to participate in the defense of any such claim, demand or suit referred to in this Section 13.4 utilizing attorneys of its choice, at its own expense, provided, however, that the indemnifying Party shall have full authority and control to handle any such claim, demand or suit.

13.5 Other Third Party Claims. In the event of the institution after the Signing Date of any suit by a Third Party against either Trubion or Facet, in respect of the Development, Manufacture, use, handling, storage, promotion, use, sale, license, offer for sale, marketing, import or export of a Collaboration Product within the Field anywhere in the Territory for such activities during the Term for which neither Party is responsible under Section 13.2 or Section 13.3 the Parties shall cooperate and jointly control the defense and settlement of the suit and all out-of-pocket litigation expenses incurred by the Parties in the defense or settlement of the suit as well as all damages awarded against a Party or agreed to by the Parties in a settlement shall be considered Development Costs, if incurred prior to the First Commercial Sale of such

Collaboration Product, or Commercialization Costs, if incurred after the First Commercial Sale of such Collaboration Product, or [ * ] under Section [ * ] if [ * ] the [ * ] or [ * ] by a [ * ] of the [ * ] for the applicable [ * ].

13.6 Insurance. During the Term and for a period of [ * ] after the Term, or, in the case of a Party that has exercised or is deemed to have exercised its Opt-Out Option in respect of all Products under this Agreement until [ * ] after the final Opt-Out Effective Date, each Party shall obtain and/or maintain, respectively, at its sole cost and expense, product liability insurance in amounts, respectively, which are reasonable and customary in the pharmaceutical industry for companies of comparable size and activities at the respective place of business of each Party; provided that such amounts shall not be less than [ * ] Dollars ($[ * ]) before the first dosing of the first patient in the initial Phase III Clinical Study (or the transition to the pivotal phase of a Phase II/III Clinical Study) of a Product and shall not be less than [ * ] Dollars ($[ * ]) thereafter. Such product liability insurance shall insure against all liability, including personal injury, physical injury, or property damage arising out of the manufacture, sale, distribution, or marketing of the Collaboration Products and the Royalty Products (solely in the event that the policy holder is the Non-Opt-Out Party with respect thereto) in the Territory. Each Party shall provide written proof of the existence of such insurance to the other Party upon request.

14. TERM AND TERMINATION.

14.1 Term. This Agreement shall become effective on the Signing Date and, unless earlier terminated pursuant to this Article 14, shall expire on a Product-by-Product and country-by-country basis (a) in respect of Royalty Products, upon expiration of the Royalty Period for the Royalty Product in the country and (b) in respect of Collaboration Products, at such time as Facet and Trubion and their Affiliates and permitted sublicensees have all stopped selling the Collaboration Product in the country and the Commercialization Plan does not contemplate future sales of the Collaboration Product in the country (the “Term”). If the Term or license has not been earlier terminated, upon the expiration of the Term on a Product-by-Product and country-by-country basis, the licenses granted to each Party hereunder shall, with respect to such Product(s) and country(ies), upon and after such expiration, become nonexclusive, royalty-free, paid-up and irrevocable.

14.2 Termination by Either Party for Breach.

(a) Breach. Subject to Section 14.2(c), each Party shall have the right to terminate this Agreement upon written notice to the other Party if the other Party materially breaches its obligations under this Agreement and, after receiving written notice from the non-breaching Party identifying such material breach in reasonable detail, fails to cure such material breach within [ * ] from the date of such notice (or within [ * ] from the date of such notice in the event such material breach is solely based upon the breaching Party’s failure to pay any amounts due hereunder); provided that if such material breach is not reasonably subject to cure within the [ * ] period from notice, then the breaching Party shall have an additional [ * ] to effect such cure if it is undertaking Diligent Efforts to cure such breach and shall have provided a written plan reasonably acceptable to the non-breaching Party to cure such breach within such additional period. Notwithstanding anything to the contrary in this Agreement, the breaching Party shall not have the right to exercise its Opt-Out Option pursuant to Section 7.2 and Facet shall not have

the right to terminate the Agreement under Section 14.3 during the period between its receipt of the notice of a material breach and its cure of such material breach or the resolution of any dispute with respect thereto pursuant to Section 14.2(c); provided that if such dispute is resolved in the favor of such alleged breaching Party, such Party shall be entitled to exercise its Opt-Out Option pursuant to Section 7.2 or, in the case of Facet, its right to terminate the Agreement under Section 14.3 within [ * ] of such resolution if it was deprived of the ability to exercise its Opt-Out Option on account of this sentence.

(b) Continuation. If the non-breaching Party has the right to terminate this Agreement under Section 14.2(a), then, instead of terminating this Agreement, the non-breaching Party may elect to continue this Agreement by notice to the breaching Party, provided, however, if the non-breaching Party elects to continue this Agreement, upon written notice of continuation from the non-breaching Party, then the breaching Party shall be deemed to have exercised its Opt-Out Option and the notice pursuant to this Section 14.2(b) shall be deemed an “Opt-Out Notice” and a “Pursuit Notice” with respect to all Products under this Agreement regardless of whether such breach related to any particular Product and the provisions of Section 7.5 shall apply with respect to all Products under this Agreement and the breaching Party shall bear [ * ] percent ([ * ]%) of the reasonable expenses incurred by the non-breaching Party in the course of performing its transfer obligations pursuant to Sections 7.5(b)(iii), 7.5(b)(iv), 7.5(vi)(2) and 7.5(vii). The preceding sentence shall not in any event limit in any manner the non-breaching Party’s other remedies for an uncured material breach of this Agreement.

(c) Disputed Breach. If the alleged breaching Party disputes in good faith the existence or materiality of a breach specified in a notice provided by the other Party in accordance with Section 14.2(a), and such alleged breaching Party provides the other Party notice of such dispute and its intention to seek arbitration or judgment by a court pursuant to Article 15 within such [ * ] period (or [ * ] period for failure to make any payment), then the non-breaching Party shall not have the right to terminate this Agreement under Section 14.2(a) unless and until an arbitrator or court, in accordance with Article 15, has determined that the alleged breaching Party has materially breached this Agreement and that such Party fails to cure such breach within [ * ] following such decision of such arbitrator or court (except to the extent such breach involves the failure to make a payment when due, which breach must be cured within [ * ] following such decision of such arbitrator or court). It is understood and agreed that during the pendency of such dispute, all of the terms and conditions of this Agreement shall remain in effect and the Parties shall continue to perform all of their respective obligations hereunder.

14.3 Termination by Facet at Will. Facet shall have the right to terminate this Agreement in its entirety upon [ * ] prior written notice to Trubion, provided that, within eighteen (18) months after the Signing Date, such notice shall only be effective if accompanied by the payment of a termination fee equal to Ten Million Dollars ($10,000,000.00). Notwithstanding anything to the contrary in this Agreement, Facet shall have no right to terminate this Agreement pursuant to the preceding sentence after Facet has been deemed to have exercised its Opt-Out Option on account of an uncured breach pursuant to Section 14.2(b).

14.4 Effects of Termination by Facet at Will. Upon termination of this Agreement by Facet under Section 14.3, the following shall apply (in addition to any other rights and obligations under this Agreement with respect to such termination):

(a) Licenses. The licenses granted in Article 8 shall terminate. Notwithstanding the foregoing, Facet hereby grants to Trubion, effective only upon such termination, a [ * ] license, with [ * ] to [ * ] of [ * ], under the [ * ] to Develop, make, have made, use, import, export, offer for sale, sell and Commercialize any Products that are in active clinical development or are Commercialized as of the date of termination for the Field in the Territory, provided that if [ * ] in [ * ] within [ * ] after the [ * ] of [ * ], [ * ] will [ * ] to [ * ], with [ * ] to [ * ] of [ * ], under the [ * ] to [ * ] and [ * ] any [ * ] that are [ * ] or are [ * ] as of the [ * ] of [ * ] for the [ * ] in the [ * ], upon [ * ] to [ * ] to be [ * ] in [ * ] by the [ * ], provided that if the [ * ] are [ * ] to [ * ] the [ * ] for such [ * ] within [ * ], the [ * ] for such [ * ] shall be [ * ] by [ * ] pursuant to Section [15.3(c)]. In all cases where any element of the Facet Applied Technology is licensed to Facet by a Third Party, as a condition precedent for a license to be granted to Trubion pursuant to this Section 14.4(a), Trubion shall be required to agree in writing within [ * ] of the effective date of termination to pay any payments, including royalties on sales by Trubion or its permitted sublicensees, that accrue and become payable to such Third Party licensor after the effective date of the license to Trubion. Facet will not be obligated to maintain any Third Party license agreement in effect unless Trubion timely exercises its rights as provided in the foregoing sentence or to grant sublicenses under this Section 14.4(a), if Facet is prohibited from granting such sublicenses under its agreement(s) with its licensor(s), but shall be required to use Diligent Efforts to obtain permission to grant such a sublicense from any such licensor(s).

(b) Marks. Facet shall, as promptly as commercially practicable, assign to Trubion all of Facet’s right, title and interest in and to the Marks used or to be used with the Products (excluding any such Marks that include, in whole or part, any corporate name or logo of Facet or its Affiliates or permitted sublicensees), including any goodwill associated therewith. For the avoidance of doubt, only those Marks which have been (i) identified prior to the effective date of termination of this Agreement as the single designated lead candidate Mark for a non-commercialized Product, or (ii) actually used in connection with a Commercialized Product, shall be assigned. Trubion shall be responsible for recording such assignment in the Territory with the appropriate Governmental Authority and will bear all costs associated with such assignment and recordation. Facet shall cooperate in facilitating such assignment and recordation by timely executing all necessary documents provided to it by Trubion.

(c) Regulatory Materials. Facet shall transfer and assign to Trubion in the form and format in which such materials are maintained by Facet in the ordinary course of business, all Regulatory Materials for Products in the Territory that are Controlled by Facet or its Affiliates or permitted sublicensees.

(d) Transition Assistance. Facet shall, [ * ], provide Transition Assistance for the purpose of transferring or transitioning to Trubion, (i) in the form and format in which such Facet Applied Know-How is maintained by Facet in the ordinary course of business, all Facet Applied Know-How not already in Trubion’s possession, and (ii) at Trubion’s request, all then-existing Third Party agreements relating solely to Products hereunder and that Facet is able, using Diligent Efforts to, assign to Trubion, in each case, to the extent reasonably necessary for Trubion to continue researching, Developing, Manufacturing, or Commercializing Products, provided, however, that Facet shall be required to assign any such agreement solely to the extent assignment is permitted by such agreement, and Facet is not required to pay any consideration or commence litigation in order to effect an assignment of any such agreement to Trubion.

(e) Remaining Inventories. Trubion shall have the right to purchase from Facet [ * ] (less any portion of the cost previously shared by Trubion as a Development Cost or Commercialization Cost) any or all of the inventory of Bulk API and/or Products held by or for Facet or its Affiliates as of the effective date of termination pursuant to the terms of this Agreement or the Commercial Supply Agreement, as applicable. Trubion shall notify Facet within [ * ] after the effective date of termination whether Trubion elects to exercise such right.

14.5 Effect of Termination by Trubion for Uncured Breach. Upon termination of this Agreement by Trubion under Section 14.2(a), the licenses granted under Article 8 shall terminate. Notwithstanding the foregoing, Facet hereby grants Trubion, effective only upon such termination, a [ * ] license, with [ * ] to [ * ] of [ * ], under [ * ], to Develop, make, have made, use, import, export, offer for sale, sell and Commercialize any Products that are [ * ] or are [ * ] as of the [ * ] of [ * ] for the [ * ] in the [ * ]. In addition, Facet shall comply with Section 14.4(c).

14.6 Other Remedies. Termination or expiration of this Agreement for any reason shall not release either Party from any liability or obligation that already has accrued prior to such expiration or termination, nor affect the survival of any provision of this Agreement to the extent it is expressly stated to survive such termination. Termination or expiration of this Agreement for any reason shall not constitute a waiver or release of, or otherwise be deemed to prejudice or adversely affect, any rights, remedies or claims, whether for damages or otherwise, that a Party may have hereunder or that may arise out of or in connection with such termination or expiration.

14.7 Rights in Bankruptcy. All rights and licenses granted under or pursuant to this Agreement by Trubion and Facet are, and shall otherwise be deemed to be, for purposes of Section 365(n) of the United States Bankruptcy Code, licenses of rights to “intellectual property” as defined under Section 101 of the United States Bankruptcy Code. The Parties agree that each Party, as licensee of certain rights under this Agreement, shall retain and may fully exercise all of its rights and elections under the United States Bankruptcy Code. The Parties further agree that, in the event of the commencement of a bankruptcy proceeding by or against a Party (such Party, the “Bankrupt Party”) under the United States Bankruptcy Code, (a) the other Party shall be entitled to a complete duplicate of (or complete access to, as appropriate) any intellectual property licensed to such other Party and all embodiments of such intellectual property, which, if not already in such other Party’s possession, shall be promptly delivered to it (x) upon any such commencement of a bankruptcy proceeding upon such other Party’s written request therefor, unless the Bankrupt Party elects to continue to perform all of its obligations under this Agreement or (y) if not delivered under clause (x), following the rejection of this Agreement by the Bankrupt Party upon written request therefor by the other Party and (b) the Bankrupt Party shall not interfere with the other Party’s rights to intellectual property and all embodiments of intellectual property, and shall assist and not interfere with the other Party in obtaining intellectual property and all embodiments of intellectual property from another entity. The “embodiments” of intellectual property includes all tangible, intangible, electronic or other embodiments of rights and licenses hereunder, including all compounds and products embodying intellectual property, Products, filings with Regulatory Authorities and related rights and Trubion Know-How in the case that Trubion is the Bankrupt Party and Facet Applied Know-How in the case Facet is the Bankrupt Party.

