ABEONA THERAPEUTICS INC COM NEW 00289Y206 3344710 746587 SH SOLE 746587 0 0 ABEONA THERAPEUTICS INC COM NEW 00289Y206 448000 100000 SH Call SOLE 100000 0 0 ACADIA PHARMACEUTICALS INC COM 004225108 2226000 100000 SH Call SOLE 100000 0 0 ADICET BIO INC COM NEW 007002207 1511514 221955 SH SOLE 221955 0 0 ADMA BIOLOGICS INC COM 000899104 6667400 740000 SH SOLE 740000 0 0 ADMA BIOLOGICS INC COM 000899104 10361500 1150000 SH Call SOLE 1150000 0 0 ALEXANDRIA REAL ESTATE EQ IN COM 015271109 2321000 50000 SH Call SOLE 50000 0 0 AN2 THERAPEUTICS INC COM 037326105 2441350 713845 SH SOLE 713845 0 0 ARDELYX INC COM 039697107 898500 150000 SH Call SOLE 150000 0 0 ARVINAS INC COM 04335A105 291500 27500 SH SOLE 27500 0 0 AYTU BIOPHARMA INC COM 054754858 2162949 792289 SH SOLE 792289 0 0 BIOAGE LABS INC COM 09077V100 874500 50000 SH SOLE 50000 0 0 BIOATLA INC COM 09077B104 10527 65387 SH SOLE 65387 0 0 BOUNDLESS BIO INC COM 10170A100 657450 597682 SH SOLE 597682 0 0 CABALETTA BIO INC COM 12674W109 134500 50000 SH SOLE 50000 0 0 CAMP4 THERAPEUTICS CORP COM 13463J101 6128233 1389622 SH SOLE 1389622 0 0 CANDEL THERAPEUTICS INC COM 137404109 502250 102500 SH SOLE 102500 0 0 CNS PHARMACEUTICALS INC COM 18978H508 145790 61000 SH SOLE 61000 0 0 CODEXIS INC COM 192005106 681330 417994 SH SOLE 417994 0 0 COMPUGEN LTD ORD M25722105 222159 104300 SH SOLE 104300 0 0 CONNECT BIOPHARMA HLDGS LTD SHS G23549101 812200 310000 SH SOLE 310000 0 0 CORBUS PHARMACEUTICALS HLDGS COM NEW 21833P301 3600708 383462 SH SOLE 383462 0 0 CRESCENT BIOPHARMA INC. COM G2545C104 1561450 85000 SH SOLE 85000 0 0 CURIS INC COM 231269309 2039462 3726406 SH SOLE 3726406 0 0 CYBIN INC COM NEW 23256X407 643488 134060 SH SOLE 134060 0 0 CYTOMX THERAPEUTICS INC. COM 23284F105 940000 200000 SH Call SOLE 200000 0 0 CYTOMX THERAPEUTICS INC. COM 23284F105 940000 200000 SH SOLE 200000 0 0 DELCATH SYS INC COM NEW 24661P807 928000 100000 SH Call SOLE 100000 0 0 EDESA BIOTECH INC COM NEW 27966L306 156900 30000 SH SOLE 30000 0 0 ELEDON PHARMACEUTICALS INC COM 28617K101 107800 35000 SH SOLE 35000 0 0 ESTABLISHMENT LABS HLDGS INC COM G31249108 2839000 50000 SH Call SOLE 50000 0 0 ESTABLISHMENT LABS HLDGS INC COM G31249108 340680 6000 SH SOLE 6000 0 0 EVAXION AS SPONSORED ADS 29970R303 73332 19713 SH SOLE 19713 0 0 EVOLUS INC COM 30052C107 7229864 1759091 SH SOLE 1759091 0 0 EVOLUS INC COM 30052C107 1726200 420000 SH Call SOLE 420000 0 0 HERON THERAPEUTICS INC COM 427746102 1121893 1402191 SH SOLE 1402191 0 0 HERON THERAPEUTICS INC COM 427746102 800100 1000000 SH Call SOLE 1000000 0 0 IN8BIO INC COM NEW 45674E208 981850 663412 SH SOLE 663412 0 0 INHIBIKASE THERAPEUTICS INC COM NEW 45719W205 1608099 957202 SH SOLE 957202 0 0 JANUX THERAPEUTICS INC COM 47103J105 278000 20000 SH SOLE 20000 0 0 KALARIS THERAPEUTICS INC COM 482929106 117708 20400 SH SOLE 20400 0 0 KAZIA THERAPEUTICS LTD SPONSORED ADS 48669G303 2568132 345179 SH SOLE 345179 0 0 MANNKIND CORP