X0306 4 2015-12-21 0 0001493566 Otonomy, Inc. OTIC 0001439275 LeBel Carl C/O OTONOMY, INC. 6275 NANCY RIDGE DRIVE, SUITE 100 SAN DIEGO CA 92121 0 1 0 0 Chief Scientific Officer Common Stock 2015-12-21 4 M 0 16576 6.33 A 25496 D Common Stock 2015-12-21 4 M 0 4674 3.17 A 30170 D Common Stock 2015-12-21 4 S 0 13189 27.8318 D 16981 D Common Stock 2015-12-21 4 S 0 8061 28.3778 D 8920 D Employee stock option (right to buy) 6.33 2015-12-21 4 M 0 16576 0.00 D 2024-06-30 Common Stock 16576 51380 D Employee stock option (right to buy) 3.17 2015-12-21 4 M 0 4674 0.00 D 2020-11-19 Common Stock 4674 25189 D The sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan. The sale price reported in Column 4 of Table I represents the weighted average sale price of the shares sold ranging from $27.22 to $28.21 per share. Upon request by the Commission staff, the Issuer, or a security holder of the Issuer, the Reporting Person will provide full information regarding the number of shares sold at each separate price. The sale price reported in Column 4 of Table I represents the weighted average sale price of the shares sold ranging from $28.22 to $29.04 per share. Upon request by the Commission staff, the Issuer, or a security holder of the Issuer, the Reporting Person will provide full information regarding the number of shares sold at each separate price. One-fourth of the shares subject to the option vested on April 23, 2015 and one forty-eighth of the shares vest monthly thereafter. In addition to the options to purchase 21,250 shares of common stock as set forth in Table II, the Reporting Person currently holds options to purchase up to an aggregate of 280,781 shares of common stock, which options vest according to their terms. One-fourth of the shares subject to the option vested on November 19, 2011 and one forty-eighth of the shares vested monthly thereafter. /s/ Eric J. Loumeau, by power of attorney 2015-12-22