14.8 Continuing Rights and Obligations. Termination or expiration of this Agreement shall not affect rights or obligations of the Parties under this Agreement that have accrued prior to the date of termination or expiration of this Agreement. Notwithstanding anything to the contrary, the following provisions shall survive and apply after expiration or termination of this Agreement: Sections [ * ], and [ * ], Article [ * ] (other than Section [ * ]), Article [ * ] (other than Section [ * ]), Article [ * ], Sections [ * ] (only with respect to the [ * ]), [ * ], and [ * ], Article [ * ], and Article [ * ]. In addition, the other applicable provisions of Article 9 shall survive to the extent required to make final reimbursements, reconciliations or other payments with respect to Product Profits, Net Sales and costs and expenses incurred or accrued prior to the date of termination or expiration. Furthermore, any other provision required to interpret or to enforce the Parties’ remaining rights and obligations under this Agreement shall also survive, but only to the extent required for the full observation and performance of this Agreement. All provisions not surviving in accordance with the foregoing shall terminate upon expiration or termination of this Agreement and be of no further force and effect.

15. DISPUTE RESOLUTION; LIABILITY.

15.1 General. Any controversy, claim or dispute arising out of or relating to this Agreement shall be settled, if possible, through good faith negotiations between the Parties. If, however, the Parties are unable to settle such dispute after good faith negotiations, the matter shall be referred to the Executive Officers to be resolved by negotiation in good faith as soon as is practicable but in no event later than [ * ] after referral.

15.2 Failure of Executive Officers to Resolve Dispute. If the Executive Officers are unable to settle the dispute after good faith negotiation in the manner set forth above or in Section 2.7, the matter (a) shall be resolved in accordance with Section 15.3, and (b) either Party may seek injunctive or other equitable relief in any court in any jurisdiction where appropriate.

15.3 Arbitration. Matters under Section 15.2 which are to be resolved through binding arbitration shall be settled by traditional arbitration or, for matters specifically identified in Section 2.7(c)(a), baseball arbitration, in accordance with the Commercial Arbitration Rules of the American Arbitration Association (“AAA”) then in effect, except to the extent such rules are inconsistent with this Section 15.3. The proceedings and decisions of the arbitrators shall be confidential, final and binding on the Parties, and judgment upon the award of such arbitrator(s) may be entered in any court having jurisdiction thereof.

(a) The arbitration shall take place in [ * ] (if [ * ]) or [ * ] (if [ * ]).

(b) Traditional arbitration shall be conducted by an arbitration panel consisting of three (3) independent arbitrators, and the award or decision shall be rendered by a majority of the members of the arbitration panel. Each arbitrator shall have not less than fifteen (15) years of experience in the biotechnology or pharmaceutical industry and subject matter expertise with respect to the matter subject to arbitration. Each Party shall appoint one arbitrator, and the third arbitrator shall be selected jointly by the two arbitrators appointed by the Parties, unless the Parties otherwise agree as to the identity of the third arbitrator. If the two arbitrators appointed by the Parties are unable to agree upon the third arbitrator within [ * ] of any request for arbitration, such arbitrator shall be selected by the AAA. Any arbitrator chosen hereunder

shall have educational training and industry experience sufficient to demonstrate a reasonable level of scientific, financial, medical and industry knowledge relevant to the particular dispute. The written decision of the arbitrators shall state the panel’s findings of material facts and the grounds for its conclusions and shall be final, conclusive and binding on the Parties and enforceable by any court of competent jurisdiction.

(c) Baseball Arbitration will be conducted by one (1) arbitrator who shall be reasonably acceptable to the Parties and who shall be appointed in accordance with AAA rules. If the Parties are unable to select an arbitrator within [ * ] of the notice that initiated the baseball arbitration, then the arbitrator shall be appointed in accordance with AAA rules. Any arbitrator chosen hereunder shall have educational training and industry experience sufficient to demonstrate a reasonable level of scientific, financial, medical and industry knowledge relevant to the particular dispute. Within [ * ] after the selection of the arbitrator, each Party shall submit to the arbitrator and the other Party a proposed resolution of the dispute that is the subject of the arbitration, together with any relevant evidence in support thereof (the “Proposals”). Within [ * ] after the delivery of the last Proposal to the arbitrator, each Party may submit a written rebuttal of the other Party’s Proposal and may also amend and re-submit its original Proposal. The Parties and the arbitrator shall meet within [ * ] after the Parties have submitted their final Proposals (and rebuttals, if any), at which time each Party shall have [ * ] to argue in support of its Proposal. The Parties shall not have the right to call any witnesses in support of their arguments, nor compel any production of documents or take any discovery from the other Party in preparation for the meeting. Within [ * ] after such meeting, the arbitrator shall select one of the final Proposals so submitted by one of the Parties as the resolution of the dispute, but may not alter the terms of either final Proposal and may not resolve the dispute in a manner other than by selection of one of the submitted final Proposals. If a Party fails to submit a Proposal within the initial [ * ] time frame set forth in the fourth sentence of this Section 15.3(c), the arbitrator shall select the Proposal of the other Party as the resolution of the dispute. Any time period set forth in this Section 15.3(c) may be extended by mutual agreement of the Parties.

(d) Each Party shall bear its own costs and expenses (including legal fees and expenses) relating to the arbitration proceeding, except that the fees of the arbitrator(s) and other related costs of the arbitration shall be shared equally by the Parties, unless the arbitrator(s) determine(s) that a Party has incurred unreasonable expenses due to vexatious or bad faith positions taken by the other Party, in which event the arbitrator(s) may make an award of all or any portion of such expenses so incurred.

(e) The arbitrator(s) shall be required to render their decision in writing and to comply with, and their award shall be limited by, any express provisions of this Agreement relating to damages or the limitation thereof. No arbitrator shall have the power to award punitive damages under this Agreement regardless of whether any such damages are contained in a Proposal, and such award is expressly prohibited.

15.4 Patent and Trademark Disputes. Notwithstanding Section 15.2, any dispute, controversy or claim relating to the scope, validity, enforceability or infringement of any Patent Rights or trademark rights covering the manufacture, use, importation, offer for sale or sale of Products shall be submitted to a court of competent jurisdiction in the country in which such Patent Rights or trademark rights were granted or arose.

16. MISCELLANEOUS.

16.1 Assignment. Except as provided in subsections (a) and (b) below, neither this Agreement nor any interest hereunder shall be assignable by either Party, without the prior written consent of the other Party, which consent shall not be unreasonably withheld or delayed. This Agreement shall be binding upon the successors and permitted assigns of the Parties, and the name of a Party appearing herein shall be deemed to include the names of such Party’s successors and permitted assigns to the extent necessary to carry out the intent of this Agreement. In addition to the foregoing, each Party may assign its right, in whole or part, to receive payments under this Agreement. Any assignment not in accordance with this Section 16.1 shall be void. Notwithstanding anything to the contrary in this Agreement, in the event that a Party undergoes an acquisition by a Third Party, no intellectual property rights of the Third Party assignee, acquiror or successor of such Party or any Affiliate of such Third Party shall be included in the subject matter licensed hereunder, to the extent that such intellectual property rights were held by the Third Party prior to the acquisition, or are created outside of any activities under this Agreement by personnel who were not employees of the acquired Party at the time of the acquisition. Notwithstanding anything to the contrary in this Agreement, in the event that a Party makes an assignment pursuant to subsection (b) below to a Third Party, no intellectual property rights of the Third Party assignee or any Affiliate of such Third Party shall be included in the subject matter licensed hereunder, to the extent that such intellectual property rights were held by the Third Party prior to the assignment, or are created outside of any activities under this Agreement by personnel who were not employees of the assigning Party at the time of the assignment.

(a) Each Party may assign all of its rights and delegate all of its obligations under this Agreement without the other Party’s consent to an Affiliate or to a successor to substantially all of the business of such Party to which this Agreement relates, whether in merger, sale of stock, sale of assets or other transaction.

(b) Each Party may assign all of its rights and delegate all of its obligations under this Agreement without the other Party’s consent to a Third Party who is not a successor to such Party as described in Section 16.1(a), if such Third Party is not a CD37 Competitor, provided that: (i) before commencing negotiations with such a Third Party for such an assignment, the assigning Party shall notify the other Party, and the Parties shall have [ * ] to negotiate in good faith a non-binding term sheet setting forth the principal terms and conditions under which the assigning Party would assign such rights and delegate such obligations to the other Party. If the Parties agree on such non-binding term sheet within the [ * ]-period, then the Parties shall have an additional time period, not to exceed [ * ] from the receipt of the notice from the assigning Party, to enter into a definitive agreement based on the terms of the non-binding term sheet. Notwithstanding anything to the contrary above, the assigning Party shall at all times be free to engage in concurrent negotiations with one or more Third Parties but shall not conclude an assignment with a Third Party during the [ * ] period described above during which the Parties are negotiating the term sheet and/or during the [ * ] period described above during which the Parties are negotiating the definitive agreement; and (iii) the assigning Party shall also assign or otherwise grant a license to such Third Party assignee to all of its Patent Rights and Know-How under its Control that are specific to the Products, and grant to such Third Party assignee all other rights and deliver to such Third Party assignee all information and materials in

each case that is reasonably necessary for such Third Party assignee to perform the assigning Party’s obligations under this Agreement.

16.2 Further Actions. Each Party agrees to execute, acknowledge and deliver such further instruments, and to do all such other acts, as may be necessary or appropriate in order to carry out the purposes and intent of this Agreement.

16.3 Government Approvals. Trubion and Facet will cooperate and use respectively Diligent Efforts to make all registrations, filings and applications, to give all notices and to obtain as soon as practicable all governmental or other consents, transfers, approvals, orders, qualifications authorizations, permits and waivers, if any, and to do all other things necessary or desirable for the consummation of the transactions as contemplated hereby.

16.4 Force Majeure. Neither Party shall be liable to the other for delay or failure in the performance of the obligations on its part contained in this Agreement if and to the extent that such failure or delay is due to circumstances beyond its control which it could not have avoided by the exercise of reasonable diligence. It shall notify the other Party promptly should such circumstances arise, giving an indication of the likely extent and duration thereof, and shall use all Diligent Efforts to resume performance of its obligations as soon as practicable; provided, however, that neither Party shall be required to settle any labor dispute or disturbance.

16.5 Correspondence and Notices.

(a) Ordinary Notices. Correspondence, reports, documentation, and any other communication in writing between the Parties in the course of ordinary implementation of this Agreement shall be delivered by hand, or sent by facsimile transmission, email or airmail to the employee or representative of the other Party who is designated by such other Party to receive such written communication.

(b) Extraordinary Notices. Extraordinary notices and other communications hereunder (including without limitation, any notice of force majeure, breach, termination, change of address, etc.) shall be in writing and shall be deemed given if delivered personally or by facsimile transmission (receipt verified), mailed by registered or certified mail (return receipt requested), postage prepaid, or sent by nationally recognized express courier service, to the Parties at the following addresses (or at such other address for a Party as shall be specified by like notice; provided, however, that notices of a change of address shall be effective only upon receipt thereof):

All correspondence to Facet shall be addressed as follows:

Facet Biotech Corporation

1500 Seaport Blvd.

Redwood City, CA 94063

Attn: Chief Executive Officer

Fax: (650) 454-2000

with a copy to:

Facet Biotech Corporation

1500 Seaport Blvd.

Redwood City, CA 94063

Attn: General Counsel

Fax: (650) 454-2000

and a copy to:

Cooley Godward Kronish LLP

Five Palo Alto Square

3000 El Camino Real

Palo Alto, CA 94306-2155

Attn: Glen Sato

Fax: (650) 849-7400

All correspondence to Trubion shall be addressed as follows:

Trubion Pharmaceuticals, Inc.

2401 4th Avenue

Suite 1050

Seattle, Washington 98121

Attn: President & CEO

Fax: (206) 838-0503

with a copy to:

Trubion Pharmaceuticals, Inc.

2401 4th Avenue

Suite 1050

Seattle, Washington 98121

Attn: General Counsel

Fax: (206) 838-0503

and a copy to: Fenwick & West LLP

1191 Second Avenue

10th Floor

Seattle, WA 98101

Attn: Alan C. Smith

Fax: (206) 389-4511

16.6 Representation by Legal Counsel. Each Party hereto represents that it has been represented by legal counsel in connection with this Agreement and acknowledges that it has participated in the drafting of this Agreement. In interpreting and applying the terms and provisions of this Agreement, the Parties agree that no presumption shall exist or be implied against the Party which drafted such terms and provisions.

16.7 Amendment. No amendment, modification or supplement of any provision of this Agreement shall be valid or effective unless made in writing and signed by a duly authorized officer of each Party.

16.8 Waiver. Except as expressly limited by the terms of this Agreement, no failure on the part of any Person to exercise any power, right, privilege or remedy under this Agreement, and no delay on the part of any Person in exercising any power, right, privilege or remedy under this Agreement, shall operate as a waiver of such power, right, privilege or remedy; and no single or partial exercise of any such power, right privilege or remedy shall preclude any other or further exercise thereof or of any other power, right, privilege or remedy. No provision of this Agreement shall be waived by any act, omission or knowledge of a Party or its agents or employees except by an instrument in writing expressly waiving such provision and signed by a duly authorized officer of the waiving Party. The waiver by either of the Parties of any breach of any provision of this Agreement by the other Party shall not be construed to be a waiver of any succeeding breach of such provision or a waiver of the provision itself.

16.9 Severability. If any clause or portion thereof in this Agreement is for any reason held to be invalid, illegal or unenforceable, the same shall not affect any other portion of this Agreement, as it is the intent of the Parties that this Agreement shall be construed in such fashion as to maintain its existence, validity and enforceability to the greatest extent possible. In any such event, this Agreement shall be construed as if such clause of portion thereof had never been contained in this Agreement, and there shall be deemed substituted therefor such provision as will most nearly carry out the intent of the Parties as expressed in this Agreement to the fullest extent permitted by applicable Law.

16.10 Construction

(a) The descriptive headings of this Agreement are for convenience only, and shall be of no force or effect in construing or interpreting any of the provisions of this Agreement.

(b) Any rule of construction to the effect that ambiguities are to be resolved against the drafting party shall not be applied in the construction or interpretation of this Agreement.

(c) Except as otherwise indicated, all references in this Agreement to “Articles”, “Sections,” “Exhibits” and “Schedules” are intended to refer to Articles and Sections of this Agreement, and Exhibits and Schedules to this Agreement.

