Income Taxes - Schedule of Deferred Tax Assets (Liabilities) (Detail) - USD ($) $ in Thousands	Dec. 31, 2016	Dec. 31, 2015
Deferred tax assets:
Net operating loss carryforwards	$ 53,474	$ 44,551
Tax credit carryforwards	52,564	47,978
Acquired intangible assets	22,714	13,524
Equity based compensation	16,087	24,930
Accrued expenses	8,605	11,593
Other accrued compensation	5,059	1,664
Charitable contributions	4,495	3,930
State taxes	3,168	2,321
Deferred revenue	481	1,309
Other		434
Valuation allowance	(164,907)	(151,808)
Net deferred tax assets	1,740	426
Deferred tax liabilities:
Deferred rent	(69)	(675)
Depreciation	(7,215)	(5,777)
Other	(247)
Net deferred tax liabilities	(7,531)	(6,452)
Net deferred taxes	$ (5,791)	$ (6,026)