X0303 4 2010-06-17 0001003124 PHARMACEUTICAL PRODUCT DEVELOPMENT INC PPDI 0001440766 Dingivan Christine A 929 NORTH FRONT STREET WILMINGTON NC 28401 0 1 0 0 EVP/Chief Medical Officer Stock Option (to buy) 26.64 2010-06-17 4 A 0 20000 0 A 2011-06-17 2020-06-17 Common Stock 20000 20000 D Stock Option (to buy) 20.45 2011-02-25 2020-02-25 Common Stock 41403 41403 D Stock Options (to buy) 25.74 2010-02-18 2019-02-18 Common Stock 31052 31052 D Stock Options (to buy) 19.94 2009-11-20 2018-11-20 Common Stock 7763 7763 D Stock Options (to buy) 37.69 2009-10-03 2018-10-03 Common Stock 7763 7763 D Stock Options (to buy) 36.65 2009-07-28 2018-07-28 Common Stock 93156 93156 D The options will vest in equal increments of 1/3 on June 17, 2011, June 17 2012 and June 17, 2013. Exercise price and share amounts reflect an anti-dilution adjustment made in connection with the June 14, 2010 spin-off of Furiex Pharmaceuticals, Inc. The options will vest in equal increments of 1/3 on February 25, 2011, February 25, 2012 and February 25, 2013. The options will vest in equal increments of 1/3 on February 18, 2010, February 18, 2011 and February 18, 2012. The options will vest in equal increments of 1/3 on November 20, 2009, November 20, 2010 and November 20, 2011. The options will vest in equal increments of 1/3 on October 3, 2009, October 3, 2010 and October 3, 2011. The options vest in equal increments of 1/3 on July 28, 2009, July 28, 2010 and July 28, 2011. Lisa C. Noecker attorney-in-fact for Christine A. Dingivan 2010-06-18