16.11 Governing Law. This Agreement shall be governed by and interpreted in accordance with the substantive laws of the State of California, without regard to conflict of law principles thereof.

16.12 Entire Agreement of the Parties. This Agreement constitutes and contains the complete, final and exclusive understanding and agreement of the Parties and cancels and supersedes any and all prior negotiations, correspondence, understandings and agreements, whether oral or written, among the Parties respecting the subject matter of this Agreement and thereof. For clarity, the rights and obligations of the Parties on and after the Signing Date with

Exhibit B

Initial Development Plan

This is the Initial Development Plan under the Collaboration and License Agreement (the “Collaboration Agreement”), dated August 27, 2009, between Facet Biotech Corporation (“Facet”) and Trubion Pharmaceuticals, Inc. (“Trubion”).

TRU-016 Development Plan

All protocols and development plans involving TRU-016 and amendments thereto will be reviewed and approved in accordance with the Collaboration Agreement. The [ * ] Trubion and Facet have agreed to develop for TRU-016 are [ * ]. Trubion and Facet shall make good faith efforts to agree upon the definitive Initial Development Plan and have it appropriately approved by the JSC within [ * ] after the Signing Date. The Development Plan will be reviewed and revised periodically and, if necessary, after [ * ] in accordance with the terms of the Collaboration Agreement.

Clinical Development Plan

[ * ] of TRU-016 is [ * ] and [ * ] are being [ * ] for [ * ] in [ * ]. The [ * ] clinical study [ * ] will be [ * ] if possible, to examine the [ * ] of [ * ] and [ * ] in [ * ] in [ * ] setting; additionally, the study will be [ * ] to allow [ * ] with [ * ] until [ * ].

[ * ] additional trials will be in [ * ]; [ * ] will be [ * ] with [ * ] and [ * ] will be [ * ] with [ * ] based on the [ * ] of these [ * ] in [ * ] study. The [ * ] additional study will examine [ * ] of [ * ], [ * ] and possibly [ * ] or [ * ] in [ * ] in a [ * ] setting. The outline of the programs in [ * ] and [ * ] are in the figures below. [ * ] criteria for [ * ] in [ * ] and [ * ] in [ * ] are described as a way of example. The exact criteria for [ * ] will be [ * ] in the field of [ * ] within the [ * ].

[ * ]

The table below outlines the timing and costs of the [ * ] and [ * ] trials. These are estimates and will require refinement as the projects are developed. The costs are [ * ] and include [ * ], and [ * ]; [ * ] and [ * ] are [ * ].

Trial

Trial
Start

DBL

Cost [ * ]

[ * ] Program

$[ * ]

[ * ], Phase [ * ] (Protocol [ * ])

[ * ]

[ * ], Phase [ * ], [ * ]; [ * ]

[ * ]

[ * ], Phase [ * ], [ * ]; [ * ]

[ * ]

[ * ], Phase [ * ]; [ * ]; [ * ]

[ * ]

[ * ] Program

[ * ], Phase [ * ]; [ * ]

[ * ]

[ * ], Phase [ * ], [ * ]; [ * ]

[ * ]

[ * ], Phase [ * ]; [ * ]; [ * ]

[ * ]

In addition to studies outlined above, [ * ] studies may be [ * ] by the [ * ]. These may include a [ * ] and [ * ] in [ * ] with [ * ] or [ * ] to be conducted at appropriate times.

Studies in [ * ] and [ * ] ([ * ]) will be [ * ] after [ * ] are [ * ] from the [ * ]. It is possible that trials in [ * ] ([ * ]) and [ * ] ([ * ]) [ * ] could [ * ] in the [ * ] of [ * ]. [ * ] but [ * ] and are [ * ] from the [ * ]. Hence, these [ * ] may be a [ * ] in [ * ]. The objective of [ * ] trials in [ * ] and [ * ] would be to prove that [ * ] is [ * ]. Such [ * ] is necessary in order to [ * ] a [ * ] that [ * ] in [ * ], as [ * ] and [ * ] are required for these [ * ].

There are currently [ * ] FTEs supporting [ * ] ([ * ], [ * ], [ * ]). [ * ] FTEs at [ * ] or [ * ] may be required to support the planned studies in [ * ] and [ * ].

Manufacturing and Process Development Plans

Manufacturing History

[ * ] Product ([ * ] of [ * ])

The [ * ] of [ * ] which is [ * ] in the [ * ] was manufactured at [ * ] ([ * ]) [ * ] ([ * ]), where about [ * ] of the product ([ * ]) were made in [ * ].

The [ * ] and [ * ] used to produce this [ * ] were a [ * ] with the [ * ] and [ * ] using [ * ] of [ * ] and [ * ] with [ * ]. The [ * ] of [ * ] containing the [ * ] was prepared at [ * ] and supplied to [ * ] ([ * ]) to prepare the [ * ] ([ * ]). The [ * ] was [ * ] by [ * ] and is [ * ] at [ * ].

The manufacturing process (referred to as [ * ]) was [ * ] at [ * ] and [ * ] to [ * ] for [ * ]. [ * ] standard [ * ] of [ * ] was generated at [ * ] in [ * ] during the [ * ] of the [ * ] to [ * ]. Subsequently, [ * ] manufactured the [ * ] of [ * ] in a [ * ], followed by [ * ], [ * ], and [ * ]. The [ * ] had a [ * ] of [ * ]. The ensuing overall recovery of [ * ] was [ * ], with a total of [ * ] of [ * ] generated.

The [ * ] of this [ * ] of [ * ] was packaged as a [ * ] for [ * ]. Each of the [ * ] contains [ * ] of [ * ] (or [ * ]) in the [ * ], as shown in the following table. The [ * ] system is a [ * ], with a [ * ], [ * ] with an [ * ] with a [ * ]. The [ * ] are [ * ] at [ * ] at [ * ] ([ * ]).

Composition of [ * ], [ * ]

Ingredient	Reference	Function	Quantity (per mL)
[ * ]	[ * ]	[ * ]	[ * ]
[ * ]	[ * ]	[ * ]	[ * ]
[ * ]	[ * ]	[ * ]	[ * ]
[ * ]	[ * ]	[ * ]	[ * ]

[ * ] of [ * ]

A [ * ] process for [ * ] was [ * ] to [ * ] the [ * ] and [ * ] the [ * ] of [ * ] at the [ * ] in [ * ]. The [ * ] by [ * ] was [ * ], to [ * ] it from the [ * ] ([ * ]) [ * ] in the [ * ]. The [ * ] and [ * ] system was [ * ] from [ * ]. The [ * ] based on the [ * ] ([ * ]) [ * ], and [ * ] were [ * ] in [ * ] containing the [ * ] ([ * ]). A [ * ] of the [ * ] was [ * ] at [ * ] and [ * ] to [ * ] to [ * ] and [ * ] an [ * ] for [ * ]. This [ * ] is [ * ] at [ * ] was [ * ] at [ * ] to [ * ] of [ * ] in [ * ]. [ * ] process has [ * ] to the [ * ] procedure, [ * ] that the [ * ] was [ * ] to [ * ] to [ * ] from the [ * ].

To provide a product that can be [ * ] and [ * ], a [ * ] for [ * ] was developed with [ * ] than [ * ]. The [ * ] was found to be [ * ] with [ * ] of a [ * ] of [ * ] at [ * ] (or [ * ]) in a [ * ] of [ * ], [ * ], and [ * ] at a [ * ] of [ * ], as shown in the following table.

Composition of [ * ], [ * ]

Ingredient	Reference	Function	Quantity (per mL)
[ * ]	[ * ]	[ * ]	[ * ]
[ * ]	[ * ]	[ * ]	[ * ]
[ * ]	[ * ]	[ * ]	[ * ]
[ * ]	[ * ]	[ * ]	[ * ]

Following the development work, a [ * ] production of [ * ] was executed with the [ * ] process in [ * ] at [ * ] in [ * ]. The [ * ] contained [ * ] of [ * ], or a total of [ * ] of [ * ]. The overall cumulative yield of the [ * ] was [ * ].

The [ * ] of [ * ] into [ * ] and its [ * ] into [ * ] was done at [ * ] ([ * ]) in [ * ]. The [ * ] of the [ * ] and the [ * ] of [ * ] was [ * ], and the [ * ] of the [ * ] of [ * ] is [ * ]. A total of [ * ] were manufactured, and after retaining some [ * ] for [ * ] and [ * ], [ * ] (for a total of [ * ] of [ * ]) are available for [ * ]. [ * ] of this [ * ] to [ * ] standard [ * ] by [ * ] and [ * ] has been established, and an [ * ] to [ * ] on [ * ] to pave the way for [ * ] the [ * ] to the [ * ].

Further [ * ] Plans

The current [ * ] process with [ * ] of about [ * ] and [ * ] of [ * ] is suitable for [ * ] for [ * ] and represnts the [ * ] for [ * ] of [ * ]. However, improvements to [ * ] and [ * ] are [ * ] to further [ * ] and [ * ] in [ * ] manufacturing. [ * ] changes, such as [ * ] to [ * ] materials ([ * ], etc.), will [ * ]. Throughout these [ * ], the [ * ] of the product from the [ * ] to the current [ * ] in [ * ] will be demonstrated.

Work is currently under way in [ * ] to [ * ] the [ * ] of the [ * ] process. So far, areas already successful have been:

· To [ * ] the [ * ] of [ * ] (currently at [ * ]) in the [ * ] process leading to the [ * ] to allow [ * ];

· To [ * ] the [ * ] of [ * ] in the [ * ] to achieve [ * ]

· To design a process with [ * ] for [ * ].

With some of these changes [ * ], a [ * ] process [ * ] in the [ * ] and of [ * ] to [ * ] has already been demonstrated in [ * ] and will shortly be tested with [ * ].

The [ * ] of the [ * ] process will also be examined. Attempts are currently being made to:

· [ * ] the [ * ] to allow the [ * ]. [ * ] of [ * ] conditions is being pursued to [ * ] the [ * ].

· [ * ] the amount of [ * ] entering the [ * ] by treating the [ * ] or [ * ] to further [ * ] the [ * ].

For the drug product, [ * ] efforts will look into [ * ] of [ * ] in [ * ], and [ * ] through:

· [ * ] the product [ * ] to [ * ] and [ * ] in [ * ] to get a [ * ] of [ * ] ([ * ] data indicate [ * ] of [ * ] or [ * ] are [ * ]). The need for this effort will be assessed in light of the intended [ * ] in consulation with the program team.

· Assessing [ * ] of [ * ]. The current [ * ] capacity at [ * ] ([ * ]) is in the process of being [ * ] which would offer the possibility of [ * ].

· An evaluation of [ * ] data on [ * ] would be done to assess [ * ] of a [ * ] should that be considered desirable for [ * ] purposes.

In the area of [ * ], the following [ * ] will be investigated as [ * ] to the [ * ] process:

· A [ * ] to determine [ * ] of the [ * ] in various process [ * ], including [ * ] and [ * ];

· A [ * ];

· [ * ] methods to [ * ] current [ * ] methods

· A [ * ] method as [ * ] test;

· More [ * ] methods to characterize [ * ] and [ * ] improvements.

· Other [ * ] for [ * ] characterization of [ * ] and [ * ] for various [ * ] evaluations [ * ] by [ * ] and [ * ] and [ * ] for various [ * ] and [ * ]

Clinical Drug [ * ]

The current [ * ] drug product ([ * ], [ * ]) will be used in the Phase [ * ] study. Additional drug product ([ * ]) from the [ * ] manufacturing process is expected in [ * ]. [ * ] between the [ * ] and the [ * ] has been established and an [ * ] for the [ * ] of [ * ] on [ * ]. The timing of [ * ] will depend on [ * ] needs; at a minimum, a [ * ] in [ * ] will be [ * ] to [ * ] the [ * ] in [ * ].

For planning purposes, the best estimate of [ * ] at this time is assumed to be [ * ], for a total of [ * ]. The table on the next page lists the projected material requirements for the [ * ] in [ * ].

[ * ]

Study

Start

DBL

[ * ]

[ * ]

Total [ * ]

[ * ]

No. of [ * ]:

[ * ]

[ * ]

[ * ]

[ * ]

[ * ]

[ * ]

[ * ]

[ * ]

[ * ]

Assumptions

[ * ]

[ * ]

The current [ * ] for TRU-016 are [ * ]. Key inputs for [ * ] calculations are [ * ] and [ * ]. The current trial has reached a [ * ] so the [ * ] is if the [ * ] does not [ * ] from that level. The [ * ] range for [ * ] is estimated around [ * ] per [ * ]. While considering these [ * ] variables, [ * ] parameters have to be taken into account in estimating the [ * ]. For illustration purposes, calculations below assume that the [ * ] is [ * ], [ * ] per [ * ], and the total [ * ] is [ * ] (for a [ * ]). As the [ * ] and [ * ] will play an important role in determining the [ * ], the following table focuses on these [ * ].

*[ ]**	*[ ]**	Total [ * ] per [ * ] (including [ * ])		[ * ] as a percentage of $[ * ]
[ * ]	[ * ]	$	[ * ]	[ * ]	%
[ * ]	[ * ]	$	[ * ]	[ * ]	%
	[ * ] (Currently [ * ])	$	[ * ]	[ * ]	%
[ * ]	[ * ] (per [ * ])	$	[ * ]	[ * ]	%
	[ * ] (currently [ * ])	$	[ * ]	[ * ]	%

As seen from the above estimates, the [ * ] are [ * ] and could be [ * ] by implementing]the [ * ] and selecting a [ * ]. Since the process that will be [ * ] at [ * ] will [ * ] be the [ * ] process, the decision for [ * ] will be made after careful, detailed discussion regarding the [ * ] for [ * ].

[ * ] and [ * ]

[ * ] and [ * ] activities have to be planned to meet the [ * ] time line. The [ * ] of the [ * ] process will consist of [ * ] testing of [ * ], during which [ * ] and [ * ] for the [ * ], and [ * ] will be identified and characterized, followed by the [ * ] of the [ * ] to [ * ] and [ * ] composed of [ * ] ([ * ] of up to [ * ]), [ * ] of [ * ], and [ * ] on both [ * ] and [ * ]. [ * ] will be conducted [ * ] to [ * ].