COM NEW 56400P706 1225000 500000 SH Call SOLE 500000 0 0 MANNKIND CORP COM NEW 56400P706 39935 16300 SH SOLE 16300 0 0 MAXCYTE INC COM 57777K106 705783 1004673 SH SOLE 1004673 0 0 NEKTAR THERAPEUTICS COM NEW 640268306 6115750 85000 SH SOLE 85000 0 0 NEUMORA THERAPEUTICS INC. COM 640979100 975000 500000 SH Call SOLE 500000 0 0 NEUMORA THERAPEUTICS INC. COM 640979100 195000 100000 SH SOLE 100000 0 0 OKYO PHARMA LTD SHS NEW G6724L116 1368500 850000 SH SOLE 850000 0 0 OMNIAB INC COM 68218J103 257551 164045 SH SOLE 164045 0 0 ONKURE THERAPEUTICS INC COM CL A 68277Q105 548873 132578 SH SOLE 132578 0 0 OPUS GENETICS INC COM 67577R102 312530 68688 SH SOLE 68688 0 0 OVID THERAPEUTICS INC COM 690469101 88800 40000 SH SOLE 40000 0 0 PASITHEA THERAPEUTICS CORP COM NEW 70261F202 616659 831301 SH SOLE 831301 0 0 PHATHOM PHARMACEUTICALS INC COM 71722W107 555611 50010 SH SOLE 50010 0 0 PLIANT THERAPEUTICS INC COM 729139105 283059 224650 SH SOLE 224650 0 0 PMV PHARMACEUTICALS INC COM 69353Y103 878046 708102 SH SOLE 708102 0 0 PRECISION OPTICS CORP INC MA COM NEW 740294400 439000 100000 SH SOLE 100000 0 0 PROCESSA PHARMACEUTICALS INC COM SHS 74275C403 138875 55000 SH SOLE 55000 0 0 PULMONX CORP COM 745848101 991092 768288 SH SOLE 768288 0 0 QUOIN PHARMACEUTICALS LTD SPONSORED ADS 74907L409 352836 53460 SH SOLE 53460 0 0 RADIOPHARM THERANOSTICS LTD SPONSORED ADS 75041J101 738977 51000000 SH SOLE 51000000 0 0 SAB BIOTHERAPEUTICS INC COM NEW 78397T202 191500 50000 SH SOLE 50000 0 0 SATELLOS BIOSCIENCE INC COM 80401L803 563000 100000 SH SOLE 100000 0 0 SI BONE INC COM 825704109 1263000 100000 SH Call SOLE 100000 0 0 SI BONE INC COM 825704109 188995 14964 SH SOLE 14964 0 0 SOL-GEL TECHNOLOGIES LTD SHS NEW M8694L137 2200573 27778 SH SOLE 27778 0 0 SPDR SERIES TRUST STATE STREET SPD 78464A870 51092000 400000 SH Put SOLE 400000 0 0 SPDR SERIES TRUST STATE STREET SPD 78464A870 51092000 400000 SH Call SOLE 400000 0 0 SURROZEN INC COM NEW 86889P208 961436 33005 SH SOLE 33005 0 0 TELA BIO INC COM 872381108 1622696 2617252 SH SOLE 2617252 0 0 TENAX THERAPEUTICS INC COM NEW 88032L605 15593448 975200 SH SOLE 975200 0 0 TERNS PHARMACEUTICALS INC COM 880881107 5272000 100000 SH Call SOLE 100000 0 0 UPSTREAM BIO INC COM 91678A107 315000 35000 SH SOLE 35000 0 0 VERASTEM INC COM NEW 92337C203 17502190 3302300 SH SOLE 3302300 0 0 VERRICA PHARMACEUTICALS INC COM SHS 92511W207 527598 99735 SH SOLE 99735 0 0 X4 PHARMACEUTICALS INC COM NEW 98420X202 1384826 335309 SH SOLE 335309 0 0 XERIS BIOPHARMA HOLDINGS INC COM 98422E103 1624000 280000 SH Call SOLE 280000 0 0 XERIS BIOPHARMA HOLDINGS INC COM 98422E103 232174 40030 SH SOLE 40030 0 0 XILIO THERAPEUTICS INC COM NEW 98422T209 539602 64162 SH SOLE 64162 0 0 XOMA ROYALTY CORPORATION COM NEW 98419J206 2180215 69500 SH SOLE 69500 0 0 ZENTALIS PHARMACEUTICALS INC COM 98943L107 629694 269100 SH SOLE 269100 0 0 ZEVRA THERAPEUTICS INC COM NEW 488445206 4473600 480000 SH SOLE 480000 0 0