The [ * ] is expected to require [ * ] from the [ * ] of the [ * ] to [ * ] of the [ * ], with the [ * ] studies [ * ] that.

The estimated timeline, [ * ] requirements and [ * ] estimates for [ * ] are shown in the Figure below based on [ * ] assumptions. Please note that [ * ] in [ * ] for [ * ] are [ * ] only in the [ * ], although [ * ] would be [ * ] to [ * ] the [ * ] activities in the [ * ]. [ * ] indicated are estimates for [ * ] for activities at [ * ] and [ * ].

[ * ]*

[ * ]

* [ * ] would be [ * ] to [ * ] the [ * ] activities. [ * ] indicated are estimates for [ * ] for activities at [ * ] and [ * ].

[ * ]

For the purpose of [ * ], it is assumed that the [ * ] process with [ * ] in [ * ] will be implemented for the [ * ] in [ * ]. Also, assuming the need for [ * ] along with [ * ], [ * ] are planned. In the table below, separate estimates for [ * ] and [ * ] are shown for the [ * ]. These estimates were developed by [ * ] prior to [ * ] and may [ * ] as a [ * ] a [ * ] in the [ * ].

[ * ] Process, [ * ] — [ * ] and [ * ]

Timing	*[ ]**	*[ ]**	*[ ]**	*[ ]**
Activity	*[ ]**	*[ ]**	*[ ]**	*[ ]**
*No. of [ ]**	*[ ]**	*[ ]**	*[ ]**	*[ ]**
*[ ]**	*[ ]**	*[ ]**	*[ ]**	*[ ]**
*[ ]**		[ * ]*		[ * ]**

*[ * ]

**[ * ]

Preclinical Development Plan

The purpose of the research program is to:

· provide [ * ] for [ * ] from [ * ] and other [ * ] for [ * ] and [ * ]

· explore [ * ] of [ * ] and provide [ * ] for [ * ] in the [ * ]

· [ * ] and [ * ] in clinical development by [ * ] patient populations responsive] or [ * ] to [ * ]

[ * ]

[ * ] of the [ * ]

Technology exists at [ * ] to facilitate [ * ] of the [ * ] on [ * ] for [ * ]. The studies would employ either [ * ] or [ * ] of the [ * ] followed by [ * ] studies of [ * ]. Requirements for this approach would be the identification of a [ * ] that allows for [ * ] and [ * ] of [ * ] to [ * ] with [ * ].

[ * ] for [ * ]

[ * ]

Studies to date have shown that [ * ] from [ * ] in the [ * ] and [ * ] for [ * ] on [ * ] ([ * ]; [ * ] data). This work will be extended to a [ * ] of [ * ] from [ * ] and available [ * ]. ([ * ] are defined in this preclinical section as [ * ] from [ * ] without [ * ].) [ * ] activity will also be [ * ] with other [ * ] on [ * ] as has been done on [ * ]. (See table below.)

Studies [ * ] Activity [ * ] and [ * ]

*[ ]**	*[ ]**	Scope of Work	[ * ] Resources	*[ ]**
[ * ]	[ * ]	[ * ]	[ * ]	[ * ]
[ * ]	[ * ]	[ * ]	[ * ]	[ * ]
[ * ]	[ * ]	[ * ]	[ * ]	[ * ]

Key [ * ]

In addition, previous studies have shown that [ * ] to [ * ] on [ * ] by a [ * ] that is [ * ] from [ * ] and other [ * ] ([ * ]). These and further studies detailing [ * ] of [ * ] will also be used to guide [ * ] of [ * ] to [ * ] with [ * ]. The timing for completion of the studies in Table 1 is as follows:

· [ * ]: prior to [ * ] of the [ * ].

· [ * ]: prior to [ * ] of [ * ]

· [ * ]: prior to [ * ]

Finally, [ * ] studies which include [ * ] should be included to examine the [ * ] of [ * ] in the [ * ] responses. In addition, [ * ] studies (e.g., [ * ]) of [ * ] to a variety of [ * ] should be conducted.

[ * ]

Previous studies have shown that [ * ] has [ * ] activity on [ * ] when [ * ] to [ * ] or [ * ]. These studies will be [ * ] to [ * ] from [ * ] of [ * ] and also examined on [ * ]. In addition, studies suggest that [ * ] can [ * ] ([ * ]). [ * ] studies with [ * ] will be performed to see if the [ * ] of [ * ] by [ * ] it [ * ] to this [ * ] to [ * ].

[ * ] — [ * ] Studies

The following table outlines the planned [ * ] of [ * ] activity and [ * ]. The studies are designed to examine [ * ] in a [ * ] and when [ * ] serve as the [ * ] for [ * ].

[ * ] Activity

*[ ]**	*[ ]**	Resources
[ * ]	[ * ]	[ * ]
[ * ]*	[ * ]	[ * ]

* [ * ]

[ * ] Drug [ * ] Studies

As presented in the [ * ] section of this document, [ * ], particularly for [ * ], will involve [ * ] of [ * ] in [ * ]. Therefore, [ * ] work has begun to provide [ * ] for [ * ] likely to [ * ]. The figure below shows the [ * ] results of [ * ] with [ * ] on [ * ] of the [ * ] and on the [ * ]. [ * ] with [ * ] often giving [ * ] activity and [ * ] have been [ * ].

[ * ] with [ * ] on [ * ] by [ * ] Analysis

[ * ]

The tables below provide a summary of [ * ] experiments [ * ] and [ * ], respectively.

[ * ] Drug [ * ] Studies

*[ ]**	*[ ]**	Scope of work	[ * ] resources	*[ ]**
*[ ]**	*[ ]**	*[ ]**	*[ ]**	*[ ]**
*[ ]**	*[ ]**	*[ ]**	*[ ]**	*[ ]**
*[ ]**	*[ ]**	*[ ]**	*[ ]**	*[ ]**
*[ ]**	*[ ]**	*[ ]**	*[ ]**

Key: [ * ]

[ * ] Drug [ * ] Studies

*[ ]**	*[ ]**	*[ ]**	Notes
[ * ]	[ * ]	[ * ]	[ * ]
[ * ]	[ * ]	[ * ]	[ * ]
	[ * ]	[ * ]	[ * ]
	[ * ]	[ * ]	[ * ]
[ * ]	[ * ]	[ * ]	[ * ]
[ * ]	[ * ]	[ * ]
[ * ]	[ * ]	[ * ]
[ * ]	[ * ]	[ * ]
[ * ]	[ * ]	[ * ]
	[ * ]	[ * ]	[ * ]

Identification of [ * ] for [ * ] Study

Typically, attempts to identify [ * ] for [ * ] occur during the [ * ] of [ * ] investigation as they require [ * ] of [ * ] prior to [ * ] with the [ * ] and then [ * ] with [ * ]. [ * ] samples are used to [ * ] the [ * ]. These studies often require [ * ] and [ * ] such as [ * ], [ * ], [ * ], or [ * ] for [ * ] in [ * ].

However, [ * ] is [ * ] to [ * ] in [ * ] investigation and has [ * ] to [ * ] including those from [ * ] in the [ * ]. Studies will [ * ] to identify [ * ] of the [ * ] of [ * ] activity on [ * ] and then test [ * ] these [ * ] also [ * ]. [ * ] is creating [ * ] of these [ * ] for [ * ] studies. A similar strategy is contemplated for [ * ] such as [ * ].

If the current studies of [ * ] activity [ * ] that [ * ] from some [ * ] to [ * ] or in [ * ], then [ * ] will be [ * ] by:

· [ * ] whether the [ * ] has a [ * ] with [ * ] and [ * ] for [ * ] in [ * ] and

· [ * ] with [ * ] (e.g. [ * ]) that have [ * ] and [ * ] in place to [ * ] for [ * ] to [ * ].

The [ * ] status and [ * ] would then be [ * ] for [ * ] from [ * ] were [ * ] with [ * ] to [ * ] if the [ * ] of [ * ] do [ * ] with [ * ].

Additional [ * ] studies that have been identified:

· Examine [ * ] data for [ * ] on [ * ] and [ * ] to [ * ] to [ * ] or [ * ] a [ * ] of [ * ].

· Examine [ * ] of [ * ] following [ * ] with [ * ] to [ * ] with [ * ] (in [ * ] in [ * ])

· [ * ] studies to [ * ] with [ * ] in [ * ]:

· Examine [ * ] and [ * ] in [ * ]

· Examine [ * ] and [ * ] in [ * ] (e.g., [ * ] and [ * ] for [ * ], or other [ * ]).

[ * ] — [ * ]

[ * ]

[ * ]

Status: [ * ].

[ * ] have been [ * ] with [ * ], the [ * ] of [ * ], for the purposes of pursuing the following research:

1. Further defining [ * ] in [ * ].

a. Identification of [ * ] for [ * ].

b. Investigation of the [ * ].

c. Looking at [ * ] in [ * ] other [ * ], including those that [ * ], namely [ * ] and [ * ].

2. [ * ] model.

a. [ * ] including in [ * ].

b. Investigate [ * ].

c. Investigate role of [ * ] and [ * ].

i. [ * ].

ii. [ * ] of [ * ] such as with [ * ].

iii. If a role for [ * ] is determined, investigate the [ * ] of [ * ] in the model.

3. [ * ] model

a. Investigate [ * ] in a [ * ] model

b. Investigate [ * ] of [ * ]. If so, investigate whether this [ * ] for [ * ]

4. Investigate whether [ * ] is [ * ] by [ * ] than [ * ] due to [ * ].

5. Investigate whether [ * ] and [ * ] show [ * ].

a. If so, what is the [ * ]? Possibly [ * ] or [ * ].

Results from [ * ] were [ * ]:

Effect of [ * ] on [ * ] in [ * ] via [ * ] of the [ * ], [ * ].

The studies demonstrated that [ * ] in [ * ] occurs via [ * ] of [ * ]. This work demonstrates that [ * ] utilizes a [ * ] of [ * ] in [ * ] other [ * ] for [ * ]. Additionally, the data provides a [ * ] for the [ * ] of [ * ] ([ * ]) observed to date in [ * ].

[ * ]

[ * ]

Status: [ * ].

[ * ] will be [ * ] with [ * ], a [ * ]. This [ * ] is the [ * ] of the [ * ].

The [ * ] has [ * ] objectives.

1. The [ * ] activity of [ * ] will be studied [ * ] using [ * ] ([ * ]) and [ * ] ([ * ]) [ * ].

This [ * ] has been developed to [ * ] as [ * ] and [ * ] represent a [ * ] of [ * ]. This [ * ] has been utilized previously by [ * ] to examine the [ * ] of other [ * ] for [ * ], including [ * ] and [ * ] ([ * ]), [ * ] ([ * ]) and [ * ] ([ * ]).

2. The effects of [ * ] will be tested [ * ] and [ * ] with [ * ] to [ * ] of [ * ] in [ * ].

[ * ] will be [ * ] with (and [ * ]) [ * ], [ * ] or [ * ] into [ * ] (carrying [ * ]). [ * ] and [ * ] will be determined utilizing appropriate [ * ].

[ * ]

[ * ]

Status: [ * ].

[ * ] to use [ * ] technology to [ * ] some [ * ] and [ * ] in [ * ] to determine if [ * ] is [ * ] to [ * ]. Specifically, [ * ] and [ * ] will be explored using [ * ] for [ * ] analysis of [ * ] (e.g. [ * ] or [ * ])

[ * ]

[ * ]

Status: [ * ]. [ * ] plans to study the [ * ] of [ * ] and whether [ * ] by [ * ] renders it [ * ] to [ * ] by [ * ].

[ * ] for [ * ] and [ * ] ([ * ])

The major approach for [ * ] from [ * ] for [ * ] will involve [ * ] of [ * ] on [ * ] that have [ * ] and [ * ] of [ * ] between [ * ] and [ * ] on [ * ]. This [ * ] of [ * ] data that:

· [ * ] that [ * ] and [ * ] does [ * ] for the [ * ] ([ * ]), with [ * ] on more [ * ] such as [ * ]

· and that [ * ] may also be [ * ] on [ * ] such as [ * ] and some [ * ] and play a role in [ * ] ([ * ]; and [ * ] data on [ * ])

[* ] = Certain confidential information contained in this document, marked by brackets, has been omitted and filed separately with the Securities and Exchange Commission pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as amended.

Because [ * ] may [ * ] in the [ * ] of [ * ] such as [ * ], and [ * ], [ * ] on [ * ] could [ * ] of [ * ] from [ * ]. The following table outlines the [ * ] studies.

Another approach to [ * ] will be [ * ] of the [ * ] of [ * ] and [ * ] to [ * ] from [ * ] after [ * ] into [ * ].

[ * ] on [ * ] and the [ * ] of these studies, [ * ] demonstrating [ * ] on [ * ] by [ * ] in the [ * ] of [ * ] will be [ * ] for [ * ] with [ * ].

Studies to Examine [ * ] and [ * ]

*[ ]**	*[ ]**	*[ ]**	*[ ]**	*[ ]**
[ * ]	[ * ]	[ * ]	[ * ]	[ * ]
	[ * ]	[ * ]	[ * ]	[ ]
[ * ]	[ * ]	[ * ]	[ * ]	[ * ]
	[ * ]	[ * ]	[ * ]	[ ]
[ * ]	[ * ]	[ * ]	[ * ]	[ ]
[ * ]	[ * ]	[ * ]	[ * ]
[ * ]	[ * ]	[ * ]	[ * ]	[ * ]**

*[ * ] studies for [ * ] will involve studies on [ * ] and [ * ].

**Given that [ * ] does [ * ] with [ * ] or [ * ], examining [ * ] of [ * ] in [ * ] is [ * ]. As [ * ], [ * ] of [ * ] in the [ * ] would allow for the [ * ] of [ * ] and other [ * ] (e.g., [ * ]) [ * ]. [ * ] at [ * ] would be [ * ]. However, [ * ] is [ * ] of a [ * ] that may be [ * ] for [ * ] of experiments.

[ * ] studies will be undertaken to [ * ] the [ * ] by [ * ] can be [ * ] into [ * ]. [ * ] will be [ * ] to provide a [ * ]. The timing for [ * ] of these studies is as follows:

· [ * ] studies: Prior to [ * ]

· [ * ]: Prior to [ * ]

[ * ] — [ * ]

[ * ]

[ * ]

Status: [ * ]

[ * ] will develop [ * ] and [ * ] ([ * ]) [ * ] and [ * ] in [ * ]. In addition, a [ * ] will be [ * ] and [ * ] in [ * ] will be [ * ] in [ * ]. [ * ] will be [ * ], including [ * ].

[ * ] Costs

Estimated [ * ]

Dept		*[ ]**	*[ ]**	*[ ]**	*[ ]**
*[ ]**	[ * ]	[ * ]	[ * ]	[ * ]	[ * ]
	[ * ]			[ * ]	[ * ]
	[ * ]	[ * ]	[ * ]	[ * ]	[ * ]
		*[ ]**	*[ ]**	*[ ]**	*[ ]**

Estimated [ * ] Costs ([ * ] $)

Dept		*[ ]**	*[ ]**	*[ ]**	*[ ]**
*[ ]**	[ * ]		[ * ]	[ * ]	[ * ]
	[ * ]	[ * ]	[ * ]	[ * ]	[ * ]
	[ * ]		[ * ]	[ * ]	[ * ]
	[ * ]		[ * ]	[ * ]
	Total	*[ ]**	*[ ]**	*[ ]**	*[ ]**

EXHIBIT C

STOCK PURCHASE AGREEMENT

This Stock Purchase Agreement (this “Agreement”) is made and entered into as of August 27, 2009 (the “Execution Date”) by and between Trubion Pharmaceuticals, Inc., a Delaware corporation having a principal place of business at 2401 4th Avenue, Suite 1050, Seattle, Washington 98121 (including, unless the context otherwise requires, its subsidiaries, the “Company”), and Facet Biotech Corporation, a Delaware corporation having a principal place of business at 1500 Seaport Blvd., Redwood City, CA 94063 (“Purchaser”). The Company and Purchaser are sometimes referred to herein individually as a “Party” and collectively as the “Parties.”

RECITALS

WHEREAS, concurrently herewith, the Company and Purchaser have entered into an arrangement whereby Purchaser will license certain technology from the Company pursuant to that certain Collaboration and License Agreement dated as of the Execution Date (the “Collaboration Agreement”); and

WHEREAS, in connection with the transactions contemplated by the Collaboration Agreement, the Company and Purchaser each desire for Purchaser to purchase from the Company newly issued shares of the Company’s common stock, $0.001 par value per share (the “Common Stock”), in the amounts and on the terms and conditions set forth in this Agreement.

AGREEMENT

NOW, THEREFORE, in consideration of the foregoing recitals and the following mutual promises and covenants, the Parties agree as follows:

1. AUTHORIZATION AND SALE OF SHARES

1.1 Authorization. The Company has authorized the issuance and sale of the shares of Common Stock pursuant to the terms and conditions of this Agreement.

1.2 Issuance and Sale. Subject to the terms and conditions of this Agreement, on the Closing Date (as defined in Section 2.1(a)), the Company shall issue and sell to Purchaser, and Purchaser shall purchase from the Company 2,243,649 shares of Common Stock (the “Shares”) for an aggregate purchase price of Ten Million Dollars ($10,000,000). In the event of any stock split, stock dividend, combination of shares, recapitalization or other change in the structure of the Company prior to the Closing Date that affects or relates to the Common Stock, the number of Shares shall be adjusted proportionately.

2. CLOSING; CLOSING DELIVERIES

2.1 Closing.

(a) Closing Date. The closing of the purchase and sale of the Shares as contemplated in this Agreement (the “Closing”) and the delivery of documents contemplated to be delivered at the Closing shall take place at 10:00 a.m. Pacific Time on the date which is 3 business days after the date on which all conditions to the obligations of the Parties to consummate the transactions hereunder regarding the Shares shall have been satisfied and/or waived, or such other place or later time as Purchaser and the Company shall agree (the date on which the Closing occurs being referred to herein as the “Closing Date”).

(b) Location of Closing. The Closing shall be held at the Company’s principal offices, 2401 4th Avenue, Suite 1050, Seattle, Washington 98121, or at such other place as the Company and Purchaser may agree in writing.

2.2 Closing Deliveries.

(a) Deliveries by the Company. Subject to the terms and conditions of this Agreement, at the Closing the Company shall deliver to Purchaser:

(i) a copy of irrevocable instructions from the Company to the Company’s stock transfer agent dated no later than the Closing Date, which directs the Company’s transfer agent to prepare and deliver to Purchaser a stock certificate representing the Shares as soon as practicable following the Closing;

(ii) a legal opinion of counsel to the Company in a form reasonably acceptable to counsel for Purchaser, dated as of the Closing Date;

(iii) a certificate executed by the Company’s Chief Executive Officer and Senior Vice President, General Counsel and Corporate Secretary, dated as of the Closing Date, to the effect that the conditions set forth in Sections 7.1(a) and 7.1(b) have been satisfied.

(b) Deliveries by Purchaser. Subject to the terms and conditions of this Agreement, at the Closing, Purchaser shall deliver to the Company:

(i) Ten Million Dollars ($10,000,000) by wire transfer in immediately available funds to such account as the Company may notify Purchaser in writing (including by email) at least two trading days prior to the Closing Date; and

(ii) a certificate executed by an executive officer of Purchaser, dated as of the Closing Date, to the effect that the conditions set forth in Sections 7.2(a) and 7.2(b) have been satisfied.

3. REPRESENTATIONS AND WARRANTIES OF THE COMPANY

3.1 Representations and Warranties. Except as set forth in the Disclosure Schedule delivered by the Company to Purchaser prior to the execution of this Agreement (the “Company Disclosure Schedule”), and then to the extent the Company Disclosure Schedule specifically

identifies each exception by specific subsection references (it being understood that any information disclosed therein shall be deemed to be disclosed and incorporated in any other section where such disclosure would be appropriate and reasonably apparent), the Company hereby represents and warrants the following as of the Execution Date and as of the Closing Date:

(a) Corporate Organization and Authority. The Company:

(i) is a corporation duly organized, validly existing and in good standing under the laws of the State of Delaware;

(ii) has the corporate power and authority to own, lease and operate its properties and to carry on its business as now conducted and as proposed to be conducted;

(iii) has the corporate power and authority to enter into this Agreement and to carry out the transactions contemplated herein; and

(iv) is qualified as a foreign corporation and in good standing in all jurisdictions in which such qualification is required, except for any such jurisdiction in which the Company’s failure to qualify would not have a Material Adverse Effect (as defined in Section 3.1(c)(ii)).

(b) Authorization. All necessary corporate action on the part of the Company for the execution and delivery of this Agreement and the issuance and delivery of the Shares being issued on the Closing Date has been taken. This Agreement constitutes a valid and legally binding obligation of the Company enforceable in accordance with its terms.

(c) No Conflicts; Required Filings.

(i) The performance by the Company of this Agreement and the transactions contemplated herein do not violate, conflict with or constitute a default under, and will not result in any violation of, be in conflict with or constitute a default under, with or without the passage of time or the giving of notice of (1) any provision of the Company’s charter or bylaws as in effect on the Execution Date and the Closing Date; (2) any provision of any judgment, decree or order to which the Company is a party or by which it or any of its properties is bound; (3) any contract, obligation or commitment to which the Company is a party or by which it or any of its properties is bound, which violation or default would, individually or in the aggregate, have a Material Adverse Effect; or (4) any statute, rule or governmental regulation applicable to the Company, which violation or default would, individually or in the aggregate, (A) prevent or materially delay consummation of the transaction contemplated under this Agreement, (B) otherwise have a material adverse effect on the ability of the Company to perform its obligations under this Agreement or (C) individually or in the aggregate, result in any change, event, development, effect or condition that is or is reasonably likely to be materially adverse to the assets, liabilities, business, financial condition or results of operations of the Company and its subsidiaries, taken as a whole (each of the foregoing items in (A), (B) or (C) being referred to herein as “Material Adverse Effect”).

100

(ii) The execution, delivery and performance by the Company of this Agreement and the transactions contemplated herein do not and will not require any consent, approval, authorization or permit of, or filing with or without notification to, any governmental or regulatory authority, United States or foreign, except for applicable requirements, if any, of the Securities Act of 1933, as amended (the “Securities Act”) and the Securities Exchange Act of 1934, as amended, including the rules and regulations promulgated thereunder (the “Exchange Act”), or securities laws of the various states of the United States (the “Blue Sky Laws”).

(d) Capital Stock.

(i) As of August 26, 2009 (the “Capitalization Date”), the authorized capital stock of the Company consisted of 150,000,000 shares of Common Stock, $0.001 par value per share, of which 18,110,515 shares were issued and outstanding. As of the Capitalization Date, 2,403,375 shares of Common Stock were reserved for issuance under outstanding stock options pursuant to the Company’s stock option plans, and 1,780,016 shares were reserved for future issuance in connection with the Company’s stock option plans. All of the outstanding shares of the Company’s capital stock are validly issued, fully paid and nonassessable and were issued in compliance with all applicable federal and state securities laws, except as would not have a Material Adverse Effect. Except as described above and as set forth in the SEC Reports (as defined in Section 3.1(f)(i)), (1) the Company has not agreed to register the sale of any of its securities under the Securities Act and (2) there are no outstanding subscriptions, options, warrants, calls, contracts, demands, commitments, conversion rights or other agreements or arrangements of any character or nature whatever under which the Company is or may be obligated to issue its Common Stock, preferred stock or warrants, options or other securities exercisable for the purchase of, convertible into or exchangeable or extinguishable for, Common Stock or preferred stock.

(ii) The Company has reserved a sufficient number of shares of Common Stock for issuance to Purchaser in accordance with the Company’s obligations under this Agreement.

(iii) Except as disclosed in the SEC Reports, there are no outstanding contractual obligations of the Company (1) restricting the transfer of, (2) affecting the voting rights of, (3) requiring the repurchase, redemption or disposition of, or containing any right of first refusal with respect to, (4) requiring the registration for sale of, or (5) granting any preemptive or antidilutive right with respect to, any Common Stock or any capital stock of, or other equity interests of, the Company. Except as disclosed in the SEC Reports, there are no outstanding contractual obligations of the Company or any subsidiary of the Company to provide material funds to, or make any material investment (in the form of a loan, capital contribution or otherwise) in, any subsidiary of the Company or any other person, other than guarantees by the Company of any indebtedness or other obligations of any wholly-owned subsidiary of the Company.

(e) Validity of Shares. The Shares issued on the Closing Date, when issued, sold and delivered in accordance with the terms and for the consideration set forth in this Agreement, shall be duly and validly issued and outstanding, fully paid, nonassessable and free and clear of all security interests, pledges, mortgages, liens, taxes, proxies, charges, adverse claims of ownership or use, and restrictions, including preemptive rights, rights of first refusal and other

101

similar rights, restrictions on the resale, use, voting, receipt of income or other exercise of any attributes of ownership and restrictions on transfer, defects of title or other encumbrance of any kind or character entitling any person to purchase or acquire an ownership interest in any of such Shares, other than restrictions on transfer set forth in this Agreement and under federal and state securities laws.

(f) SEC Filings; Financial Statements.

(i) The Company has timely filed all forms, reports and documents required to be filed by it with the Securities and Exchange Commission (the “SEC”) and has heretofore made available to Purchaser, in the form filed with the SEC, its: (1) most recent Annual Report on Form 10-K and Quarterly Report on Form 10-Q; (2) most recent proxy statement for the annual meeting of stockholders and (3) all Current Reports on Form 8-K filed with the SEC since the date of the Company’s most recent report on Form 10-Q, if any (collectively, the “SEC Reports”). The SEC Reports: (A) complied as to form in all material respects in accordance with the requirements of the Exchange Act and (B) did not at the time they were filed contain any untrue statement of a material fact or omit to state a material fact required to be stated therein or necessary in order to make the statements therein, in light of the circumstances under which they were made, not misleading. Except to the extent that information contained in any SEC Report has been updated, revised, supplemented or amended by a later-filed SEC Report, none of the SEC Reports contains, as of the Execution Date or as of the Closing Date, as applicable, an untrue statement of material fact or omits to state a material fact required to be stated therein or necessary in order to make the statements therein, in light of the circumstances under which they were made, not misleading. As of the date of this Agreement, no subsidiary of the Company is subject to the reporting requirements of the Exchange Act.

(ii) Each of the financial statements (including, in each case, any notes thereto) contained in the SEC Reports (collectively, the “Financial Statements”): (1) complied as to form in all material respects with the published rules and regulations of the SEC applicable thereto; (2) were prepared in accordance with generally accepted accounting principles applied on a consistent basis throughout the periods covered (except as may be indicated in the notes to such financial statements or, in the case of unaudited statements, as permitted by Form 10-Q of the SEC, and except that the unaudited financial statements may not contain footnotes and are subject to normal and recurring year-end adjustments that did not and will not, individually or in the aggregate, be material in amount); and (3) fairly present the consolidated financial position of the Company as of the respective dates thereof and the consolidated results of operations and cash flows of the Company for the periods covered thereby. The books and records of the Company have been and are being maintained in accordance with applicable material legal and accounting requirements. The auditors who have certified the financial statements of the Company contained in the SEC Reports are registered public accounting firms as required by the Securities Act and the Exchange Act and the rules and regulations under the Securities Act and the Exchange Act. Except as disclosed in the SEC Reports or set forth in the Financial Statements, and except for matters which are not, individually or in the aggregate, reasonably expected to have a Material Adverse Effect, the Company has no obligations or liabilities, whether or not accrued, contingent or otherwise and whether or not required to be disclosed.

102

(g) Absence of Certain Changes. Except as disclosed in the SEC Reports, since June 30, 2009, there has been no event, occurrence or development that has had or that would reasonably be expected to result in a Material Adverse Effect, and the Company has not (i) varied its business plan or practices, in any material respect, from past practices, (ii) entered into any material financing, joint venture, license or similar arrangements or (iii) suffered or permitted to be incurred any liability or obligation against any of its properties or assets that would limit or restrict its ability to perform its obligations hereunder.

(h) Sarbanes-Oxley. There is and has been no failure on the part of the Company or any of the Company’s directors or officers, in their capacities as such, to comply in all material respects with any provision of the Sarbanes-Oxley Act of 2002 and the rules and regulations promulgated in connection therewith (the “Sarbanes-Oxley Act”), including Section 402 related to loans and Sections 302 and 906 related to certifications.

(i) Disclosure Controls. The Company maintains “disclosure controls and procedures” (as defined in Rule 13a-15(e) of the Exchange Act) designed to ensure that information required to be disclosed by the Company in reports that it files or submits under the Exchange Act is recorded, processed, summarized and reported within the time periods specified in the SEC’s rules and forms. The Company’s management (with the participation of its principal executive officer and the principal financial officer) have evaluated the effectiveness of the Company’s disclosure controls and procedures as of the end of the period covered by the Company’s Annual Report on Form 10-K for the fiscal year ended December 31, 2008 and as of the end of the periods covered by the Company’s Quarterly Reports on Form 10-Q for the periods ended March 31, 2009 and June 30, 2009, and its principal executive officer and principal financial officer have concluded that such disclosure controls and procedures are effective to ensure that information required to be disclosed by the Company in reports that it files or submits under the Exchange Act is recorded, processed, summarized and reported within the time periods specified in the rules and forms of the SEC.

(j) Internal Control Over Financial Reporting. The Company maintains “internal control over financial reporting” (as defined in Rule 13a-15(f) of the Exchange Act) that complies with the requirements of the Exchange Act and has been designed to provide reasonable assurance regarding the reliability of financial reporting and the preparation of financial statements for external purposes in accordance with generally accepted accounting principles. Except as disclosed in the SEC Reports, there are no material weaknesses in the design or operation of the Company’s internal control over financial reporting which are reasonably likely to adversely affect the Company’s ability to record, process, summarize and report financial information that have come to the attention of the Company’s management.

(k) Private Offering. Subject to the accuracy of Purchaser’s representations set forth in Section 4.1(c), Section 4.1(f) and Section 4.1(g), the offer, sale and issuance of the Shares in accordance with the terms of this Agreement is in compliance with all applicable laws, exempt from the registration requirements of Section 5 of the Securities Act and exempt from applicable state registration or qualification requirements, other than those with which the Company has complied or will comply.

103

(l) Subsidiaries. Except as disclosed in the SEC Reports, the Company does not presently own or control, directly or indirectly, any interest in any other corporation, partnership, trust, joint venture, association or other entity.

(m) Permits; Compliance With Law. The Company is in possession of all material authorizations, licenses, permits, certificates, approvals and clearances, and has submitted notices to, all governmental entities (including all authorizations under the Federal Food, Drug and Cosmetic Act of 1938, as amended (the “FDCA”), and the regulations of the United States Food and Drug Administration (the “FDA”) promulgated thereunder) necessary for the Company to own, lease and operate its properties or other assets and to carry on its business in the manner described in the SEC Reports (the “Company Permits”), and all such Company Permits are valid, and in full force and effect, except where the failure to have, or the suspension or cancellation of, or failure to be valid or in full force and effect of, any of the Company Permits would not, individually or in the aggregate, reasonably be expected to have a Material Adverse Effect. The Company is not in conflict with, or in default or violation of, (1) any federal, state, local or foreign statute, law, ordinance, regulation, rule, code, order, judgment, writ, stipulation, award, injunction, decree or arbitration award or finding or rule of common law applicable to the Company or by which any property or asset of the Company is bound or affected, including, but not limited to, rules and regulations promulgated by the FDA, laws, rules and regulations relating to the protection of human health and safety, the environment or hazardous or toxic substances and the Employee Retirement Income Security Act of 1974, as amended, including the regulations and published interpretations thereunder (each of the foregoing collectively referred to as “Law”) or (2) any Company Permits, except in the case of the foregoing (1) or (2) for any such conflicts, defaults or violations that would not, individually or in the aggregate, reasonably be expected to result in a Material Adverse Effect.

(n) Intellectual Property. The Company owns or possesses adequate rights or licenses to use all material trademarks, trade names, service marks, service mark registrations, service names, patents, patent rights, copyrights, inventions, licenses, approvals, governmental authorizations, trade secrets and rights (the “Proprietary Rights”) necessary to conduct its business as described in the SEC Reports, except where the failure to so own or possess such Proprietary Rights will not, singularly or in the aggregate, have a Material Adverse Effect. The Company takes commercially reasonable security measures to provide adequate trade secret protection in its non-patented technology. Except as disclosed in the SEC Reports, the Company does not have any knowledge of any infringement by the Company of any Proprietary Rights of others which could reasonably be expected to result in a Material Adverse Effect, and, except as disclosed in the SEC Reports, there is no claim, action or proceeding being made or brought against, or to the Company’s knowledge, being threatened against, the Company regarding the infringement by the Company of the Proprietary Rights of others that, if successful, could reasonably be expected to have a Material Adverse Effect. Except as disclosed in the SEC Reports, the Company is not subject to any judgment, order, writ, injunction or decree of any court or any Federal, state, local, foreign or other governmental department, commission, board, bureau, agency or instrumentality, domestic or foreign, or any arbitrator, nor, has it entered into or is a party to any contract which restricts or impairs the use of any such Proprietary Rights in a manner which would have a Material Adverse Effect. The Company has complied, in all material respects, with its respective contractual obligations relating to the protection of the

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Proprietary Rights used pursuant to licenses, except as would not have a Material Adverse Effect. Except as disclosed in the SEC Reports, to the knowledge of the Company, no person is infringing on or violating the Proprietary Rights owned or used by the Company in a manner that could reasonably be expected to have a Material Adverse Effect.

(o) Environmental Laws. The Company (i) is in compliance with all applicable foreign federal, state and local laws and regulations relating to the protection of human health and safety, the environment or hazardous or toxic substances or wastes, pollutants or contaminants (“Environmental Laws”), (ii) has received all permits, licenses or other approvals required of them under applicable Environmental Laws to conduct its business and (iii) is in compliance with all terms and conditions of any such permit, license or approval where, in each of the three foregoing clauses, the failure to so comply would have, individually or in the aggregate, a Material Adverse Effect.

(p) NASDAQ Compliance. The Common Stock is registered pursuant to Section 12(b) of the Exchange Act and is listed on the NASDAQ Global Market, and the Company has taken no action designed to, or likely to have the effect of, terminating the registration of the Common Stock under the Exchange Act or delisting the Common Stock from the NASDAQ Global Market.

(q) Contracts. Except as disclosed in the SEC Reports and except for matters which are not reasonably likely to have a Material Adverse Effect, the contracts listed as exhibits to the SEC Reports that are material to the Company are in full force and effect, and neither the Company nor, to the Company’s knowledge, any other party to such contracts is in material breach of or default under any of such contracts.

(r) No Manipulation of Stock. The Company has not taken and will not, in violation of applicable Law, take any action outside the ordinary course of business designed to or that might reasonably be expected to cause or result in unlawful manipulation of the price of the Common Stock.

(s) Taxes. The Company has filed all federal, state and local income and franchise tax returns required to be filed and has paid all taxes due thereon, and no tax deficiency has been determined adversely to the Company which has had (nor does the Company have any knowledge of any tax deficiency which, if determined adversely to the Company would reasonably be expected to have) a Material Adverse Effect.

(t) Title to Assets. The Company has good title to or a valid leasehold interest in all of its properties that are material to its business, in each case free and clear of any lien, charge, claim, security interest, encumbrance, right of first refusal or other restriction (“Liens”), except for (1) statutory liens not yet delinquent which are being contested in good faith by appropriate proceedings, and liens for taxes not yet due, (2) pledges of assets in the ordinary course of business to secure public deposits, (3) defects and irregularities of title and encumbrances that do not materially impair the use thereof for the purposes for which they are held, (4) mechanics’, materialmen’s, workmen’s, repairmen’s, warehousemen’s, carriers’ and other similar liens arising in the ordinary course of business, (5) properties and assets the loss of which would not,

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individually or in the aggregate, have a Material Adverse Effect, and (6) Liens disclosed in the SEC Reports.

(u) Transfer Taxes. All stock transfer or other taxes (other than income taxes) which are required to be paid in connection with the sale and transfer of the Shares to be sold to Purchaser hereunder will be, or will have been, fully paid or provided for by the Company and all laws imposing such taxes will be or will have been fully complied with.

(v) Transactions With Affiliates. No relationship, direct or indirect, exists between or among the Company, on the one hand, and the directors, officers or stockholders of the Company, on the other hand, which is required to be described in the SEC Reports which is not so described.

(w) No Brokers. The Company has taken no action which would give rise to any claim by any person for brokerage commissions, finder’s fees or similar payments relating to this Agreement.

(x) Investment Company. The Company is not an “investment company” or an “affiliated person” of, or “promoter” or “principal underwriter” for an investment company, within the meaning of the Investment Company Act of 1940, as amended.

(y) Private Placement. Neither the Company nor any of its subsidiaries or affiliates, nor any person acting on its or their behalf, (i) has engaged in any form of general solicitation or general advertising (within the meaning of Regulation D under the Securities Act) in connection with the offer or sale of the Common Stock, (ii) has, directly or indirectly, made any offers or sales of any security or solicited any offers to buy any security, under any circumstances that would require registration of the Shares under the Securities Act or (iii) has issued any shares of Common Stock or shares of any series of preferred stock or other securities or instruments convertible into, exchangeable for or otherwise entitling the holder thereof to acquire shares of Common Stock which would be integrated with the sale of the Shares to Purchaser for purposes of the Securities Act or of any applicable stockholder approval provisions, including, without limitation, under the rules and regulations of any exchange or automated quotation system on which any of the securities of the Company are listed or designated, nor will the Company or any of its subsidiaries or affiliates take any action or steps that would require registration of any of the Shares under the Securities Act or cause the offering of the Shares to be integrated with other offerings. Assuming the accuracy of the representations and warranties of Purchaser, the offer and sale of the Shares by the Company to Purchaser pursuant to this Agreement will be exempt from the registration requirements of the Securities Act.

(z) Litigation. Except as disclosed in the SEC Reports, there is no legal action, suit, arbitration or other legal, administrative, arbitration or governmental proceeding pending or, to the Company’s knowledge, threatened against the Company that could reasonably be expected to have a Material Adverse Effect.

(aa) Employees. Except as disclosed in the SEC Reports, (i) the Company is not aware that any executive officer or key employee, or that any group of executive officers or key employees, intends to terminate their employment with the Company, (ii) the Company does not have any

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present intention to terminate the employment of any executive officer, key employee or group of key employees and (iii) the Company is in compliance with all federal, state, local and foreign laws and regulations respecting employment and employment practices, terms and conditions of employment and wages and hours, in each case where such terminations or non-compliance could reasonably be expected to have a Material Adverse Effect.

(bb) Application of Takeover Protections. There is no control share acquisition, business combination, poison pill (including any distribution under a rights agreement) or other similar anti-takeover provision under the Company’s charter documents or the laws of its state of incorporation that is or could become applicable to Purchaser as a result of Purchaser and the Company fulfilling their obligations or exercising their rights under this Agreement, including, without limitation, as a result of the Company’s issuance of the Common Stock and Purchaser’s ownership of the Common Stock.

(cc) Reporting Status; Eligibility to Use Form S-3. The Common Stock is registered under Section 12(b) of the Exchange Act. The Company currently meets the “registrant eligibility” requirements set forth in the general instructions to Form S-3 to enable the registration of the Common Stock.

(dd) Disclosure. None of the representations or warranties of the Company contained herein and the information contained in the Company Disclosure Schedule, when taken as a whole, contains any untrue statement of a fact or omits to state a fact required to be stated herein or therein necessary to make the statements herein or therein, in light of the circumstances under which they were made, not misleading, except for facts which are disclosed in the SEC Reports or are not reasonably likely to have a Material Adverse Effect.

4. REPRESENTATIONS AND WARRANTIES OF PURCHASER; RESTRICTIONS ON TRANSFER OF THE SHARES

4.1 Representations and Warranties. Purchaser hereby represents and warrants to the Company the following:

(a) Authorization. All necessary corporate action on the part of Purchaser for the execution, delivery and performance of its obligations under this Agreement and for the consummation of the transactions contemplated hereby has been taken. This Agreement constitutes a valid and legally binding obligation of Purchaser enforceable in accordance with its terms.

(b) Corporate Organization and Authority. Purchaser is a corporation duly organized, validly existing, and in good standing under the laws of the State of Delaware. Purchaser has the corporate power, authority and capacity to execute and deliver this Agreement and to perform its obligations under this Agreement and any document contemplated to be delivered hereby.

(c) Purchase Entirely for Own Account. This Agreement is made with Purchaser in reliance upon Purchaser’s representation to the Company, which by Purchaser’s execution of this Agreement Purchaser hereby confirms, that the Shares to be purchased by Purchaser will be acquired for investment for Purchaser’s own account, not as a nominee or agent, and not with a view to the resale or distribution of any part thereof. Purchaser has no present intention of

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selling, granting any participation in or otherwise distributing the same. By executing this Agreement, Purchaser further represents that Purchaser does not presently have any contract, undertaking, agreement or arrangement with any person to sell, transfer or grant participations to such person or to any third person, with respect to any of the Shares and Purchaser has not been formed for the specific purpose of acquiring the Shares.

(d) Restricted Securities. Purchaser understands that the Shares have not been, and will not be, registered under the Securities Act, by reason of a specific exemption from the registration provisions of the Securities Act, which depends upon, among other things, the bona fide nature of the investment intent and the accuracy of Purchaser’s representations as expressed in Section 4.1(c). Purchaser understands that the Shares are “restricted securities” under applicable U.S. federal and state securities laws and that, pursuant to these laws, Purchaser must hold the Shares indefinitely unless they are registered with the SEC and qualified by state authorities, or an exemption from such registration and qualification requirements is available. Purchaser further acknowledges that if an exemption from registration or qualification is available, it may be conditioned on various requirements including, but not limited to, the time and manner of sale, the holding period for the Shares, and on requirements relating to the Company that are outside of Purchaser’s control.

(e) Legend. Purchaser understands that the Shares may bear the following legend:

THESE SECURITIES HAVE NOT BEEN REGISTERED WITH THE SECURITIES AND EXCHANGE COMMISSION OR THE SECURITIES COMMISSION OF ANY STATE IN RELIANCE UPON AN EXEMPTION FROM REGISTRATION UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE “SECURITIES ACT”), AND, ACCORDINGLY, MAY NOT BE OFFERED OR SOLD OR OTHERWISE TRANSFERRED, PLEDGED OR HYPOTHECATED EXCEPT PURSUANT TO AN EFFECTIVE REGISTRATION STATEMENT UNDER THE SECURITIES ACT OR PURSUANT TO AN AVAILABLE EXEMPTION FROM, OR IN A TRANSACTION NOT SUBJECT TO, THE REGISTRATION REQUIREMENTS OF THE SECURITIES ACT AND IN ACCORDANCE WITH APPLICABLE STATE SECURITIES LAWS AS EVIDENCED BY A LEGAL OPINION OF COUNSEL TO THE TRANSFEROR TO SUCH EFFECT, THE SUBSTANCE OF WHICH SHALL BE REASONABLY ACCEPTABLE TO THE COMPANY.

(f) Accredited Investor. Purchaser is an accredited investor as defined in Rule 501(a) of Regulation D promulgated under the Securities Act.

(g) Investment Experience. Purchaser has such knowledge and experience in financial and business matters that Purchaser is capable of evaluating the merits and risks of the investment in the Shares.

(h) Trading in Company Common Stock. Since January 1, 2009, except pursuant to this Agreement, neither Purchaser nor any affiliate of Purchaser has directly, or indirectly through an agent, broker, financial advisor or other third party, sold, bought, made any short sale of, loaned, granted or received any option for the purchase or sale of, or otherwise directly acquired or disposed of any securities of the Company, whether on the NASDAQ Global Market or otherwise.

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5. COVENANTS OF THE COMPANY

The Company covenants and agrees with Purchaser that from and after the Execution Date:

5.1 Registration Rights.

(a) At any time after the date that is six (6) months after the Execution Date, upon the written request of Purchaser, the Company shall prepare and file, as expeditiously as reasonably possible, a registration statement under the Securities Act (“Registration Statement”) on Form S-3 (“Form S-3”) covering the resale of the Shares. In the event that Form S-3 is unavailable for such a registration, then the Company will (i) file a Registration Statement on such form as is then available to effect a registration of all of the Shares, and (ii) undertake to register the Shares on Form S-3 as soon as such form is available, provided that the Company shall maintain the effectiveness of the Registration Statement then in effect until such time as a Registration Statement on Form S-3 covering the Shares has been declared effective by the SEC. The Company shall use its reasonable best efforts to have the Registration Statement declared effective by the SEC as soon as practicable. On the business day following the effective date of such Registration Statement, the Company shall file with the SEC in accordance with Rule 424 under the Securities Act the final prospectus to be used in connection with sales pursuant to such Registration Statement. If for any reason the SEC does not permit all of the Shares to be included in such Registration Statement, or for any other reason any Shares are not then included in a Registration Statement filed pursuant to this Agreement, then the Company shall prepare, and, as soon as practicable, file with the SEC an additional Registration Statement covering the resale of all Shares not already covered by an existing and effective Registration Statement for an offering to be made on a continuous basis pursuant to Rule 415. The Company shall use its reasonable best efforts to cause each such Registration Statement to be declared effective under the Securities Act as soon as possible. On the business day following the effective date of such Registration Statement, the Company shall file with the SEC in accordance with Rule 424 under the Securities Act the final prospectus to be used in connection with sales pursuant to such Registration Statement.

(b) If, at any time before October 17, 2015, the Company decides to register any of its securities for its own account or for the account of others, then the Company will promptly give Purchaser written notice thereof and will use its reasonable best efforts to include in such registration all or any part of the Shares requested by Purchaser to be included therein. This requirement does not apply to Company registrations on Form S-4 or S-8 or their equivalents relating to equity securities to be issued solely in connection with an acquisition of any entity or business or equity securities issuable in connection with stock option or other employee benefit plans. Purchaser must give its request for registration under this paragraph to the Company in writing within 15 days after receipt from the Company of notice of such pending registration. If the registration for which the Company gives notice is an underwritten public offering, the Company will so advise Purchaser as part of the above-described written notice. If the managing underwriter of any proposed underwritten public offering advises the Company that the total amount of shares of Common Stock that Purchaser and any other persons intend to include in such offering exceeds the number that can be sold in such offering without being likely to have an adverse effect on the price, timing or distribution of the Common Stock offered or the market

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for the Common Stock, then the shares of Common Stock to be included in such underwritten offering shall include the number of shares of Common Stock that such managing underwriter advises the Company can be sold without having such adverse effect, with such number to be allocated (i) first, among the Company and the investors who are party to that certain Amended and Restated Investor Rights Agreement, dated July 13, 2004 (the “Existing IRA”), by and among the Company and the investors set forth on Exhibit A thereto, pursuant to the terms thereof; (ii) second, to Purchaser; and (iii) third, to any other person holding Company securities who may also be including any such securities for sale in such underwritten offering. No registration rights that further limit or subordinate the rights of Purchaser to register the Shares will be granted by the Company until one or more registration statements covering all of the Shares have become effective.

(c) The Company will file all reports required to be filed by the Company with the SEC in a timely manner so as to preserve its eligibility for the use of Form S-3.

5.2 Consents. The Company shall use its commercially reasonable efforts to procure, in a timely manner upon reasonable terms and conditions, all consents and approvals, complete all filings, registrations and certificates, and satisfy all other requirements prescribed by Law, which are necessary to consummate the transactions contemplated in this Agreement prior to the Closing Date.

5.3 Cooperation. The Company shall cooperate fully, completely and promptly with Purchaser in connection with satisfying all conditions to, and effecting the transactions contemplated by, this Agreement.

5.4 Commercially Reasonable Efforts. The Company shall use its commercially reasonable efforts to cause the conditions set forth in Sections 7.1 and 7.3 to be satisfied on or prior to the Closing Date.

5.5 Further Assurances. The Company agrees to use its commercially reasonable efforts to take, or cause to be taken, any appropriate action, and do, or cause to be done, all things necessary, proper or advisable under any applicable Law to consummate and make effective the sale and assignment of the Shares contemplated by this Agreement as promptly as practicable after the Execution Date.

5.6 Operation of Business. The Company agrees prior to the Closing to (a) maintain its existence in good standing under applicable Law, (b) conduct its operations in all material respects only in the ordinary and usual course of business consistent with past practice and (c) not take any action or establish a record date for the taking of any action with respect to any stock split, stock dividend, combination of shares, recapitalization or other change in the structure of the Company which affects or relates to the Common Stock.

5.7 Form D; Blue Sky Laws. The Company will timely file a Notice of Sale of Securities on Form D with respect to the Shares, under Regulation D promulgated by the Commission under the Securities Act. The Company will, on or before the Closing Date, take such action as it reasonably determines to be necessary to qualify the Shares for sale to Purchaser under this

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Agreement under applicable securities (or “blue sky”) laws of the states of the United States (or to obtain an exemption from such qualification).

5.8 Issuance of Certificates. The Company will, or will instruct its transfer agent to, issue certificates registered in the name of Purchaser or its nominee, for the Shares. All such certificates will bear the restrictive legend described in Section 4.1(e), except as otherwise specified in Section 5.9. The Company will not give to its transfer agent any instruction other than as described in this Section 5.8 and Section 5.9 and stop transfer instructions to give effect to Section 4.1(e) (prior to registration of the Shares under the Securities Act). Nothing in this Section 5.8 and Section 5.9 affects in any way Purchaser’s obligation to comply with all applicable prospectus delivery requirements, if any, upon resale of the Shares.

5.9 Unrestricted Securities. If, unless otherwise required by applicable state securities laws, (a) the Shares represented by a certificate have been registered under an effective Registration Statement, (b) Purchaser and/or its nominee provides the Company and its transfer agent with an opinion of counsel, in form, substance and scope customary for opinions of counsel in comparable transactions, to the effect that a public sale or transfer of such Shares may be made without registration under the Securities Act and such sale may occur without restriction on the manner of such sale or transfer, (c) such holder provides the Company and its transfer agent with reasonable assurances that such Shares can be sold under Rule 144 promulgated by the SEC pursuant to the Securities Act, as such Rule may be amended from time to time, or any similar rule or regulation hereafter adopted by the SEC having substantially the same effect as such Rule (“Rule 144”), or (d) the Shares represented by a certificate can be sold without restriction as to the number of securities sold under Rule 144, the Company will permit the transfer of the Shares, and the Company will instruct its transfer agent to issue one or more certificates, free from any restrictive legend, in such name and in such denominations as specified by such holder. Notwithstanding anything herein to the contrary, the Shares may be pledged as collateral in connection with a bona fide margin account or other lending arrangement; provided, that such pledge will not alter the provisions of this Section 5.9 with respect to the removal of restrictive legends.

6. COVENANTS OF PURCHASER

Purchaser covenants and agrees with the Company that from and after the Execution Date:

6.1 Consents. Purchaser shall use its commercially reasonable efforts to procure, in a timely manner upon reasonable terms and conditions, all consents and approvals, complete all filings, registrations and certificates, and satisfy all other requirements prescribed by Law, which are necessary to consummate the transactions contemplated in this Agreement.

6.2 Cooperation. Purchaser shall cooperate fully, completely and promptly with the Company in connection with satisfying all conditions to, and effecting the transactions contemplated by, this Agreement.

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6.3 Commercially Reasonable Efforts. Purchaser shall use its commercially reasonable efforts to cause the conditions set forth in Section 7.2 and Section 7.3 to be satisfied on or prior to the Closing Date.

6.4 Further Assurances. Purchaser agrees to use its commercially reasonable efforts to take, or cause to be taken, any appropriate action, and do, or cause to be done, all things necessary, proper or advisable under any applicable Law to consummate and make effective the sale and assignment of the Shares contemplated by this Agreement as promptly as practicable after the Execution Date.

7. CLOSING CONDITIONS

7.1 Conditions to Obligations of Purchaser at Closing. At the Closing, the obligation of Purchaser to purchase the Shares shall be subject to the satisfaction or Purchaser’s waiver, on or prior to the Closing Date, of each of the following conditions:

(a) Each of the representations and warranties of the Company contained in this Agreement shall be true and correct in all material respects.

(b) All covenants, agreements and conditions contained in this Agreement to be performed by the Company on or prior to the Closing Date shall have been performed or complied with in all material respects at or prior to the Closing Date. The Company shall have obtained any and all consents and waivers necessary or appropriate for the consummation of the transactions contemplated by this Agreement.

(c) Purchaser shall have received each of the documents to be delivered to it pursuant to Section 2.2(a).

(d) The Company shall have executed and delivered this Agreement and the Collaboration Agreement, such agreements shall be in full force and effect.

(e) The holders of at least a majority of the shares of Common Stock that constitute Registrable Securities (as defined in the Existing IRA) shall have consented to the Company granting to the Purchaser the registration rights contained in Section 5.1 of this Agreement.

7.2 Conditions to Obligations of the Company at the Closing. At Closing, the obligation of the Company to sell and issue the Shares shall be subject to the satisfaction or the Company’s waiver, on or prior to the Closing Date, of each of the following conditions:

(a) Each of the representations and warranties of Purchaser contained in this Agreement shall be true and correct in all material respects.

(b) All covenants, agreements and conditions contained in this Agreement to be performed by Purchaser on or prior to the Closing Date shall have been performed or complied with in all material respects at or prior to the Closing Date.

(c) The Company shall have received each of the documents to be delivered to it pursuant to Section 2.2(b).

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(d) Purchaser shall have executed and delivered this Agreement and the Collaboration Agreement, such agreements shall be in full force and effect.

(e) The holders of at least a majority of the shares of Common Stock that constitute Registrable Securities shall have consented to the Company granting to the Purchaser the registration rights contained in Section 5.1 of this Agreement.

7.3 Conditions to Obligations of Each Party. At the Closing, the obligation of Purchaser to purchase the Shares and the obligation of the Company to sell and issue the Shares to be sold and issued at the Closing shall be subject to the satisfaction or waiver, on or prior to the Closing Date, of each of the following conditions:

(a) All statutory requirements for the valid consummation by the Parties of the transactions contemplated in this Agreement to be consummated at the Closing shall have been fulfilled, and all consents, authorizations, permits, waivers and approvals (including of all U.S. federal, state and local and non-U.S. governmental agencies and authorities) required to be obtained in order to permit the consummation by Parties of the transactions contemplated by this Agreement to be consummated at the Closing shall have been obtained.

(b) No action or claim shall be pending or threatened before any court or quasi-judicial or administrative agency of any federal, state, local or foreign jurisdiction or before any arbitrator wherein an unfavorable injunction, judgment, order, decree, ruling or charge would (i) prevent consummation of any of the transactions contemplated by this Agreement, (ii) cause any of the transactions contemplated by this Agreement to be rescinded following consummation or (iii) have the effect of making illegal the purchase of, or payment for, any of the Shares by Purchaser.

(c) There shall be no temporary restraining order, preliminary injunction or permanent injunction or other order preventing the consummation of the transaction contemplated by this Agreement to be completed at the Closing issued by any court that remains in effect.

8. TERMINATION

8.1 Termination. This Agreement may be terminated:

(a) at any time by the mutual written consent of the Company and Purchaser;

(b) by the Company, on the one hand, or Purchaser, on the other hand, by written notice to the other Party, if the Closing shall not have been consummated on or before September 18, 2009, unless the failure to consummate the Closing on or prior to such date is the result of a default under this Agreement by the Party seeking to terminate this Agreement pursuant to the terms of this Section 8.1(b);

(c) at any time by Purchaser upon written notice to the Company if (i) the Company fails to perform any of its covenants or agreements contained herein in any material respect and such breach shall not have been cured within twenty (20) business days of the delivery of written notice by Purchaser to the Company of such breach, or (ii) any of the conditions to Purchaser’s

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obligation to consummate the transactions provided for herein shall have become impossible to satisfy;

(d) by the Company upon written notice to Purchaser if (i) Purchaser fails to perform any of its covenants or agreements contained herein in any material respect and such breach shall not have been cured within twenty (20) business days of the delivery of written notice by the Company to Purchaser of such breach, or (ii) any of the conditions to the Company’s obligation to consummate the transactions provided for herein shall have become impossible to satisfy; and

(e) by Purchaser or the Company (the “Terminating Party”) if (i) any proceeding seeking liquidation, reorganization or other relief with respect to the other Party under any bankruptcy, insolvency or other similar Law now or hereafter in effect has not been dismissed within sixty (60) days after the commencement thereof, (ii) such other Party is adjudged as bankrupt or insolvent, or a final and non-appealable order for relief under any bankruptcy, insolvency or other similar Law now or hereafter in effect has been entered against such other Party, (iii) the other Party has filed a voluntary petition under any bankruptcy, insolvency or other similar Law or under the reorganization provisions of any such Law seeking liquidation, reorganization or other relief under any bankruptcy, insolvency or other similar Law now or hereafter in effect, (iv) the other Party executes and delivers a general assignment for the benefit of creditors, (v) the other Party seeks, consents to or acquiesces in the appointment of a trustee, receiver or liquidator for such other Party or for all or any substantial part of such other Party’s properties, (vi) the other Party files an answer or other pleading admitting or failing to contest the material allegations of a petition filed against such other Party in any proceeding of the nature described in clause (ii) above, (vii) the other Party is unable to confirm in writing that it is, following a request by the Terminating Party upon 48 hours notice (or otherwise indicates that it is not), able to pay its debts as they mature, (viii) the appointment without the other Party’s consent or acquiescence of a trustee, receiver or liquidator has not been vacated or stayed within ninety (90) days of such appointment, or (ix) an appointment referred to in clause (viii) above is not vacated within ninety (90) days after the expiration of any such stay.

8.2 Effect of Termination. In the event that this Agreement shall be terminated pursuant to Section 8.1, all further obligations of the parties hereto under this Agreement (other than pursuant to Section 10.9, which shall continue in full force and effect) shall terminate without further liability or obligation of either Party to the other Party hereunder; provided that, no Party shall be released from liability accrued hereunder prior to the date of termination.

9. SURVIVAL OF REPRESENTATIONS, WARRANTIES AND COVENANTS; INDEMNIFICATION

9.1 Survival. Each of the parties’ representations, warranties, covenants and agreements set forth in this Agreement shall survive the Closing for the full applicable statute of limitations.

9.2 Indemnity by the Company. The Company shall indemnify and hold Purchaser and its affiliates and its and their officers, directors and agents (the “Purchaser Indemnitees”) harmless from and against, and shall pay to Purchaser the full amount of, any loss, claim, damage, liability or expense (including reasonable attorneys’ fees) (hereafter referred to as a “Claim”) resulting to

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a Purchaser Indemnitee from any inaccuracy in any representation or warranty as of the Closing Date or any breach of any covenant or agreement, by the Company contained in this Agreement.

9.3 Indemnity by Purchaser. Purchaser shall indemnify and hold the Company harmless from and against, and shall pay to the Company and its affiliates and its and their officers, directors and agents (the “Company Indemnitees”) the full amount of, any Claim resulting to a Company Indemnitee from any inaccuracy in any representation or warranty, or any breach of any covenant or agreement, by Purchaser contained in this Agreement.

9.4 Remedies. Upon the occurrence of any event for which the Company or Purchaser is entitled to indemnification under this Agreement, such party shall have all the rights and remedies in Law and in equity available to it.

10. MISCELLANEOUS

10.1 Entire Agreement; Amendment. This Agreement constitutes the entire Agreement between the Parties with respect to the within subject matter and supersedes all previous Agreements, whether written or oral. This Agreement shall not be changed or modified orally, but only by an instrument in writing signed by both Parties.

10.2 Governing Law; Choice of Law. This Agreement and the validity, performance, construction and effect of this Agreement shall be governed in all respects by the laws of the State of Delaware, excluding its provisions governing the conflict of laws.

10.3 Assignment. This Agreement may not be assigned by either Party without the prior written consent of the other, except that, (a) Purchaser may assign this Agreement to an “affiliate” (as such term is defined in Rule 501(b) of Regulation D promulgated under the Securities Act) of Purchaser and (b) the Company may assign this Agreement to a party that acquires all or substantially all of the Company’s business, whether by merger, sale of assets or otherwise. A merger, consolidation or other reorganization shall be deemed to constitute an assignment. Any assignment in contravention of this Section 10.3 shall be void.

10.4 Notices. Any notices required or permitted hereunder shall be given to the appropriate Party at the address specified below or at such other address as the Party shall specify in writing. Such notice shall be in writing sent by: (i) certified mail, postage prepaid, return receipt requested; (ii) nationally recognized courier service; or (iii) facsimile. Notice shall be deemed given (a) if sent by certified mail, on the earlier of the date the return receipt is signed or on the third business day (fifth business day if sent internationally) after the notice is mailed; (b) if sent by nationally recognized courier service, on the day the notice is delivered according to the records of such courier service; or (c) if sent by facsimile, upon the date such notice is transmitted by facsimile, provided that such transmission is subsequently confirmed by a hard copy sent by nationally recognized courier service within twenty-four (24) hours of the transmission.

For Company:	Facet Biotech Corporation
	1500 Seaport Blvd.
	Redwood City, CA 94063

115

Attn: General Counsel

Facsimile: (650) 454-2000

with a copy to:

Cooley Godward Kronish LLP

Five Palo Alto Square

3000 El Camino Real

Palo Alto, CA 94306-2155

Attn: Glen Sato

Facsimile: (650) 849-7400

For Purchaser: Trubion Pharmaceuticals, Inc.

2401 4th Avenue

Suite 1050

Seattle, WA 98121

Attn: General Counsel

Facsimile: (206) 838-0503

with a copy to:

Fenwick & West LLP

1191 Second Avenue

10th Floor

Seattle, WA 98101

Attn: Alan C. Smith

Facsimile: (206) 389-4511

10.5 Waiver. The failure of either Party to assert a right hereunder or to insist upon compliance with any term or condition of this Agreement shall not constitute a waiver of that right or excuse a similar subsequent failure to perform any such term or condition by the other Party. None of the terms, covenants and conditions of this Agreement can be waived except by the written consent of the Party waiving compliance.

10.6 No Third-Party Beneficiary. This Agreement is for the benefit of, and may be enforced only by, the Company and Purchaser and their respective successors and permitted transferees and assignees, and is not for the benefit of, and may not be enforced by, any third party.

10.7 Finder’s Fees.

(a) The Company hereby agrees to indemnify and to hold Purchaser and its affiliates and agents harmless from and against any costs, expenses or liability for any commission or compensation in the nature of a finder’s fee to any investment banker, finder, broker or other person or firm (including legal fees and other costs and expense of defending against such liability or asserted liability) resulting from or arising out of acts or alleged acts of the Company, its affiliates or its or their representatives.

116

(b) Purchaser (i) represents and warrants that it has retained no investment bankers, finders or brokers in connection with the transactions contemplated by this Agreement and (ii) hereby agrees to indemnify and hold the Company harmless from and against any costs, expenses or liability for any commission or compensation in the nature of a finder’s fee to any investment banker, finder, broker or other person or firm (including legal fees and other costs and expense of defending against such liability or asserted liability) resulting from or arising out of acts or alleged acts of Purchaser, its affiliates or its or their representatives.

10.8 Expenses. The Company and Purchaser shall each bear its respective expenses and legal fees incurred with respect to the negotiation, execution, delivery and performance of this Agreement and the transactions contemplated hereby.

10.9 Counterparts. This Agreement may be executed in counterparts, all of which taken together shall be regarded as one and the same instrument. Execution and delivery of this Agreement by exchange of facsimile copies bearing the facsimile signature of a Party hereto shall constitute a valid and binding execution and delivery of this Agreement by such Party. Such facsimile copies shall constitute enforceable original documents.

10.10 Severability. If any provision of this Agreement is declared invalid by a court of last resort or by any court from the decision of which an appeal is not taken within the time provided by Law, then and in such event, this Agreement will be deemed to have been terminated only as to the portion thereof that relates to the provision invalidated by that decision, but this Agreement, in all other respects will remain in force; provided, however, that if the provision so invalidated is essential to this Agreement as a whole, then the Parties shall negotiate in good faith to amend the terms of this Agreement as nearly as practical to carry out the original intent of the Parties.

10.11 Time of the Essence. Time is of the essence for purposes of this Agreement.

10.12 Rules of Interpretation. Within this Agreement (a) a reference to any individual, firm, trust, corporation, partnership, limited liability company, governmental entity or business organization includes such entity’s permitted successors and permitted assigns; (b) the words “include,” “includes” and “including” are not limiting; (c) references to any document, instrument or agreement (i) shall include all exhibits, schedules and other attachments thereto, (ii) shall include all documents, instruments or agreements issued or executed in replacement thereof, and (iii) shall mean such document, instrument or agreement, or replacement thereof, as amended, modified and supplemented from time to time and in effect at any given time; (d) the words “hereof,” “herein” and “hereunder” and words of similar import when used shall refer to this Agreement as a whole and not to any particular provision of this Agreement; and (e) the headings used in this Agreement have been inserted for convenience only, and they are not intended to be a part of or to affect the meaning or interpretation of this Agreement.

(Signature page follows.)

117

Schedule 1.132 (Trubion Core Patent Rights)

TRBN Ref.	Country	App / Patent No.	Status
*[ ]**
[ * ]	[ * ]	[ * ]	[ * ]
[ * ]	[ * ]	[ * ]	[ * ]
[ * ]	[ * ]	[ * ]	[ * ]
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[ * ]	[ * ]	[ * ]	[ * ]
[ * ]	[ * ]	[ * ]	[ * ]
[ * ]	[ * ]	[ * ]	[ * ]

119

TRBN Ref.	Country	App / Patent No.	Status
[ * ]	[ * ]	[ * ]	[ * ]
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120

TRBN Ref.	Country	App / Patent No.	Status
[ * ]	[ * ]	[ * ]	[ * ]
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*[ ]**
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121

TRBN Ref.	Country	App / Patent No.	Status
[ * ]	[ * ]	[ * ]	[ * ]
[ * ]	[ * ]	[ * ]	[ * ]
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122

Schedule 1.134 (Trubion Product Patent Rights)

TRBN Ref.	Country	App / Patent No.	Status
*[ ]**
[ * ]	[ * ]	[ * ]	[ * ]
[ * ]	[ * ]	[ * ]	[ * ]
[ * ]	[ * ]	[ * ]	[ * ]
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123

Schedule 3.7 (Pre-existing Obligations)

· [ * ] Manufacturing Services Agreement, dated [ * ], as amended [ * ] and [ * ]

· [ * ] Research Evaluation Agreement, dated [ * ], as amended [ * ]

· [ * ] Supply Agreement, dated [ * ]

· [ * ] Services Agreement dated [ * ]

· [ * ] Quality Agreement, dated [ * ]

· [ * ] Development and Manufacturing Services Agreement, dated [ * ], as amended [ * ] and [ * ], and [ * ] dated [ * ].

· [ * ] Services Agreement, dated [ * ] and [ * ] (the “[ * ]”) [ * ] to the [ * ] dated [ * ] and [ * ] to the [ * ] dated [ * ].

· [ * ] Services Agreement dated [ * ] as amended [ * ]

· [ * ] Services Agreement dated [ * ], including [ * ] Agreement dated [ * ] (the “[ * ]”), [ * ] to the [ * ] dated [ * ]

· [ * ] Supply

· [ * ] Purchase Order [ * ]

· [ * ] Service Agreement dated [ * ]

· [ * ] Laboratory Services Agreement dated [ * ] and amended

· [ * ] Exemplar Quotes [ * ] and [ * ]

· [ * ] Agreement, dated [ * ] and [ * ] dated [ * ] and [ * ] dated [ * ]

· [ * ] Services Agreement dated [ * ] and [ * ]

· [ * ] Consulting Agreement dated [ * ]

· [ * ] Consulting Services Agreement dated [ * ]

· [ * ] Consulting Agreement dated [ * ]

· [ * ] Consulting Services Agreement dated [ * ] as amended by Amendment No. 1 dated [ * ]

· [ * ] Consulting Services Agreement dated [ * ] as amended [ * ]

· [ * ] Consulting Services Agreement dated [ * ]

· [ * ] Consulting Agreement dated [ * ]

· [ * ] Consulting Services Agreement dated [ * ]

· [ * ] Clinical Trial Agreement dated [ * ] as amended [ * ] and [ * ]

· [ * ] and [ * ] Clinical Trial Agreement dated [ * ] as amended [ * ]

· [ * ] Clinical Trial Agreement dated [ * ], 2008] as amended [ * ]

· [ * ] dated [ * ] as amended [ * ]

· [ * ] Clinical Trial Agreement dated [ * ]

124

FACET BIOTECH CORPORATION		TRUBION PHARMACEUTICALS, INC.


By	/s/ Faheem Hasnain	By	/s/ Peter A. Thompson

Name:	Faheem Hasnain	Name:	Peter A. Thompson

Title:	President and Chief Executive Officer	Title:	President and Chief Executive Officer

COMPANY:		PURCHASER:

TRUBION PHARMACEUTICALS, INC.		FACET BIOTECH CORPORATION


By:	/s/ Peter A. Thompson	By:	/s/ Faheem Hasnain
	Peter A. Thompson, M.D., FACP		Faheem Hasnain
	President and Chief Executive Officer		President and Chief Executive Officer

Exhibit A		— TRU-016 Description
Exhibit B		— Initial Development Plan
Exhibit C		— Stock Purchase Agreement

Schedule 1.132		— Trubion Core Patent Rights
Schedule 1.134		— Trubion Product Patent Rights
Schedule 3.7		— Pre-existing Obligations
Schedule 12.2		— Disclosure Schedule